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List of works by C. Ryan Miller

ARID1A-deficient bladder cancer is dependent on PI3K signaling and sensitive to EZH2 and PI3K inhibitors

scientific article published in 2022

ASC deficiency suppresses proliferation and prevents medulloblastoma incidence

scientific article published on 27 January 2014

An animal model of MYC-driven medulloblastoma

scientific article published on February 2012

An in vivo model of glioblastoma radiation resistance identifies long noncoding RNAs and targetable kinases

scientific article published in 2022

Application of molecular biology studies to gene therapy treatment strategies.

scientific article

Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling.

scientific article published on 13 March 2018

Cancer gene therapy

article

Cerebellar granule neuron progenitors are the source of Hk2 in the postnatal cerebellum.

scientific article published on 11 June 2013

ClearCode34: A prognostic risk predictor for localized clear cell renal cell carcinoma

scientific article

Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma.

scientific article published on 30 March 2017

Combined kinase inhibitors of MEK1/2 and either PI3K or PDGFR are efficacious in intracranial triple-negative breast cancer.

scientific article published on 9 May 2017

Contemporary murine models in preclinical astrocytoma drug development

scientific article

Copy-number analysis of topoisomerase and thymidylate synthase genes in frozen and FFPE DNAs of colorectal cancers

scientific article published on October 2008

Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide.

scientific article published on 28 January 2016

Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma.

scientific article

Delta24-hyCD adenovirus suppresses glioma growth in vivo by combining oncolysis and chemosensitization.

scientific article

Development of DNA damage response signaling biomarkers using automated, quantitative image analysis

scientific article published on 05 December 2013

Differential pathogenesis of lung adenocarcinoma subtypes involving sequence mutations, copy number, chromosomal instability, and methylation

scientific article (publication date: 2012)

Effects of tumor microenvironment heterogeneity on nanoparticle disposition and efficacy in breast cancer tumor models

scientific article

Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer

scientific article

Erratum: Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation

scientific article published on 01 July 2015

Erythropoietin promotes breast tumorigenesis through tumor-initiating cell self-renewal

scientific article published on 02 January 2014

Gene expression profiling of gliomas: merging genomic and histopathological classification for personalised therapy.

scientific article

Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer.

scientific article

Genomic profiles of low-grade murine gliomas evolve during progression to glioblastoma.

scientific article published on 7 April 2017

Gray zones in brain tumor classification: evolving concepts.

scientific article published on September 2008

HIF1α and HIF2α independently activate SRC to promote melanoma metastases

scientific article

Hematopoietic Stem cell transplantation and lentiviral vector-based gene therapy for Krabbe's disease: Present convictions and future prospects.

scientific article

Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma

scientific article published on 23 January 2013

High XRCC1 protein expression is associated with poorer survival in patients with head and neck squamous cell carcinoma.

scientific article published on 09 September 2011

IL-11 Induces Encephalitogenic Th17 Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

scientific article published on 24 July 2019

IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma

scientific article published on May 2015

In Situ Hybridization

2014 article

Intra-cavity stem cell therapy inhibits tumor progression in a novel murine model of medulloblastoma surgical resection

scientific article published in PLoS ONE

Intrinsic Astrocyte Heterogeneity Influences Tumor Growth in Glioma Mouse Models

scientific article published on 13 January 2016

LCCC 1025: a phase II study of everolimus, trastuzumab, and vinorelbine to treat progressive HER2-positive breast cancer brain metastases

scientific article published on 25 June 2018

LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma

scientific article published on June 2012

MERTK receptor tyrosine kinase is a therapeutic target in melanoma.

scientific article

Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases.

scientific article published on 29 April 2008

MerTK as a therapeutic target in glioblastoma.

scientific article published on 12 June 2017

Modeling astrocytoma pathogenesis in vitro and in vivo using cortical astrocytes or neural stem cells from conditional, genetically engineered mice

scientific article published on 12 August 2014

PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition

scientific article published in PLoS ONE

Pharmacokinetics and efficacy of PEGylated liposomal doxorubicin in an intracranial model of breast cancer.

scientific article

Pharmacokinetics and efficacy of doxorubicin-loaded plant virus nanoparticles in preclinical models of cancer

scientific article published on 27 September 2017

Putting "multiforme" back into glioblastoma: intratumoral transcriptome heterogeneity is a consequence of its complex morphology.

scientific article published on 23 August 2017

Ras-mediated modulation of pyruvate dehydrogenase activity regulates mitochondrial reserve capacity and contributes to glioblastoma tumorigenesis.

scientific article

Reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model.

scientific article published on 13 June 2016

Recent developments and future directions in adult lower-grade gliomas: Society for Neuro-Oncology (SNO) and European Association of Neuro-Oncology (EANO) consensus

scientific article published on 01 July 2019

Risk of recurrence of resected stage I non-small cell lung cancer in elderly patients as compared with younger patients.

scientific article published in November 2009

Significance of necrosis in grading of oligodendroglial neoplasms: a clinicopathologic and genetic study of newly diagnosed high-grade gliomas.

scientific article published in December 2006

Sustained Delivery of Doxorubicin via Acetalated Dextran Scaffold Prevents Glioblastoma Recurrence after Surgical Resection.

scientific article published on 17 January 2018

The Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation.

scientific article

The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation

scientific article published on May 2017

Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma.

scientific article

Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process

scientific article

Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy.

scientific article published on 13 November 2006

Tryptase staining of mast cells may differentiate eosinophilic esophagitis from gastroesophageal reflux disease ⬇️

scientific article published on October 26, 2010

Tryptophan Metabolism Contributes to Radiation-Induced Immune Checkpoint Reactivation in Glioblastoma.

scientific article

Tumor-homing cytotoxic human induced neural stem cells for cancer therapy.

scientific article published in February 2017

Where are we now? And where are we going? A report from the Accelerate Brain Cancer Cure (ABC2) low-grade glioma research workshop.

scientific article published on 04 December 2013

αB-crystallin: a novel regulator of breast cancer metastasis to the brain

scientific article

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