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List of works by Christina F Spiropoulou

25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation

scientific article published on 20 December 2016

4'-Azidocytidine (R1479) inhibits henipaviruses and other paramyxoviruses with high potency

scientific article published on 16 June 2017

646. Activated Macrophages as Pathogenesis Factors in Ebola Virus Disease in Humans

A Case of Human Lassa Virus Infection With Robust Acute T-Cell Activation and Long-Term Virus-Specific T-Cell Responses

scientific article published on June 2017

A Conserved Basic Patch and Central Kink in the Nipah Virus Phosphoprotein Multimerization Domain Are Essential for Polymerase Function

scientific article published on 21 February 2019

A Molecular Sensor To Characterize Arenavirus Envelope Glycoprotein Cleavage by Subtilisin Kexin Isozyme 1/Site 1 Protease

scientific article

A chronological review of experimental infection studies of the role of wild animals and livestock in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus

scientific article

A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus

scientific article published in Nature Communications

A single mutation in Crimean-Congo hemorrhagic fever virus discovered in ticks impairs infectivity in human cells

scientific article published on 21 October 2020

Activation and cell death in human dendritic cells infected with Nipah virus

scientific article published on 13 April 2013

Adaptive immune responses in humans during Nipah virus acute and convalescent phases of infection

article

Alterations in Blood Chemistry Levels Associated With Nipah Virus Disease in the Syrian Hamster Model

scientific article published on 20 November 2019

Andes and Prospect Hill hantaviruses differ in early induction of interferon although both can downregulate interferon signaling

scientific article published on 3 January 2007

Andes virus disrupts the endothelial cell barrier by induction of vascular endothelial growth factor and downregulation of VE-cadherin

scientific article

Antibodies Against Henipa-Like Viruses in Brazilian Bats

scientific article published on 19 January 2017

Assessment of Inhibitors of Pathogenic Crimean-Congo Hemorrhagic Fever Virus Strains Using Virus-Like Particles

scientific article published in December 2015

Biomarker correlates of survival in pediatric patients with Ebola virus disease

scientific article

Biomarkers for understanding Ebola virus disease

scientific article published on January 2014

Broad-spectrum Investigational Agent GS-5734 for the Treatment of Ebola, MERS Coronavirus and Other Pathogenic Viral Infections with High Outbreak Potential.

scientific article published on 4 October 2017

CD4 T cells, CD8 T cells, and monocytes coordinate to prevent Rift Valley fever virus encephalitis

scientific article published on 27 November 2018

Characterisation of infectious Ebola virus from the ongoing outbreak to guide response activities in the Democratic Republic of the Congo: a phylogenetic and in vitro analysis

scientific article published on 09 July 2019

Characterization of the cellular receptors for the South American hemorrhagic fever viruses Junin, Guanarito, and Machupo.

scientific article published on 30 March 2006

Characterization of the interaction of lassa fever virus with its cellular receptor alpha-dystroglycan

scientific article published on May 2005

Clinical care of two patients with Ebola virus disease in the United States

scientific article published on 12 November 2014

Corrigendum to: In Situ Imaging of Fluorescent Nipah Virus Respiratory and Neurological Tissue Tropism in the Syrian Hamster Model

scientific article published on 31 December 2019

Crimean-Congo Hemorrhagic Fever Virus Suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease.

scientific article published on September 2017

Crimean-Congo Hemorrhagic Fever in Humanized Mice Reveals Glial Cells as Primary Targets of Neurological Infection

scientific article published on 08 May 2017

Crimean-Congo hemorrhagic fever and expansion from endemic regions

scientific article published on 16 January 2019

Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination

scientific article published on 15 August 2016

Development of a reverse genetics system for Sosuga virus allows rapid screening of antiviral compounds

scientific article published on 9 March 2018

Distinct and overlapping roles of Nipah virus P gene products in modulating the human endothelial cell antiviral response

scientific article

Ebola Virus Diagnostics: The US Centers for Disease Control and Prevention Laboratory in Sierra Leone, August 2014 to March 2015.

