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List of works by Jean-Claude Martinou

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2.

scientific article published in October 1998

A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression.

scientific article

A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function.

scientific article

A retention factor keeps death at bay.

scientific article

Amelioration of hippocampal neuronal damage after global ischemia by neuronal overexpression of BCL-2 in transgenic mice.

scientific article published in December 1998

An anti-apoptotic viral protein that recruits Bax to mitochondria

scientific article published on 5 March 2004

Anti-apoptotic effect of Bcl-2 overexpression in RIN cells infected with Semliki Forest virus.

scientific article published in January 1997

Apoptosis. Key to the mitochondrial gate

scientific article published on 01 June 1999

Apoptosis: bombarding the mitochondria

scientific article published on January 2003

Apoptotic Cells Provide an Unexpected Source of Wnt3 Signaling to Drive Hydra Head Regeneration

scientific article published on 01 August 2009

Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia

scientific article published in 2012

Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia.

scientific article

Bax does not directly participate in the Ca(2+)-induced permeability transition of isolated mitochondria.

scientific article published on 30 June 2004

Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein.

scientific article published in December 2002

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

scientific article

Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions ⬇️

scientific article published on October 5, 1998

Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease

scientific journal article

Bcl-2 prevents activation of CPP32 cysteine protease and cleavage of poly (ADP-ribose) polymerase and U1-70 kD proteins in staurosporine-mediated apoptosis.

scientific article published in January 1997

Bcl-2 promotes regeneration of severed axons in mammalian CNS

scientific journal article

Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1.

scientific article

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

scientific journal article

Bioenergetic defect associated with mKATP channel opening in a mouse model carrying a mitofusin 2 mutation

scientific article published on 01 February 2011

Breaking the mitochondrial barrier

scientific article

C11orf83, a mitochondrial cardiolipin-binding protein involved in bc1 complex assembly and supercomplex stabilization

scientific article

Ca(2+) homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1

scientific article

Cardiolipin or MTCH2 can serve as tBID receptors during apoptosis

scientific article published on 22 January 2016

Channels and transporters in cell metabolism.

scientific article published on 2 June 2016

Characterization of two factors enhancing choline acetyltransferase activity in cultures of purified rat motoneurons

scientific article published on 01 October 1989

Conformational change of Bax: a question of life or death

scientific article published on 01 September 2001

Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL

scientific article published on 4 February 2016

Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL

scientific article published on 9 February 2017

Cytochrome c release from mitochondria: all or nothing

scientific article published on 01 March 2000

Death‐signalling cascade in mouse cerebellar granule neurons ⬇️

scientific article published on April 1, 1998

Differential effects of Bcl-2 overexpression on fibre outgrowth and survival of embryonic dopaminergic neurons in intracerebral transplants.

scientific article

Direct addition of BimL to mitochondria does not lead to cytochrome c release

scientific article (publication date: 3 July 2002)

Direct evidence for membrane pore formation by the apoptotic protein Bax

scientific article published on 01 November 2002

Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis

scientific article

Efficient Mitochondrial Glutamine Targeting Prevails Over Glioblastoma Metabolic Plasticity.

scientific article

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A.

scientific article published in May 2010

Expression of the CTL-associated protein TIA-1 during murine embryogenesis.

scientific article published in August 1996

Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia.

scientific article published in October 1998

FASTKD1 and FASTKD4 have opposite effects on expression of specific mitochondrial RNAs, depending upon their endonuclease-like RAP domain

scientific article

Fatty acids enhance membrane permeabilization by pro-apoptotic Bax.

scientific article published in January 2004

Fear decrease in transgenic mice overexpressing bcl-2 in neurons.

scientific article published in July 1997

Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1

scientific article

Fusion of mitochondria in mammalian cells is dependent on the mitochondrial inner membrane potential and independent of microtubules or actin

scientific article published on 01 March 2003

GRSF1 regulates RNA processing in mitochondrial RNA granules.

scientific article published on March 2013

Grafting of embryonic motoneurons into adult spinal cord and brain

scientific article published on 01 January 1990

ICE-like proteases execute the neuronal death program.

scientific article published on October 1996

Identification and functional expression of the mitochondrial pyruvate carrier

scientific article

Influence of the culture substratum on the expression of choline acetyltransferase activity in purified motoneurons from rat embryos

scientific article published on 01 June 1989

Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis.

