List of works - Jeffrey P MacKeigan

A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress

scientific article published on 19 September 2018

A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels

scientific article (publication date: 8 May 2014)

A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration.

scientific article

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

scientific article (publication date: 30 July 2010)

Bidirectional transport of amino acids regulates mTOR and autophagy

scientific article (publication date: 6 February 2009)

Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression

scientific article published on 16 December 2010

Characterization of differential protein tethering at the plasma membrane in response to epidermal growth factor signaling

scientific article published on 15 May 2012

Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas

scientific article

Combined gene expression profiling and RNAi screening in clear cell renal cell carcinoma identify PLK1 and other therapeutic kinase targets

scientific article published on 3 June 2011

Computational analysis of an autophagy/translation switch based on mutual inhibition of MTORC1 and ULK1

scientific article

Computational model for autophagic vesicle dynamics in single cells ⬇️

scientific article published on November 29, 2012

Cytokine Receptor-Like Factor 1 (CRLF1) Protects against 6-Hydroxydopamine Toxicity Independent of the gp130/JAK Signaling Pathway ⬇️

scientific article published on June 20, 2013

DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways.

scientific article

Determining the Impact of Metabolic Nutrients on Autophagy

scientific article published on 01 January 2019

Development of a Center for Personalized Cancer Care at a Regional Cancer Center: Feasibility Trial of an Institutional Tumor Sequencing Advisory Board

scientific article published on 30 August 2015

Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib

scientific article

Differentiating the mTOR inhibitors everolimus and sirolimus in the treatment of tuberous sclerosis complex.

scientific article

Down-regulation of class II phosphoinositide 3-kinase alpha expression below a critical threshold induces apoptotic cell death.

scientific article

Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death

scientific article

Dual Roles of Fer Kinase Are Required for Proper Hematopoiesis and Vascular Endothelium Organization during Zebrafish Development

scientific article published on 23 November 2017

Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing

scientific article published on 25 December 2011

From sequence to function: using RNAi to elucidate mechanisms of human disease.

scientific article

Graded mitogen-activated protein kinase activity precedes switch-like c-Fos induction in mammalian cells.

scientific article

Identification of Kinases Responsible for p53-Dependent Autophagy

scientific article published on 23 April 2019

Identification of PTPsigma as an autophagic phosphatase.

scientific article

Identification of SRC3/AIB1 as a Preferred Coactivator for Hormone-activated Androgen Receptor

scientific article

Identification of a lysosomal pathway that modulates glucocorticoid signaling and the inflammatory response.

scientific article

Identification of small molecule inhibitors of PTPσ through an integrative virtual and biochemical approach

scientific article

Integrating virtual and biochemical screening for protein tyrosine phosphatase inhibitor discovery.

scientific article

Kinase targets in renal-cell carcinomas: reassessing the old and discovering the new.

scientific article published on 08 April 2010

LRRK2 deficiency impairs trans-Golgi to lysosome trafficking and endocytic cargo degradation in human renal proximal tubule epithelial cells

scientific article published on 08 August 2018

Leaving the lysosome behind: novel developments in autophagy inhibition

scientific article

MEK inhibition enhances paclitaxel-induced tumor apoptosis

scientific article published on 01 December 2000

MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis

scientific article

Metabolic profiling of triple-negative breast cancer cells reveals metabolic vulnerabilities.

scientific article

Mitochondria in cancer: at the crossroads of life and death ⬇️

scientific article published on August 1, 2011

Mitochondrial morphological features are associated with fission and fusion events

scientific article

Mitochondrial phosphorylation in apoptosis: flipping the death switch.

scientific article published on 07 December 2012

Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system

scientific article

Origins of cancer

scientific article published on 01 December 2008

PI3K-C2α knockdown decreases autophagy and maturation of endocytic vesicles.

scientific article

Patient-Derived Xenograft Models of Colorectal Cancer: Procedures for Engraftment and Propagation

scientific article published on 01 January 2018

Persistent mitochondrial hyperfusion promotes G2/M accumulation and caspase-dependent cell death

scientific article

Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.

scientific article

STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma.

scientific article

Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

scientific article

Synthesis of improved lysomotropic autophagy inhibitors

scientific article

Tailoring tyrosine kinase inhibitors to fit the lung cancer genome.

scientific article

The genomic landscape of tuberous sclerosis complex

scientific article

List of works by Jeffrey P MacKeigan

A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress

A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels

A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration.

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

Bidirectional transport of amino acids regulates mTOR and autophagy

Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression

Characterization of differential protein tethering at the plasma membrane in response to epidermal growth factor signaling

Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas

Combined gene expression profiling and RNAi screening in clear cell renal cell carcinoma identify PLK1 and other therapeutic kinase targets

Computational analysis of an autophagy/translation switch based on mutual inhibition of MTORC1 and ULK1

Computational model for autophagic vesicle dynamics in single cells ⬇️

Cytokine Receptor-Like Factor 1 (CRLF1) Protects against 6-Hydroxydopamine Toxicity Independent of the gp130/JAK Signaling Pathway ⬇️

DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways.

Determining the Impact of Metabolic Nutrients on Autophagy

Development of a Center for Personalized Cancer Care at a Regional Cancer Center: Feasibility Trial of an Institutional Tumor Sequencing Advisory Board

Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib

Differentiating the mTOR inhibitors everolimus and sirolimus in the treatment of tuberous sclerosis complex.

Down-regulation of class II phosphoinositide 3-kinase alpha expression below a critical threshold induces apoptotic cell death.

Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death

Dual Roles of Fer Kinase Are Required for Proper Hematopoiesis and Vascular Endothelium Organization during Zebrafish Development

Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing

From sequence to function: using RNAi to elucidate mechanisms of human disease.

Graded mitogen-activated protein kinase activity precedes switch-like c-Fos induction in mammalian cells.

Identification of Kinases Responsible for p53-Dependent Autophagy

Identification of PTPsigma as an autophagic phosphatase.

Identification of SRC3/AIB1 as a Preferred Coactivator for Hormone-activated Androgen Receptor

Identification of a lysosomal pathway that modulates glucocorticoid signaling and the inflammatory response.

Identification of small molecule inhibitors of PTPσ through an integrative virtual and biochemical approach

Integrating virtual and biochemical screening for protein tyrosine phosphatase inhibitor discovery.

Kinase targets in renal-cell carcinomas: reassessing the old and discovering the new.

LRRK2 deficiency impairs trans-Golgi to lysosome trafficking and endocytic cargo degradation in human renal proximal tubule epithelial cells

Leaving the lysosome behind: novel developments in autophagy inhibition

MEK inhibition enhances paclitaxel-induced tumor apoptosis

MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis

Metabolic profiling of triple-negative breast cancer cells reveals metabolic vulnerabilities.

Mitochondria in cancer: at the crossroads of life and death ⬇️

Mitochondrial morphological features are associated with fission and fusion events

Mitochondrial phosphorylation in apoptosis: flipping the death switch.

Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system

Origins of cancer

PI3K-C2α knockdown decreases autophagy and maturation of endocytic vesicles.

Patient-Derived Xenograft Models of Colorectal Cancer: Procedures for Engraftment and Propagation

Persistent mitochondrial hyperfusion promotes G2/M accumulation and caspase-dependent cell death

Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.

STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma.

Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

Synthesis of improved lysomotropic autophagy inhibitors

Tailoring tyrosine kinase inhibitors to fit the lung cancer genome.

The genomic landscape of tuberous sclerosis complex