scientific article published on 30 July 2015

Ebola Virus Disease Diagnostics, Sierra Leone: Analysis of Real-time Reverse Transcription-Polymerase Chain Reaction Values for Clinical Blood and Oral Swab Specimens

scientific article

Ebola Virus Persistence in Semen of Male Survivors

scientific article

Ebola Virus Replication and Disease Without Immunopathology in Mice Expressing Transgenes to Support Human Myeloid and Lymphoid Cell Engraftment

scientific article published on 6 September 2016

Ebola hemorrhagic Fever: novel biomarker correlates of clinical outcome

scientific article

Ebola virus infection of human PBMCs causes massive death of macrophages, CD4 and CD8 T cell sub-populations in vitro.

scientific article published on 27 March 2007

Effect of Vandetanib on Andes virus survival in the hamster model of Hantavirus pulmonary syndrome

scientific article

Endocytic Pathways Used by Andes Virus to Enter Primary Human Lung Endothelial Cells

scientific article

Evaluation of a Single-Dose Nucleoside-Modified Messenger RNA Vaccine Encoding Hendra Virus-Soluble Glycoprotein Against Lethal Nipah virus Challenge in Syrian Hamsters

scientific article published on 21 November 2019

Evaluation of luciferase and GFP-expressing Nipah viruses for rapid quantitative antiviral screening

scientific article

Evaluation of the Activity of Lamivudine and Zidovudine against Ebola Virus

scientific article published on 30 November 2016

Flex-nucleoside analogues - Novel therapeutics against filoviruses

scientific article

Fluorescent Crimean-Congo hemorrhagic fever virus illuminates tissue tropism patterns and identifies early mononuclear phagocytic cell targets in Ifnar-/- mice

scientific article published on 02 December 2019

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses

scientific article

Genome Sequences of Crimean-Congo Hemorrhagic Fever Virus Strains Isolated in South Africa, Namibia, and Turkey

scientific article published on 19 October 2017

Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge

scientific article published on 10 February 2020

Hantavirus Infection Is Inhibited by Griffithsin in Cell Culture

scientific article published on 04 November 2020

Hantavirus pulmonary syndrome

scientific article published on 17 September 2011

Heterologous protection against Crimean-Congo hemorrhagic fever in mice after a single dose of replicon particle vaccine

scientific article published on 01 August 2019

Host mTORC1 Signaling Regulates Andes Virus Replication ⬇️

scientific article published on November 7, 2012

Host-Species Transferrin Receptor 1 Orthologs Are Cellular Receptors for Nonpathogenic New World Clade B Arenaviruses

scientific article (publication date: April 2009)

Human Biomarkers of Outcome following Rift Valley fever virus Infection

scientific article published on 01 October 2018

Human Ebola virus infection results in substantial immune activation

scientific article

Human immune cell engraftment does not alter development of severe acute Rift Valley fever in mice

scientific article published in PLoS ONE

Human immune system mouse models of Ebola virus infection.

scientific article published on 11 August 2017

Humanized Mouse Model of Ebola Virus Disease Mimics the Immune Responses in Human Disease

scientific article published on 17 November 2015

Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus

scientific article published on 9 October 2017

Identification of broadly neutralizing monoclonal antibodies against Crimean-Congo hemorrhagic fever virus

scientific article published on 22 August 2017

Immunologic timeline of Ebola virus disease and recovery in humans

scientific article published on 21 May 2020

In Situ Imaging of Fluorescent Nipah Virus Respiratory and Neurological Tissue Tropism in the Syrian Hamster Model

scientific article published on 30 October 2019

Inference of Nipah virus evolution, 1999–2015

scientific article published on 13 August 2020

Inhibition of Nipah Virus by Defective Interfering Particles

scientific article published on 28 February 2020

Inhibitors of cellular kinases with broad-spectrum antiviral activity for hemorrhagic fever viruses

scientific article published on 16 May 2015

Inhibitors of the tick-borne, hemorrhagic fever-associated flaviviruses.

scientific article

Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase.

scientific article published on 9 February 2018

In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses

scientific article

Kinetic Analysis of Biomarkers in a Cohort of US Patients With Ebola Virus Disease

scientific article published on 27 June 2016

Kyasanur Forest disease virus infection in mice is associated with higher morbidity and mortality than infection with the closely related Alkhurma hemorrhagic fever virus

scientific article

Laboratory Response to Ebola - West Africa and United States

scientific article published on 08 July 2016

Lassa Virus Targeting of Anterior Uvea and Endothelium of Cornea and Conjunctiva in Eye of Guinea Pig Model

scholarly article by Joy M Gary et al published May 2019 in Emerging Infectious Diseases

Lassa and Ebola virus inhibitors identified using minigenome and recombinant virus reporter systems.

scientific article published on 19 October 2016

Lassa virus antigen distribution and inflammation in the ear of infected strain 13/N guinea pigs

scientific article published on 05 September 2020

Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection

scientific article published on 16 May 2019

Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans

scientific article published in 2019

Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus

scientific article

New World arenavirus clade C, but not clade A and B viruses, utilizes alpha-dystroglycan as its major receptor

scientific article

Nipah virus outbreaks: still small but extremely lethal

scientific article published on 01 May 2019

Novel paramyxovirus associated with severe acute febrile disease, South Sudan and Uganda, 2012

scientific article

Old World and clade C New World arenaviruses mimic the molecular mechanism of receptor recognition used by alpha-dystroglycan's host-derived ligands

scientific article published on 14 March 2007

Personal protective equipment for filovirus epidemics: a call for better evidence

journal article published in 2015

Posttranslational modification of alpha-dystroglycan, the cellular receptor for arenaviruses, by the glycosyltransferase LARGE is critical for virus binding.

scientific article

Potent in vitro activity of β-D-4'-chloromethyl-2'-deoxy-2'-fluorocytidine against Nipah virus

scientific article published on 11 January 2020

Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity

scientific article published on 02 September 2019

Protection From Lethal Lassa Disease Can Be Achieved Both Before and After Virus Exposure by Administration of Single-Cycle Replicating Lassa Virus Replicon Particles

scientific article published on 01 September 2019

RIG-I Mediates an Antiviral Response to Crimean-Congo Hemorrhagic Fever Virus

scientific article

RIG-I activation inhibits ebolavirus replication

scientific article

Rapid determination of ebolavirus infectivity in clinical samples using a novel reporter cell line

scientific article published on 23 September 2017

Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome

scientific article published on April 2004

Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses

scholarly article

Recovery of Recombinant Crimean Congo Hemorrhagic Fever Virus Reveals a Function for Non-structural Glycoproteins Cleavage by Furin

scientific article

Reduced virus replication, proinflammatory cytokine production, and delayed macrophage cell death in human PBMCs infected with the newly discovered Bundibugyo ebolavirus relative to Zaire ebolavirus

scientific article published on 14 April 2010

Relationship Between Ebola Virus Real-Time Quantitative Polymerase Chain Reaction-Based Threshold Cycle Value and Virus Isolation From Human Plasma

scientific article

Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge

scientific article published on 01 May 2019

Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases

scientific article

Reply to Fedson

scientific article published on 25 August 2014

Reverse genetics recovery of Lujo virus and role of virus RNA secondary structures in efficient virus growth

scientific article

Rift Valley fever virus clearance and protection from neurologic disease are dependent on CD4+ T cell and virus-specific antibody responses

scientific article published on 27 March 2013

Rift Valley fever virus vaccination induces long-lived, antigen-specific human T cell responses

scientific article published on 28 February 2020

Rift Valley fever virus vaccine lacking the NSs and NSm genes is safe, nonteratogenic, and confers protection from viremia, pyrexia, and abortion following challenge in adult and pregnant sheep

scientific article

Rift valley Fever virus encephalitis is associated with an ineffective systemic immune response and activated T cell infiltration into the CNS in an immunocompetent mouse model

scientific article (publication date: June 2014)

