List of works - Michael C Lawrence

A Molecular Mechanism for Bacterial Susceptibility to Zinc

scientific article

A designed ankyrin repeat protein evolved to picomolar affinity to Her2

scientific article

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

scientific article

A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

scientific article published on 01 June 2020

A thermodynamic study of ligand binding to the first three domains of the human insulin receptor: relationship between the receptor alpha-chain C-terminal peptide and the site 1 insulin mimetic peptides.

scientific article

Aromatic anchor at an invariant hormone-receptor interface: function of insulin residue B24 with application to protein design.

scientific article

Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY.

scientific article published on 14 November 2016

How insulin engages its primary binding site on the insulin receptor

scientific article

How ligand binds to the type 1 insulin-like growth factor receptor.

scientific article published on 26 February 2018

Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor

scientific article

Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity

scientific article published on 8 December 2017

Protective hinge in insulin opens to enable its receptor engagement

scientific article

Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change

scientific article published on 14 October 2009

Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors

scientific article

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

scientific article

Structure and Function of Ecdysone Receptors—Interactions with Ecdysteroids and Synthetic Agonists

scientific article published in 2012

Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III

scientific article

The X-ray structure of a hemipteran ecdysone receptor ligand-binding domain: comparison with a lepidopteran ecdysone receptor ligand-binding domain and implications for insecticide design

scientific article published on 4 April 2005

The insulin receptor changes conformation in unforeseen ways on ligand binding: sharpening the picture of insulin receptor activation

scientific article published on 28 August 2013

α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase

scientific article

List of works by Michael C Lawrence

A Molecular Mechanism for Bacterial Susceptibility to Zinc

A designed ankyrin repeat protein evolved to picomolar affinity to Her2

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

A thermodynamic study of ligand binding to the first three domains of the human insulin receptor: relationship between the receptor alpha-chain C-terminal peptide and the site 1 insulin mimetic peptides.

Aromatic anchor at an invariant hormone-receptor interface: function of insulin residue B24 with application to protein design.

Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY.

How insulin engages its primary binding site on the insulin receptor

How ligand binds to the type 1 insulin-like growth factor receptor.

Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor

Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity

Protective hinge in insulin opens to enable its receptor engagement

Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change

Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

Structure and Function of Ecdysone Receptors—Interactions with Ecdysteroids and Synthetic Agonists

Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III

The X-ray structure of a hemipteran ecdysone receptor ligand-binding domain: comparison with a lepidopteran ecdysone receptor ligand-binding domain and implications for insecticide design

The insulin receptor changes conformation in unforeseen ways on ligand binding: sharpening the picture of insulin receptor activation

α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase