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List of works by Nicolas Dzamko

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

scientific article

A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells

scientific article published in 2024

AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance

scientific article

AMPK-independent pathways regulate skeletal muscle fatty acid oxidation.

scientific article published on 9 October 2008

An emerging role for LRRK2 in the immune system ⬇️

scientific article published on October 1, 2012

Autophagy activation promotes clearance of α-synuclein inclusions in fibril-seeded human neural cells

scientific article published on 02 August 2019

CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.

scientific article published on 9 April 2006

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

scientific article published on 6 March 2011

Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent

scientific article

DNA extraction from fresh-frozen and formalin-fixed, paraffin-embedded human brain tissue

scientific article published on 30 August 2013

Increased peripheral inflammation in asymptomatic leucine-rich repeat kinase 2 mutation carriers

scientific article published on 25 February 2016

Inflammation is genetically implicated in Parkinson's disease.

scientific article

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

scientific article published on September 2010

Inhibitor treatment of peripheral mononuclear cells from Parkinson's disease patients further validates LRRK2 dephosphorylation as a pharmacodynamic biomarker

scientific article published on 9 August 2016

LRRK2 inhibitors and their potential in the treatment of Parkinson's disease: current perspectives

scientific article

LRRK2 levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies.

scientific article published on 2 December 2016

LRRK2-mediated Rab10 phosphorylation in immune cells from Parkinson's disease patients

scientific article published on 30 December 2018

Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity.

scientific article published on November 2010

Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease

scientific article

Measurement of LRRK2 and Ser910/935 phosphorylated LRRK2 in peripheral blood mononuclear cells from idiopathic Parkinson's disease patients.

scientific article

Optimisation of LRRK2 inhibitors and assessment of functional efficacy in cell-based models of neuroinflammation.

scientific article published on 3 March 2015

Parkinson's disease-implicated kinases in the brain; insights into disease pathogenesis

scientific article

Parkinson's progression prediction using machine learning and serum cytokines

scientific article published on 25 July 2019

Recent Developments in LRRK2-Targeted Therapy for Parkinson's Disease

scientific article published on 01 July 2019

Reduced glucocerebrosidase activity in monocytes from patients with Parkinson's disease

scientific article published in Scientific Reports

Rosiglitazone Treatment Enhances Acute AMP-Activated Protein Kinase-Mediated Muscle and Adipose Tissue Glucose Uptake in High-Fat-Fed Rats

scientific article published on 01 October 2006

Sex-specific lipid dysregulation in the Abca7 knockout mouse brain

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones

scientific article published on 29 October 2013

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

scientific article published on 23 October 2009

The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling

scientific article

Toll-like receptor 2 is increased in neurons in Parkinson's disease brain and may contribute to alpha-synuclein pathology.

scientific article

Unlocking the secrets of LRRK2 function with selective kinase inhibitors

Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity.

scientific article

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