List of works - Katherine L. Seley-Radtke

"Reverse" carbocyclic fleximers: synthesis of a new class of adenosine deaminase inhibitors

scientific article published on January 2013

1,6-Bis[(benzyloxy)methyl]uracil derivatives-Novel antivirals with activity against HIV-1 and influenza H1N1 virus.

scientific article

1-Benzyl derivatives of 5-(arylamino)uracils as anti-HIV-1 and anti-EBV agents.

scientific article published on 7 October 2010

Advances in antiviral nucleoside analogues and their prodrugs.

scientific article

An Efficient Route to Novel Uracil-Based Drug-Like Molecules

article published in 2015

An Expedient Synthesis of Flexible Nucleosides through Enzymatic Glycosylation of Proximal and Distal Fleximer Bases

scientific article published on 03 January 2020

Anticancer Properties of Halogenated Pyrrolo[3,2-d]pyrimidines with Decreased Toxicity via N5 Substitution

scientific article published on 28 November 2017

Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines

scientific article

Carbocyclic 5'-nor "reverse" fleximers. Design, synthesis, and preliminary biological activity

scientific article published on July 2011

Carbocyclic thymidine analogues for use as potential therapeutic agents.

scientific article published on May 2009

Design and synthesis of a series of truncated neplanocin fleximers

scientific article published on 16 December 2014

Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity

scientific article published on 23 May 2015

Discovery, Design, Synthesis, and Application of Nucleoside/Nucleotides

scientific article published on 27 March 2020

Flexibility-Not just for yoga anymore!

scientific article published in January 2018

Investigation of 5'-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents

scientific article published on 21 September 2019

Mechanistic studies in the synthesis of a series of thieno-expanded xanthosine and guanosine nucleosides.

scientific article

Mitotic arrest of breast cancer MDA-MB-231 cells by a halogenated thieno[3,2-d]pyrimidine

scientific article

Modified synthesis of 3'-O-TBDPS-protected furanoid glycal.

scientific article published in April 2012

N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase.

scientific article published on 3 January 2013

NMR studies reveal an unexpected binding site for a redox inhibitor of AP endonuclease 1.

scientific article published on 9 November 2011

Novel 5'-Norcarbocyclic Pyrimidine Derivatives as Antibacterial Agents

Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity

scientific article published on 02 September 2019

Recent advances in synthetic approaches for medicinal chemistry of C-nucleosides.

scientific article published on 5 April 2018

Scaffold hopping: exploration of acetanilide-containing uracil analogues as potential NNRTIs

scientific article

Small molecule antivirals - Still our best hope for a cure

scientific article published on 01 January 2020

Structural and Biological Investigations for a Series of N-5 Substituted Pyrrolo[3,2-d]pyrimidines as Potential Anti-Cancer Therapeutics

scientific article published on 23 July 2019

Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof

scientific article published on 16 May 2013

Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2'-deoxy nucleoside analogues

scientific article published on 12 March 2012

Synthesis of 2'-deoxy-9-deaza nucleosides using Heck methodology.

scientific article published on 5 July 2013

Synthetic Routes to a Series of Proximal and Distal 2'-Deoxy Fleximers

scientific article published on January 2012

The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold

scientific article published on 08 December 2018

The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold.

scientific article published on 9 April 2018

Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides.

scientific article

Tricyclic 2'-C-modified nucleosides as potential anti-HCV therapeutics.

scientific article

List of works by Katherine L. Seley-Radtke

"Reverse" carbocyclic fleximers: synthesis of a new class of adenosine deaminase inhibitors

1,6-Bis[(benzyloxy)methyl]uracil derivatives-Novel antivirals with activity against HIV-1 and influenza H1N1 virus.

1-Benzyl derivatives of 5-(arylamino)uracils as anti-HIV-1 and anti-EBV agents.

Advances in antiviral nucleoside analogues and their prodrugs.

An Efficient Route to Novel Uracil-Based Drug-Like Molecules

An Expedient Synthesis of Flexible Nucleosides through Enzymatic Glycosylation of Proximal and Distal Fleximer Bases

Anticancer Properties of Halogenated Pyrrolo[3,2-d]pyrimidines with Decreased Toxicity via N5 Substitution

Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines

Carbocyclic 5'-nor "reverse" fleximers. Design, synthesis, and preliminary biological activity

Carbocyclic thymidine analogues for use as potential therapeutic agents.

Design and synthesis of a series of truncated neplanocin fleximers

Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity

Discovery, Design, Synthesis, and Application of Nucleoside/Nucleotides

Flexibility-Not just for yoga anymore!

Investigation of 5'-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents

Mechanistic studies in the synthesis of a series of thieno-expanded xanthosine and guanosine nucleosides.

Mitotic arrest of breast cancer MDA-MB-231 cells by a halogenated thieno[3,2-d]pyrimidine

Modified synthesis of 3'-O-TBDPS-protected furanoid glycal.

N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase.

NMR studies reveal an unexpected binding site for a redox inhibitor of AP endonuclease 1.

Novel 5'-Norcarbocyclic Pyrimidine Derivatives as Antibacterial Agents

Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity

Recent advances in synthetic approaches for medicinal chemistry of C-nucleosides.

Scaffold hopping: exploration of acetanilide-containing uracil analogues as potential NNRTIs

Small molecule antivirals - Still our best hope for a cure

Structural and Biological Investigations for a Series of N-5 Substituted Pyrrolo[3,2-d]pyrimidines as Potential Anti-Cancer Therapeutics

Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof

Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2'-deoxy nucleoside analogues

Synthesis of 2'-deoxy-9-deaza nucleosides using Heck methodology.

Synthetic Routes to a Series of Proximal and Distal 2'-Deoxy Fleximers

The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold

The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold.

Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides.

Tricyclic 2'-C-modified nucleosides as potential anti-HCV therapeutics.