List of works - Anthony Pawson

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

scientific article (publication date: 10 January 2002)

Assembly of Cell Regulatory Systems Through Protein Interaction Domains

scientific article (publication date: 18 April 2003)

A global protein kinase and phosphatase interaction network in yeast

scientific article

Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

scientific journal article

Histone recognition and large-scale structural analysis of the human bromodomain family

scientific article

The CRAPome: a contaminant repository for affinity purification-mass spectrometry data

scientific article

Systematic Discovery of In Vivo Phosphorylation Networks

scientific article (publication date: June 2007)

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization

scientific article

The Hippo pathway regulates Wnt/beta-catenin signaling

scientific article

Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor

scientific article (publication date: 23 June 2000)

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions

scientific article

Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes

scientific article

A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells

scientific article (publication date: 5 May 2006)

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor

scientific article published on June 26, 2011

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells

scientific article

The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling

scientific article (publication date: 23 June 2006)

Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cells

scientific article

Temporal regulation of EGF signalling networks by the scaffold protein Shc1

scientific article

Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease

scientific article

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

scientific journal article

Defining the specificity space of the human SRC homology 2 domain

scientific article

Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development

scientific article (publication date: March 2013)

Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation

scientific article

Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration

scientific article

WW domains provide a platform for the assembly of multiprotein networks

scientific article

Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi

scientific article

PreBIND and Textomy--mining the biomedical literature for protein-protein interactions using a support vector machine

scientific article

The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling

scientific article (publication date: December 2002)

Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity

scientific article

The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network

scientific article

High-throughput phosphotyrosine profiling using SH2 domains

scientific article

The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics

scientific article

ShcA signalling is essential for tumour progression in mouse models of human breast cancer

scientific journal article

AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade

scientific journal article

Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain

scientific article

A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling

scientific article (publication date: 6 August 2002)

Structural basis for specific binding of the Gads SH3 domain to an RxxK motif-containing SLP-76 peptide: a novel mode of peptide recognition

scientific article (publication date: February 2003)

Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis

scientific article

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes

scientific journal article

Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction

scientific journal article

Interaction domains: from simple binding events to complex cellular behavior

scientific article (publication date: 20 February 2002)

Nck proteins maintain the adult glomerular filtration barrier

scientific article

A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases

scientific journal article

c-Abl phosphorylates Dok1 to promote filopodia during cell spreading

scientific journal article

Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9

scientific article

Nck adaptor proteins control the organization of neuronal circuits important for walking

scientific article

Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins

scientific article

Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide

scientific article

A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome

scientific article

Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages

scientific journal article

List of works by Anthony Pawson

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

Assembly of Cell Regulatory Systems Through Protein Interaction Domains

A global protein kinase and phosphatase interaction network in yeast

Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

Histone recognition and large-scale structural analysis of the human bromodomain family

The CRAPome: a contaminant repository for affinity purification-mass spectrometry data

Systematic Discovery of In Vivo Phosphorylation Networks

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization

The Hippo pathway regulates Wnt/beta-catenin signaling

Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions

Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes

A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells

The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling

Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cells

Temporal regulation of EGF signalling networks by the scaffold protein Shc1

Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

Defining the specificity space of the human SRC homology 2 domain

Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development

Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation

Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration

WW domains provide a platform for the assembly of multiprotein networks

Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi

PreBIND and Textomy--mining the biomedical literature for protein-protein interactions using a support vector machine

The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling

Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity

The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network

High-throughput phosphotyrosine profiling using SH2 domains

The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics

ShcA signalling is essential for tumour progression in mouse models of human breast cancer

AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade

Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain

A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling

Structural basis for specific binding of the Gads SH3 domain to an RxxK motif-containing SLP-76 peptide: a novel mode of peptide recognition

Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes

Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction

Interaction domains: from simple binding events to complex cellular behavior

Nck proteins maintain the adult glomerular filtration barrier

A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases

c-Abl phosphorylates Dok1 to promote filopodia during cell spreading

Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9

Nck adaptor proteins control the organization of neuronal circuits important for walking

Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins

Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide

A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome

Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages