List of works - Robert J Gilbert

Application of In-Fusion™ cloning for the parallel construction of E. coli expression vectors.

scientific article

Biophysical Analysis of Kindlin-3 Reveals an Elongated Conformation and Maps Integrin Binding to the Membrane-distal β-Subunit NPXY Motif ⬇️

scientific article published on September 18, 2012

Biophysical Approaches to Protein Folding and Disease, a satellite meeting to the IUPAB-EBSA congress

article

Cholesterol-dependent cytolysins.

scientific article published on January 2010

Classification and three-dimensional reconstruction of unevenly distributed or symmetry mismatched features of icosahedral particles.

scientific article published on 19 April 2005

Crystal structure of a soluble CD28-Fab complex

scientific article

DNA-templated protein arrays for single-molecule imaging

scientific article

Direct observation of distinct A/P hybrid-state tRNAs in translocating ribosomes.

scientific article

Domain Metastability: A Molecular Basis for Immunoglobulin Deposition?

scientific article

Dual interaction of JAM-C with JAM-B and alpha(M)beta2 integrin: function in junctional complexes and leukocyte adhesion

scientific journal article

Effects of MACPF/CDC proteins on lipid membranes.

scientific article

Efficient production and purification of recombinant murine kindlin-3 from insect cells for biophysical studies.

scientific article published on 19 March 2014

Glucocerebrosidase rescues alpha-synuclein from amyloid formation

Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling

scientific article published on 09 December 2021

Human perforin employs different avenues to damage membranes

scientific article

Hybrid vigor: hybrid methods in viral structure determination

scientific article

Improved crystallization and diffraction of caffeine-induced death suppressor protein 1 (Cid1).

scientific article published on 21 February 2015

Inactivation and activity of cholesterol-dependent cytolysins: what structural studies tell us.

scientific article

Incomplete pneumolysin oligomers form membrane pores.

scientific article published on 23 April 2014

Initiation of T cell signaling by CD45 segregation at 'close contacts'

scientific article (publication date: May 2016)

Measuring kinetic drivers of pneumolysin pore structure.

scientific article published on 23 February 2016

Membrane pore formation at protein-lipid interfaces

scientific article

Membrane pores: from structure and assembly, to medicine and technology

scientific article

O-glycan sialylation and the structure of the stalk-like region of the T cell co-receptor CD8.

scientific article

Oligomerisation of pneumolysin on cholesterol crystals: similarities to the behaviour of polyene antibiotics.

scientific article

Optimal translational termination requires C4 lysyl hydroxylation of eRF1.

scientific article published on 30 January 2014

Peptidoglycan recognition protein-SD provides versatility of receptor formation in Drosophila immunity.

scholarly article

Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes.

scientific article

Picornavirus uncoating intermediate captured in atomic detail

scientific article

Protein-lipid interactions and non-lamellar lipidic structures in membrane pore formation and membrane fusion.

scientific article

Reconfiguration of yeast 40S ribosomal subunit domains by the translation initiation multifactor complex.

scholarly article

Repurposing a pore: highly conserved perforin-like proteins with alternative mechanisms.

scientific article published on August 2017

Ribosomal acrobatics in post-transcriptional control.

scientific article published on August 2008

Signaling lymphocytic activation molecule (CDw150) is homophilic but self-associates with very low affinity.

scientific article

Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly.

scientific article

Spacer-length dependence of programmed −1 or −2 ribosomal frameshifting on a U 6 A heptamer supports a role for messenger RNA (mRNA) tension in frameshifting ⬇️

scientific article published on June 28, 2012

Structural Basis for Plexin Activation and Regulation

scientific article

Structural and Functional Characterization of the Kindlin-1 Pleckstrin Homology Domain

scientific article

Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin

scientific article

Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76

scientific article (publication date: 2 June 2003)

Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase

scientific article

Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2

scientific article

Structural basis of pore formation by cholesterol-binding toxins.

scientific article published on October 2000

Structural features of cholesterol dependent cytolysins and comparison to other MACPF-domain containing proteins

scientific article published on January 2014

Structural investigations of pneumolysin/lipid complexes.

scientific article

Structural plasticity of Cid1 provides a basis for its distributive RNA terminal uridylyl transferase activity.

scientific article published on 20 February 2015

Structural transitions of the conserved and metastable hantaviral glycoprotein envelope

scientific article

Structure and functional analysis of the IGF-II/IGF2R interaction

scientific article

Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain ⬇️

scientific article published on 14 December 2016

Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity

scientific article published on 29 January 2020

Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development

scientific article published on 4 May 2016

Structure of the Repulsive Guidance Molecule (RGM)-Neogenin Signaling Hub

scientific article

Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function

scientific article

Structures of Lysenin Reveal a Shared Evolutionary Origin for Pore-Forming Proteins And Its Mode of Sphingomyelin Recognition

scientific article

Structures of monomeric and oligomeric forms of the Toxoplasma gondii perforin-like protein 1.

scientific article published on 21 March 2018

Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity to accommodate foreign proteins ⬇️

scientific article published on April 2015

The communication, development, and promotion of biophysical science in a European and international context.

scientific article published on 21 December 2015

The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus.

scientific article published on July 2006

The histone H3K4 demethylase JARID1A directly interacts with haematopoietic transcription factor GATA1 in erythroid cells through its second PHD domain

scientific article published on 29 January 2020

The mechanics of translocation: a molecular "spring-and-ratchet" system.

scientific article published on May 2008

The nsp9 replicase protein of SARS-coronavirus, structure and functional insights

scientific article

The role of cholesterol in the activity of pneumolysin, a bacterial protein toxin.

scientific article published on May 2004

The structure of CrgA from Neisseria meningitidis reveals a new octameric assembly state for LysR transcriptional regulators

scientific article

Three distinct ribosome assemblies modulated by translation are the building blocks of polysomes

scientific article

Use of the α-mannosidase I inhibitor kifunensine allows the crystallization of apo CTLA-4 homodimer produced in long-term cultures of Chinese hamster ovary cells.

scientific article

List of works by Robert J Gilbert

Application of In-Fusion™ cloning for the parallel construction of E. coli expression vectors.

