List of works - Julie K Andersen

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-resistant, flat-cell PC12 variants having a partial loss of transformed phenotype.

scientific article published in August 1990

A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans

scientific article published on October 2013

A disruption in iron-sulfur center biogenesis via inhibition of mitochondrial dithiol glutaredoxin 2 may contribute to mitochondrial and cellular iron dysregulation in mammalian glutathione-depleted dopaminergic cells: implications for Parkinson's d

scientific article

A novel iron (II) preferring dopamine agonist chelator D-607 significantly suppresses α-syn- and MPTP-induced toxicities in vivo

scientific article published on 19 May 2017

A possible novel anti-inflammatory mechanism for the pharmacological prolyl hydroxylase inhibitor 3,4-dihydroxybenzoate: implications for use as a therapeutic for Parkinson's disease.

scientific article published on 14 May 2012

Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: implications for early intervention on disease progression

scientific article published on 01 August 2011

Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: implications for early intervention on disease progression.

scientific article

Acute and long‐term response of dopamine nigrostriatal synapses to a single, low‐dose episode of 3‐nitropropionic acid‐mediated chemical hypoxia ⬇️

scientific article published on October 8, 2010

Age-related behavioral phenotype of an astrocytic monoamine oxidase-B transgenic mouse model of Parkinson's disease

scientific article

An inducible MAO-B mouse model of Parkinson’s disease: a tool towards better understanding basic disease mechanisms and developing novel therapeutics

scientific article published on 30 April 2018

Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson's Disease

scientific article

Anti-inflammatory role of the isoflavone diadzein in lipopolysaccharide-stimulated microglia: implications for Parkinson's disease.

scientific article published on 10 May 2012

Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin.

scientific article

Caspase 3 inhibition attenuates hydrogen peroxide-induced DNA fragmentation but not cell death in neuronal PC12 cells.

scientific article published in March 2001

Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease

scientific article (publication date: 15 December 2001)

Catecholamine metabolism drives generation of mitochondrial DNA deletions in dopaminergic neurons.

scientific article published on 24 October 2013

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease.

scientific article published on 28 January 2018

Cellular senescence and the aging brain

scientific article

Chronic expression of H-ferritin in dopaminergic midbrain neurons results in an age-related expansion of the labile iron pool and subsequent neurodegeneration: implications for Parkinson's disease.

scientific article published on 21 August 2009

Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration.

scientific article published on 2 May 2006

Cloning/brain localization of mouse glutamylcysteine synthetase heavy chain mRNA ⬇️

scientific article published on May 27, 1997

Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors.

scientific article published in January 1994

Correction: MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology.

scientific article published on 6 August 2012

Coupling endoplasmic reticulum stress to the cell death program in dopaminergic cells: effect of paraquat

scientific article

Decreases in protective enzymes correlates with increased oxidative damage in the aging mouse brain.

scientific article published in July 1995

Detrimental effects of oxidative losses in parkin activity in a model of sporadic Parkinson's disease are attenuated by restoration of PGC1alpha.

scientific article published on 13 May 2016

Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson's disease?

scientific article

Dopaminergic neurons.

scientific article

Elevated expression of glutathione peroxidase in PC12 cells results in protection against methamphetamine but not MPTP toxicity.

scientific article published in June 1997

Fibroblast growth factor 2 enhances striatal and nigral neurogenesis in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

scientific article

Gene transfer into mammalian central nervous system using herpes virus vectors: extended expression of bacterial lacZ in neurons using the neuron-specific enolase promoter

scientific article published on October 1, 1992

Gene transfer to sensory neurons using herpes virus vectors.

scientific article published in January 1994

Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease

scientific article published in March 2003

Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease.

scientific article published on August 2000

Glutathione depletion in a midbrain-derived immortalized dopaminergic cell line results in limited tyrosine nitration of mitochondrial complex I subunits: implications for Parkinson's disease

scientific article published on July 2005

Glutathione depletion in immortalized midbrain-derived dopaminergic neurons results in increases in the labile iron pool: implications for Parkinson's disease.

scientific article published on 03 December 2008

Herpesvirus-mediated gene delivery into the rat brain: specificity and efficiency of the neuron-specific enolase promoter

scientific article published on 01 October 1993

Hsp90 Co-chaperone p23 contributes to dopaminergic mitochondrial stress via stabilization of PHD2: Implications for Parkinson's disease.

scientific article published on 19 February 2018

In vitro and in vivo neuroprotection by gamma-glutamylcysteine ethyl ester against MPTP: relevance to the role of glutathione in Parkinson's disease.

scientific article published on 27 April 2006

Increased murine neonatal iron intake results in Parkinson-like neurodegeneration with age.

scientific article published on 12 June 2006

Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration.

scientific article

Inducible dopaminergic glutathione depletion in an alpha-synuclein transgenic mouse model results in age-related olfactory dysfunction ⬇️

scientific article published on November 3, 2010

Inhibition of caspases protects cerebellar granule cells of the weaver mouse from apoptosis and improves behavioral phenotype.

scientific article published on 6 September 2002

Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data

scientific article

Integrating glutathione metabolism and mitochondrial dysfunction with implications for Parkinson's disease: a dynamic model.

scientific article

Iron and paraquat as synergistic environmental risk factors in sporadic Parkinson's disease accelerate age-related neurodegeneration.

scientific article

Iron dysregulation and Parkinson's disease.

scientific article published in December 2004

Iron promotes protein insolubility and aging in C. elegans

scientific article published on November 2014

Ironing out Parkinson's disease: is therapeutic treatment with iron chelators a real possibility?

scientific article

Late-life hemoglobin and the incidence of Parkinson's disease

scientific article

Lithium prevents parkinsonian behavioral and striatal phenotypes in an aged parkin mutant transgenic mouse model

scientific article

MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology

scientific article (publication date: 2008)

Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans

scientific article published on 24 July 2014

Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

scientific journal article

Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease.

scientific article published on 16 June 2012

Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin

scientific article

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo ⬇️

scientific article published on September 29, 2010

Mutant α-synuclein and aging reduce neurogenesis in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

scientific article published on 29 December 2010

Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration

scientific article

Nitrosylation and nitration of mitochondrial complex I in Parkinson's disease.

scientific article published on 06 September 2010

Oxidative and nitrative protein modifications in Parkinson's disease

scientific article published on 18 March 2008

Oxidative stress in neurodegeneration: cause or consequence?

scientific article

Perspectives on MAO-B in aging and neurological disease: where do we go from here?

scientific article

Pharmacological prolyl hydroxylase domain inhibition as a therapeutic target for Parkinson's disease

scientific article published on February 2014

Preferentially increased nitration of alpha-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson's disease.

scientific article published on September 2009

Rapid purification and mass spectrometric characterization of mitochondrial NADH dehydrogenase (Complex I) from rodent brain and a dopaminergic neuronal cell line.

scientific article

Reactive oxygen and nitrogen species in neurodegeneration

scientific article published in September 2013

Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria.

scientific article published on April 2009

Regulation of ATP13A2 via PHD2-HIF1α Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease

scientific journal article

Reversible inhibition of mitochondrial complex I activity following chronic dopaminergic glutathione depletion in vitro: implications for Parkinson's disease

scientific article published on 07 August 2006

Role of HIF-1 in iron regulation: potential therapeutic strategy for neurodegenerative disorders.

scientific article published on December 2006

Role of oxidative stress in paraquat-induced dopaminergic cell degeneration.

scientific article published in May 2005

Screening Method for Identifying Toxicants Capable of Inducing Astrocyte Senescence

scientific article published on 01 November 2018

Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease

scientific journal article

Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer's Disease

scientific article published on 22 June 2017

Survival in transgenic ALS mice does not vary with CNS glutathione peroxidase activity.

scientific article published in September 2002

Synergistic effects of environmental risk factors and gene mutations in Parkinson's disease accelerate age-related neurodegeneration ⬇️

scientific article published on November 4, 2010

The Hunt for a Cure for Parkinson’s Disease ⬇️

scientific article published on October 3, 2001

The combination of lithium and l-Dopa/Carbidopa reduces MPTP-induced abnormal involuntary movements (AIMs) via calpain-1 inhibition in a mouse model: Relevance for Parkinson׳s disease therapy.

scientific article

The herbicide paraquat induces dopaminergic nigral apoptosis through sustained activation of the JNK pathway.

scientific article published on 20 May 2004

The high-affinity D2/D3 agonist D512 protects PC12 cells from 6-OHDA-induced apoptotic cell death and rescues dopaminergic neurons in the MPTP mouse model of Parkinson's disease

scientific article (publication date: October 2014)

The role of c-Jun N-terminal kinase (JNK) in Parkinson's disease.

scientific article

Time to talk SENS: critiquing the immutability of human aging.

scientific article

Use of genetically engineered mice as models for exploring the role of oxidative stress in neurodegenerative diseases.

scientific article published on 25 March 1998

Use of genetically engineered mice as models for understanding human neurodegenerative disease.

scientific article published on June 1996

Vacuolar localization of wound-induced carboxypeptidase inhibitor in potato leaves

scientific article published on 01 May 1985

Wound signals in plants: A systemic plant wound signal alters plasma membrane integrity.

scientific article

mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance

scientific article published in December 2017

List of works by Julie K Andersen

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-resistant, flat-cell PC12 variants having a partial loss of transformed phenotype.

A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans

A disruption in iron-sulfur center biogenesis via inhibition of mitochondrial dithiol glutaredoxin 2 may contribute to mitochondrial and cellular iron dysregulation in mammalian glutathione-depleted dopaminergic cells: implications for Parkinson's d

A novel iron (II) preferring dopamine agonist chelator D-607 significantly suppresses α-syn- and MPTP-induced toxicities in vivo

A possible novel anti-inflammatory mechanism for the pharmacological prolyl hydroxylase inhibitor 3,4-dihydroxybenzoate: implications for use as a therapeutic for Parkinson's disease.

Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: implications for early intervention on disease progression

Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: implications for early intervention on disease progression.

Acute and long‐term response of dopamine nigrostriatal synapses to a single, low‐dose episode of 3‐nitropropionic acid‐mediated chemical hypoxia ⬇️

Age-related behavioral phenotype of an astrocytic monoamine oxidase-B transgenic mouse model of Parkinson's disease

An inducible MAO-B mouse model of Parkinson’s disease: a tool towards better understanding basic disease mechanisms and developing novel therapeutics

Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson's Disease

Anti-inflammatory role of the isoflavone diadzein in lipopolysaccharide-stimulated microglia: implications for Parkinson's disease.

Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin.

Caspase 3 inhibition attenuates hydrogen peroxide-induced DNA fragmentation but not cell death in neuronal PC12 cells.

Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease

Catecholamine metabolism drives generation of mitochondrial DNA deletions in dopaminergic neurons.

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease.

Cellular senescence and the aging brain

Chronic expression of H-ferritin in dopaminergic midbrain neurons results in an age-related expansion of the labile iron pool and subsequent neurodegeneration: implications for Parkinson's disease.

Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration.

Cloning/brain localization of mouse glutamylcysteine synthetase heavy chain mRNA ⬇️

Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors.

Correction: MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology.

Coupling endoplasmic reticulum stress to the cell death program in dopaminergic cells: effect of paraquat

Decreases in protective enzymes correlates with increased oxidative damage in the aging mouse brain.

Detrimental effects of oxidative losses in parkin activity in a model of sporadic Parkinson's disease are attenuated by restoration of PGC1alpha.

Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson's disease?

Dopaminergic neurons.

