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List of works by Hiroshi Ueda

(-)1-(Benzofuran-2-yl)-2-propylaminopentane shows survival effect on cortical neurons under serum-free condition through sigma receptors

scientific article published on 01 December 2000

A mimetic of the mSin3-binding helix of NRSF/REST ameliorates abnormal pain behavior in chronic pain models.

scientific article published on 7 September 2017

A novel analgesic dipeptide from bovine brain is a possible Met-enkephalin releaser ⬇️

scientific article published on November 22, 1979

A rapid, comprehensive system for assaying DNA repair activity and cytotoxic effects of DNA-damaging reagents

scientific article published on 4 December 2014

Abrogation of lysophosphatidic acid receptor 1 ameliorates murine vasculitis

scientific article published on 20 August 2019

Absence of morphine analgesia and its underlying descending serotonergic activation in an experimental mouse model of fibromyalgia

scientific article published on 4 February 2010

Activation of Gi1 by lysophosphatidic acid receptor without ligand in the baculovirus expression system.

scientific article published on May 1999

Adrenaline involvement in the presynaptic β-adrenoceptor-mediated mechanism of dopamine release from slices of the rat hypothalamus ⬇️

scientific article published on March 12, 1984

Age‐dependent dystonia in striatal Gγ7 deficient mice is reversed by the dopamine D2 receptor agonist pramipexole ⬇️

scientific article published on February 19, 2013

Altered tonic L-3,4-dihydroxyphenylalanine systems in the nucleus tractus solitarii and the rostral ventrolateral medulla of spontaneously hypertensive rats

scientific article published on 01 July 1995

Amlexanox inhibits cerebral ischemia-induced delayed astrocytic high-mobility group box 1 release and subsequent brain damage

scientific article published on 12 January 2018

An LPA Species (18:1 LPA) Plays Key Roles in the Self-Amplification of Spinal LPA Production in the Peripheral Neuropathic Pain Model ⬇️

scientific article published on June 17, 2013

Analgesic dipeptide, kyotorphin (Tyr-Arg), is highly concentrated in the synaptosomal fraction of the rat brain ⬇️

scientific article published on January 7, 1982

Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception.

scientific article

Antiamnesic action of cromakalim, a potassium channel opener, in mice treated with hypoxia- and cerebral ischemia-type stress stimuli ⬇️

scientific article published on August 1, 1998

Attempts to classify dependence-liable drugs by using a simple drug-discrimination test in mice.

scientific article published in May 1998

Autotaxin and lysophosphatidic acid1 receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidylcholine

scientific article published on 9 November 2010

Binding of [35S]GTPgammaS stimulated by (+)-pentazocine sigma receptor agonist, is abundant in the guinea pig spleen

scientific article published on 01 June 2000

Blockade of analgesic effects following systemic administration of N-methyl-kyotorphin, NMYR and arginine in mice deficient of preproenkephalin or proopiomelanocortin gene

scientific article published on 21 July 2018

Botulinum toxin C3 inhibits hyperalgesia in mice with partial sciatic nerve injury

scientific article published on 01 June 2000

Characterization of nociceptin-stimulated in situ [35S]GTPgammaS binding in comparison with opioid agonist-stimulated ones in brain regions of the mice

scientific article published in November 1997

Circadian-dependent learning and memory enhancement in nociceptin receptor-deficient mice with a novel KUROBOX apparatus using stress-free positive cue task

scientific article published on 05 January 2007

Comparison of the analgesic effects of various opioid peptides by a newly devised intracisternal injection technique in conscious mice

scientific article published on June 15, 1979

Complete inhibition of purinoceptor agonist-induced nociception by spinorphin, but not by morphine

scientific article published on 01 August 2000

Critical Functionality Effects from Storage Temperature on Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Suspensions

scientific article published on 27 February 2019

Curcumin blocks chronic morphine analgesic tolerance and brain-derived neurotrophic factor upregulation.

scientific article

Donepezil reverses intermittent stress-induced generalized chronic pain syndrome in mice.

scientific article published on 24 March 2015

Ecto-F0/F1 ATPase as a novel candidate of prothymosin α receptor

scholarly article by Hiroshi Ueda et al published 31 May 2018 in Expert Opinion on Biological Therapy

Emerging functions for tuberoinfundibular peptide of 39 residues.

scientific article

Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain.

scientific article published in March 2010

Evidence for ProTα-TLR4/MD-2 binding: molecular dynamics and gravimetric assay studies.

scientific article published on 21 January 2015

Evidence for a metabostatic opioid kappa-receptor inhibiting pertussis toxin-sensitive metabotropic glutamate receptor-currents in Xenopus oocytes.

scientific article published in November 1995

G(i1) and G(oA) differentially determine kinetic efficacies of agonists for kappa-opioid receptor

scientific article

Gγ7-specific prothymosin alpha deletion causes stress- and age-dependent motor dysfunction and anxiety

scientific article published on 20 November 2019

HDAC inhibitors restore C-fibre sensitivity in experimental neuropathic pain model.

scientific article published on November 2013

High-Throughput Screening and Prediction Model Building for Novel Hemozoin Inhibitors Using Physicochemical Properties.

scientific article published on 5 December 2016

Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury

scientific article published on 06 August 2015

Hydrolytic deactivation of kyotorphin by the rodent brain homogenates and sera.

scientific article published in July 1984

Interleukin-1β plays key roles in LPA-induced amplification of LPA production in neuropathic pain model.

scientific article

Involvement of SNARE Protein Interaction for Non-classical Release of DAMPs/Alarmins Proteins, Prothymosin Alpha and S100A13

scientific article published on 27 August 2020

Involvement of epinephrine in the presynaptic beta adrenoceptor mechanism of norepinephrine release from rat hypothalamic slices.

scientific article

Involvement of lysophosphatidic acid-induced astrocyte activation underlying the maintenance of partial sciatic nerve injury-induced neuropathic pain

scientific article published on 01 November 2018

Is BoNT/B useful for pain treatment?

scientific article published on 16 January 2014

LPA receptor signaling as a therapeutic target for radical treatment of neuropathic pain and fibromyalgia

scientific article published on 19 December 2019

LPA1 receptor involvement in fibromyalgia-like pain induced by intermittent psychological stress, empathy

scientific article published on 01 January 2017

LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model.

scientific article published on 2 February 2018

Low-density induced apoptosis of cortical neurons is inhibited by serum factors.

scientific article published in October 1998

Lys39-Lysophosphatidate Carbonyl Oxygen Interaction Locks LPA1 N-terminal Cap to the Orthosteric Site and partners Arg124 During Receptor Activation

scientific article

Lysophosphatidic Acid Receptor 1- and 3-Mediated Hyperalgesia and Hypoalgesia in Diabetic Neuropathic Pain Models in Mice

scientific article published on 16 August 2020

Lysophosphatidic acid LPA1 and LPA3 receptors play roles in the maintenance of late tissue plasminogen activator-induced central poststroke pain in mice

scientific article published on 20 July 2018

Lysophosphatidic acid signaling is the definitive mechanism underlying neuropathic pain

scientific article published in April 2017

Lysophosphatidic acid-induced membrane ruffling and brain-derived neurotrophic factor gene expression are mediated by ATP release in primary microglia.

scientific article

Mechanism of kyotorphin-induced release of Met-enkephalin from guinea pig striatum and spinal cord.

scientific article published in September 1981

Melittin, a metabostatic peptide inhibiting Gs activity.

scientific article published on January 1998

Microglia activation precedes the anti-opioid BDNF and NMDA receptor mechanisms underlying morphine analgesic tolerance.

scientific article published in January 2013

Minocycline Does Not Decrease Intensity of Neuropathic Pain Intensity, But Does Improve Its Affective Dimension

scientific article published on 20 February 2015

Molecular dynamics study-based mechanism of nefiracetam-induced NMDA receptor potentiation

scientific article published on 23 January 2015

Morphine-induced chemotaxis and brain-derived neurotrophic factor expression in microglia.

scientific article

Morphine-like analgesia by a new dipeptide, L-Tyrosyl-L-Arginine (kyotorphin) and its analogue ⬇️

scientific article published on April 1, 1979

Multiple Forms of AMPA-Type Glutamate Receptor mRNA Phenotypes in Goldfish Retina and Tectum ⬇️

scientific article published on October 1, 1997

NR2A-NMDA Receptor Blockade Reverses the Lack of Morphine Analgesia Without Affecting Chronic Pain Status in a Fibromyalgia-Like Mouse Model

scientific article published on 15 January 2020

Neuron-specific non-classical release of prothymosin alpha: a novel neuroprotective damage-associated molecular patterns.

scientific article published on 23 August 2012

Neuroprotective DAMPs member prothymosin alpha has additional beneficial actions against cerebral ischemia-induced vascular damages

scientific article published on 27 May 2016

Neuroprotective impact of prothymosin alpha-derived hexapeptide against retinal ischemia-reperfusion

scientific article published on 9 January 2016

Neurosteroid-induced hyperalgesia through a histamine release is inhibited by progesterone and p,p'-DDE, an endocrine disrupting chemical.