Biophysical Analysis of Kindlin-3 Reveals an Elongated Conformation and Maps Integrin Binding to the Membrane-distal β-Subunit NPXY Motif ⬇️

Biophysical Approaches to Protein Folding and Disease, a satellite meeting to the IUPAB-EBSA congress

Cholesterol-dependent cytolysins.

Classification and three-dimensional reconstruction of unevenly distributed or symmetry mismatched features of icosahedral particles.

Crystal structure of a soluble CD28-Fab complex

DNA-templated protein arrays for single-molecule imaging

Direct observation of distinct A/P hybrid-state tRNAs in translocating ribosomes.

Domain Metastability: A Molecular Basis for Immunoglobulin Deposition?

Dual interaction of JAM-C with JAM-B and alpha(M)beta2 integrin: function in junctional complexes and leukocyte adhesion

Effects of MACPF/CDC proteins on lipid membranes.

Efficient production and purification of recombinant murine kindlin-3 from insect cells for biophysical studies.

Glucocerebrosidase rescues alpha-synuclein from amyloid formation

Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling

Human perforin employs different avenues to damage membranes

Hybrid vigor: hybrid methods in viral structure determination

Improved crystallization and diffraction of caffeine-induced death suppressor protein 1 (Cid1).

Inactivation and activity of cholesterol-dependent cytolysins: what structural studies tell us.

Incomplete pneumolysin oligomers form membrane pores.

Initiation of T cell signaling by CD45 segregation at 'close contacts'

Measuring kinetic drivers of pneumolysin pore structure.

Membrane pore formation at protein-lipid interfaces

Membrane pores: from structure and assembly, to medicine and technology

O-glycan sialylation and the structure of the stalk-like region of the T cell co-receptor CD8.

Oligomerisation of pneumolysin on cholesterol crystals: similarities to the behaviour of polyene antibiotics.

Optimal translational termination requires C4 lysyl hydroxylation of eRF1.

Peptidoglycan recognition protein-SD provides versatility of receptor formation in Drosophila immunity.

Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes.

Picornavirus uncoating intermediate captured in atomic detail

Protein-lipid interactions and non-lamellar lipidic structures in membrane pore formation and membrane fusion.

Reconfiguration of yeast 40S ribosomal subunit domains by the translation initiation multifactor complex.

Repurposing a pore: highly conserved perforin-like proteins with alternative mechanisms.

Ribosomal acrobatics in post-transcriptional control.

Signaling lymphocytic activation molecule (CDw150) is homophilic but self-associates with very low affinity.

Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly.

Spacer-length dependence of programmed −1 or −2 ribosomal frameshifting on a U 6 A heptamer supports a role for messenger RNA (mRNA) tension in frameshifting ⬇️

Structural Basis for Plexin Activation and Regulation

Structural and Functional Characterization of the Kindlin-1 Pleckstrin Homology Domain

Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin

Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76

Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase

Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2

Structural basis of pore formation by cholesterol-binding toxins.

Structural features of cholesterol dependent cytolysins and comparison to other MACPF-domain containing proteins

Structural investigations of pneumolysin/lipid complexes.

Structural plasticity of Cid1 provides a basis for its distributive RNA terminal uridylyl transferase activity.

Structural transitions of the conserved and metastable hantaviral glycoprotein envelope

Structure and functional analysis of the IGF-II/IGF2R interaction

Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain ⬇️

Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity

Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development

Structure of the Repulsive Guidance Molecule (RGM)-Neogenin Signaling Hub

Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function

Structures of Lysenin Reveal a Shared Evolutionary Origin for Pore-Forming Proteins And Its Mode of Sphingomyelin Recognition

Structures of monomeric and oligomeric forms of the Toxoplasma gondii perforin-like protein 1.

Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity to accommodate foreign proteins ⬇️

The communication, development, and promotion of biophysical science in a European and international context.

The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus.

The histone H3K4 demethylase JARID1A directly interacts with haematopoietic transcription factor GATA1 in erythroid cells through its second PHD domain

The mechanics of translocation: a molecular "spring-and-ratchet" system.

The nsp9 replicase protein of SARS-coronavirus, structure and functional insights

The role of cholesterol in the activity of pneumolysin, a bacterial protein toxin.

The structure of CrgA from Neisseria meningitidis reveals a new octameric assembly state for LysR transcriptional regulators

Three distinct ribosome assemblies modulated by translation are the building blocks of polysomes

Use of the α-mannosidase I inhibitor kifunensine allows the crystallization of apo CTLA-4 homodimer produced in long-term cultures of Chinese hamster ovary cells.