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List of works by Thomas Wieland

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

scientific article published on 24 March 2017

A cellular model of Brugada syndrome with SCN10A variants using human-induced pluripotent stem cell-derived cardiomyocytes

scientific article published on 01 September 2019

A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domain

scientific article

A novel player in cellular hypertrophy: Giβγ/PI3K-dependent activation of the RacGEF TIAM-1 is required for α₁-adrenoceptor induced hypertrophy in neonatal rat cardiomyocytes

scientific article published on May 4, 2012

A systemic Pasteurella multocida toxin aggravates cardiac hypertrophy and fibrosis in mice

scientific article

ADP receptor‐induced activation of guanine‐nucleotide‐binding proteins in human platelet membranes ⬇️

scientific article published on July 1, 1992

Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta

scientific article (publication date: 28 February 2003)

Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Specific activation of Gsalpha by an NDPK B.Gbetagamma complex in H10 cells

scientific journal article

Activation of signal-transducing guanine-nucleotide-binding regulatory proteins by guanosine 5'-[gamma-thio]triphosphate. Information transfer by intermediately thiophosphorylated beta gamma subunits

scientific article published on 01 March 1991

Alignment-Annotator web server: rendering and annotating sequence alignments

scientific article published on 09 May 2014

Alterations in cardiac DNA methylation in human dilated cardiomyopathy

scientific article

Alterations in reversible protein histidine phosphorylation as intracellular signals in cardiovascular disease

scientific article

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.

scientific article published on 26 January 2018

Anaphylactic shock depends on endothelial Gq/G11.

scientific article published on 26 January 2009

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

scientific article

Angiotensin II modulates VEGF-driven angiogenesis by opposing effects of type 1 and type 2 receptor stimulation in the microvascular endothelium

scientific article published on 20 February 2012

Angiotensin II type 2 receptor inhibits vascular endothelial growth factor-induced migration and in vitro tube formation of human endothelial cells.

scientific article published on 24 July 2003

Biallelic Mutations in NBAS Cause Recurrent Acute Liver Failure with Onset in Infancy

scientific article

Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure.

scientific article published on May 2017

Calmodulin mutations associated with recurrent cardiac arrest in infants

scientific article published on 06 February 2013

Can a GDP-liganded G-protein be active?

scientific article

Chronic hyperglycemia inhibits vasoregression in a transgenic model of retinal degeneration ⬇️

scientific article published on June 15, 2013

Competition for Gβγ dimers mediates a specific cross-talk between stimulatory and inhibitory G protein α subunits of the adenylyl cyclase in cardiomyocytes ⬇️

scientific article published on April 26, 2013

Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome

scientific article published on 26 February 2014

Constitutive serum response factor activation by the viral chemokine receptor homologue pUS28 is differentially regulated by Galpha(q/11) and Galpha(16).

scientific article published on 24 April 2008

Contribution of nucleoside diphosphokinase to guanine nucleotide regulation of agonist binding to formyl peptide receptors

article

DHTKD1 mutations cause 2-aminoadipic and 2-oxoadipic aciduria

scientific article

DYT16 revisited: exome sequencing identifies PRKRA mutations in a European dystonia family

scientific article published on 20 August 2014

Deficiency of ECHS1 causes mitochondrial encephalopathy with cardiac involvement.

scientific article

Differential coupling of m-cholinoceptors to Gi/Go-proteins in failing human myocardium.

scientific article published on October 2003

Direct stimulation of receptor-controlled phospholipase D1 by phospho-cofilin

scientific article

Dissecting Gq/11-Mediated Plasma Membrane Translocation of Sphingosine Kinase-1

scientific article published on 29 September 2020

Dissociation of guanosine 5'-[gamma-thio]triphosphate from guanine-nucleotide-binding regulatory proteins in native cardiac membranes. Regulation by nucleotides and muscarinic acetylcholine receptors

scientific article published on 01 March 1992

Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin.

scientific article

Dopamine and lipophilic derivates protect cardiomyocytes against cold preservation injury

scientific article published on 17 October 2013

Drug Testing in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1

scientific article published on 13 May 2019

Dual role of protein kinase C on BK channel regulation.

scientific article

Dynamics of Gαq-protein-p63RhoGEF interaction and its regulation by RGS2.

scientific article published on February 2014

ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy

scientific article

Endotoxin induces desensitization of cardiac endothelin-1 receptor signaling by increased expression of RGS4 and RGS16 ⬇️

scientific article published on January 1, 2002

Enhanced G protein activation in immortalized lymphoblasts from patients with essential hypertension.

scientific article published on August 1995

Epac1 links prostaglandin E2 to β-catenin-dependent transcription during epithelial-to-mesenchymal transition

scientific article published on 17 June 2016

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 23 January 2018

Evidence for receptor-regulated phosphotransfer reactions involved in activation of the adenylate cyclase inhibitory G protein in human platelet membranes

scientific article published on 01 July 1989

Exome sequencing reveals de novo WDR45 mutations causing a phenotypically distinct, X-linked dominant form of NBIA.

scientific article

Expression of ten RGS proteins in human myocardium: functional characterization of an upregulation of RGS4 in heart failure.

scientific article

Further intracellular proteins and signaling pathways regulated by angiotensin-(1-7) in human endothelial cells

scientific article published on 08 December 2016

G protein-coupled receptor kinase 2 promotes cardiac hypertrophy

scientific article

Galpha q allosterically activates and relieves autoinhibition of p63RhoGEF.

scientific article

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

scientific article

High energy phosphate transfer by NDPK B/Gbetagammacomplexes--an alternative signaling pathway involved in the regulation of basal cAMP production

scientific article published on August 2006

Highly invasive melanoma cells activate the vascular endothelium via an MMP-2/integrin αvβ5-induced secretion of VEGF-A.

scientific article

Hypertension-evoked RhoA activity in vascular smooth muscle cells requires RGS5.

scientific article published on 5 December 2017

Hyperthermia Influences the Effects of Sodium Channel Blocking Drugs in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

scientific article

Identification of G protein-coupled receptors potently stimulating migration of human transitional-cell carcinoma cells ⬇️

scientific article published on December 1, 1997

Identification of intracellular proteins and signaling pathways in human endothelial cells regulated by angiotensin-(1-7)

scientific article

Impaired riboflavin transport due to missense mutations in SLC52A2 causes Brown-Vialetto-Van Laere syndrome

scientific article

Inflammation leads through PGE/EP3 signaling to HDAC5/MEF2-dependent transcription in cardiac myocytes.

scientific article published in July 2018

Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis

scientific article

Interaction of recombinant rho A GTP-binding proteins with photoexcited rhodopsin.

scientific article

Interaction of small G proteins with photoexcited rhodopsin

scientific article published on 01 April 1990

Interleukin-1beta mediates endotoxin- and tumor necrosis factor alpha-induced RGS16 protein expression in cultured cardiac myocytes

scientific article

Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity

scientific article published on 19 October 2020

Ion Channel Dysfunctions in Dilated Cardiomyopathy in Limb-Girdle Muscular Dystrophy

scientific article published on 01 March 2018

LARG links histamine-H1-receptor-activated Gq to Rho-GTPase-dependent signaling pathways ⬇️

scientific article published on November 10, 2011

Lack of the mitochondrial protein acylglycerol kinase causes Sengers syndrome

scientific article

Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function

scientific article published in 2022

Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease

scientific article

M2 muscarinic receptors induce airway smooth muscle activation via a dual, Gbetagamma-mediated inhibition of large conductance Ca2+-activated K+ channel activity.

scientific article published on 4 June 2008

Managing risks in drug discovery: reproducibility of published findings

scientific article

Mechanism and functional impact of CD40 ligand-induced von Willebrand factor release from endothelial cells.

