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List of works by Fatima Bosch

AAV-mediated Sirt1 overexpression in skeletal muscle activates oxidative capacity but does not prevent insulin resistance

scientific article published on 16 November 2016

AAV-mediated pancreatic overexpression of Igf1 counteracts progression to autoimmune diabetes in mice.

scientific article

AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease.

scientific article published on October 2014

ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance.

scientific article published on 3 May 2016

Activation by vanadate of glycolysis in hepatocytes from diabetic rats.

scientific article

Adipose overexpression of phosphoenolpyruvate carboxykinase leads to high susceptibility to diet-induced insulin resistance and obesity

scientific article published in February 2006

Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance.

scientific article published on 20 April 2012

Adult onset global loss of the fto gene alters body composition and metabolism in the mouse

scientific article (publication date: 2013)

Altered glucose-stimulated insulin secretion in a mouse line with activated polyamine catabolism

scientific article published on 18 December 2011

Attenuation of vision loss and delay in apoptosis of photoreceptors induced by proinsulin in a mouse model of retinitis pigmentosa.

scientific article published on 30 May 2008

BMP4 Gene Therapy in Mature Mice Reduces BAT Activation but Protects from Obesity by Browning Subcutaneous Adipose Tissue

scientific article published on August 2017

BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice

scientific article published on 17 December 2019

BMP7 overexpression in adipose tissue induces white adipogenesis and improves insulin sensitivity in ob/ob mice

scientific article published on 27 October 2020

Beta cell expression of IGF-I leads to recovery from type 1 diabetes.

scientific article

Biochemical, histological and functional correction of mucopolysaccharidosis type IIIB by intra-cerebrospinal fluid gene therapy

scientific article published on 18 December 2014

CDK4 is an essential insulin effector in adipocytes

scientific journal article

CNS-directed gene therapy for the treatment of neurologic and somatic mucopolysaccharidosis type II (Hunter syndrome)

scientific article

Calcium-mobilizing effectors inhibit P-enolpyruvate carboxykinase gene expression in cultured rat hepatocytes.

scientific article

Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material

scientific article

Contribution of Intronic miR-338-3p and Its Hosting Gene AATK to Compensatory β-Cell Mass Expansion

scientific article

Control of glycogen synthase and phosphorylase in hepatocytes from diabetic rats. Effects of glucagon, vasopressin, and vanadate.

scientific article published in June 1989

Correction of diabetic alterations by glucokinase.

scientific article published on July 1996

Correction of pathological accumulation of glycosaminoglycans in central nervous system and peripheral tissues of MPSIIIA mice through systemic AAV9 gene transfer

scientific article published on 17 October 2012

Counteraction of type 1 diabetic alterations by engineering skeletal muscle to produce insulin: insights from transgenic mice.

scientific article

Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age.

scientific article published on 11 September 2010

Deletion of the RabGAP TBC1D1 Leads to Enhanced Insulin Secretion and Fatty Acid Oxidation in Islets From Male Mice

scientific article published on 22 February 2018

Diabetic neuropathy: electrophysiological and morphological study of peripheral nerve degeneration and regeneration in transgenic mice that express IFNbeta in beta cells.

scientific article published in May 2010

Different effects of glucagon and epinephrine on the kinetic properties of liver glycogen synthase

scientific article published on 01 January 1983

Disease correction by AAV-mediated gene therapy in a new mouse model of mucopolysaccharidosis type IIID.

scientific article published on 17 February 2017

Effects of lithium ions on glycogen synthase and phosphorylase in rat hepatocytes

scientific article published on 01 December 1986

Effects of vanadate on protein kinases in rat hepatocytes.

scientific article published on September 1989

Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain

scientific article published on April 2010

Erratum to: Targeting the association of calgranulin B (S100A9) with insulin resistance and type 2 diabetes

scholarly article by Francisco J. Ortega et al published 8 March 2013 in Journal of Molecular Medicine

Evidence from Transgenic Mice That Interferon-β May Be Involved in the Onset of Diabetes Mellitus

scientific article published in Journal of Biological Chemistry

Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver

scientific article published on 01 August 1996

Evidence from transgenic mice that myc regulates hepatic glycolysis

scientific article published on 01 August 1995

Expression of GLUT-2 antisense RNA in beta cells of transgenic mice leads to diabetes

scientific article published on 18 November 1994

Expression of Glucokinase in Skeletal Muscle: A New Approach to Counteract Diabetic Hyperglycemia

scientific article published on 20 July 2000

Expression of IGF-I in pancreatic islets prevents lymphocytic infiltration and protects mice from type 1 diabetes

scientific article published in December 2006

Expression of the neomycin-resistance (neo) gene induces alterations in gene expression and metabolism.

scientific article published on April 1994

FGF21 gene therapy as treatment for obesity and insulin resistance

article

Gene and cellular therapy in Spain: moving forward

scientific article published on 01 September 2009

Glucose metabolism in transgenic mice containing a chimeric P-enolpyruvate carboxykinase/bovine growth hormone gene

scientific article published on 01 June 1993

Glucose-regulated glucose uptake by transplanted muscle cells expressing glucokinase counteracts diabetic hyperglycemia

scientific article published in December 2002

Glycogen synthase activation by sugars in isolated hepatocytes

scientific article published on 01 July 1988

Good news on the clinical gene transfer front

scientific article published on 01 May 2008

HMGA1 overexpression in adipose tissue impairs adipogenesis and prevents diet-induced obesity and insulin resistance.

scientific article published on 28 September 2015

Hormonal effects on the phosphorylation of glycogen synthase in rat hepatocytes

scientific article published on 01 May 1984

Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.

scientific article

IFN beta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice

scientific article published in December 2004

IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice.

scientific article

Identification of miRNAs Involved in Reprogramming Acinar Cells into Insulin Producing Cells

scientific article published on 21 December 2015

Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease

scientific article published on 17 January 2017

In vivo adeno-associated viral vector-mediated genetic engineering of white and brown adipose tissue in adult mice

scientific article published on 16 September 2013

In vivo gene transfer to healthy and diabetic canine pancreas.

scientific article published on 5 December 2005

In vivo genetic engineering of murine pancreatic beta cells mediated by single-stranded adeno-associated viral vectors of serotypes 6, 8 and 9.

scientific article published on 11 February 2011

Inactivation of basal glycogen synthase by glucagon and epinephrine in hepatocytes from fed rats

scientific article published on 01 May 1986

Increased Atherosclerotic Lesion Calcification in a Novel Mouse Model Combining Insulin Resistance, Hyperglycemia, and Hypercholesterolemia

scientific article published on 13 September 2007

Increased fatty acid re-esterification by PEPCK overexpression in adipose tissue leads to obesity without insulin resistance

scientific article

Increased intraocular insulin-like growth factor-I triggers blood-retinal barrier breakdown

scientific article published on 27 May 2009

Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease.

scientific article published on April 2004

Insulin activation of basal hepatic glycogen synthase

scientific article published on 01 June 1981

Insulin inhibits liver expression of the CCAAT/enhancer-binding protein beta

scientific article published on 01 March 1995

Insulin-like Growth Factor 2 Overexpression Induces β-Cell Dysfunction and Increases Beta-cell Susceptibility to Damage

scientific article published on 13 May 2015

Insulin-like growth factor I (IGF-I)-induced chronic gliosis and retinal stress lead to neurodegeneration in a mouse model of retinopathy

scientific article published on 25 April 2013

LRH-1-dependent glucose sensing determines intermediary metabolism in liver

scientific article

Lack of Hypophagia in CB1 Null Mice is Associated to Decreased Hypothalamic POMC and CART Expression.

scientific article

Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice

scientific article

Lithium inhibits hepatic gluconeogenesis and phosphoenolpyruvate carboxykinase gene expression ⬇️

scientific article (publication date: 15 February 1992)

Lithium restores glycogen synthesis from glucose in hepatocytes from diabetic rats

scientific article published on 01 March 1993

Liver production of sulfamidase reverses peripheral and ameliorates CNS pathology in mucopolysaccharidosis IIIA mice

scientific article published on 18 October 2011

Long-Term Efficacy and Safety of Insulin and Glucokinase Gene Therapy for Diabetes: 8-Year Follow-Up in Dogs

scientific article published on 5 April 2017

Long-Term Retinal PEDF Overexpression Prevents Neovascularization in a Murine Adult Model of Retinopathy ⬇️

scientific article published on July 20, 2012

Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance.

scientific article published on 12 November 2003

Manufacturing and characterization of a recombinant adeno-associated virus type 8 reference standard material.

scientific article

Molecular signature of the immune and tissue response to non-coding plasmid DNA in skeletal muscle after electrotransfer ⬇️

scientific article published on December 15, 2011

Morphofunctional changes underlying intestinal dysmotility in diabetic RIP-I/hIFNβ transgenic mice.

scientific article published on 3 November 2011

New insights into adipose tissue VEGF-A actions in the control of obesity and insulin resistance.

scientific article published on April 2013

Nonviral-mediated hepatic expression of IGF-I increases Treg levels and suppresses autoimmune diabetes in mice

scientific article published on 25 October 2012

Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation.

scientific article published on 15 August 2017

Operant behavior to obtain palatable food modifies neuronal plasticity in the brain reward circuit.

scientific article

Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance

scientific article published on 27 February 2017

Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice.

scientific article published on 24 April 2008

Overexpression of c-myc in diabetic mice restores altered expression of the transcription factor genes that regulate liver metabolism

scientific article published on December 2002

Overexpression of c-myc in the liver prevents obesity and insulin resistance.

scientific article published on 18 July 2003

Overexpression of kinase-negative protein kinase Cdelta in pancreatic beta-cells protects mice from diet-induced glucose intolerance and beta-cell dysfunction

scientific article published on 13 October 2009

Overexpression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in transgenic mice causes hepatic hyperketogenesis

scientific article published in Journal of Biological Chemistry

PED/PEA-15 regulates glucose-induced insulin secretion by restraining potassium channel expression in pancreatic beta-cells

scientific article published on March 2007

Pancreatic transduction by helper-dependent adenoviral vectors via intraductal delivery.

scientific article published on September 2014

Phosphofructo-1-kinase deficiency leads to a severe cardiac and hematological disorder in addition to skeletal muscle glycogenosis

scientific journal article

Prevention of diabetic alterations in transgenic mice overexpressing Myc in the liver.

scientific article published on March 1996

Prevention of obesity and insulin resistance by glucokinase expression in skeletal muscle of transgenic mice.

scientific article published on 18 September 2003

Production, purification and characterization of adeno-associated vectors.

scientific article published on December 2010

Progressive neurologic and somatic disease in a novel mouse model of human mucopolysaccharidosis type IIIC.

scientific article published on 04 August 2016

Proinsulin protects against age-related cognitive loss through anti-inflammatory convergent pathways.

scientific article published on 14 June 2017

Proinsulin slows retinal degeneration and vision loss in the P23H rat model of retinitis pigmentosa

scientific article

Proliferative retinopathies: animal models and therapeutic opportunities

scientific article

Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1.

scientific article

Protein kinase Cδ regulates nuclear export of FOXO1 through phosphorylation of the chaperone 14-3-3ζ.

scientific article

Regulated expression of human insulin in the liver of transgenic mice corrects diabetic alterations.

scientific article published in April 1994

Regulated production of mature insulin by non-beta-cells.

scientific article

Relevance of an academic GMP Pan-European vector infra-structure (PEVI).

scientific article published on December 2010

Response to Comment on: Elias et al. Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance. Diabetes 2012;61:1801-1813.

scientific article published on January 2013

Reversal of type 1 diabetes by engineering a glucose sensor in skeletal muscle.

scientific article published in June 2006

Scavenger function of resident autofluorescent perivascular macrophages and their contribution to the maintenance of the blood-retinal barrier.

scientific article published on 15 July 2009

Skeletal muscle metabolism in the pathology and treatment of type 1 diabetes.

scientific article published on January 2010

Sustained stimulation and expansion of Tregs by IL2 control autoimmunity without impairing immune responses to infection, vaccination and cancer

scientific article published on 19 February 2014

Targeting the association of calgranulin B (S100A9) with insulin resistance and type 2 diabetes

scientific article published on 4 December 2012

Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction

scientific article published on 18 December 2014

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

scientific article

Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia

scientific article

The Deep Genome Project

scientific article published on 03 February 2020

The suppressor of cytokine signalling 2 (SOCS2) is a key repressor of insulin secretion.

scientific article published on 25 May 2010

Tissue-specific expression and dietary regulation of chimeric mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase/human growth hormone gene in transgenic mice.

scientific article published in March 1996

Toward a gene therapy for neurological and somatic MPSIIIA

scientific article published on 12 December 2013

Transgenic mice overexpressing human G972R IRS-1 show impaired insulin action and insulin secretion.

scientific article published on 19 January 2008

Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes.

scientific article published on March 2000

Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus.

scientific article published on September 1994

Treatment of diabetes and long-term survival after insulin and glucokinase gene therapy.

scientific article

Treatment of skeletal and non-skeletal alterations of Mucopolysaccharidosis type IVA by AAV-mediated gene therapy

scientific article published on 09 September 2021

Vanadate treatment restores the expression of genes for key enzymes in the glucose and ketone bodies metabolism in the liver of diabetic rats

scientific journal article

Vascular endothelial growth factor-mediated islet hypervascularization and inflammation contribute to progressive reduction of β-cell mass.

scientific article published on 6 September 2012

Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapy

scientific article

mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue

scientific article published on 15 January 2016

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