List of works - Basil P Hubbard

A conserved NAD+ binding pocket that regulates protein-protein interactions during aging

scientific article

A conserved acetylation switch enables pharmacological control of tubby-like protein stability

scientific article published on 13 November 2020

Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene

scientific article published on 15 January 2012

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis

scientific article

Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism

scientific article published on July 2013

Characterization of murine SIRT3 transcript variants and corresponding protein products

scientific article published on November 2010

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

scientific article

Evidence for a common mechanism of SIRT1 regulation by allosteric activators

scientific article

Identification of a SIRT1 mutation in a family with type 1 diabetes

scientific article published on March 2013

Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity

scientific article published on 13 April 2018

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.

scientific article

Kinase-targeted cancer therapies: progress, challenges and future directions

scientific article

Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay

scientific article published on January 2013

Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein

scientific article

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

scientific article

SRT1720 improves survival and healthspan of obese mice

scientific article

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

scientific article published on 16 January 2014

List of works by Basil P Hubbard

A conserved NAD+ binding pocket that regulates protein-protein interactions during aging

A conserved acetylation switch enables pharmacological control of tubby-like protein stability

Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis

Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism

Characterization of murine SIRT3 transcript variants and corresponding protein products

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

Evidence for a common mechanism of SIRT1 regulation by allosteric activators

Identification of a SIRT1 mutation in a family with type 1 diabetes

Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.

Kinase-targeted cancer therapies: progress, challenges and future directions

Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay

Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

SRT1720 improves survival and healthspan of obese mice

Small molecule SIRT1 activators for the treatment of aging and age-related diseases