List of works - Ruby H Law

A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent

scientific article published on 18 September 2018

A common fold mediates vertebrate defense and bacterial attack

scientific article

A mechanism for hereditary angioedema caused by a lysine 311–to–glutamic acid substitution in plasminogen

scientific article published on 31 January 2022

A structural basis for loop C-sheet polymerization in serpins

scientific article

ATP synthase from Saccharomyces cerevisiae

scientific article published on 01 January 1995

An overview of the serpin superfamily

scientific article

Antibodies: From novel repertoires to defining and refining the structure of biologically important targets.

scientific article

Assembly of imported subunit 8 into the ATP synthase complex of isolated yeast mitochondria

scientific article published on 01 March 1990

COOH-Terminal Clustering of Autoantibody and T-Cell Determinants on the Structure of GAD65 Provide Insights Into the Molecular Basis of Autoreactivity

scientific article published on 09 January 2008

Cloning and expression of the major secreted cathepsin B-like protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection.

scientific article

Comparative expression and purification of human glutamic acid decarboxylase from Saccharomyces cerevisiae and Pichia pastoris.

scientific article published in June 2000

Conformational changes during pore formation by the perforin-related protein pleurotolysin

scientific article (publication date: February 2015)

Contribution of Conserved Lysine Residues in the α2-Antiplasmin C Terminus to Plasmin Binding and Inhibition ⬇️

scientific article published on May 4, 2011

Defining the interaction of perforin with calcium and the phospholipid membrane

scientific article

Development and application of a fecal antigen diagnostic sandwich ELISA for estimating prevalence of Fasciola gigantica in cattle in central Java, Indonesia

scientific article

Dimerization is not a determining factor for functional high affinity human plasminogen binding by the group A streptococcal virulence factor PAM and is mediated by specific residues within the PAM a1a2 domain.

scientific article

Expression in Saccharomyces cerevisiae of antigenically and enzymatically active recombinant glutamic acid decarboxylase.

scientific article published in March 1998

GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop

scientific article

High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster

scientific article

Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma

scientific article published in Nature Communications

Managing and mining protein crystallization data.

scientific article

Molecular genetic analysis of the central hydrophobic domain of subunit 8 of yeast mitochondrial ATP synthase

scientific article

Molecular pathogenesis of plasminogen Hakodate: the second Japanese family case of severe type I plasminogen deficiency manifested late-onset multi-organic chronic pseudomembranous mucositis.

scientific article

New insights into the structure and function of the plasminogen/plasmin system.

scientific article

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.

scientific article published on 7 February 2018

Perforin-A key (shaped) weapon in the immunological arsenal.

scientific article

Preferential Acquisition and Activation of Plasminogen Glycoform II by PAM Positive Group A Streptococcal Isolates.

scientific article

Prodepth: predict residue depth by support vector regression approach from protein sequences only

scientific article

Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite.

scientific article

Reconciling the Structural Attributes of Avian Antibodies

scientific article

Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation

scientific article published on 14 August 2017

Serpins in Prokaryotes

Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes

scientific article

Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates

scientific article

Structural mechanisms of inactivation in scabies mite serine protease paralogues

scientific article

Structural studies of plasmin inhibition

scientific article published on 05 March 2019

Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding

scientific article published on 08 July 2019

Structure of granzyme C reveals an unusual mechanism of protease autoinhibition

scientific article

Structure of the poly-C9 component of the complement membrane attack complex

scientific journal article

Structure/function analysis of yeast mitochondrial ATP synthase subunit 8.

scientific article

Studies on the import into mitochondria of yeast ATP synthase subunits 8 and 9 encoded by artificial nuclear genes

scientific article published on 01 August 1988

The C-terminal positively charged region of subunit 8 of yeast mitochondrial ATP synthase is required for efficient assembly of this subunit into the membrane F0 sector ⬇️

scientific article published on July 1, 1991

The N terminus of the serpin, tengpin, functions to trap the metastable native state

scientific article

The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates

scientific article

The X-Ray Crystal Structure of Escherichia coli Succinic Semialdehyde Dehydrogenase; Structural Insights into NADP+/Enzyme Interactions

scientific article

The X-ray crystal structure of full-length human plasminogen

scientific article

The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1

scientific article published on 19 September 2019

The crystal structure of the transthyretin-like protein from Salmonella dublin, a prokaryote 5-hydroxyisourate hydrolase.

