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List of works by Samuel J Klempner

A Space-Time Continuum for Immunotherapy Biomarkers in Gastroesophageal Cancer?

scientific article published on 06 October 2020

ALK F1174V mutation confers sensitivity while ALK I1171 mutation confers resistance to alectinib. The importance of serial biopsy post progression.

scientific article

ALK translocation in non-small cell lung cancer with adenocarcinoma and squamous cell carcinoma markers.

scientific article

Advances in immuno-oncology biomarkers for gastroesophageal cancer: Programmed death ligand 1, microsatellite instability, and beyond.

scientific article published on 7 July 2018

Alectinib induced CNS radiation necrosis in an ALK+NSCLC patient with a remote (7 years) history of brain radiation.

scientific article published on 26 March 2016

Anti-Yo Antibody Associated With Occult Fallopian Tube Carcinoma

scientific article published on 01 November 2011

Beyond microsatellite testing: assessment of tumor mutational burden identifies subsets of colorectal cancer who may respond to immune checkpoint inhibition

Bone mineral density loss in thoracic and lumbar vertebrae following radiation for abdominal cancers

scientific article

Broad Detection of Alterations Predicted to Confer Lack of Benefit From EGFR Antibodies or Sensitivity to Targeted Therapy in Advanced Colorectal Cancer

scientific article published on 28 September 2016

Can the Help Match the Hype? KRASG12C-Specific Inhibitors and Beyond

scientific article published on 01 January 2020

Carving out another slice of the pie: Exceptional response to single agent imatinib in an asian female never-smoker with advanced NSCLC with a de-novo PDGFR-α N848 K mutation

article

Cis-oriented solvent-front EGFR G796S mutation in tissue and ctDNA in a patient progressing on osimertinib: a case report and review of the literature.

scientific article published on 6 December 2017

Clinical Acquired Resistance to KRAS<sup>G12C</sup> Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS-MAPK Reactivation

publication published on 06 April 2021

Clinical investigation of receptor and non-receptor tyrosine kinase inhibitors for the treatment of epithelial ovarian cancer

scientific article

Complementary and alternative medicines in prostate cancer: from bench to bedside?

scientific article

Comprehensive Genomic Profiling Aids in Distinguishing Metastatic Recurrence from Second Primary Cancers.

scientific article

Comprehensive genomic profiling of anal squamous cell carcinoma reveals distinct genomically defined classes

scientific article published on 6 April 2016

Correlating programmed death ligand 1 (PD-L1) expression, mismatch repair deficiency, and outcomes across tumor types: implications for immunotherapy.

scientific article

Emergence of Preexisting MET Y1230C Mutation as a Resistance Mechanism to Crizotinib in NSCLC with MET Exon 14 Skipping.

scientific article published on 22 September 2016

Endoscopic history and provider characteristics influence gastric cancer survival in Asian Americans

scientific article published on 19 June 2020

FGFR2-Altered Gastroesophageal Adenocarcinomas Are an Uncommon Clinicopathologic Entity with a Distinct Genomic Landscape

scientific article published on 27 June 2019

Focal Hepatic Fluorodeoxyglucose Uptake Mimics Liver Metastasis Following External Beam Radiation for Gastroesophageal Cancers: A Case and Review of the Literature.

scientific article published on 9 August 2016

Focus on Alectinib and Competitor Compounds for Second-Line Therapy in ALK-Rearranged NSCLC

scientific article

HER2 Transmembrane Domain (TMD) Mutations (V659/G660) That Stabilize Homo- and Heterodimerization Are Rare Oncogenic Drivers in Lung Adenocarcinoma That Respond to Afatinib.

scientific article published on 26 November 2016

Hybrid capture-based genomic profiling of circulating tumor DNA from patients with advanced cancers of the gastrointestinal tract or anus.

scientific article published on 23 January 2018

Identification and characterization of RET fusions in advanced colorectal cancer

scientific article published on 30 May 2015

Identification of BRAF Kinase Domain Duplications Across Multiple Tumor Types and Response to RAF Inhibitor Therapy.

scientific article

Immunotherapy for advanced gastric and esophageal cancer: preclinical rationale and ongoing clinical investigations

scientific article

Initial Report of Second-Line FOLFIRI in Combination with Ramucirumab in Advanced Gastroesophageal Adenocarcinomas: A Multi-Institutional Retrospective Analysis

scientific article published on 23 November 2018

Intracranial Activity of Cabozantinib in MET Exon 14-Positive NSCLC with Brain Metastases

scientific article published on 27 September 2016

Lineage-specific epigenomic and genomic activation of oncogene HNF4A promotes gastrointestinal adenocarcinomas

scientific article published on 24 April 2020

Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal adenocarcinoma

scientific article published on 13 August 2019

Neoadjuvant Chemotherapy Improves Survival in Patients with Clinical T4b Colon Cancer

scientific article published on 20 September 2017

Next-generation sequencing reveals a Novel NSCLC ALK F1174V mutation and confirms ALK G1202R mutation confers high-level resistance to alectinib (CH5424802/RO5424802) in ALK-rearranged NSCLC patients who progressed on crizotinib.

scientific article

PD-1 and PD-L1 as emerging therapeutic targets in gastric cancer: current evidence

scientific article

PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients

scientific article

Prevalence of established and emerging biomarkers of immune checkpoint inhibitor response in advanced hepatocellular carcinoma.

scientific article published on 18 June 2019

Profile of rociletinib and its potential in the treatment of non-small-cell lung cancer.

scientific article published on 18 May 2016

Progress and challenges in HER2-positive gastroesophageal adenocarcinoma

scientific article published on 17 May 2019

Pulse Dose Erlotinib and Zuckerguss Improvement in EGFR-Mutant NSCLC.

scientific article published on 31 July 2017

Radiation dermatitis caused by a bolus effect from an abdominal compression device.

scientific article published on 2 June 2016

Ramucirumab plus pembrolizumab: can we make the maths work?

scientific article published on 10 July 2019

Rapamycin-insensitive companion of mTOR (RICTOR) amplification defines a subset of advanced gastric cancer and is sensitive to AZD2014-mediated mTORC1/2 inhibition.

scientific article published on 27 December 2016

Real-Time Targeted Genome Profile Analysis of Pancreatic Ductal Adenocarcinomas Identifies Genetic Alterations That Might Be Targeted With Existing Drugs or Used as Biomarkers

scientific article published on 02 March 2019

Receptor Tyrosine Kinase fusions and BRAF kinase fusions are rare but actionable resistance mechanisms to EGFR tyrosine kinase inhibitors.

scientific article

Refining the management of resectable esophagogastric cancer: FLOT4, CRITICS, OE05, MAGIC-B and the promise of molecular classification.

scientific article published in June 2018

Severe Pazopanib-Induced Hepatotoxicity: Clinical and Histologic Course in Two Patients

scientific article published on 16 July 2012

Targeted therapy for gastric cancer: molecular pathways and ongoing investigations.

scientific article published on 22 May 2014

Targeting the MET Pathway in Gastric and Oesophageal Cancers: Refining the Optimal Approach.

scientific article published on 12 February 2016

Targeting the Phosphatidylinositol-3-kinase Pathway in Gastric Cancer: Can Omics Improve Outcomes?

scientific article

The Clinical Use of Genomic Profiling to Distinguish Intrapulmonary Metastases From Synchronous Primaries in Non-Small-Cell Lung Cancer: A Mini-Review

scientific article published on 26 March 2015

The impact of gender, race, socioeconomic status, and treatment on outcomes in esophageal cancer: A population-based analysis

scientific article published on 18 September 2017

Toward optimizing outcomes in Her2-positive gastric cancer: timing and genomic context matter

scientific article published on 01 April 2018

Tumor Mutational Burden Guides Therapy in a Treatment Refractory POLE-Mutant Uterine Carcinosarcoma.

scientific article published on 31 January 2018

Tumor Mutational Burden as a Predictive Biomarker for Response to Immune Checkpoint Inhibitors: A Review of Current Evidence

scientific article published on 02 October 2019

Variety Is the Spice of Life, but Maybe Not in Gastroesophageal Adenocarcinomas

scientific article published on 01 February 2019

What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway

scientific article

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