List of works - Nimesh Mody

Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis

scientific article

Alterations in vitamin A/retinoic acid homeostasis in diet-induced obesity and insulin resistance.

scientific article published on 27 June 2017

Direct comparison of methionine restriction with leucine restriction on the metabolic health of C57BL/6J mice.

scientific article published on 30 August 2017

Effects of hepatic protein tyrosine phosphatase 1B and methionine restriction on hepatic and whole-body glucose and lipid metabolism in mice

scientific article

Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice.

scientific article published on 03 March 2017

Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue

scientific article published on 21 November 2015

Fenretinide prevents obesity in aged female mice in association with increased retinoid and estrogen signaling.

scientific article published on 14 July 2015

Fenretinide treatment prevents diet-induced obesity in association with major alterations in retinoid homeostatic gene expression in adipose, liver, and hypothalamus.

scientific article published on 27 November 2012

Hepatic protein tyrosine phosphatase 1B (PTP1B) deficiency protects against obesity-induced endothelial dysfunction.

scientific article published on 30 October 2014

In vivo differential effects of fasting, re-feeding, insulin and insulin stimulation time course on insulin signaling pathway components in peripheral tissues.

scientific article published on 15 September 2010

Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice.

scientific article published on 6 July 2013

Methionine restriction improves renal insulin signalling in aged kidneys.

scientific article

Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21.

scientific article published on 17 June 2014

Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE-/- mouse model of atherosclerosis with alterations in IL10/AMPKα pathway

scientific article

Neuronal human BACE1 knockin induces systemic diabetes in mice.

scientific article published on 02 May 2016

Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis.

scientific article published on 12 September 2017

Regulation of growth hormone induced JAK2 and mTOR signalling by hepatic protein tyrosine phosphatase 1B.

scientific article published on 16 June 2014

The mechanisms of Fenretinide-mediated anti-cancer activity and prevention of obesity and type-2 diabetes.

scientific article

List of works by Nimesh Mody

Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis

Alterations in vitamin A/retinoic acid homeostasis in diet-induced obesity and insulin resistance.

Direct comparison of methionine restriction with leucine restriction on the metabolic health of C57BL/6J mice.

Effects of hepatic protein tyrosine phosphatase 1B and methionine restriction on hepatic and whole-body glucose and lipid metabolism in mice

Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice.

Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue

Fenretinide prevents obesity in aged female mice in association with increased retinoid and estrogen signaling.

Fenretinide treatment prevents diet-induced obesity in association with major alterations in retinoid homeostatic gene expression in adipose, liver, and hypothalamus.

Hepatic protein tyrosine phosphatase 1B (PTP1B) deficiency protects against obesity-induced endothelial dysfunction.

In vivo differential effects of fasting, re-feeding, insulin and insulin stimulation time course on insulin signaling pathway components in peripheral tissues.

Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice.

Methionine restriction improves renal insulin signalling in aged kidneys.

Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21.

Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE-/- mouse model of atherosclerosis with alterations in IL10/AMPKα pathway

Neuronal human BACE1 knockin induces systemic diabetes in mice.

Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis.

Regulation of growth hormone induced JAK2 and mTOR signalling by hepatic protein tyrosine phosphatase 1B.

The mechanisms of Fenretinide-mediated anti-cancer activity and prevention of obesity and type-2 diabetes.