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List of works by Patrick Zeeuwen

3D skin models for 3R research: The potential of 3D reconstructed skin models to study skin barrier function.

scientific article published on 8 March 2018

A comprehensive analysis of pattern recognition receptors in normal and inflamed human epidermis: upregulation of dectin-1 in psoriasis.

scientific article published on 15 July 2010

A molecular signature of epithelial host defense: comparative gene expression analysis of cultured bronchial epithelial cells and keratinocytes.

scientific article

A null mutation in the cystatin M/E gene of ichq mice causes juvenile lethality and defects in epidermal cornification

scientific journal article

A partial transcriptome of human epidermis

scientific article published on 01 May 2002

Absent in Melanoma 2 is predominantly present in primary melanoma and primary squamous cell carcinoma, but largely absent in metastases of both tumors

scientific article published on 15 October 2014

Accurate, high-throughput typing of copy number variation using paralogue ratios from dispersed repeats.

scientific article published on 14 December 2006

An In vitro Model for Bacterial Growth on Human Stratum Corneum.

scientific article

Analysis of protein-protein interaction between late cornified envelope proteins and corneodesmosin

scientific article published on 01 October 2014

Assignment of the human gene encoding the epidermal serine proteinase inhibitor SKALP (PI3) to chromosome region 20q12-->q13

scientific article

Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin

scientific article

CD26/dipeptidyl-peptidase IV in psoriatic skin: upregulation and topographical changes.

scientific article

Cathepsin B as a potential cystatin M/E target in the mouse hair follicle.

scientific article published on 08 June 2017

Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis

scientific article

Combination of pantothenamides with vanin inhibitors as a novel antibiotic strategy against gram-positive bacteria.

scientific article published on 22 July 2013

Construction of a Microstructured Collagen Membrane Mimicking the Papillary Dermis Architecture and Guiding Keratinocyte Morphology and Gene Expression

article

Cystatin M / E expression in inflammatory and neoplastic skin disorders.

scientific article

Cystatin M/E expression is restricted to differentiated epidermal keratinocytes and sweat glands: a new skin-specific proteinase inhibitor that is a target for cross-linking by transglutaminase.

scientific article

Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification.

scientific article

Cystatin M/E knockdown by lentiviral delivery of shRNA impairs epidermal morphogenesis of human skin equivalents

scientific article published on 01 November 2012

Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin

scientific article published on 14 November 2018

Deletion of Late Cornified Envelope 3B and 3C genes is not associated with atopic dermatitis.

scientific article published on 8 April 2010

Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis

scientific article

Discovery of small molecule vanin inhibitors: new tools to study metabolism and disease.

scientific article

Drosomycin-like defensin, a human homologue of Drosophila melanogaster drosomycin with antifungal activity

scientific article

Epidermal Expression of Host Response Genes upon Skin Barrier Disruption in Normal Skin and Uninvolved Skin of Psoriasis and Atopic Dermatitis Patients ⬇️

scientific article published on September 23, 2010

Epidermal equivalents of filaggrin null keratinocytes do not show impaired skin barrier function

scientific article published on 11 October 2016

Evidence that unrestricted legumain activity is involved in disturbed epidermal cornification in cystatin M/E deficient mice.

scientific article published on 25 March 2004

Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines.

scientific article published on 26 March 2009

Expression profile of cornified envelope structural proteins and keratinocyte differentiation-regulating proteins during skin barrier repair.

scientific article published in June 2012

Genetics of psoriasis: evidence for epistatic interaction between skin barrier abnormalities and immune deviation.

scientific article published in October 2012

Genotype-phenotype correlations in a prospective cohort study of paediatric plaque psoriasis: lack of correlation between HLA-C*06 and family history of psoriasis

scientific article published on 01 November 2014

Gram-positive anaerobe cocci are underrepresented in the microbiome of filaggrin-deficient human skin

scientific article published on 08 October 2016

Host defense effector molecules in mucosal secretions

scientific article published on 09 April 2005

Ichthyosis bullosa of Siemens is caused by mutations in the keratin 2e gene

scientific article published on 01 September 1994

Identification and sequence analysis of two new members of the SKALP/elafin and SPAI-2 gene family. Biochemical properties of the transglutaminase substrate motif and suggestions for a new nomenclature.