Rift valley fever viral load correlates with the human inflammatory response and coagulation pathway abnormalities in humans with hemorrhagic manifestations.

scientific article

Serology and cytokine profiles in patients infected with the newly discovered Bundibugyo ebolavirus

scientific article

Severe hemorrhagic fever in strain 13/N guinea pigs infected with Lujo virus

scientific article

Severity of Disease in Humanized Mice Infected with Ebola Virus or Reston Virus is Associated with Magnitude of Early Viral Replication in Liver

scientific article published on 26 October 2017

Single-dose replication-defective VSV-based Nipah virus vaccines provide protection from lethal challenge in Syrian hamsters

scientific article published on 30 October 2013

Single-dose replicon particle vaccine provides complete protection against Crimean-Congo hemorrhagic fever virus in mice

scientific article published on 01 January 2019

Site 1 protease is required for proteolytic processing of the glycoproteins of the South American hemorrhagic fever viruses Junin, Machupo, and Guanarito

scientific article

Small interfering RNA inhibition of Andes virus replication

scientific article

Stable Occupancy of the Crimean-Congo Hemorrhagic Fever Virus-Encoded Deubiquitinase Blocks Viral Infection

scientific article published on 23 July 2019

Statins Suppress Ebola Virus Infectivity by Interfering with Glycoprotein Processing

scientific article published in May 2018

Suboptimal Handling of Piccolo Samples or Reagent Discs for Consideration in Ebola Response

scientific article published on 17 June 2019

Susceptibility of paramyxoviruses and filoviruses to inhibition by 2'-monofluoro- and 2'-difluoro-4'-azidocytidine analogs

scientific article published on 27 March 2018

The Crimean-Congo Hemorrhagic Fever Virus NSm Protein is Dispensable for Growth In Vitro and Disease in Ifnar-/- Mice

scientific article published on 21 May 2020

The S Genome Segment Is Sufficient to Maintain Pathogenicity in Intra-Clade Lassa Virus Reassortants in a Guinea Pig Model

scientific article published on 11 July 2018

The Use of TKM-100802 and Convalescent Plasma in 2 Patients With Ebola Virus Disease in the United States

scientific article

The lipid moiety of brincidofovir is required for in vitro antiviral activity against Ebola virus

scientific article published on 22 October 2015

The role of endothelial activation in dengue hemorrhagic fever and hantavirus pulmonary syndrome

scientific article published on 10 July 2013

The use of mice lacking type I or both type I and type II interferon responses in research on hemorrhagic fever viruses. Part 2: Vaccine efficacy studies

scientific article published on 22 January 2020

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

scientific article

Towards a Sustainable One Health Approach to Crimean-Congo Hemorrhagic Fever Prevention: Focus Areas and Gaps in Knowledge

scientific article published on 07 July 2020

Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses

scientific article

Twenty Years of Nipah Virus Research: Where Do We Go From Here?

scientific article published on 01 May 2020

Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses

scientific article

Use of a Scalable Replicon-Particle Vaccine to Protect Against Lethal Lassa Virus Infection in the Guinea Pig Model

scientific article published in 2018

Use of monoclonal antibodies against Hendra and Nipah viruses in an antigen capture ELISA

scientific article

Utility of Oral Swab Sampling for Ebola Virus Detection in Guinea Pig Model

scientific article

Vascular events in viral hemorrhagic fevers: a comparative study of dengue and hantaviruses

scientific article

Von Willebrand factor is elevated in individuals infected with Sudan virus and is associated with adverse clinical outcomes

scientific article

Whole Blood-Based Multiplex Immunoassays for the Evaluation of Human Biomarker Responses to Emerging Viruses in Resource-Limited Regions

scientific article published on 22 September 2017

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