scientific article published on 11 May 2006

The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins

scientific article

The structure and function of mammalian membrane-attack complex/perforin-like proteins.

scientific article published on 22 September 2010

Tranexamic acid is an active site inhibitor of urokinase plasminogen activator

scientific article published on 01 March 2019

X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors

scientific article published on 09 May 2017

X-ray crystal structure of the fibrinolysis inhibitor alpha2-antiplasmin

scientific article

X-ray crystal structure of the streptococcal specific phage lysin PlyC. ⬇️

scientific article

List of works by Ruby H Law

A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent

A common fold mediates vertebrate defense and bacterial attack

A mechanism for hereditary angioedema caused by a lysine 311–to–glutamic acid substitution in plasminogen

A structural basis for loop C-sheet polymerization in serpins

ATP synthase from Saccharomyces cerevisiae

An overview of the serpin superfamily

Antibodies: From novel repertoires to defining and refining the structure of biologically important targets.

Assembly of imported subunit 8 into the ATP synthase complex of isolated yeast mitochondria

COOH-Terminal Clustering of Autoantibody and T-Cell Determinants on the Structure of GAD65 Provide Insights Into the Molecular Basis of Autoreactivity

Cloning and expression of the major secreted cathepsin B-like protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection.

Comparative expression and purification of human glutamic acid decarboxylase from Saccharomyces cerevisiae and Pichia pastoris.

Conformational changes during pore formation by the perforin-related protein pleurotolysin

Contribution of Conserved Lysine Residues in the α2-Antiplasmin C Terminus to Plasmin Binding and Inhibition ⬇️

Defining the interaction of perforin with calcium and the phospholipid membrane

Development and application of a fecal antigen diagnostic sandwich ELISA for estimating prevalence of Fasciola gigantica in cattle in central Java, Indonesia

Dimerization is not a determining factor for functional high affinity human plasminogen binding by the group A streptococcal virulence factor PAM and is mediated by specific residues within the PAM a1a2 domain.

Expression in Saccharomyces cerevisiae of antigenically and enzymatically active recombinant glutamic acid decarboxylase.

GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop

High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster

Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma

Managing and mining protein crystallization data.

Molecular genetic analysis of the central hydrophobic domain of subunit 8 of yeast mitochondrial ATP synthase

Molecular pathogenesis of plasminogen Hakodate: the second Japanese family case of severe type I plasminogen deficiency manifested late-onset multi-organic chronic pseudomembranous mucositis.

New insights into the structure and function of the plasminogen/plasmin system.

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.

Perforin-A key (shaped) weapon in the immunological arsenal.

Preferential Acquisition and Activation of Plasminogen Glycoform II by PAM Positive Group A Streptococcal Isolates.

Prodepth: predict residue depth by support vector regression approach from protein sequences only

Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite.

Reconciling the Structural Attributes of Avian Antibodies

Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation

Serpins in Prokaryotes

Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes

Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates

Structural mechanisms of inactivation in scabies mite serine protease paralogues

Structural studies of plasmin inhibition

Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding

Structure of granzyme C reveals an unusual mechanism of protease autoinhibition

Structure of the poly-C9 component of the complement membrane attack complex

Structure/function analysis of yeast mitochondrial ATP synthase subunit 8.

Studies on the import into mitochondria of yeast ATP synthase subunits 8 and 9 encoded by artificial nuclear genes

The C-terminal positively charged region of subunit 8 of yeast mitochondrial ATP synthase is required for efficient assembly of this subunit into the membrane F0 sector ⬇️

The N terminus of the serpin, tengpin, functions to trap the metastable native state

The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates

The X-Ray Crystal Structure of Escherichia coli Succinic Semialdehyde Dehydrogenase; Structural Insights into NADP+/Enzyme Interactions

The X-ray crystal structure of full-length human plasminogen

The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1

The crystal structure of the transthyretin-like protein from Salmonella dublin, a prokaryote 5-hydroxyisourate hydrolase.

The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins

The structure and function of mammalian membrane-attack complex/perforin-like proteins.

Tranexamic acid is an active site inhibitor of urokinase plasminogen activator

X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors

X-ray crystal structure of the fibrinolysis inhibitor alpha2-antiplasmin

X-ray crystal structure of the streptococcal specific phage lysin PlyC. ⬇️