List of works - Peter C Butler

11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls

scientific article published on 17 February 2009

Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway.

scientific article

Activation of the HIF1α/PFKFB3 stress response pathway in beta cells in type 1 diabetes

scientific article published on 13 November 2019

Augmented effect of short-term pulsatile versus continuous insulin delivery on lipid metabolism but similar effect on whole-body glucose metabolism in obese subjects.

scientific article

Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity

scientific article

Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes.

scientific article published in July 2006

Beta-cell selective K(ATP)-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity.

scientific article

Brief report: treatment of insulin-resistant diabetic ketoacidosis with insulin-like growth factor I in an adolescent with insulin-dependent diabetes

scientific article published on September 17, 1992

Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes

scientific article

Comment to: Patti ME, McMahon G, Mun EC et al. (2005) Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia. Diabetologia 48:2236-2240

scientific article published on 31 January 2006

Comparison of the ability of bread versus bread plus meat to treat and prevent subsequent hypoglycemia in patients with insulin-dependent diabetes mellitus.

scientific article published on April 1996

Cyclin-dependent kinase 5 promotes pancreatic β-cell survival via Fak-Akt signaling pathways.

scientific article

Diabetes mellitus in cystic fibrosis is characterized by islet amyloidosis

scientific article published on 01 March 1996

Disorderly and nonstationary insulin secretion in relatives of patients with NIDDM

scientific article published on 01 February 1997

Diversion of the gastroduodenal vein: a canine model for comparing portal versus systemic insulin delivery

scientific article published on 01 April 1990

Diversion of the gastroduodenal vein: an in situ model of systemic insulin drainage.

scientific article published in August 1989

Effect of insulin on oxidation of intracellularly and extracellularly derived glucose in patients with NIDDM. Evidence for primary defect in glucose transport and/or phosphorylation but not oxidation

scientific article published on 01 November 1990

Effects of fasting on physiologically pulsatile insulin release in healthy humans

scientific article published in February 2002

Effects of glucose ingestion versus infusion on pulsatile insulin secretion. The incretin effect is achieved by amplification of insulin secretory burst mass

scientific article published on 01 October 1996

Effects of growth hormone on insulin sensitivity and forearm metabolism in normal man

scientific article published on 01 February 1989

Effects of meal ingestion on plasma amylin concentration in NIDDM and nondiabetic humans.

scientific article

Effects of somatostatin on pulsatile insulin secretion: elective inhibition of insulin burst mass.

scientific article published in June 1996

Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway

scientific article

Farewell statement from Dr. Peter Butler as outgoing editor in chief of diabetes.

scientific article published on December 2011

Glucagon like peptide-1 receptor expression in the human thyroid gland

scientific article

Glucagon-like Peptide 1 Drugs as Second-line Therapy for Type 2 Diabetes.

scientific article published on August 2016

Glucagon-like peptide-1 therapy and the exocrine pancreas: innocent bystander or friendly fire?

scientific article

Glucagonlike Peptide 1-based drugs and pancreatitis: clarity at last, but what about pancreatic cancer?

scientific article published on 01 April 2013

Hepatic and extrahepatic responses to insulin in NIDDM and nondiabetic humans. Assessment in absence of artifact introduced by tritiated nonglucose contaminants.

scientific article published in February 1990

Human islet amyloid polypeptide expression in COS-1 cells. A model of intracellular amyloidogenesis ⬇️

scientific article published on September 1, 1995

Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions

scientific article

IGF-I inhibits burst mass of pulsatile insulin secretion at supraphysiological and low IGF-I infusion rates

scientific article published on 01 March 1997

Impact of sampling technique on appraisal of pulsatile insulin secretion by deconvolution and cluster analysis.

scientific article published in December 1995

In humans at least 75% of insulin secretion arises from punctuated insulin secretory bursts

scientific article published on 01 November 1997

In the setting of β-cell stress, the pancreatic duct gland transcriptome shows characteristics of an activated regenerative response

scientific article published on 10 August 2018

Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP.

scientific article published on 18 July 2006

Insulin glargine controversy: a tribute to the editorial team at Diabetologia.

scientific article published on November 2009

Insulin-degrading enzyme inhibition, a novel therapy for type 2 diabetes?

scientific article published on August 2014

Interactions of poliovirus with montmorillonite clay in phosphate-buffered saline

scientific article published on 01 October 1983

Islet amyloid and islet amyloid polypeptide in cynomolgus macaques (Macaca fascicularis): an animal model of human non-insulin-dependent diabetes mellitus

scientific article published on 01 September 1996

Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis

scientific article

Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes.

scientific article published on January 2006

Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide.

scientific article published in May 1998

Islet amyloidosis in a patient with chronic massive insulin resistance due to antiinsulin receptor antibodies

scientific article published on 01 July 1994

Lack of growth hormone effect on insulin-associated suppression of insulinlike growth factor binding protein 1 in humans.

scientific article published in October 1990

Low Grade Islet but Marked Exocrine Pancreas Inflammation in an Adult with Autoimmune Pre-Diabetes

scientific article published on 19 December 2019

Many commercially available antibodies for detection of CHOP expression as a marker of endoplasmic reticulum stress fail specificity evaluation.

scientific article

Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors

scientific article

Measurement of insulin pulsatility by sampling directly from the portal vein: a surgical model for placement of long-term prehepatic vascular sampling catheters.

scientific article published in April 1996

Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption.

scientific article

Membrane Protein Insertion into and Compatibility with Biomimetic Membranes

scientific article published on 16 June 2017

Methods for assessment of the rate of onset and offset of insulin action during nonsteady state in humans.

scientific article published in April 1993

Non-haematological solid tumours as surrogate granulocytes: a possible mechanism for metastatic spread

scientific article published on 01 May 2001

Overnight inhibition of insulin secretion restores pulsatility and proinsulin/insulin ratio in type 2 diabetes.

scientific article published on September 2000

Pattern of postprandial carbohydrate metabolism and effects of portal and peripheral insulin delivery

scientific article published on 01 February 1990

Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes.

scientific article

Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes

scientific article

Recovery of high-quality RNA from laser capture microdissected human and rodent pancreas

scientific article

Regulation of carbohydrate metabolism and response to hypoglycemia.

scientific article published on March 1989

Relationship between beta-cell mass and diabetes onset.

scientific article

Replication increases beta-cell vulnerability to human islet amyloid polypeptide-induced apoptosis.

scientific article

Small heat shock proteins inhibit in vitro A beta(1-42) amyloidogenesis

scientific article published on 01 October 1997

The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity ⬇️

scientific article published on November 10, 2010

The effects of human proinsulin on glucose turnover and intermediary metabolism

scientific article published on 01 September 1991

The mass, but not the frequency, of insulin secretory bursts in isolated human islets is entrained by oscillatory glucose exposure.

scientific article published on 8 November 2005

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

scientific article published in March 1999

The nocturnal increase in growth hormone is not the cause of the nocturnal increase in serum osteocalcin.

scientific article published in August 1991

The potential for stem cell therapy in diabetes.

scientific article

Treatment with growth hormone and dexamethasone in mice transgenic for human islet amyloid polypeptide causes islet amyloidosis and beta-cell dysfunction

scientific article published on 01 August 1996

Type 2 diabetes as a protein misfolding disease.

scientific article published on 18 May 2015

UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy

scientific journal article

Underestimation of glucose turnover corrected with high-performance liquid chromatography purification of [6-3H]glucose.

scientific article published in January 1990

β-Cell failure in type 2 diabetes: a case of asking too much of too few?

scientific article published on February 2013

β-cell mass and turnover in humans: effects of obesity and aging

scientific article

List of works by Peter C Butler

11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls

Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway.

Activation of the HIF1α/PFKFB3 stress response pathway in beta cells in type 1 diabetes

Augmented effect of short-term pulsatile versus continuous insulin delivery on lipid metabolism but similar effect on whole-body glucose metabolism in obese subjects.

Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity

Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes.

Beta-cell selective K(ATP)-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity.

Brief report: treatment of insulin-resistant diabetic ketoacidosis with insulin-like growth factor I in an adolescent with insulin-dependent diabetes

Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes

Comment to: Patti ME, McMahon G, Mun EC et al. (2005) Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia. Diabetologia 48:2236-2240

Comparison of the ability of bread versus bread plus meat to treat and prevent subsequent hypoglycemia in patients with insulin-dependent diabetes mellitus.

Cyclin-dependent kinase 5 promotes pancreatic β-cell survival via Fak-Akt signaling pathways.

Diabetes mellitus in cystic fibrosis is characterized by islet amyloidosis

Disorderly and nonstationary insulin secretion in relatives of patients with NIDDM

Diversion of the gastroduodenal vein: a canine model for comparing portal versus systemic insulin delivery

Diversion of the gastroduodenal vein: an in situ model of systemic insulin drainage.

Effect of insulin on oxidation of intracellularly and extracellularly derived glucose in patients with NIDDM. Evidence for primary defect in glucose transport and/or phosphorylation but not oxidation

Effects of fasting on physiologically pulsatile insulin release in healthy humans

Effects of glucose ingestion versus infusion on pulsatile insulin secretion. The incretin effect is achieved by amplification of insulin secretory burst mass

Effects of growth hormone on insulin sensitivity and forearm metabolism in normal man

Effects of meal ingestion on plasma amylin concentration in NIDDM and nondiabetic humans.

Effects of somatostatin on pulsatile insulin secretion: elective inhibition of insulin burst mass.

Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway

Farewell statement from Dr. Peter Butler as outgoing editor in chief of diabetes.

Glucagon like peptide-1 receptor expression in the human thyroid gland

Glucagon-like Peptide 1 Drugs as Second-line Therapy for Type 2 Diabetes.

Glucagon-like peptide-1 therapy and the exocrine pancreas: innocent bystander or friendly fire?

Glucagonlike Peptide 1-based drugs and pancreatitis: clarity at last, but what about pancreatic cancer?

Hepatic and extrahepatic responses to insulin in NIDDM and nondiabetic humans. Assessment in absence of artifact introduced by tritiated nonglucose contaminants.

Human islet amyloid polypeptide expression in COS-1 cells. A model of intracellular amyloidogenesis ⬇️

Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions

IGF-I inhibits burst mass of pulsatile insulin secretion at supraphysiological and low IGF-I infusion rates

Impact of sampling technique on appraisal of pulsatile insulin secretion by deconvolution and cluster analysis.

In humans at least 75% of insulin secretion arises from punctuated insulin secretory bursts

In the setting of β-cell stress, the pancreatic duct gland transcriptome shows characteristics of an activated regenerative response

Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP.

Insulin glargine controversy: a tribute to the editorial team at Diabetologia.

Insulin-degrading enzyme inhibition, a novel therapy for type 2 diabetes?

Interactions of poliovirus with montmorillonite clay in phosphate-buffered saline

Islet amyloid and islet amyloid polypeptide in cynomolgus macaques (Macaca fascicularis): an animal model of human non-insulin-dependent diabetes mellitus

Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis

Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes.

Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide.

Islet amyloidosis in a patient with chronic massive insulin resistance due to antiinsulin receptor antibodies

Lack of growth hormone effect on insulin-associated suppression of insulinlike growth factor binding protein 1 in humans.

Low Grade Islet but Marked Exocrine Pancreas Inflammation in an Adult with Autoimmune Pre-Diabetes

Many commercially available antibodies for detection of CHOP expression as a marker of endoplasmic reticulum stress fail specificity evaluation.

Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors

Measurement of insulin pulsatility by sampling directly from the portal vein: a surgical model for placement of long-term prehepatic vascular sampling catheters.

Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption.

Membrane Protein Insertion into and Compatibility with Biomimetic Membranes

Methods for assessment of the rate of onset and offset of insulin action during nonsteady state in humans.

Non-haematological solid tumours as surrogate granulocytes: a possible mechanism for metastatic spread

Overnight inhibition of insulin secretion restores pulsatility and proinsulin/insulin ratio in type 2 diabetes.

Pattern of postprandial carbohydrate metabolism and effects of portal and peripheral insulin delivery

Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes.

Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes

Recovery of high-quality RNA from laser capture microdissected human and rodent pancreas

Regulation of carbohydrate metabolism and response to hypoglycemia.

Relationship between beta-cell mass and diabetes onset.

Replication increases beta-cell vulnerability to human islet amyloid polypeptide-induced apoptosis.

Small heat shock proteins inhibit in vitro A beta(1-42) amyloidogenesis

The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity ⬇️

The effects of human proinsulin on glucose turnover and intermediary metabolism

The mass, but not the frequency, of insulin secretory bursts in isolated human islets is entrained by oscillatory glucose exposure.

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

The nocturnal increase in growth hormone is not the cause of the nocturnal increase in serum osteocalcin.

The potential for stem cell therapy in diabetes.

Treatment with growth hormone and dexamethasone in mice transgenic for human islet amyloid polypeptide causes islet amyloidosis and beta-cell dysfunction

Type 2 diabetes as a protein misfolding disease.

UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy

Underestimation of glucose turnover corrected with high-performance liquid chromatography purification of [6-3H]glucose.

β-Cell failure in type 2 diabetes: a case of asking too much of too few?

β-cell mass and turnover in humans: effects of obesity and aging