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List of works by Christopher Langendorf

1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors.

scientific article

AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965.

scientific article published on 25 April 2018

ATP sensitive bi-quinoline activator of the AMP-activated protein kinase.

scientific article published on 8 December 2013

An Analysis of the Cross-Reactivity of Autoantibodies to GAD65 and GAD67 in Diabetes ⬇️

scientific article published on April 8, 2011

Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder

scientific article

CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins

scientific article published on 09 September 2020

Choreography of AMPK activation.

scientific article published on 5 December 2014

Conformational change in the chromatin remodelling protein MENT

scientific article

Fake Inhibitors: AMPK Activation Trumps Inhibition

scientific article published in July 2017

Functional analysis of an R311C variant of Ca2+ -calmodulin-dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder

scientific article published on 25 March 2020

GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop

scientific article

In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds

scientific article published on 13 January 2020

Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release.

scientific article published on June 2015

Protein kinase A negatively regulates VEGF-induced AMPK activation by phosphorylating CaMKK2 at serine 495

scientific article published on 01 September 2020

Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling.

scientific article

Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4.

scientific article published on 7 April 2018

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

scientific article published on 8 March 2016

Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates

scientific article

Structural mechanisms of inactivation in scabies mite serine protease paralogues

scientific article

The X-Ray Crystal Structure of Escherichia coli Succinic Semialdehyde Dehydrogenase; Structural Insights into NADP+/Enzyme Interactions

scientific article

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

scientific article published on 18 September 2017

Visualizing AMPK Drug Binding Sites Through Crystallization of Full-Length Phosphorylated α2β1γ1 Heterotrimer

scientific article published on 01 January 2018

X-ray crystal structure of the fibrinolysis inhibitor alpha2-antiplasmin

scientific article

mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress

scientific article published on 20 January 2020

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