scientific article

Nociceptin/orphanin FQ-induced nociceptive responses through substance P release from peripheral nerve endings in mice ⬇️

scientific article published on September 1, 1998

Nonopioid and neuropathy-specific analgesic action of the nootropic drug nefiracetam in mice.

scientific article published in October 2002

Novel expression of vanilloid receptor 1 on capsaicin-insensitive fibers accounts for the analgesic effect of capsaicin cream in neuropathic pain.

scientific article published in March 2003

Novel neuroprotective action of prothymosin α-derived peptide against retinal and brain ischemic damages.

scientific article published on 28 January 2013

P-glycoprotein inhibitors improve effective dose and time of pregabalin to inhibit intermittent cold stress-induced central pain.

scientific article published on 14 January 2016

Pain and QOL--morphine-tolerance and morphine-resistant neuropathic pain

scientific article published in September 2003

Pain and the bulbospinal noradrenergic system: pain-induced increase in normetanephrine content in the spinal cord and its modification by morphine

scientific article published on February 15, 1979

Peripheral non-opioid analgesic effects of kyotorphin in mice.

scientific article published in October 1997

Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants

scientific article

Presynaptic mediation by α2-, β1- and β2-adrenoceptors of endogenous noradrenaline and dopamine release from slices of rat hypothalamus ⬇️

scientific article published on July 25, 1983

Presynaptic α2- and dopamine-receptor-mediated inhibitory mechanisms and dopamine nerve terminals in the rat hypothalamus ⬇️

scientific article published on September 30, 1983

Prolonged gabapentin analgesia in an experimental mouse model of fibromyalgia

scientific article published on 6 November 2008

Prothymosin alpha and its mimetic hexapeptide improve delayed tissue plasminogen activator-induced brain damage following cerebral ischemia

scientific article published on 27 August 2019

Prothymosin alpha plays a key role in cell death mode-switch, a new concept for neuroprotective mechanisms in stroke.

scientific article published on 05 January 2008

Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory functions and neurogenesis.

scientific article published on 25 January 2017

Prothymosin α plays multifunctional cell robustness roles in genomic, epigenetic, and nongenomic mechanisms

scientific article published on 01 October 2012

Prothymosin-alpha preconditioning activates TLR4-TRIF signaling to induce protection of ischemic retina

scientific article published on 14 September 2015

Regional distribution of a novel analgesic dipeptide kyotorphin (Tyr-Arg) in the rat brain and spinal cord

scientific article published on 01 October 1980

Regulation of a opioid receptor chaperone protein, RTP4, by morphine

scientific article published on 22 October 2018

Retinal cell type-specific prevention of ischemia-induced damages by LPS-TLR4 signaling through microglia

scientific article published on 13 May 2013

Serum-free induced neuronal apoptosis-like cell death is independent of caspase activity

scientific article published on 01 May 2000

Signaling of lysophosphatidic acid-evoked chloride current: calcium release from inositol trisphosphate-sensitive store.

scientific article published in October 1998

Simultaneous stimulation of spinal NK1 and NMDA receptors produces LPC which undergoes ATX-mediated conversion to LPA, an initiator of neuropathic pain

scientific article

Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling.

scientific article

Studies on peptides. XCIV. Synthesis and activity of kyotorphin and its analogs

scientific article published on 01 June 1980

Subconvulsive doses of intracisternal bicuculline methiodide, a GABAA receptor antagonist, produce potent analgesia as measured in the tail pinch test in mice

scientific article published in April 1987

Supersensitization of neurochemical responses by L-DOPA and dopamine receptor agonists in the striatum of experimental Parkinson's disease model rats.

scientific article published in January 1995

Switching of bradykinin-mediated nociception following partial sciatic nerve injury in mice

scientific article published on 21 November 2003

Synthesis and analgesic activity of neo-kyotorphin analogs

Systems Pathology of Neuropathic Pain and Fibromyalgia

scientific article published on 01 January 2019

The cognition-enhancer nefiracetam is protective in BDNF-independent neuronal cell death under the serum-free condition ⬇️

scientific article published on February 1, 2002

Tyrosyl-tRNA synthetase: A potential kyotorphin synthetase in mammals.

scientific article published on 28 December 2017

Voltage-dependent N-type Ca2+ channel activity regulates the interaction between FGF-1 and S100A13 for stress-induced non-vesicular release.

scientific article published on 21 April 2006

[Lysophosphatidic Acid Receptor Signaling Underlying Chronic Pain and Neuroprotective Mechanisms through Prothymosin α]

scientific article published on 01 January 2019

[Lysophosphatidic acid as initiator of neuropathic pain]

scientific article published on 01 March 2006

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