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List of works by Sam Brundin

"NeuroStem Chip": a novel highly specialized tool to study neural differentiation pathways in human stem cells

scientific article published on 8 February 2007

A Proposed Roadmap for Parkinson's Disease Proof of Concept Clinical Trials Investigating Compounds Targeting Alpha-Synuclein

scholarly article by Kalpana M Merchant et al published 29 October 2018 in Journal of Parkinson's disease

A cell culture model for monitoring α-synuclein cell-to-cell transfer

scientific article

A new approach to disease-modifying drug trials in Parkinson's disease

scientific article published on June 2013

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

scientific article

A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP ⬇️

scientific article published on April 30, 2013

Absence of striatal newborn neurons with mature phenotype following defined striatal and cortical excitotoxic brain injuries

scientific article

Acceleration of α-synuclein aggregation by exosomes

scientific article

Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment

scientific article published on 30 July 2009

Adsorption of α-synuclein to supported lipid bilayers: positioning and role of electrostatics

scientific article

Alpha-Synuclein to the Rescue: Immune Cell Recruitment by Alpha-Synuclein during Gastrointestinal Infection

scientific article published on 2 September 2017

Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo

scientific article

Alpha-synuclein propagation: New insights from animal models

scientific article published on 08 September 2015

Alpha-synuclein transfers from neurons to oligodendrocytes

scientific article

Amphetamine-induced abnormal movements occur independently of both transplant- and host-derived serotonin innervation following neural grafting in a rat model of Parkinson's disease

scientific article published on 8 April 2009

An Efficient Procedure for Removal and Inactivation of Alpha-Synuclein Assemblies from Laboratory Materials

scientific article

Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016?

scientific article

Are synucleinopathies prion-like disorders?

scientific article published on 16 September 2010

Asialoerythropoietin is not effective in the R6/2 line of Huntington's disease mice

scientific article

Basic science breaks through: New therapeutic advances in Parkinson's disease

scientific article published on 16 July 2015

Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice

scientific article published in July 2005

Beyond the brain: widespread pathology in Huntington's disease

scientific article

Biomarker-driven phenotyping in Parkinson's disease: A translational missing link in disease-modifying clinical trials

scientific article published on 24 February 2017

Calpain activation is involved in early caspase-independent neurodegeneration in the hippocampus following status epilepticus

scientific article

Can Parkinson's disease pathology be propagated from one neuron to another? ⬇️

scientific article published on November 18, 2011

Cancer enzyme affects Parkinson's disease

scientific article published in Science

Caspase signalling controls microglia activation and neurotoxicity

scientific article published on 9 March 2011

Cell transplantation in Parkinson's disease: problems and perspectives

scientific article published on August 2010

Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease

scientific article published in June 2010

Cholinergic neuronal defect without cell loss in Huntington's disease

scientific article published on 20 September 2006

Cocaine- and amphetamine-regulated transcript is increased in Huntington disease

scientific article

Combining neuroprotective treatment of embryonic nigral donor tissue with mild hypothermia of the graft recipient

scientific article published in January 2005

Comparison between survival of lazaroid-treated embryonic nigral neurons in cell suspensions, cultures and transplants

scientific article published in November 2002

Critical issues of clinical human embryonic stem cell therapy for brain repair

scientific article

Cyclosporin A and Bcl-2 do not inhibit quinolinic acid-induced striatal excitotoxicity in rodents

scientific article published in October 2003

Delayed recovery of movement-related cortical function in Parkinson's disease after striatal dopaminergic grafts

scientific article published on 01 November 2000

Delayed recovery of movement‐related cortical function in Parkinson's disease after striatal dopaminergic grafts

scholarly article by Paola Piccini et al published November 2000 in Annals of Neurology

Depletion of rabphilin 3A in a transgenic mouse model (R6/1) of Huntington's disease, a possible culprit in synaptic dysfunction

scientific article published on 20 June 2005

Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium

scientific article

Dissecting the potential molecular mechanisms underlying alpha-synuclein cell-to-cell transfer in Parkinson's disease

scientific article

Dyskinesias following neural transplantation in Parkinson's disease

scientific article published in July 2002

EXPRESSION OF PLATELET-DERIVED GROWTH FACTOR IN AND AROUND INTRASTRIATAL EMBRYONIC MESENCEPHALIC GRAFTS.

scientific article

Editorial: Pathogenic templating proteins in Neurodegenerative Disease.

scientific article published in January 2018

Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line

scientific article published on 26 July 2002

Emerging restorative treatments for Parkinson's disease

scientific article

Enriched environment attenuates cell genesis in subventricular zone after focal ischemia in mice and decreases migration of newborn cells to the striatum

scientific article published on 28 September 2006

Enrichment of risk SNPs in regulatory regions implicate diverse tissues in Parkinson's disease etiology

scientific article published on 27 July 2016

Evidence for dopaminergic re-innervation by embryonic allografts in an optimized rat model of the Parkinsonian variant of multiple system atrophy

scientific article published on 3 October 2005

Exendin-4 Treatment Improves LPS-Induced Depressive-Like Behavior Without Affecting Pro-Inflammatory Cytokines

scientific article

Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain

scientific article published on 02 May 2016

Failure of transdifferentiation of adult hematopoietic stem cells into neurons

scientific article published on 23 March 2006

Fibroblast growth factor-20 increases the yield of midbrain dopaminergic neurons derived from human embryonic stem cells

scientific article published on 30 December 2007

Foxa2 and Nurr1 synergistically yield A9 nigral dopamine neurons exhibiting improved differentiation, function, and cell survival

scientific article

Free radicals and ailing proteins--the culprits behind Parkinson disease?

scientific article published in April 2003

From bench to bed: the potential of stem cells for the treatment of Parkinson's disease

scientific article

Future Cell- and Gene-Based Therapies for Parkinson's Disease

article

GDNF treatment in Parkinson's disease: time for controlled clinical trials?

scientific article published in October 2002

Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice

scientific article

Growth factors and feeder cells promote differentiation of human embryonic stem cells into dopaminergic neurons: a novel role for fibroblast growth factor-20

scientific journal article

Gut feelings about smoking and coffee in Parkinson's disease

scientific article

Harnessing endogenous stem cells to treat neurodegenerative disorders of the basal ganglia

scientific article published in July 2004

How I examine my patient: the art of neurological examination for Parkinson's disease

scientific article published in January 2014

How strong is the evidence that Parkinson's disease is a prion disorder?

scientific article published on June 2016

Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease

scientific article published on 19 March 2011

Huntington's disease: a synaptopathy? ⬇️

scientific article published on October 1, 2003

Huntington's disease: the mystery unfolds?

scientific article

Immunotherapy in Parkinson's Disease: Micromanaging Alpha-Synuclein Aggregation

scientific article

Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease

scientific article

Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor

scientific article published in July 2005

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

scientific article published in March 2002

Increased thirst and drinking in Huntington's disease and the R6/2 mouse

scientific article published on 9 January 2008

Induction of dopaminergic neurons from growth factor expanded neural stem/progenitor cell cultures derived from human first trimester forebrain

scientific article published on 21 July 2006

Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis

scientific article

Is Axonal Degeneration a Key Early Event in Parkinson's Disease?

scientific article

Islet beta-cell area and hormone expression are unaltered in Huntington's disease

scientific article published on 8 February 2008

Journal of Parkinson's Disease – an Excellent First Year and a New Sister ⬇️

scientific article published on January 1, 2012

Lentiviral gene delivery of GDNF into the striatum of R6/2 Huntington mice fails to attenuate behavioral and neuropathological changes

scientific article

Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease

scientific article published in 2014

Long-term clinical outcome of fetal cell transplantation for Parkinson disease: two case reports

scientific article

Membrane Interaction of α-Synuclein in Different Aggregation States

article by Marie Grey et al published January 2012 in Biophysical Journal

Membrane interaction of α-synuclein in different aggregation states

scientific article published on January 2011

Microchannel acoustophoresis does not impact survival or function of microglia, leukocytes or tumor cells

scientific article

Midbrain expression of Delta-like 1 homologue is regulated by GDNF and is associated with dopaminergic differentiation

scientific article published on 24 January 2007

Mind the gut: secretion of α-synuclein by enteric neurons

scientific article

Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease

scientific article published in December 2016

Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion

scientific article

Neural grafting in Parkinson's disease Problems and possibilities

scientific article published on January 2010

Neural transplantation for the treatment of Parkinson's disease

scientific article

Neuregulin-1 receptor tyrosine kinase ErbB4 is upregulated in midbrain dopaminergic neurons in Parkinson disease ⬇️

scientific article published on November 2, 2012

Neurogenin2 directs granule neuroblast production and amplification while NeuroD1 specifies neuronal fate during hippocampal neurogenesis

scientific article

Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease

scientific article published on 3 July 2008

Neuronal properties, in vivo effects, and pathology of a Huntington's disease patient-derived induced pluripotent stem cells

scientific article published on September 2012

Neuropathology in transplants in Parkinson's disease: implications for disease pathogenesis and the future of cell therapy

scientific article published on January 2012

Nilotinib - Differentiating the Hope from the Hype

scientific article published on 12 July 2016

No evidence for new dopaminergic neurons in the adult mammalian substantia nigra

scientific article

Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease

scientific article

Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein

scientific article published on 8 August 2017

On the move to stimulate cell plasticity in the substantia nigra in Parkinson's disease

scientific article published on 27 June 2006

Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression

scientific article

Oxidative stress in neurodegenerative disease: causation or association?

scientific article published on 13 January 2017

Parkinson Matters

scholarly article by Sirwan K L Darweesh et al published 20 August 2018 in Journal of Parkinson's disease

Parkinson disease

scientific article

Parkinson's Disease and Alpha Synuclein: Is Parkinson's Disease a Prion‐Like Disorder? ⬇️

scientific article published on January 1, 2013

Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

scientific article

Patterns of Cell Death and Dopaminergic Neuron Survival in Intrastriatal Nigral Grafts

scholarly article by Mia Emgård et al published November 1999 in Experimental Neurology

Precision medicine for disease modification in Parkinson disease

scientific article published on 20 January 2017

Prion-like transmission of protein aggregates in neurodegenerative diseases

scientific article

Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease

scientific article published on 13 April 2006

Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease

scientific article

Prying into the Prion Hypothesis for Parkinson's Disease

scientific article

Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson's disease

scientific article

Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting.

scientific article published on 13 December 2017

Reduced expression of PSA-NCAM in the hippocampus and piriform cortex of the R6/1 and R6/2 mouse models of Huntington's disease

scientific article published on 20 December 2006

Reduced hippocampal neurogenesis in R6/2 transgenic Huntington's disease mice

scientific article published on 13 June 2005

Reduced neurogenesis in the rat hippocampus following high fructose consumption

scientific article

Reduction of GnRH and infertility in the R6/2 mouse model of Huntington's disease

scientific article published in September 2005

Research in motion: the enigma of Parkinson's disease pathology spread

scientific article published on 04 September 2008

Restorative cell therapy for Parkinson's disease: a quest for the perfect cell

scientific article

Short- and long-term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson's disease

scientific article published in July 1997

Signs of degeneration in 12-22-year old grafts of mesencephalic dopamine neurons in patients with Parkinson's disease

scientific article

Silencing synuclein at the synapse with PLK2

scientific article published on 26 September 2013

Solving the conundrum of insoluble protein aggregates

scientific article published on 23 February 2017

Sorting out release, uptake and processing of alpha-synuclein during prion-like spread of pathology

scientific article

Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term

scientific article published on 5 December 2017

Spreading of α-synuclein in the face of axonal transport deficits in Parkinson's disease: a speculative synthesis

scientific article

Stage-Specific Modulation of Cortical Neuronal Development by Mmu-miR-134 ⬇️

scientific article published on January 12, 2011

Stem cell therapy for Parkinson's disease: where do we stand?

scientific article published on 11 August 2004

Stem cell-based therapy for Parkinson's disease

scientific article

Stem cells: hype or hope?

scientific article

Stromal cell-derived inducing activity does not promote dopaminergic differentiation, but enhances differentiation and proliferation of neural stem cell-derived astrocytes

scientific article

Targeted therapies for Parkinson's disease: From genetics to the clinic

scientific article published on 27 April 2018

Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration.

scientific article published on 24 May 2018

The Origin, Development and Molecular Diversity of Rodent Olfactory Bulb Glutamatergic Neurons Distinguished by Expression of Transcription Factor NeuroD1

scientific article (publication date: 2015)

The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis

scientific article published on 13 January 2005

The Times They Are a-Changin': Parkinson's Disease 20 Years from Now

scholarly article by Patrik Brundin & Bastiaan R Bloem published 2018 in Journal of Parkinson's disease

The adult human brain harbors multipotent perivascular mesenchymal stem cells

scientific article (publication date: 2012)

The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy

scientific article published on January 2008

The concept of alpha-synuclein as a prion-like protein: ten years after

scientific article published on 26 February 2018

The effect of alpha-synuclein knockdown on MPP+ toxicity in models of human neurons

scientific article

The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases

scientific article published on 20 December 2016

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

scientific article published on October 2003

The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies

scientific article

Therapeutic approaches to target alpha-synuclein pathology

scientific article published on 4 October 2017

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice ⬇️

scientific article published on August 8, 2013

Transplantation in Parkinson's disease: The future looks bright

scientific article published on January 2006

Tyrosine hydroxylase expression is unstable in a human immortalized mesencephalic cell line--studies in vitro and after intracerebral grafting in vivo

scientific article published on 10 January 2007

Ultrastructural characterization of dissociated embryonic ventral mesencephalic tissue treated with neuroprotectants.

scientific article

What’s to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease? ⬇️

scientific article published on January 1, 2013

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

scientific article

α‐Synuclein: The Long Distance Runner ⬇️

scientific article published on May 1, 2013

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