Advanced search

Authors whose works are in public domain in at least one jurisdiction

List of works by Anthony A. Hyman

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

scientific article

A Protein Domain-Based Interactome Network for C. elegans Early Embryogenesis

A comparison of the ability of XMAP215 and tau to inhibit the microtubule destabilizing activity of XKCM1

scientific article

A cytokinesis furrow is positioned by two consecutive signals

scientific article published in August 2005

A focused ion beam milling and lift-out approach for site-specific preparation of frozen-hydrated lamellas from multicellular organisms.

scientific article published on 24 July 2015

A genome-scale resource for in vivo tag-based protein function exploration in C. elegans

scientific article

A genomic toolkit to investigate kinesin and myosin motor function in cells

scientific article

A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue

scientific article

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

scientific article

A locus in Pristionchus pacificus that is responsible for the ability to give rise to fertile offspring at higher temperatures

scientific article published on 18 July 2016

A protein domain-based interactome network for C. elegans early embryogenesis

scientific article

A recombineering pipeline for functional genomics applied to Caenorhabditis elegans

scientific article published in October 2006

A requirement for Rho and Cdc42 during cytokinesis in Xenopus embryos.

scientific article

A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility

scientific article

APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.

scientific article published on 24 September 2012

ATP as a biological hydrotrope.

scientific article published in May 2017

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes ⬇️

scientific article published on February 28, 2011

Acto-myosin reorganization and PAR polarity in C. elegans

scientific article published on 7 February 2007

Amyloid-like Self-Assembly of a Cellular Compartment

scientific article published on July 2016

An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles.

scientific article published in August 2005

Analysis of the distribution of the kinetochore protein Ndc10p in Saccharomyces cerevisiae using 3-D modeling of mitotic spindles ⬇️

scientific article published on March 18, 2003

Are aberrant phase transitions a driver of cellular aging?

scientific article (publication date: October 2016)

Asymmetric cell division in C. elegans: cortical polarity and spindle positioning

scientific article published in January 2004

Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules

scientific article published on September 2005

Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis

scientific article published on 19 September 2005

Automated stitching of microtubule centerlines across serial electron tomograms

scientific article

Automated tracing of microtubules in electron tomograms of plastic embedded samples of Caenorhabditis elegans embryos

scientific article

Automated tracking and analysis of centrosomes in early Caenorhabditis elegans embryos

scientific article

BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals

scientific article

BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures

scientific article

Beyond Oil and Water--Phase Transitions in Cells

scientific article published in Science

Beyond Stereospecificity: Liquids and Mesoscale Organization of Cytoplasm ⬇️

scientific article published on July 19, 2011

Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation

scientific article

Boveri revisited

scientific article

Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A

scientific article

C11ORF24 is a novel type I membrane protein that cycles between the Golgi apparatus and the plasma membrane in Rab6-positive vesicles

scientific article (publication date: 2013)

CDC-42 and RHO-1 coordinate acto-myosin contractility and PAR protein localization during polarity establishment in C. elegans embryos

scientific article published on 9 August 2006

CDK1 Inactivation Regulates Anaphase Spindle Dynamics and Cytokinesis In Vivo ⬇️

scientific article published on July 28, 1997

CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis

scientific article published in June 2000

Caenorhabditis elegans TAC-1 and ZYG-9 form a complex that is essential for long astral and spindle microtubules

scientific journal article

Cdk1-dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinement

scientific article

Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication

scientific article

Cell fate determination. When is a determinant a determinant?

scientific article published on May 1994

Cell polarity. The importance of being polar

scientific article published on October 1995

Cell structure and dynamics

Centriole assembly in Caenorhabditis elegans

scientific article published on November 2006

Centrosome size sets mitotic spindle length in Caenorhabditis elegans embryos

scientific article published on 4 February 2010

Centrosomes are autocatalytic droplets of pericentriolar material organized by centrioles

scientific article

Centrosomes direct cell polarity independently of microtubule assembly in C. elegans embryos

scientific article

Centrosomes. Regulated assembly of a supramolecular centrosome scaffold in vitro

scientific article published on May 2015

Centrosomes: Sic transit gloria centri

article by Anthony A. Hyman published 2000

Characterization of RNA content in individual phase-separated coacervate microdroplets

