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List of works by Fatima Bosch

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Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance.

scientific article published on 20 April 2012
Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

scientific article
Increased fatty acid re-esterification by PEPCK overexpression in adipose tissue leads to obesity without insulin resistance

scientific article
Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus.

scientific article published on September 1994
Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapy

scientific article
Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.

scientific article
Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice.

scientific article published on 24 April 2008
Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes.

scientific article published on March 2000
Beta cell expression of IGF-I leads to recovery from type 1 diabetes.

scientific article
Adult onset global loss of the fto gene alters body composition and metabolism in the mouse

scientific article (publication date: 2013)
Correction of pathological accumulation of glycosaminoglycans in central nervous system and peripheral tissues of MPSIIIA mice through systemic AAV9 gene transfer

scientific article published on 17 October 2012
Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease.

scientific article published on April 2004
Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver

scientific article published on 01 August 1996
Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age.

scientific article published on 11 September 2010
Correction of diabetic alterations by glucokinase.

scientific article published on July 1996
Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material

scientific article
Expression of the neomycin-resistance (neo) gene induces alterations in gene expression and metabolism.

scientific article published on April 1994
Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction

scientific article published on 18 December 2014
Production, purification and characterization of adeno-associated vectors.

scientific article published on December 2010
Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance.

scientific article published on 12 November 2003
LRH-1-dependent glucose sensing determines intermediary metabolism in liver

scientific article
mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue

scientific article published on 15 January 2016
Vascular endothelial growth factor-mediated islet hypervascularization and inflammation contribute to progressive reduction of β-cell mass.

scientific article published on 6 September 2012
Adipose overexpression of phosphoenolpyruvate carboxykinase leads to high susceptibility to diet-induced insulin resistance and obesity

scientific article published in February 2006
Evidence from transgenic mice that myc regulates hepatic glycolysis

scientific article published on 01 August 1995
In vivo genetic engineering of murine pancreatic beta cells mediated by single-stranded adeno-associated viral vectors of serotypes 6, 8 and 9.

scientific article published on 11 February 2011
Increased Atherosclerotic Lesion Calcification in a Novel Mouse Model Combining Insulin Resistance, Hyperglycemia, and Hypercholesterolemia

scientific article published on 13 September 2007
IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice.

scientific article
IFN beta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice

scientific article published in December 2004
Vanadate treatment restores the expression of genes for key enzymes in the glucose and ketone bodies metabolism in the liver of diabetic rats

scientific journal article
Manufacturing and characterization of a recombinant adeno-associated virus type 8 reference standard material.

scientific article
Overexpression of kinase-negative protein kinase Cdelta in pancreatic beta-cells protects mice from diet-induced glucose intolerance and beta-cell dysfunction

scientific article published on 13 October 2009
CDK4 is an essential insulin effector in adipocytes

scientific journal article
Liver production of sulfamidase reverses peripheral and ameliorates CNS pathology in mucopolysaccharidosis IIIA mice

scientific article published on 18 October 2011
Reversal of type 1 diabetes by engineering a glucose sensor in skeletal muscle.

scientific article published in June 2006
Scavenger function of resident autofluorescent perivascular macrophages and their contribution to the maintenance of the blood-retinal barrier.

scientific article published on 15 July 2009
Treatment of diabetes and long-term survival after insulin and glucokinase gene therapy.

scientific article
Expression of IGF-I in pancreatic islets prevents lymphocytic infiltration and protects mice from type 1 diabetes

scientific article published in December 2006
New insights into adipose tissue VEGF-A actions in the control of obesity and insulin resistance.

scientific article published on April 2013
Increased intraocular insulin-like growth factor-I triggers blood-retinal barrier breakdown

scientific article published on 27 May 2009
Phosphofructo-1-kinase deficiency leads to a severe cardiac and hematological disorder in addition to skeletal muscle glycogenosis

scientific journal article
Biochemical, histological and functional correction of mucopolysaccharidosis type IIIB by intra-cerebrospinal fluid gene therapy

scientific article published on 18 December 2014
Long-Term Retinal PEDF Overexpression Prevents Neovascularization in a Murine Adult Model of Retinopathy

scientific article published on July 20, 2012
Evidence from Transgenic Mice That Interferon-β May Be Involved in the Onset of Diabetes Mellitus

scientific article published in Journal of Biological Chemistry
Attenuation of vision loss and delay in apoptosis of photoreceptors induced by proinsulin in a mouse model of retinitis pigmentosa.

scientific article published on 30 May 2008
Sustained stimulation and expansion of Tregs by IL2 control autoimmunity without impairing immune responses to infection, vaccination and cancer

scientific article published on 19 February 2014
In vivo adeno-associated viral vector-mediated genetic engineering of white and brown adipose tissue in adult mice

scientific article published on 16 September 2013
Regulated production of mature insulin by non-beta-cells.

scientific article
FGF21 gene therapy as treatment for obesity and insulin resistance

article
Expression of GLUT-2 antisense RNA in beta cells of transgenic mice leads to diabetes

scientific article published on 18 November 1994

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