scientific article published in August 1997

Immortalized N/TERT keratinocytes as an alternative cell source in 3D human epidermal models.

scientific article published on 19 September 2017

Increased expression of carbonic anhydrase II (CA II) in lesional skin of atopic dermatitis: regulation by Th2 cytokines

scientific article published on 15 March 2007

Induction of SLPI (ALP/HUSI-I) in Epidermal Keratinocytes

scientific article published on 01 December 1998

Induction of normal and psoriatic phenotypes in submerged keratinocyte cultures

scientific article published on 01 August 1996

Influence of FLG loss-of-function mutations in host–microbe interactions during atopic skin inflammation

Keratolysis exfoliativa (dyshidrosis lamellosa sicca): a distinct peeling entity

scientific article published on 05 October 2012

Koebner phenomenon in psoriasis is not associated with deletion of late cornified envelope genes LCE3B and LCE3C

scientific article published on 03 November 2011

Late cornified envelope (LCE) proteins: distinct expression patterns of LCE2 and LCE3 members suggest nonredundant roles in human epidermis and other epithelia

scientific article published on 03 January 2016

Mast-cell interleukin-1β, neutrophil interleukin-17 and epidermal antimicrobial proteins in the neutrophilic urticarial dermatosis in Schnitzler's syndrome

scientific article published on 20 July 2015

Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6.

scientific article

Microbiome dynamics of human epidermis following skin barrier disruption.

scientific article

Molecular diagnostics of psoriasis, atopic dermatitis, allergic contact dermatitis and irritant contact dermatitis.

scientific article

Paediatric-onset psoriasis is associated with ERAP1 and IL23R loci, LCE3C_LCE3B deletion and HLA-C*06.

scientific article

Pattern recognition receptors in immune disorders affecting the skin.

scientific article published on 06 March 2012

Pattern recognition receptors in infectious skin diseases.

scientific article published on 31 March 2012

Perfusion Intensity Correlates with Expression Levels of Psoriasis-Related Genes and Proteins

scientific article published on 12 September 2015

Phenotypical and functional differences in germinative subpopulations derived from normal and psoriatic epidermis.

scientific article published in February 2005

Polymorphisms in CD84, IL12B and TNFAIP3 are associated with response to biologics in patients with psoriasis

scientific article published on 10 April 2017

Psoriasis risk genes of the late cornified envelope-3 group are distinctly expressed compared with genes of other LCE groups.

scientific article published on April 2011

Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have Antibacterial Activity.

scientific article published on 17 June 2017

Replication of LCE3C–LCE3B CNV as a Risk Factor for Psoriasis and Analysis of Interaction with Other Genetic Risk Factors

article

Reply to Meisel et al

scientific article published on 22 November 2016

Rho kinase inhibitor Y-27632 prolongs the life span of adult human keratinocytes, enhances skin equivalent development, and facilitates lentiviral transduction.

scientific article published on 5 June 2012

Serial analysis of gene expression in differentiated cultures of human epidermal keratinocytes

scientific article published on 01 January 2001

Skin microbiota in health and disease: From sequencing to biology

scientific article published on 17 August 2020

Strong induction of AIM2 expression in human epidermis in acute and chronic inflammatory skin conditions.

scientific article published in December 2012

Terminal keratinocyte differentiation in vitro is associated with a stable DNA methylome

scientific article published on 17 July 2020

The Effects of Human Beta-Defensins on Skin Cells in vitro.

scientific article published on 8 July 2017

The biology of cystatin M/E and its cognate target proteases.

scientific article published on 05 March 2009

The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea.

scientific article published on 21 May 2010

The effect of adalimumab on key drivers in the pathogenesis of psoriasis.

scientific article

The human cystatin M/E gene (CST6): exclusion candidate gene for harlequin ichthyosis.

scientific article

The skin barrier: Epidermis vs environment

scientific article published on 01 August 2018

Towards a role of interleukin-32 in atherosclerosis ⬇️

scientific article published on May 30, 2013

Transcriptional regulation of the elafin gene in human keratinocytes.

scientific article published on February 2003

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