scientific article published on 12 May 2022

Characterization of protein dynamics in asymmetric cell division by scanning fluorescence correlation spectroscopy

scientific article published on 19 September 2008

Codon adaptation–based control of protein expression in C. elegans

scientific article published on 30 January 2011

Coiled-coil proteins facilitated the functional expansion of the centrosome

scientific article

Common Molecular Pathways in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

scientific article

Comparative profiling identifies C13orf3 as a component of the Ska complex required for mammalian cell division

scientific article

Conserved TCP domain of Sas-4/CPAP is essential for pericentriolar material tethering during centrosome biogenesis

scientific article published on 02 January 2014

Controlling compartmentalization by non-membrane-bound organelles

scientific article published in May 2018

Correct spindle elongation at the metaphase/anaphase transition is an APC-dependent event in budding yeast ⬇️

scientific article published on November 26, 2001

Cortical domain correction repositions the polarity boundary to match the cytokinesis furrow in C. elegans embryos

scientific article

Cortical domains and the mechanisms of asymmetric cell division.

scientific article published on October 1996

Coupling cell division and cell death to microtubule dynamics

scientific article published on December 1997

Crystal structure of a TOG domain: conserved features of XMAP215/Dis1-family TOG domains and implications for tubulin binding

scientific article

Cyclin E-Cdk2 temporally regulates centrosome assembly and establishment of polarity in Caenorhabditis elegans embryos

scientific article published on 19 November 2006

Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo

scientific article

Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans

scientific article

Diverse transcription factor binding features revealed by genome-wide ChIP-seq in C. elegans

scientific article

Dynamics and mechanics of the microtubule plus end ⬇️

scientific article published on April 17, 2003

EB1 recognizes the nucleotide state of tubulin in the microtubule lattice

scientific article

Efficient chaperone-mediated tubulin biogenesis is essential for cell division and cell migration in C. elegans

scientific article published on 24 October 2007

Emergent Properties of the Metaphase Spindle

scientific article published on July 2015

Encouraging innovation

scientific article published on February 2014

Erratum: Corrigendum: BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals

scholarly article published in Nature Methods

FRAP analysis of membrane-associated proteins: lateral diffusion and membrane-cytoplasmic exchange

scientific article published on October 2010

Factors required for the binding of reassembled yeast kinetochores to microtubules in vitro.

scientific article

Force probing cell shape changes to molecular resolution

scientific article published on 07 June 2011

Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans

scientific article (publication date: 24 March 2005)

Functional analysis of kinetochore assembly in Caenorhabditis elegans.

scientific article published in June 2001

Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III

scientific article (publication date: 16 November 2000)

Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression

scientific article

Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions

scientific article (publication date: 8 June 2012)

Funding Innovative Science ⬇️

scientific article published on January 11, 2013

GTP binding induces filament assembly of a recombinant septin

scientific article

GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration

scientific article (publication date: 2012)

Genome-scale RNAi profiling of cell division in human tissue culture cells

scientific article

Genome-wide identification of binding sites defines distinct functions for Caenorhabditis elegans PHA-4/FOXA in development and environmental response

scientific article

Germline P granules are liquid droplets that localize by controlled dissolution/condensation

scientific article

Global and local control of microtubule destabilization promoted by a catastrophe kinesin MCAK/XKCM1.

scientific article

Growth, fluctuation and switching at microtubule plus ends

scientific article published on 10 June 2009

HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity

scientific article

High-efficiency counterselection recombineering for site-directed mutagenesis in bacterial artificial chromosomes

scientific article

Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding

scientific article

Identification and characterization of factors required for microtubule growth and nucleation in the early C. elegans embryo

scientific article published in August 2005

Identification of essential components of the S. cerevisiae kinetochore

scientific article published in May 1993

In vitro Reconstitution of a Membrane Switch Mechanism for the Polarity Protein LGL.

scientific article published on 6 October 2016

Katanin disrupts the microtubule lattice and increases polymer number in C. elegans meiosis

scientific article published in October 2006

LET-99, GOA-1/GPA-16, and GPR-1/2 are required for aster-positioned cytokinesis

scientific article published on 28 December 2006

LGL can partition the cortex of one-cell Caenorhabditis elegans embryos into two domains

scientific article

Limiting amounts of centrosome material set centrosome size in C. elegans embryos

scientific article published on 28 July 2011

Liquid-liquid phase separation in biology

scientific article published on January 2014

Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells

scientific article

Membrane invaginations reveal cortical sites that pull on mitotic spindles in one-cell C. elegans embryos

scientific article (publication date: 2010)

Method: In vitro analysis of pericentriolar material assembly

scientific article published on 19 June 2015

Microtubule Dynamics: Kinetochores get a grip ⬇️

scientific article published on May 1, 1995

Microtubule polymerases and depolymerases

scientific article published on 20 December 2006

Microtubule structure and dynamics

scientific article

Microtubule-motor activity of a yeast centromere-binding protein complex

scientific article

Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement

scientific article

Mitotic chromatin regulates phosphorylation of Stathmin/Op18

scientific article published in Nature

Modulation of microtubule stability by kinetochores in vitro

scientific article published on May 1990

Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length

scientific article (publication date: 2016)

Molecular requirements for bi-directional movement of phagosomes along microtubules

scientific article published on April 1997

Morphogenetic properties of microtubules and mitotic spindle assembly

scientific article published on February 1996

Morphologically distinct microtubule ends in the mitotic centrosome of Caenorhabditis elegans ⬇️

scientific article published on November 10, 2003

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods

scientific article

One-step purification of assembly-competent tubulin from diverse eukaryotic sources

scientific article

Organelle growth control through limiting pools of cytoplasmic components

scientific article published on 07 May 2012

PAR proteins diffuse freely across the anterior-posterior boundary in polarized C. elegans embryos ⬇️

scientific article

PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins

scientific article

Partitioning of cancer therapeutics in nuclear condensates

scientific article published on 01 June 2020

Pericentriolar material structure and dynamics

scientific article

Phase separation of a yeast prion protein promotes cellular fitness.

scientific article published in January 2018

Phase separation provides a mechanism to reduce noise in cells

scientific article published on 01 January 2020

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes

scientific article

Pheromone Induces Programmed Cell Death in S. cerevisiae

scientific article published on 01 April 2002

Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism.

scientific article

Polarization of PAR proteins by advective triggering of a pattern-forming system

scientific article published on 20 October 2011

Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation

scientific article published on 02 September 2016

Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis

scientific article published in August 2005

Principles of PAR polarity in Caenorhabditis elegans embryos ⬇️

scientific article published on April 18, 2013

Priority of discovery in the life sciences

scientific article

Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival

scientific article

Proliferating versus differentiating stem and cancer cells exhibit distinct midbody-release behaviour.

scientific article

Protein condensates as aging Maxwell fluids

scientific article published on 01 December 2020

Purification of tubulin from porcine brain

scientific article published in January 2011

Quantification of surface tension and internal pressure generated by single mitotic cells

scientific article

Quantitative comparison of a human cancer cell surface proteome between interphase and mitosis

scientific article

Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers

scientific article

RNA buffers the phase separation behavior of prion-like RNA binding proteins.

scientific article published on 12 April 2018

RNA gets in phase

scientific article

RNA interference rescue by bacterial artificial chromosome transgenesis in mammalian tissue culture cells

scientific article

Real-time visualization of cell cycle-dependent changes in microtubule dynamics in cytoplasmic extracts

scientific article

Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

scientific article published on 17 February 2021

Regulating the Yeast Kinetochore by Ubiquitin-Dependent Degradation and Skp1p-Mediated Phosphorylation ⬇️

scientific article published on November 14, 1997

Rheology of the Active Cell Cortex in Mitosis

scientific article published on August 2016

Role of mitochondria in the pheromone- and amiodarone-induced programmed death of yeast

scientific article

SAS-4 is a C. elegans centriolar protein that controls centrosome size

scientific article published in February 2003

Samurai Sword Sets Spindle Size ⬇️

scientific article published on December 9, 2011

Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores ⬇️

scientific article published on July 16, 2012

Site-Specific Cryo-focused Ion Beam Sample Preparation Guided by 3D Correlative Microscopy

scientific article published on 5 January 2016

Soluble tubulin is locally enriched at mitotic centrosomes in C. elegans

Soluble tubulin is significantly enriched at mitotic centrosomes

scientific article published on 21 October 2019

Sororin mediates sister chromatid cohesion by antagonizing Wapl

scientific article

Spatial Organization of the Cell Cytoplasm by Position-Dependent Phase Separation

scientific article published in Physical Review Letters

Spindle oscillations during asymmetric cell division require a threshold number of active cortical force generators

scientific article published in November 2006

Spindle positioning and cell polarity.

