List of works - Giles See How Yeo

5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats

scientific article published on 14 January 2016

A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance

scientific article published in February 2006

A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD.

scientific article

A de novo mutation affecting human TrkB associated with severe obesity and developmental delay

scientific article

A frameshift mutation in MC4R associated with dominantly inherited human obesity ⬇️

scientific article published on October 1, 1998

A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia.

scholarly article

Adult onset global loss of the fto gene alters body composition and metabolism in the mouse

scientific article (publication date: 2013)

Adult-onset hyperinsulinaemic hypoglycaemia in clinical practice: diagnosis, aetiology and management.

scientific article published on 07 August 2017

Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets

scientific article published on 23 December 2015

Attractin' more attention - new pieces in the obesity puzzle?

scientific article

BarraCUDA - a fast short read sequence aligner using graphics processing units

scientific article published on 13 January 2012

Central leptin and ghrelin signalling: comparing and contrasting their mechanisms of action in the brain.

scientific article published on September 2011

Central leptin signalling: beyond the arcuate nucleus.

scientific article published on 13 June 2010

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

scientific article published on 26 April 2016

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

scientific article (publication date: 20 March 2003)

Contributions of Function-Altering Variants in Genes Implicated in Pubertal Timing and Body Mass for Self-Limited Delayed Puberty.

scientific article published on 16 November 2017

DEFLATE compression algorithm corrects for overestimation of phylogenetic diversity by Grantham approach to single-nucleotide polymorphism classification

scientific article published on 13 May 2014

Deletion of codons 88-92 of the melanocortin-4 receptor gene: a novel deleterious mutation in an obese female.

scientific article published on December 2003

Diet-induced gene expression of isolated pancreatic islets from a polygenic mouse model of the metabolic syndrome.

scientific article

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

scientific article published in July 2000

Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice

scientific journal article

FTO Biology and Obesity: Why Do a Billion of Us Weigh 3 kg More?

scientific article

FTO and obesity: a problem for a billion people.

scientific article published in February 2012

FTO expression is regulated by availability of essential amino acids.

scientific article published on 22 May 2012

FTO is necessary for the induction of leptin resistance by high-fat feeding

scientific article published on 07 February 2015

Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm.

scientific article published on 22 October 2014

From GWAS to biology: lessons from FTO.

scientific article published on March 2011

Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.

scientific article published on 18 September 2008

Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity.

scientific article published on 16 May 2006

Functional responses of human beta1 adrenoceptors with defined haplotypes for the common 389R>G and 49S>G polymorphisms.

scientific article

GDF15 and energy balance: homing in on a mechanism.

scientific article published in October 2017

Generation and analysis of 25 Mb of genomic DNA from the pufferfish Fugu rubripes by sequence scanning

scientific article

Genetic variants in human sterol regulatory element binding protein-1c in syndromes of severe insulin resistance and type 2 diabetes.

scientific article published on March 2004

Genetic variants of insulin receptor substrate-1 (IRS-1) in syndromes of severe insulin resistance. Functional analysis of Ala513Pro and Gly1158Glu IRS-1.

scientific article published in October 2002

Genetics of obesity: can an old dog teach us new tricks?

scientific article published on 24 December 2016

Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing

scientific article published on March 2017

High fat diet impairs the function of glucagon-like peptide-1 producing L-cells

scientific article published on 3 July 2015

Human embryonic genome activation initiates at the one-cell stage

publication published on 21 December 2021

Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene

scientific article published on December 2006

Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome.

scientific article published on 29 January 2018

Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.

scientific article

Identification of the global transcriptomic response of the hypothalamic arcuate nucleus to fasting and leptin.

scientific article

Impaired prohormone processing: a grand unified theory for features of Prader-Willi syndrome?

scientific article published on 12 December 2016

Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate

scientific article published in June 2012

LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal

scientific article published on 27 April 2015

Leptin and the control of body weight: a review of its diverse central targets, signaling mechanisms, and role in the pathogenesis of obesity.

scientific article

Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations

scientific article published on 25 June 2009

Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet

scientific article published on 17 April 2017

Maternal Obesity in Pregnancy Developmentally Programs Adipose Tissue Inflammation in Young, Lean Male Mice Offspring

scientific article published on September 2016

Maternal diet amplifies the hepatic aging trajectory of Cidea in male mice and leads to the development of fatty liver.

scientific article published on 30 January 2014

Melanocortin receptors weigh in.

scientific article

Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36).

scholarly article

Microarray analysis of insulin and insulin-like growth factor-1 (IGF-1) receptor signaling reveals the selective up-regulation of the mitogen heparin-binding EGF-like growth factor by IGF-1.

scientific article

Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms

article

NFIX Regulates Proliferation and Migration Within the Murine SVZ Neurogenic Niche

scientific article

Nutrition-/diet-induced changes in gene expression in pancreatic β-cells.

scientific article published on October 2012

Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence

scientific article published on 01 July 2021

Obesity and FTO: Changing Focus at a Complex Locus

scientific article

Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation.

scientific article published on 15 August 2017

Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry.

scientific article published on 8 June 2012

PP2Ce: Fat and stressed out?

scientific article published on 7 September 2013

Past, present and future strategies to study the genetics of body weight regulation.

scientific article published in October 2002

Pathological missense mutations of neural cell adhesion molecule L1 affect homophilic and heterophilic binding activities.

scientific article published on September 1999

Prevalence of loss-of-function FTO mutations in lean and obese individuals

scientific article

Role for the obesity-related FTO gene in the cellular sensing of amino acids

scientific article published on 28 January 2013

Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response.

scholarly article

Selective rab11 transport and the intrinsic regenerative ability of CNS axons. ⬇️

scientific article

Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation

scientific article

SnapShot: the hormonal control of food intake.

scientific article published in October 2008

Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension.

scientific article

Subcellular profiling reveals distinct and developmentally regulated repertoire of growth cone mRNAs.

scientific article

TCR usage, gene expression and function of two distinct FOXP3(+)Treg subsets within CD4(+)CD25(hi) T cells identified by expression of CD39 and CD45RO.

scientific article published on 15 October 2015

Tachykinin-1 in the central nervous system regulates adiposity in rodents

scientific article

The CART gene and human obesity: mutational analysis and population genetics

scientific article

The bigger picture of FTO: the first GWAS-identified obesity gene

scientific article

The biology of FTO: from nucleic acid demethylase to amino acid sensor ⬇️

scientific article published on July 30, 2013

The effects of neurokinin B upon gonadotrophin release in male rodents.

scientific article published on 23 December 2009

The expression of dynein light chain DYNLL1 (LC8-1) is persistently downregulated in glaucomatous rat retinal ganglion cells.

scientific article

The hypothalamus and metabolism: integrating signals to control energy and glucose homeostasis.

scientific article published on 24 September 2013

The leptin melanocortin pathway and the control of body weight: lessons from human and murine genetics.

scientific article published on July 2007

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

scientific article

The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system

scientific article published on 11 February 2014

The role of melanocortin signalling in the control of body weight: evidence from human and murine genetic models.

scientific article

The role of the FTO (Fat Mass and Obesity Related) locus in regulating body size and composition.

scientific article published on 16 September 2014

Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight

scientific article

Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues

scientific article published on 24 October 2016

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

scientific article published on 7 July 2016

Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity.

scientific article published on January 2016

Uncovering the biology of FTO

scientific article published on 03 August 2012

Where next for GWAS? ⬇️

scientific article published on 01 March 2011

Where to go with FTO?

scientific article published on 04 December 2010

p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1

scientific article published in Nature Communications

List of works by Giles See How Yeo

5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats

A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance

A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD.

A de novo mutation affecting human TrkB associated with severe obesity and developmental delay

A frameshift mutation in MC4R associated with dominantly inherited human obesity ⬇️

A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia.

Adult onset global loss of the fto gene alters body composition and metabolism in the mouse

Adult-onset hyperinsulinaemic hypoglycaemia in clinical practice: diagnosis, aetiology and management.

Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets

Attractin' more attention - new pieces in the obesity puzzle?

BarraCUDA - a fast short read sequence aligner using graphics processing units

Central leptin and ghrelin signalling: comparing and contrasting their mechanisms of action in the brain.

Central leptin signalling: beyond the arcuate nucleus.

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

Contributions of Function-Altering Variants in Genes Implicated in Pubertal Timing and Body Mass for Self-Limited Delayed Puberty.

DEFLATE compression algorithm corrects for overestimation of phylogenetic diversity by Grantham approach to single-nucleotide polymorphism classification

Deletion of codons 88-92 of the melanocortin-4 receptor gene: a novel deleterious mutation in an obese female.

Diet-induced gene expression of isolated pancreatic islets from a polygenic mouse model of the metabolic syndrome.

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice

FTO Biology and Obesity: Why Do a Billion of Us Weigh 3 kg More?

FTO and obesity: a problem for a billion people.

FTO expression is regulated by availability of essential amino acids.

FTO is necessary for the induction of leptin resistance by high-fat feeding

Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm.

From GWAS to biology: lessons from FTO.

Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.

Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity.

Functional responses of human beta1 adrenoceptors with defined haplotypes for the common 389R>G and 49S>G polymorphisms.

GDF15 and energy balance: homing in on a mechanism.

Generation and analysis of 25 Mb of genomic DNA from the pufferfish Fugu rubripes by sequence scanning

Genetic variants in human sterol regulatory element binding protein-1c in syndromes of severe insulin resistance and type 2 diabetes.

Genetic variants of insulin receptor substrate-1 (IRS-1) in syndromes of severe insulin resistance. Functional analysis of Ala513Pro and Gly1158Glu IRS-1.

Genetics of obesity: can an old dog teach us new tricks?

Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing

High fat diet impairs the function of glucagon-like peptide-1 producing L-cells

Human embryonic genome activation initiates at the one-cell stage

Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene

Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome.

Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.

Identification of the global transcriptomic response of the hypothalamic arcuate nucleus to fasting and leptin.

Impaired prohormone processing: a grand unified theory for features of Prader-Willi syndrome?

Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate

LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal

Leptin and the control of body weight: a review of its diverse central targets, signaling mechanisms, and role in the pathogenesis of obesity.

Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations

Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet

Maternal Obesity in Pregnancy Developmentally Programs Adipose Tissue Inflammation in Young, Lean Male Mice Offspring

Maternal diet amplifies the hepatic aging trajectory of Cidea in male mice and leads to the development of fatty liver.

Melanocortin receptors weigh in.

Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36).

Microarray analysis of insulin and insulin-like growth factor-1 (IGF-1) receptor signaling reveals the selective up-regulation of the mitogen heparin-binding EGF-like growth factor by IGF-1.

Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms

NFIX Regulates Proliferation and Migration Within the Murine SVZ Neurogenic Niche

Nutrition-/diet-induced changes in gene expression in pancreatic β-cells.

Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence

Obesity and FTO: Changing Focus at a Complex Locus

Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation.

Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry.

PP2Ce: Fat and stressed out?

Past, present and future strategies to study the genetics of body weight regulation.

Pathological missense mutations of neural cell adhesion molecule L1 affect homophilic and heterophilic binding activities.

Prevalence of loss-of-function FTO mutations in lean and obese individuals

Role for the obesity-related FTO gene in the cellular sensing of amino acids

Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response.

Selective rab11 transport and the intrinsic regenerative ability of CNS axons. ⬇️

Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation

SnapShot: the hormonal control of food intake.

Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension.

Subcellular profiling reveals distinct and developmentally regulated repertoire of growth cone mRNAs.

TCR usage, gene expression and function of two distinct FOXP3(+)Treg subsets within CD4(+)CD25(hi) T cells identified by expression of CD39 and CD45RO.

Tachykinin-1 in the central nervous system regulates adiposity in rodents

The CART gene and human obesity: mutational analysis and population genetics

The bigger picture of FTO: the first GWAS-identified obesity gene

The biology of FTO: from nucleic acid demethylase to amino acid sensor ⬇️

The effects of neurokinin B upon gonadotrophin release in male rodents.

The expression of dynein light chain DYNLL1 (LC8-1) is persistently downregulated in glaucomatous rat retinal ganglion cells.

The hypothalamus and metabolism: integrating signals to control energy and glucose homeostasis.