scientific article published on 22 January 2015

Mediation of FoxO1 in Activated Neuroglia Deficient for Nucleoside Diphosphate Kinase B during Vascular Degeneration

scientific article published in 2018

Melatonin receptor signaling in pregnant and nonpregnant rat uterine myocytes as probed by large conductance Ca2+-activated K+ channel activity

scientific article published on 17 July 2003

Modeling Short QT Syndrome Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

scientific article published on 24 March 2018

Molecular diagnosis in mitochondrial complex I deficiency using exome sequencing

scientific article

Mutations in FBXL4, encoding a mitochondrial protein, cause early-onset mitochondrial encephalomyopathy

scientific article

Mutations in GTPBP3 cause a mitochondrial translation defect associated with hypertrophic cardiomyopathy, lactic acidosis, and encephalopathy

scientific article

Mutations in the deubiquitinase gene USP8 cause Cushing's disease

scientific article published on 8 December 2014

Nucleoside Diphosphate Kinase B Contributes to Arrhythmogenesis in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes from a Patient with Arrhythmogenic Right Ventricular Cardiomyopathy

scientific article published on 10 February 2020

Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure.

scientific article published on 07 December 2016

Nucleoside diphosphate kinase B deficiency causes a diabetes-like vascular pathology via up-regulation of endothelial angiopoietin-2 in the retina.

scientific article published on 23 April 2015

Nucleoside diphosphate kinase B is required for the formation of heterotrimeric G protein containing caveolae.

scientific article published on 16 March 2011

Nucleoside diphosphate kinase B regulates angiogenesis through modulation of vascular endothelial growth factor receptor type 2 and endothelial adherens junction proteins.

scientific article published on 21 August 2014

Nucleoside diphosphate kinase B regulates angiogenic responses in the endothelium via caveolae formation and c-Src-mediated caveolin-1 phosphorylation

scientific article

Nucleoside diphosphate kinase B-activated intermediate conductance potassium channels are critical for neointima formation in mouse carotid arteries.

scientific article

Nucleoside diphosphate kinase as protein histidine kinase

scientific article

O-GlcNAcylation of FoxO1 mediates nucleoside diphosphate kinase B deficiency induced endothelial damage.

scientific article published on 12 July 2018

Oxytocin receptors differentially signal via Gq and Gi proteins in pregnant and nonpregnant rat uterine myocytes: implications for myometrial contractility

scientific article

Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Gα(q/11)--p63RhoGEF--RhoA axis

scientific article

Paving the Rho in cancer metastasis: Rho GTPases and beyond.

scientific article

Phenotypic spectrum of eleven patients and five novel MTFMT mutations identified by exome sequencing and candidate gene screening

scientific article published on 25 December 2013

Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction.

scientific article published on 31 October 2016

Pregnancy switches adrenergic signal transduction in rat and human uterine myocytes as probed by BKCa channel activity

scientific article published on 01 April 2000

Progress on Nme (NDP kinase/Nm23/Awd) gene family-related functions derived from animal model systems: studies on development, cardiovascular disease, and cancer metastasis exemplified.

scientific article

Protein kinase D selectively targets cardiac troponin I and regulates myofilament Ca2+ sensitivity in ventricular myocytes

scientific article published on 22 February 2007

RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling

scientific article

RGS5 promotes arterial growth during arteriogenesis

scientific article

Receptor-induced translocation of activated guanine-nucleotide-binding protein alpha i subunits to the cytoskeleton in myeloid differentiated human leukemia (HL-60) cells

scientific article published on 01 August 1996

Receptor-regulated formation of GTP[gamma S] with subsequent persistent Gs-protein activation in membranes of human platelets

scientific article published on 01 March 1989

Receptor-stimulated dissociation of GTP[S] from Gi-proteins in membranes of HL-60 cells.

scientific article

Receptor-stimulated guanine-nucleotide-triphosphate binding to guanine-nucleotide-binding regulatory proteins. Nucleotide exchange and beta-subunit-mediated phosphotransfer reactions.