scientific article published in September 1992

Spindle positioning by cortical pulling forces

scientific article

Stoichiometry of chromatin-associated protein complexes revealed by label-free quantitative mass spectrometry-based proteomics

scientific article published on 12 October 2012

Straight GDP-tubulin protofilaments form in the presence of taxol

scientific article published on 4 October 2007

Stress generation and filament turnover during actin ring constriction

scientific article published on 8 August 2007

Structural changes accompanying GTP hydrolysis in microtubules: information from a slowly hydrolyzable analogue guanylyl-(alpha,beta)-methylene-diphosphonate

scientific article published on January 1995

Structural transitions at microtubule ends correlate with their dynamic properties in Xenopus egg extracts

scientific article published on May 2000

Stu2 promotes mitotic spindle elongation in anaphase.

scientific article

Suppression of Ostwald ripening in active emulsions.

scientific article published on 22 July 2015

Synergy between XMAP215 and EB1 increases microtubule growth rates to physiological levels

scientific article

Systematic analysis of human protein complexes identifies chromosome segregation proteins

scientific article

Systematic phosphorylation analysis of human mitotic protein complexes.

scientific article published on 8 November 2011

Temperature Dependence of Cell Division Timing Accounts for a Shift in the Thermal Limits of C. elegans and C. briggsae

scientific article

The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly

scientific article (publication date: 12 January 2007)

The Caenorhabditis elegans centrosomal protein SPD-2 is required for both pericentriolar material recruitment and centriole duplication.

scientific article published in May 2004

The Caenorhabditis elegans pericentriolar material components SPD-2 and SPD-5 are monomeric in the cytoplasm before incorporation into the PCM matrix

scientific article

The Mitotic Spindle in the One-Cell C. elegans Embryo Is Positioned with High Precision and Stability

scientific article published on October 2016

The Rho GTPase-activating proteins RGA-3 and RGA-4 are required to set the initial size of PAR domains in Caenorhabditis elegans one-cell embryos

scientific article

The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae

scientific article

The distribution of active force generators controls mitotic spindle position

scientific article

The first cell cycle of the Caenorhabditis elegans embryo: spatial and temporal control of an asymmetric cell division

scientific article published on January 2011

The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is gamma-tubulin dependent

scientific article

The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis

scientific journal article

The mbk-2 kinase is required for inactivation of MEI-1/katanin in the one-cell Caenorhabditis elegans embryo

scientific article

The segmentation of microtubules in electron tomograms using Amira

2014 scientific article

Timing and mechanism of the initial cue establishing handed left–right asymmetry in Caenorhabditis elegans embryos

scientific article published in June 2014

Tracking mechanics and volume of globular cells with atomic force microscopy using a constant-height clamp

scientific article published on 5 January 2012

TransgeneOmics--A transgenic platform for protein localization based function exploration

scientific article

Two genes required for the binding of an essential Saccharomyces cerevisiae kinetochore complex to DNA.

scientific article

Visualizing the molecular sociology at the HeLa cell nuclear periphery

scientific article

Whither systems biology

scientific article

XMAP215 activity sets spindle length by controlling the total mass of spindle microtubules

scientific article published on 25 August 2013

XMAP215 is a processive microtubule polymerase

scientific article

XMAP215 polymerase activity is built by combining multiple tubulin-binding TOG domains and a basic lattice-binding region

scientific article

XMAP215 regulates microtubule dynamics through two distinct domains.

scientific article

XMAP215: a key component of the dynamic microtubule cytoskeleton

scientific article

Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner

scientific article

zyg-8, a gene required for spindle positioning in C. elegans, encodes a doublecortin-related kinase that promotes microtubule assembly.

scientific article published in September 2001

Paulina is supported by:

About Paulina

Help