Elevated expression of glutathione peroxidase in PC12 cells results in protection against methamphetamine but not MPTP toxicity.

Fibroblast growth factor 2 enhances striatal and nigral neurogenesis in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

Gene transfer into mammalian central nervous system using herpes virus vectors: extended expression of bacterial lacZ in neurons using the neuron-specific enolase promoter

Gene transfer to sensory neurons using herpes virus vectors.

Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease

Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease.

Glutathione depletion in a midbrain-derived immortalized dopaminergic cell line results in limited tyrosine nitration of mitochondrial complex I subunits: implications for Parkinson's disease

Glutathione depletion in immortalized midbrain-derived dopaminergic neurons results in increases in the labile iron pool: implications for Parkinson's disease.

Herpesvirus-mediated gene delivery into the rat brain: specificity and efficiency of the neuron-specific enolase promoter

Hsp90 Co-chaperone p23 contributes to dopaminergic mitochondrial stress via stabilization of PHD2: Implications for Parkinson's disease.

In vitro and in vivo neuroprotection by gamma-glutamylcysteine ethyl ester against MPTP: relevance to the role of glutathione in Parkinson's disease.

Increased murine neonatal iron intake results in Parkinson-like neurodegeneration with age.

Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration.

Inducible dopaminergic glutathione depletion in an alpha-synuclein transgenic mouse model results in age-related olfactory dysfunction ⬇️

Inhibition of caspases protects cerebellar granule cells of the weaver mouse from apoptosis and improves behavioral phenotype.

Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data

Integrating glutathione metabolism and mitochondrial dysfunction with implications for Parkinson's disease: a dynamic model.

Iron and paraquat as synergistic environmental risk factors in sporadic Parkinson's disease accelerate age-related neurodegeneration.

Iron dysregulation and Parkinson's disease.

Iron promotes protein insolubility and aging in C. elegans

Ironing out Parkinson's disease: is therapeutic treatment with iron chelators a real possibility?

Late-life hemoglobin and the incidence of Parkinson's disease

Lithium prevents parkinsonian behavioral and striatal phenotypes in an aged parkin mutant transgenic mouse model

MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology

Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans

Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease.

Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo ⬇️

Mutant α-synuclein and aging reduce neurogenesis in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration

Nitrosylation and nitration of mitochondrial complex I in Parkinson's disease.

Oxidative and nitrative protein modifications in Parkinson's disease

Oxidative stress in neurodegeneration: cause or consequence?

Perspectives on MAO-B in aging and neurological disease: where do we go from here?

Pharmacological prolyl hydroxylase domain inhibition as a therapeutic target for Parkinson's disease

Preferentially increased nitration of alpha-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson's disease.

Rapid purification and mass spectrometric characterization of mitochondrial NADH dehydrogenase (Complex I) from rodent brain and a dopaminergic neuronal cell line.

Reactive oxygen and nitrogen species in neurodegeneration

Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria.

Regulation of ATP13A2 via PHD2-HIF1α Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease

Reversible inhibition of mitochondrial complex I activity following chronic dopaminergic glutathione depletion in vitro: implications for Parkinson's disease

Role of HIF-1 in iron regulation: potential therapeutic strategy for neurodegenerative disorders.

Role of oxidative stress in paraquat-induced dopaminergic cell degeneration.

Screening Method for Identifying Toxicants Capable of Inducing Astrocyte Senescence

Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease

Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer's Disease

Survival in transgenic ALS mice does not vary with CNS glutathione peroxidase activity.

Synergistic effects of environmental risk factors and gene mutations in Parkinson's disease accelerate age-related neurodegeneration ⬇️

The Hunt for a Cure for Parkinson’s Disease ⬇️

The combination of lithium and l-Dopa/Carbidopa reduces MPTP-induced abnormal involuntary movements (AIMs) via calpain-1 inhibition in a mouse model: Relevance for Parkinson׳s disease therapy.