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List of works by Nei-Li Chan

Anthracenedione-methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profiles

scientific article published on 25 January 2012

Asymmetrical synthesis of L-homophenylalanine using engineered Escherichia coli aspartate aminotransferase.

scientific article published in March 2005

Chemical Inhibition of Human Thymidylate Kinase and Structural Insights into the Phosphate Binding Loop and Ligand-Induced Degradation

scientific article published on 17 October 2016

Crystal structure of the S-nitroso form of liganded human hemoglobin

scientific article

Crystal structure of the conserved hypothetical cytosolic protein Xcc0516 from Xanthomonas campestris reveals a novel quaternary structure assembled by five four-helix bundles

scientific article published on 01 November 2006

Crystal structure of the human prostacyclin synthase

scientific article

Crystallization and preliminary X-ray crystallographic analysis of the C-terminal domain of ParC protein from Bacillus stearothermophilus.

scientific article published on 25 February 2004

Crystallographic analysis of the interaction of nitric oxide with quaternary-T human hemoglobin

scientific article

Cys-93-betabeta-succinimidophenyl polyethylene glycol 2000 hemoglobin A. Intramolecular cross-bridging of hemoglobin outside the central cavity

scientific article published on 01 February 2000

Epoxidation Catalyzed by the Nonheme Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, AsqJ: Mechanistic Elucidation of Oxygen Atom Transfer by a Ferryl Intermediate

scientific article published on 16 March 2020

Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C. elegans.

scientific article

In trans interaction of hepatitis C virus helicase domains mediates protease activity critical for internal NS3 cleavage and cell transformation.

scientific article

Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation

scientific article published on 3 January 2018

Investigations into the binding of jadomycin DS to human topoisomerase IIβ by WaterLOGSY NMR spectroscopy.

scientific article

Mutation of a key residue in the type II secretion system ATPase uncouples ATP hydrolysis from protein translocation

scientific article published on 01 July 2007

New insights into DNA-binding by type IIA topoisomerases.

scientific article published on 21 December 2012

New mechanistic and functional insights into DNA topoisomerases.

scientific article published on 13 March 2013

On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs

scientific article

Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry

scientific article published on 24 August 2017

SMYD3-Mediated H2A.Z.1 Methylation Promotes Cell Cycle and Cancer Proliferation.

scientific article published on 28 August 2016

Strong inhibition of betanodavirus replication by ribavirin targeting RNA-dependent RNA polymerase.

scientific article

Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity

scientific article published on 09 December 2016

Structural basis of antizyme-mediated regulation of polyamine homeostasis

scientific article

Structural basis of the mercury(II)-mediated conformational switching of the dual-function transcriptional regulator MerR

scientific article

Structural characteristics of the nonallosteric human cytosolic malic enzyme

scientific article

Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate

scientific article published in Nature Communications

Structure and function of the XpsE N-terminal domain, an essential component of the Xanthomonas campestris type II secretion system

scientific article published on 14 September 2005

Structure of the topoisomerase IV C-terminal domain: a broken beta-propeller implies a role as geometry facilitator in catalysis

scientific article published on 04 October 2004

Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change

scientific article

Twisting of the DNA-binding surface by a beta-strand-bearing proline modulates DNA gyrase activity.

scientific article

XpsE oligomerization triggered by ATP binding, not hydrolysis, leads to its association with XpsL

scientific article

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