scientific article published on April 1994

Recurrent acute liver failure due to NBAS deficiency: phenotypic spectrum, disease mechanisms, and therapeutic concepts

scientific article published on 5 November 2015

Reduced expression of Rho guanine nucleotide dissociation inhibitor-alpha modulates the cytotoxic effect of busulfan in HEK293 cells.

scientific article published on March 2007

Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update

scientific article published on 16 October 2017

Regulation of the extracellular signal-regulated kinase pathway in adult myocardium: differential roles of G(q/11), Gi and G(12/13) proteins in signalling by alpha1-adrenergic, endothelin-1 and thrombin-sensitive protease-activated receptors.

scientific article published in May 2005

Regulators of G-protein signalling: multifunctional proteins with impact on signalling in the cardiovascular system.

scientific article

RhoA Activation Sensitizes Cells to Proteotoxic Stimuli by Abrogating the HSF1-Dependent Heat Shock Response

scientific article published on 20 July 2015

RhoGEF17, a Rho-specific guanine nucleotide exchange factor activated by phosphorylation via cyclic GMP-dependent kinase Iα.

scientific article published on 27 November 2012

Role of GDP in formyl-peptide-receptor-induced activation of guanine-nucleotide-binding proteins in membranes of HL 60 cells

scientific article published on 01 May 1992

Role of the Ang2-Tie2 Axis in Vascular Damage Driven by High Glucose or Nucleoside Diphosphate Kinase B Deficiency ⬇️

scientific article published on 25 May 2020

Role of the monomeric GTPase Rho in hematopoietic progenitor cell migration and transplantation.

scientific article published on January 2006

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 19 December 2017

Serum of patients with acute myocardial infarction prevents inflammation in iPSC-cardiomyocytes

scientific article published on 04 April 2019

Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension

scientific article

Specificity and Diversity in G i/o -Mediated Signaling

scientific article published on 01 March 2006

Srgap3⁻/⁻ mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes

scientific article published on 20 July 2012

Studying Brugada Syndrome With an SCN1B Variants in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes ⬇️

scientific article published on 01 November 2019

The BTB-Kelch protein KLEIP controls endothelial migration and sprouting angiogenesis.

scientific article

The Ca2+-dependent binding of calmodulin to an N-terminal motif of the heterotrimeric G protein beta subunit.

scientific article published in July 1997

The activation of RhoC in vascular endothelial cells is required for the S1P receptor type 2-induced inhibition of angiogenesis.

scientific article published on 30 August 2013

The bipartite rac1 Guanine nucleotide exchange factor engulfment and cell motility 1/dedicator of cytokinesis 180 (elmo1/dock180) protects endothelial cells from apoptosis in blood vessel development.

scientific article published on 13 January 2015

The genetic architecture of type 2 diabetes

scientific article (publication date: 11 July 2016)

The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function.

scientific article

The natriuretic peptide/guanylyl cyclase--a system functions as a stress-responsive regulator of angiogenesis in mice

scientific article published on July 2009

The orphan receptor GPRC5B modulates inflammatory and fibrotic pathways in cardiac fibroblasts and mice hearts

scientific article published on 16 May 2019

Through scaffolding and catalytic actions nucleoside diphosphate kinase B differentially regulates basal and β-adrenoceptor-stimulated cAMP synthesis.

scientific article published on 25 November 2010

Trio's Rho-specific GEF domain is the missing Galpha q effector in C. elegans

scientific article

cAMP guided his way: a life for G protein-mediated signal transduction and molecular pharmacology-tribute to Karl H. Jakobs

scientific article published on 17 May 2019

p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene

scientific article

p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts.

scientific article

p63RhoGEF—a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells ⬇️

scientific article published on August 25, 2010

β-Adrenergic receptor stimulation causes cardiac hypertrophy via a Gβγ/Erk-dependent pathway

scientific article published on July 27, 2012

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