List of works by Danyel G.J. Jennen

'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans

scientific article

A Systems Biology Approach for Identifying Hepatotoxicant Groups Based on Similarity in Mechanisms of Action and Chemical Structure

scientific article published on January 2016

Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma

scientific article (publication date: March 2016)

An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

scientific article

Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop.

scientific article published on 25 September 2017

Assessing compound carcinogenicity in vitro using connectivity mapping

scientific article

Assessing the metabolic competence of sandwich-cultured mouse primary hepatocytes.

scientific article published on 27 February 2009

Association of the FADS2 gene with omega-6 and omega-3 PUFA Concentration in the egg yolk of Japanese quail

scientific article published in January 2007

Bayesian Network Inference Enables Unbiased Phenotypic Anchoring of Transcriptomic Responses to Cigarette Smoke in Humans

scientific article published on 11 September 2015

Biotransformation pathway maps in WikiPathways enable direct visualization of drug metabolism related expression changes

scientific article (publication date: October 2010)

Can transcriptomics provide insight into the chemopreventive mechanisms of complex mixtures of phytochemicals in humans?

scientific article published on 27 February 2014

Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification

scientific article

DTNI: a novel toxicogenomics data analysis tool for identifying the molecular mechanisms underlying the adverse effects of toxic compounds

scientific article

Discrimination for genotoxic and nongenotoxic carcinogens by gene expression profiling in primary mouse hepatocytes improves with exposure time

scientific article

Distinct genotype-dependent differences in transcriptome responses in humans exposed to environmental carcinogens

scientific article published on August 2015

Dose and Time Dependencies in Stress Pathway Responses during Chemical Exposure: Novel Insights from Gene Regulatory Networks

scientific article published on 6 October 2017

Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches

scientific article published on 27 June 2019

ELIXIR and Toxicology: a community in development

ELIXIR and Toxicology: a community in development

scientific article published on 3 October 2023

Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury

article

Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis

scientific article published on 9 September 2014

Exploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity.

scientific article published on 23 June 2016

Expression of the prion protein gene (PRNP) and cellular prion protein (PrPc) in cattle and sheep fetuses and maternal tissues during pregnancy.

scientific article published in January 2007

Gender-specific transcriptomic response to environmental exposure in Flemish adults

scientific article

High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability

scientific article published on 27 August 2019

Identification of essential transcription factors for adequate DNA damage response after benzo(a)pyrene and aflatoxin B1 exposure by combining transcriptomics with functional genomics

scientific article

Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain

scientific article published on 19 February 2015

Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro

scientific article

Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells

scientific article

Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis.

scientific article

Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction

scientific article published on 14 November 2017

Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective

scientific article published on 2 November 2015

Molecular signatures of N-nitroso compounds in Caco-2 cells: implications for colon carcinogenesis

scientific article published on 16 February 2009

New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis

scientific article (publication date: June 2016)

New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids

scientific article published on 20 June 2021

Off-target effects of oral anticoagulants - vascular effects of vitamin K antagonist and non-vitamin K antagonist oral anticoagulant dabigatran etexilate

scientific article published on 28 March 2021

Omics for prediction of environmental health effects: Blood leukocyte-based cross-omic profiling reliably predicts diseases associated with tobacco smoking ⬇️

scientific article published on 3 February 2016

Pattern recognition methods to relate time profiles of gene expression with phenotypic data: a comparative study

scientific article

Performance of in vitro γH2AX assay in HepG2 cells to predict in vivo genotoxicity

scientific article published on 21 August 2012

Persistent transcriptional responses show the involvement of feed-forward control in a repeated dose toxicity study

scientific article published on 17 October 2016

QTL for the heritable inverted teat defect in pigs.

scientific article published on 25 January 2008

ROS networks: designs, aging, Parkinson's disease and precision therapies

scientific article published on 26 October 2020

Response to cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity.

scientific article

Sex-Specific Associations between Particulate Matter Exposure and Gene Expression in Independent Discovery and Validation Cohorts of Middle-Aged Men and Women.

scientific article published on 14 October 2016

Transcriptomic and metabolomic data integration

scientific article

Translational Proteomics Analysis of Anthracycline-Induced Cardiotoxicity From Cardiac Microtissues to Human Heart Biopsies

scientific article published on 15 June 2021

Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes

scientific article published on 11 August 2020

Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis.

scientific article published on August 2017

Whole-genome gene expression modifications associated with nitrosamine exposure and micronucleus frequency in human blood cells.

scientific article

Xenobiotic metabolism in differentiated human bronchial epithelial cells

scientific article published on 13 October 2016

diXa: a data infrastructure for chemical safety assessment

scientific article

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