List of works - Kaiwen W Chen

A novel flow cytometric method to assess inflammasome formation

scientific article

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.

scientific article published on 17 January 2017

An antioxidant role for catecholate siderophores in Salmonella.

scientific article published on September 2013

Antimicrobial functions of inflammasomes

scientific article published on 04 March 2013

Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis

scientific article published on 03 December 2019

Burn the house, save the day: pyroptosis in pathogen restriction

scholarly article published 1 January 2016

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

scientific article published on 28 April 2020

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity.

scientific article published on 6 February 2018

Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

scientific article published on 18 November 2020

Cutting Edge: Blockade of Inhibitor of Apoptosis Proteins Sensitizes Neutrophils to TNF- but Not Lipopolysaccharide-Mediated Cell Death and IL-1β Secretion.

scientific article published on 16 April 2018

Divide to conquer: NLRP3 is activated on dispersed trans-Golgi network

scientific article published on 01 March 2019

Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly

scientific article published on 22 March 2019

Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection

scientific article published on 14 October 2021

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

scientific article published on 24 June 2020

Inflammasomes and Inflammation

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

scientific article published on 01 August 2018

NLRP12 is a neutrophil-specific, negative regulator of in vitro cell migration but does not modulate LPS- or infection-induced NF-κB or ERK signalling

scientific article published on 23 October 2015

Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps

scientific article published on 01 August 2018

Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation

scientific article published on 07 May 2019

Pannexin-1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation

scientific article published on 29 August 2019

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling