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List of works by Yoshiaki Furukawa

A copper-deficient form of mutant Cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis

scientific article published on 15 March 2018

A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis.

scientific article published on 15 December 2016

A molecular mechanism realizing sequence-specific recognition of nucleic acids by TDP-43.

scientific article published on 3 February 2016

A primary role for disulfide formation in the productive folding of prokaryotic Cu,Zn-superoxide dismutase

scientific article

A seeded propagation of Cu, Zn-superoxide dismutase aggregates in amyotrophic lateral sclerosis.

scientific article published on 18 March 2014

A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions

scientific article

Abnormal protein oligomers for neurodegeneration

scientific article published on 19 May 2017

Aggregation of FET Proteins as a Pathological Change in Amyotrophic Lateral Sclerosis

scientific article published on 17 June 2016

Amyotrophic lateral sclerosis mutations have the greatest destabilizing effect on the apo- and reduced form of SOD1, leading to unfolding and oxidative aggregation.

scientific article published on 3 February 2005

An essential role of N-terminal domain of copper chaperone in the enzymatic activation of Cu/Zn-superoxide dismutase

scientific article published on 31 July 2017

Biochemical and morphological classification of disease-associated alpha-synuclein mutants aggregates

scientific article published on 06 December 2018

Complete loss of post-translational modifications triggers fibrillar aggregation of SOD1 in the familial form of amyotrophic lateral sclerosis

scientific article

Conformational Disorder of the Most Immature Cu, Zn-Superoxide Dismutase Leading to Amyotrophic Lateral Sclerosis.

scientific article published on 22 December 2015

Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria

scholarly article

Copper Homeostasis as a Therapeutic Target in Amyotrophic Lateral Sclerosis with SOD1 Mutations

scientific article

Cross-seeding fibrillation of Q/N-rich proteins offers new pathomechanism of polyglutamine diseases

scientific article published in April 2009

Cysteine residues in Cu,Zn-superoxide dismutase are essential to toxicity in Caenorhabditis elegans model of amyotrophic lateral sclerosis.

scientific article published on 15 June 2015

Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice

scientific article

Disulfide scrambling describes the oligomer formation of superoxide dismutase (SOD1) proteins in the familial form of amyotrophic lateral sclerosis.

scientific article published on 21 December 2012

Does wild-type Cu/Zn-superoxide dismutase have pathogenic roles in amyotrophic lateral sclerosis?

scientific article published on 19 August 2020

Electron transfer reaction in a single protein molecule observed by total internal reflection fluorescence microscopy.

scientific article published in February 2005

Electron transfer reactions in Zn-substituted cytochrome P450cam.

scientific article

Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals.

scientific article

Factors controlling the uptake of yeast copper/zinc superoxide dismutase into mitochondria.

scientific article published on 14 May 2003

Functional diversity of protein fibrillar aggregates from physiology to RNA granules to neurodegenerative diseases.

scientific article published on 15 April 2013

Identification of a novel zinc-binding protein, C1orf123, as an interactor with a heavy metal-associated domain

scientific article published in PLoS ONE

Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis

scientific article published on 05 January 2017

Intracellular seeded aggregation of mutant Cu,Zn-superoxide dismutase associated with amyotrophic lateral sclerosis

scientific article

Intranuclear aggregation of mutant FUS/TLS as a molecular pathomechanism of amyotrophic lateral sclerosis

scientific article published on 26 November 2013

Investigation of the electron-transfer mechanism by cross-linking between Zn-substituted myoglobin and cytochrome b(5).

scientific article

Local unfolding of Cu, Zn superoxide dismutase monomer determines the morphology of fibrillar aggregates

scientific article published on 21 December 2011

Molecular properties of TAR DNA binding protein-43 fragments are dependent upon its cleavage site ⬇️

scientific article published on September 16, 2011

Mutant huntingtin fragment selectively suppresses Brn-2 POU domain transcription factor to mediate hypothalamic cell dysfunction

scientific article

Mutation-dependent polymorphism of Cu,Zn-superoxide dismutase aggregates in the familial form of amyotrophic lateral sclerosis

scientific article

Oxidation-state-dependent protein docking between cytochrome c and cytochrome b(5): high-pressure laser flash photolysis study.

scientific article

Oxygen-induced maturation of SOD1: a key role for disulfide formation by the copper chaperone CCS.

scientific article published on 24 June 2004

Pathological roles of wild-type cu, zn-superoxide dismutase in amyotrophic lateral sclerosis.

scientific article published on July 2012

Post-aggregation oxidation of mutant huntingtin controls the interactions between aggregates.

scientific article

Posttranslational modifications in Cu,Zn-superoxide dismutase and mutations associated with amyotrophic lateral sclerosis.

scientific article

Redox environment is an intracellular factor to operate distinct pathways for aggregation of Cu,Zn-superoxide dismutase in amyotrophic lateral sclerosis.

scientific article published on 27 November 2013

Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31.

scientific article published on 18 March 2017

Screening of Drugs Inhibiting In vitro Oligomerization of Cu/Zn-Superoxide Dismutase with a Mutation Causing Amyotrophic Lateral Sclerosis

scientific article

Tau protein assembles into isoform- and disulfide-dependent polymorphic fibrils with distinct structural properties.

scientific article published on 9 June 2011

The unusually stable quaternary structure of human Cu,Zn-superoxide dismutase 1 is controlled by both metal occupancy and disulfide status

scientific article published on 23 August 2004

Wild-type Cu/Zn-superoxide dismutase is misfolded in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis

scientific article published on 19 November 2019

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