scientific article

Inhibition of Bax channel-forming activity by Bcl-2

scientific article

Interactions of Bax and tBid with lipid monolayers

scientific article published on 01 September 2005

Intermembrane space proteome of yeast mitochondria

scientific article

Involvement of cardiolipin in tBID-induced activation of BAX during apoptosis

scientific article published on 12 December 2013

Involvement of mitochondria in apoptosis

scientific article

Life without the mitochondrial calcium uniporter.

scientific article published in December 2013

Long-term survival of retinal ganglion cells following optic nerve section in adult bcl-2 transgenic mice

scientific article published on 01 August 1996

MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase

scientific article

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.

scientific article published on 9 May 2014

MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells.

scientific article published on 17 June 2016

Major role of BAX in apoptosis during retinal development and in establishment of a functional postnatal retina

scientific journal article

Mechanisms of mitochondrial outer membrane permeabilization.

scientific article published on January 2007

Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization

scientific article

Mitochondria and cancer: is there a morphological connection?

scientific article published on August 2006

Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics.

scientific article

Mitochondria-specific photoactivation to monitor local sphingosine metabolism and function

scientific article

Mitochondria: regulating the inevitable.

scientific article

Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics

scientific article published on 28 September 2020

Mitochondrial RNA granules: Compartmentalizing mitochondrial gene expression

scientific article published on 7 March 2016

Mitochondrial dynamics and apoptosis: a painful separation

scientific article published on 01 September 2008

Mitochondrial dynamics and cancer.

scientific article published on 24 December 2008

Mitochondrial dynamics: quantifying mitochondrial fusion in vitro.

scientific article

Mitochondrial dynamics: to be in good shape to survive

scientific article published on March 2008

Mitochondrial fission and apoptosis: an ongoing trial.

scientific article published on 20 April 2006

Mitochondrial outer membrane permeabilization during apoptosis: The role of mitochondrial fission ⬇️

scientific article published on January 28, 2011

Mitochondrial pyruvate import and its effects on homeostasis.

scientific article

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect

scientific article published on August 2015

Mouse vaginal opening is an apoptosis-dependent process which can be prevented by the overexpression of Bcl2.

scientific article

Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death.

scientific article

Nerve-dependent modulation of acetylcholine receptor epsilon-subunit gene expression.

scientific article published on May 1991

Newcomers in the process of mitochondrial permeabilization

scientific article published on 01 February 2005

Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons.

scientific article

Non-microtubular localizations of microtubule-associated protein 6 (MAP6)

scientific article

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

scientific article published on 01 October 1994

Overexpression of a Hu-bcl-2 transgene in Lurcher mutant mice delays Purkinje cell death.

scientific article published in August 1998

Overproduction of Cu/Zn-superoxide dismutase or Bcl-2 prevents the brain mitochondrial respiratory dysfunction induced by glutathione depletion.

scientific article

Oxidative stress is attenuated in mice overexpressing BCL-2

scientific article published on 01 February 1999

Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency

scientific article published in 2022

Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8.

scientific article

Postnatal expression of Hu-bcl-2 gene in Lurcher mutant mice fails to rescue Purkinje cells but protects inferior olivary neurons from target-related cell death.

scientific article published in January 1998

Preprotein Transport Machineries of Yeast Mitochondrial Outer Membrane Are not Required for Bax-induced Release of Intermembrane Space Proteins

Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA

scientific article

Pro-apoptotic Bid induces membrane perturbation by inserting selected lysolipids into the bilayer.

scientific article

Protection against murine leukemia virus-induced spongiform myeloencephalopathy in mice overexpressing Bcl-2 but not in mice deficient for interleukin-6, inducible nitric oxide synthetase, ICE, Fas, Fas ligand, or TNF-R1 genes

scientific article

Protection of C. elegans from anoxia by HYL-2 ceramide synthase

scientific article published in April 2009

Proteomic analysis of the mouse liver mitochondrial inner membrane

scientific journal article

Purification and Biochemical Properties of Soluble Recombinant Human Bax ⬇️

scientific article published on June 1, 1998

Purification and proteomic analysis of the mouse liver mitochondrial inner membrane

scientific article published on 01 January 2008

Regulation of Bcl-2 proteins and of the permeability of the outer mitochondrial membrane.

scientific article

Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1

scientific journal article

Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes

scientific article

Role of Bcl-2 family members in caspase-independent apoptosis during Chlamydia infection.

scientific article published on January 2002

Role of FAST Kinase Domains 3 (FASTKD3) in Post-transcriptional Regulation of Mitochondrial Gene Expression.

scientific article published on 27 October 2016

Role of mitochondrial membrane permeabilization in apoptosis and cancer

scientific article published on April 2004

Role of mitofusin 2 mutations in the physiopathology of Charcot-Marie-Tooth disease type 2A

scientific article (publication date: August 2009)

SLP-2 interacts with prohibitins in the mitochondrial inner membrane and contributes to their stability.

scientific article

SLP-2 is required for stress-induced mitochondrial hyperfusion

scientific article

SLP-2 negatively modulates mitochondrial sodium-calcium exchange

scientific article

Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells

scientific journal article

Selective expression of an acetylcholine receptor-lacZ transgene in synaptic nuclei of adult muscle fibers ⬇️

scientific article published on December 1, 1991

Sensitization of (colon) cancer cells to death receptor related therapies: a report from the FP6-ONCODEATH research consortium

scientific article published on May 2012

Solange Desagher and Jean-Claude Martinou: Executioners of Cell Death

scientific article published on 20 June 2016

Specific interaction with cardiolipin triggers functional activation of Dynamin-Related Protein 1

scientific article

Susceptibility of cerebellar granule neurons derived from Bcl-2-deficient and transgenic mice to cell death

scientific journal article

TAT-RasGAP317-326-mediated tumor cell death sensitization can occur independently of Bax and Bak.

scientific article published on April 2014

TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL

scientific article

TCTP protects from apoptotic cell death by antagonizing bax function

scientific article

TRAIL promotes membrane blebbing, detachment and migration of cells displaying a dysfunctional intrinsic pathway of apoptosis ⬇️

scientific article published on March 1, 2013

Targeting the retinoblastoma protein by MC007L, gene product of the molluscum contagiosum virus: detection of a novel virus-cell interaction by a member of the poxviruses.

scientific article

Temporal dissection of Bax-induced events leading to fission of the single mitochondrion in Trypanosoma brucei

scientific article

The Bcl-2 protein family

scientific article

The Destabilization of Lipid Membranes Induced by the C-terminal Fragment of Caspase 8-cleaved Bid Is Inhibited by the N-terminal Fragment

scientific article published on 01 July 2000

The FASTK family of proteins: emerging regulators of mitochondrial RNA biology.

scientific article published on 19 September 2017

The Pseudouridine Synthase RPUSD4 Is an Essential Component of Mitochondrial RNA Granules

scientific article published on 12 January 2017

The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis

scientific article

The mitochondrial pyruvate carrier in health and disease: To carry or not to carry?

scientific article published on 26 January 2016

The motoneuron degeneration in the wobbler mouse is independent of the overexpression of a Bcl2 transgene in neurons

scientific article published on 01 October 1995

The properties of the mitochondrial megachannel in mitoplasts from human colon carcinoma cells are not influenced by Bax.

scientific article published in July 2005

Transbilayer lipid diffusion promoted by Bax: implications for apoptosis.

scientific article

Transforming growth factor beta 1 is a potent survival factor for rat embryo motoneurons in culture.

scientific article

Transgenic mice with neuronal overexpression of bcl-2 gene present navigation disabilities in a water task.

scientific article published in January 2001

Upstream control of apoptosis by caspase-2 in serum-deprived primary neurons.

scientific article

Where Killers Meet--Permeabilization of the Outer Mitochondrial Membrane during Apoptosis ⬇️

scientific article published on January 1, 2013

[Caenorhabditis elegans and neuronal death in mammals]

scientific article published on 01 September 1997

[Changes in the outer mitochondrial membranes during apoptosis]

scientific article published on 01 January 2005

[Evaluation of the performance of an automatic coagulation tester: the Electra 700]

[Mitochondrial dynamics: from geometry to function]

scientific article published on 01 October 2010

hFis1, a novel component of the mammalian mitochondrial fission machinery

scientific article (publication date: 19 September 2003)

tBid interaction with cardiolipin primarily orchestrates mitochondrial dysfunctions and subsequently activates Bax and Bak.

scientific article published in June 2005

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