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List of works by Michael O'Donnell

A Central Swivel Point in the RFC Clamp Loader Controls PCNA Opening and Loading on DNA ⬇️

scientific article published on December 13, 2011

A TOPRIM domain in the crystal structure of the catalytic core of Escherichia coli primase confirms a structural link to DNA topoisomerases

scientific article published in July 2000

A consensus view of DNA binding by the C family of replicative DNA polymerases

scholarly article

A novel function for the conserved glutamate residue in the walker B motif of replication factor C.

scientific article published on March 2013

A proposal: Evolution of PCNA's role as a marker of newly replicated DNA

scientific article

A proposal: Source of single strand DNA that elicits the SOS response.

scientific article published on January 2013

A single subunit directs the assembly of the Escherichia coli DNA sliding clamp loader.

scientific article published on March 2010

A sliding-clamp toolbelt binds high- and low-fidelity DNA polymerases simultaneously.

scientific article

A slow ATP-induced conformational change limits the rate of DNA binding but not the rate of beta clamp binding by the escherichia coli gamma complex clamp loader.

scientific article

A solution to release twisted DNA during chromosome replication by coupled DNA polymerases.

scientific article published on 27 March 2013

A tale of toroids in DNA metabolism.

scientific article published in October 2000

ATP Binding to the Escherichia coli Clamp Loader Powers Opening of the Ring-shaped Clamp of DNA Polymerase III Holoenzyme ⬇️

scientific article published on September 18, 1998

ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits ⬇️

scientific article published on September 29, 1998

Action of CMG with strand-specific DNA blocks supports an internal unwinding mode for the eukaryotic replicative helicase.

scientific article published on 27 March 2017

An explanation for origin unwinding in eukaryotes

scientific article published on 8 July 2019

An interaction between DNA ligase I and proliferating cell nuclear antigen: implications for Okazaki fragment synthesis and joining

scientific article

Biochemical basis of SOS-induced mutagenesis in Escherichia coli: reconstitution of in vitro lesion bypass dependent on the UmuD'2C mutagenic complex and RecA protein.

scientific article

CMG helicase and DNA polymerase ε form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication.

scientific article

Characterization of a triple DNA polymerase replisome.

scientific article published in August 2007

Clamp loader ATPases and the evolution of DNA replication machinery ⬇️

scientific article published on April 20, 2012

Clamp loader structure predicts the architecture of DNA polymerase III holoenzyme and RFC ⬇️

scientific article published on November 13, 2001

Competitive processivity-clamp usage by DNA polymerases during DNA replication and repair.

scientific article

Conserved residues in the delta subunit help the E. coli clamp loader, gamma complex, target primer-template DNA for clamp assembly.

scientific article published on 19 April 2008

Cost of rNTP/dNTP pool imbalance at the replication fork ⬇️

scientific article published on July 23, 2013

Cross-utilization of the beta sliding clamp by replicative polymerases of evolutionary divergent organisms

scientific article published on 01 August 2000

Crystal Structure of the δ′ Subunit of the Clamp-Loader Complex of E. coli DNA Polymerase III ⬇️

scientific article published on October 31, 1997

Crystal structure of the processivity clamp loader gamma (gamma) complex of E. coli DNA polymerase III

scientific article

Ctf4 organizes sister replisomes and Pol α into a replication factory

scientific article published on 07 October 2019

DNA ligase: getting a grip to seal the deal.

scientific article

DNA polymerases are error-prone at RecA-mediated recombination intermediates.

scientific article published on 29 July 2013

DNA replication: keep moving and don't mind the gap.

scientific article published on July 2006

DNA unwinding mechanism of a eukaryotic replicative CMG helicase

scientific article published on 04 February 2020

Devoted to the lagging strand_the chi subunit of DNA polymerase III holoenzyme contacts SSB to promote processive elongation and sliding clamp assembly ⬇️

scientific article published on April 15, 1998

Direct restart of a replication fork stalled by a head-on RNA polymerase

scientific article published on 01 January 2010

Direct restart of a replication fork stalled by a head-on RNA polymerase.

scientific article

Division of labor--sequential ATP hydrolysis drives assembly of a DNA polymerase sliding clamp around DNA.

scientific article

DnaB drives DNA branch migration and dislodges proteins while encircling two DNA strands.

scientific article published in September 2002

Dual functions, clamp opening and primer-template recognition, define a key clamp loader subunit.

scientific article

Evolution of replication machines

scientific article published on 20 December 2015

Functional uncoupling of twin polymerases: mechanism of polymerase dissociation from a lagging-strand block.

scientific article published on 9 March 2004

Getting ready for DNA duplication

scientific article published on 27 September 2019

How a DNA Polymerase Clamp Loader Opens a Sliding Clamp ⬇️

scientific article published on December 23, 2011

Human CD4(+) T lymphocytes consistently respond to the latent Epstein-Barr virus nuclear antigen EBNA1.

scientific article

Human RPA (hSSB) interacts with EBNA1, the latent origin binding protein of Epstein-Barr virus ⬇️

scientific article published on January 15, 1998

Interaction of the beta sliding clamp with MutS, ligase, and DNA polymerase I.

scientific article

Involvement of the beta clamp in methyl-directed mismatch repair in vitro.

scientific article published on 25 September 2009

Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks.

scientific article

Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex.

scientific article

Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork.

scientific article published on 6 July 2014

Mechanism of beta clamp opening by the delta subunit of Escherichia coli DNA polymerase III holoenzyme.

scientific article

Mechanism of polymerase collision release from sliding clamps on the lagging strand.

scientific article

Mechanism of the E. coli tau processivity switch during lagging-strand synthesis

scientific article published on 01 February 2003

Mechanisms of DNA replication.

scientific article

Motors and switches: AAA+ machines within the replisome.

scientific article

Multiple competition reactions for RPA order the assembly of the DNA polymerase delta holoenzyme.

scientific article

New insights into replisome fluidity during chromosome replication

scientific article

Nuclease dead Cas9 is a programmable roadblock for DNA replication

scientific article published on 16 September 2019

Ordered ATP hydrolysis in the gamma complex clamp loader AAA+ machine.

scientific article

Overproduction and analysis of eukaryotic multiprotein complexes in Escherichia coli using a dual-vector strategy.

scientific article

Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest

scientific article published on 13 June 2016

Polymerase trafficking: A role for transcription factors in preventing replication fork arrest.

scientific article published on 30 August 2010

Preferential D-loop extension by a translesion DNA polymerase underlies error-prone recombination ⬇️

scientific article published on May 19, 2013

Principles and Concepts of DNA Replication in Bacteria, Archaea, and Eukarya ⬇️

scientific article published on July 1, 2013

Processivity factors

scientific article published on 01 July 1999

Protein trafficking on sliding clamps.

scientific article

Proteomic and genomic characterization of chromatin complexes at a boundary

scientific article

RecA acts as a switch to regulate polymerase occupancy in a moving replication fork.

scientific article published on 18 March 2013

Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation.

scientific article published on 14 April 2015

Reconstitution of a eukaryotic replisome reveals the mechanism of asymmetric distribution of DNA polymerases

scientific article published on 14 July 2016

Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture.

scientific article

Replication Factor C Is a More Effective Proliferating Cell Nuclear Antigen (PCNA) Opener than the Checkpoint Clamp Loader, Rad24-RFC ⬇️

scientific article published on November 24, 2011

Replication bypass of the acrolein-mediated deoxyguanine DNA-peptide cross-links by DNA polymerases of the DinB family.

scientific article published on 13 September 2008

Replication factor C clamp loader subunit arrangement within the circular pentamer and its attachment points to proliferating cell nuclear antigen.

scientific article published on 6 October 2003

Replisome Dynamics during Chromosome Duplication

scientific article published on August 2009

Replisome bypass of a protein-based R-loop block by Pif1

scientific article published on 16 November 2020

Replisome dynamics and use of DNA trombone loops to bypass replication blocks.

scientific article

Replisome fate upon encountering a leading strand block and clearance from DNA by recombination proteins

scientific article published on 02 July 2007

Replisome mechanics: insights into a twin DNA polymerase machine

scientific article

Replisome mechanics: lagging strand events that influence speed and processivity

scientific article

Role of the adenovirus DNA-binding protein in in vitro adeno-associated virus DNA replication.

scientific article published in January 1998

RuvA is a sliding collar that protects Holliday junctions from unwinding while promoting branch migration.

scientific article published on 16 November 2005

Single-molecule analysis of the Escherichia coli replisome and use of clamps to bypass replication barriers.

scientific article published on 11 April 2010

Single-molecule studies reveal the function of a third polymerase in the replisome ⬇️

scientific article published on December 11, 2011

Sliding clamps: a (tail)ored fit.

scientific article

Structural biology. Getting DNA to unwind

scientific article

Structure of eukaryotic DNA polymerase δ bound to the PCNA clamp while encircling DNA

scientific article published on 17 November 2020

Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation

scientific article

Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome

scientific article published on 22 June 2020

Subunit sharing among high- and low-fidelity DNA polymerases ⬇️

scientific article published on July 23, 2012

The ATP sites of AAA+ clamp loaders work together as a switch to assemble clamps on DNA

scientific article published on 16 January 2014

The DNA replication machine of a gram-positive organism.

scientific article published in September 2000

The Escherichia coli Clamp Loader Can Actively Pry Open the β-Sliding Clamp ⬇️

scientific article published on October 4, 2011

The Escherichia coli DNA polymerase III holoenzyme contains both products of the dnaX gene, tau and gamma, but only tau is essential.

scientific article published on September 1993

The Eukaryotic Replication Machine.

scientific article

The Eukaryotic Replisome Goes Under the Microscope

scientific article

The Mechanism of ATP-Dependent Primer-Template Recognition by a Clamp Loader Complex

scientific article

The RFC clamp loader: structure and function

scientific article

The architecture of a eukaryotic replisome.

scientific article

The beta sliding clamp binds to multiple sites within MutL and MutS.

scientific article published on 16 March 2006

The eukaryotic CMG helicase pumpjack and integration into the replisome

scientific article published on April 2016

The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading

scientific article published on 15 September 2006

The ring-shaped hexameric helicases that function at DNA replication forks

scientific article

The ring-type polymerase sliding clamp family

scientific article

The sliding clamp of DNA polymerase III holoenzyme encircles DNA.

scientific article

Thermus thermophilis dnaX homolog encoding gamma- and tau-like proteins of the chromosomal replicase

scientific article published on 01 October 1997

Three-dimensional structure of the beta subunit of E. coli DNA polymerase III holoenzyme: a sliding DNA clamp

scientific article published on May 1, 1992

Toroidal proteins: Running rings around DNA ⬇️

scientific article published on January 29, 1998

Trading places on DNA--a three-point switch underlies primer handoff from primase to the replicative DNA polymerase

scientific article published on 01 January 1999

Translesion DNA polymerases remodel the replisome and alter the speed of the replicative helicase.

scholarly article

Twin DNA Pumps of a Hexameric Helicase Provide Power to Simultaneously Melt Two Duplexes

scientific article published on 01 August 2004

What happens when replication and transcription complexes collide?

scientific article published on July 2010

cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster

scientific journal article

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