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List of works by Philip J Lowe

A mechanism-based binding model for the population pharmacokinetics and pharmacodynamics of omalizumab.

scientific article published on 10 November 2006

Applying physiological and biochemical concepts to optimize biological drug development.

scientific article published on 10 February 2010

Asthma symptom re-emergence after omalizumab withdrawal correlates well with increasing IgE and decreasing pharmacokinetic concentrations

scientific article published on 01 January 2009

Biliary protein output by isolated perfused rat livers. Effects of bile salts ⬇️

scientific article published on February 15, 1983

Breakdown of hepatic tight junctions during reoxygenation injury

scientific article published on 01 June 1992

Calcitonin and insulin in isobutylcyanoacrylate nanocapsules: protection against proteases and effect on intestinal absorption in rats

scientific article published on 01 July 1994

Colonic absorption of human calcitonin in man

scientific article published on 01 November 1992

Effect of taurochenodeoxycholate or tauroursodeoxycholate upon biliary output of phospholipids and plasma-membrane enzymes, and the extent of cell damage, in isolated perfused rat livers.

scientific article published on October 1983

Fluorescence anisotropy from diphenylhexatriene in rat liver plasma membranes

scientific article published on 01 July 1982

From Target Selection to the Minimum Acceptable Biological Effect Level for Human Study: Use of Mechanism-based PK/PD Modeling to Design Safe and Efficacious Biologics ⬇️

scientific article published on February 19, 2011

In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes

scientific article published on 13 April 2009

Integrated pharmacokinetic, pharmacodynamic and immunogenicity profiling of an anti-CCL21 monoclonal antibody in cynomolgus monkeys.

scientific article

Membrane damage caused by bile salts [proceedings]

scientific article published on 01 February 1980

New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin

scientific article published on 19 March 2008

Omalizumab decreases IgE production in patients with allergic (IgE-mediated) asthma; PKPD analysis of a biomarker, total IgE.

scientific article

Omalizumab in asthma: an update on recent developments

scientific article published on 11 June 2014

Omalizumab in the treatment of severe allergic (IgE-mediated) asthma: an update on recent developments

On setting the first dose in man: quantitating biotherapeutic drug-target binding through pharmacokinetic and pharmacodynamic models.

scientific article published on 29 December 2009

On the prediction of the human response: a recycled mechanistic pharmacokinetic/pharmacodynamic approach.

scientific article

P02-026 - Model-based characterization of the PKPD relationship for canakinumab in CAPS: a step towards personalized

scientific article

Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-IgE antibody, in atopic subjects

scientific article

Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in rats after oral and intravenous doses.

scientific article

Population modeling of filgrastim PK-PD in healthy adults following intravenous and subcutaneous administrations.

scientific article published in September 2010

Population pharmacokinetic and pharmacodynamic model-based comparability assessment of a recombinant human Epoetin Alfa and the Biosimilar HX575.

scientific article

Population pharmacokinetic modelling of filgrastim in healthy adults following intravenous and subcutaneous administrations.

scientific article published in January 2009

Rapid kinetic analysis of the bile-salt-dependent secretion of phospholipid, cholesterol and a plasma-membrane enzyme into bile.

scientific article

Relationship between omalizumab pharmacokinetics, IgE pharmacodynamics and symptoms in patients with severe persistent allergic (IgE-mediated) asthma.

scientific article published on July 2009

Revision of omalizumab dosing table for dosing every 4 instead of 2 weeks for specific ranges of bodyweight and baseline IgE.

scientific article published on 8 December 2014

Simplification of complex physiologically based pharmacokinetic models of monoclonal antibodies.

scientific article published on 29 May 2014

Visualization and communication of pharmacometric models with berkeley madonna

2014 scientific article

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