List of works - Anthony Pawson

A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome

scientific article

A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells

scientific article (publication date: 5 May 2006)

A Web Resource for Improved Analysis of AP-MS Protein Interaction Data

scientific article published in May 2013

A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases

scientific journal article

A global protein kinase and phosphatase interaction network in yeast.

scientific article

A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling

scientific article (publication date: 6 August 2002)

AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade

scientific journal article

Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase

scientific journal article

Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8

scientific article

Assembly of Cell Regulatory Systems Through Protein Interaction Domains ⬇️

scientific article (publication date: 18 April 2003)

Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction

scientific journal article

Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

scientific journal article

Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cells

scientific article

Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase

scientific article

Conformational determinants of phosphotyrosine peptides complexed with the Src SH2 domain

scientific article

Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain

scientific article

Defining the specificity space of the human SRC homology 2 domain

scientific article

Directed Network Wiring Identifies a Key Protein Interaction in Embryonic Stem Cell Differentiation

scientific article published on 19 June 2014

Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif

scientific article

FF domains of CA150 bind transcription and splicing factors through multiple weak interactions

scientific article

High-throughput phosphotyrosine profiling using SH2 domains

scientific article

Hippocampal synaptic modulation by the phosphotyrosine adapter protein ShcC/N-Shc via interaction with the NMDA receptor

scientific journal article

Histone recognition and large-scale structural analysis of the human bromodomain family

scientific article

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

scientific journal article

Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate

scientific journal article

Interaction domains: from simple binding events to complex cellular behavior

scientific article (publication date: 20 February 2002)

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes

scientific journal article

Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activity

scientific article (publication date: 21 February 2003)

Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi

scientific article

Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor

scientific article

Nck adaptor proteins control the organization of neuronal circuits important for walking

scientific article

Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes

scientific article

Nck proteins maintain the adult glomerular filtration barrier

scientific article

Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9

scientific article

Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration

scientific article

Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins

scientific article

Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity

scientific article

PreBIND and Textomy--mining the biomedical literature for protein-protein interactions using a support vector machine

scientific article

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions

scientific article

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization

scientific article

Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54).

scientific article published on 23 April 2012

Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor

scientific article (publication date: 23 June 2000)

Saccharomyces cerevisiae Ste50 binds the MAPKKK Ste11 through a head-to-tail SAM domain interaction

scientific article

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor

scientific article

Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock

scientific article

ShcA signalling is essential for tumour progression in mouse models of human breast cancer

scientific journal article

Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP

scientific journal article

Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease

scientific article

Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain

scientific article

Structural basis for specific binding of the Gads SH3 domain to an RxxK motif-containing SLP-76 peptide: a novel mode of peptide recognition

scientific article (publication date: February 2003)

Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation

scientific article

Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays

scientific article

Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide

scientific article

Systematic Discovery of In Vivo Phosphorylation Networks

scientific article (publication date: June 2007)

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

scientific article (publication date: 10 January 2002)

Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages

scientific journal article

Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis

scientific article

Temporal regulation of EGF signalling networks by the scaffold protein Shc1

scientific article

The CRAPome: a contaminant repository for affinity purification-mass spectrometry data

scientific article

The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics

scientific article

The Hippo pathway regulates Wnt/beta-catenin signaling

scientific article

The K15 protein of Kaposi's sarcoma-associated herpesvirus recruits the endocytic regulator intersectin 2 through a selective SH3 domain interaction

scientific article

The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1

scientific journal article

The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling

scientific article (publication date: December 2002)

The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier

scientific article

The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling

scientific article (publication date: 23 June 2006)

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells

scientific article

The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network

scientific article

UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways

scientific article

WW domains provide a platform for the assembly of multiprotein networks

scientific article

Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development

scientific article (publication date: March 2013)

c-Abl phosphorylates Dok1 to promote filopodia during cell spreading

scientific journal article

grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice

scientific article

List of works by Anthony Pawson

A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome

A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells

A Web Resource for Improved Analysis of AP-MS Protein Interaction Data

A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases

A global protein kinase and phosphatase interaction network in yeast.

A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling

AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade

Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase

Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8

Assembly of Cell Regulatory Systems Through Protein Interaction Domains ⬇️

Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction

Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cells

Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase

Conformational determinants of phosphotyrosine peptides complexed with the Src SH2 domain

Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain

Defining the specificity space of the human SRC homology 2 domain

Directed Network Wiring Identifies a Key Protein Interaction in Embryonic Stem Cell Differentiation

Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif

FF domains of CA150 bind transcription and splicing factors through multiple weak interactions

High-throughput phosphotyrosine profiling using SH2 domains

Hippocampal synaptic modulation by the phosphotyrosine adapter protein ShcC/N-Shc via interaction with the NMDA receptor

Histone recognition and large-scale structural analysis of the human bromodomain family

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate

Interaction domains: from simple binding events to complex cellular behavior

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes

Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activity

Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi

Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor

Nck adaptor proteins control the organization of neuronal circuits important for walking

Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes

Nck proteins maintain the adult glomerular filtration barrier

Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9

Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration

Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins

Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity

PreBIND and Textomy--mining the biomedical literature for protein-protein interactions using a support vector machine

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization

Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54).

Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor

Saccharomyces cerevisiae Ste50 binds the MAPKKK Ste11 through a head-to-tail SAM domain interaction

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor

Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock

ShcA signalling is essential for tumour progression in mouse models of human breast cancer

Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP

Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease

Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain

Structural basis for specific binding of the Gads SH3 domain to an RxxK motif-containing SLP-76 peptide: a novel mode of peptide recognition

Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation

Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays

Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide

Systematic Discovery of In Vivo Phosphorylation Networks

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages

Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis

Temporal regulation of EGF signalling networks by the scaffold protein Shc1

The CRAPome: a contaminant repository for affinity purification-mass spectrometry data

The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics

The Hippo pathway regulates Wnt/beta-catenin signaling

The K15 protein of Kaposi's sarcoma-associated herpesvirus recruits the endocytic regulator intersectin 2 through a selective SH3 domain interaction

The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1

The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling

The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier

The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells

The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network

UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways

WW domains provide a platform for the assembly of multiprotein networks

Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development

c-Abl phosphorylates Dok1 to promote filopodia during cell spreading

grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice