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List of works by Ornella Rossetto

Active-site mutagenesis of tetanus neurotoxin implicates TYR-375 and GLU-271 in metalloproteolytic activity

scientific article published on 01 August 2001

Alternative splicing of the human gene SYBL1 modulates protein domain architecture of Longin VAMP7/TI-VAMP, showing both non-SNARE and synaptobrevin-like isoforms

scientific article

Antiepileptic effects of botulinum neurotoxin E.

scientific article

Arg206 of SNAP-25 is essential for neuroexocytosis at the Drosophila melanogaster neuromuscular junction

scientific article published on 7 September 2010

Assay of diffusion of different botulinum neurotoxin type a formulations injected in the mouse leg

scientific article published on 01 September 2009

Bacterial toxins with intracellular protease activity.

scientific article

Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission.

scientific article published on 11 August 2017

Botulinum neurotoxin serotype D is poorly effective in humans: an in vivo electrophysiological study.

scientific article published on 13 December 2012

Botulinum neurotoxin serotypes A and C do not affect motor units survival in humans: an electrophysiological study by motor units counting.

scientific article published in August 2002

Botulinum neurotoxin type A is internalized and translocated from small synaptic vesicles at the neuromuscular junction.

scientific article

Botulinum neurotoxins A and E undergo retrograde axonal transport in primary motor neurons

scientific article

Botulinum neurotoxins and formalin-induced pain: central vs. peripheral effects in mice

scientific article published on 9 March 2006

Botulinum neurotoxins: genetic, structural and mechanistic insights.

scientific article published on 30 June 2014

Botulinum toxin type A selectivity for certain types of pain is associated with capsaicin-sensitive neurons

scientific article published on 2 May 2014

Calcium Influx and Mitochondrial Alterations at Synapses Exposed to Snake Neurotoxins or Their Phospholipid Hydrolysis Products

scientific article published on 20 February 2007

Calcium imaging of muscle cells treated with snake myotoxins reveals toxin synergism and presence of acceptors.

scientific article published on May 2009

Calcium overload in nerve terminals of cultured neurons intoxicated by alpha-latrotoxin and snake PLA2 neurotoxins

scientific article published on 31 March 2009

Clinical use of non-A botulinum toxins: botulinum toxin type C and botulinum toxin type F

scientific article published on 01 April 2006

Common and distinct fusion proteins in axonal growth and transmitter release

scientific article published on 01 April 1996

Comparison of the pH-induced conformational change of different clostridial neurotoxins.

scientific article

Different mechanism of blockade of neuroexocytosis by presynaptic neurotoxins.

scientific article published on April 2004

Different time courses of recovery after poisoning with botulinum neurotoxin serotypes A and E in humans.

scientific article published in November 1998

Double anchorage to the membrane and intact inter-chain disulfide bond are required for the low pH induced entry of tetanus and botulinum neurotoxins into neurons.

scientific article

Electrophysiological Characterization of the Antarease Metalloprotease from Tityus serrulatus Venom. ⬇️

scientific article published on 27 February 2017

Entering neurons: botulinum toxins and synaptic vesicle recycling

scientific article published on October 2006

Equivalent effects of snake PLA2 neurotoxins and lysophospholipid-fatty acid mixtures

scientific article

Evidence for a radial SNARE super-complex mediating neurotransmitter release at the Drosophila neuromuscular junction.

scientific article published on 17 May 2013

Evidence for anterograde transport and transcytosis of botulinum neurotoxin A (BoNT/A).

scientific article published in November 2011

Glycogen synthase kinase 3 activation is essential for the snake phospholipase A2 neurotoxin-induced secretion in chromaffin cells

High Conservation of Tetanus and Botulinum Neurotoxins Cleavage Sites on Human SNARE Proteins Suggests That These Pathogens Exerted Little or No Evolutionary Pressure on Humans

scientific article published on 19 December 2017

How do presynaptic PLA2 neurotoxins block nerve terminals?

scientific article published on 01 June 2000

Internalization and proteolytic action of botulinum toxins in CNS neurons and astrocytes.

scientific article

Long-distance retrograde effects of botulinum neurotoxin A

scientific article published on 01 April 2008

Mass spectrometry analysis of the phospholipase A(2) activity of snake pre-synaptic neurotoxins in cultured neurons.

scientific article published on 27 August 2009

Neuromuscular paralysis and recovery in mice injected with botulinum neurotoxins A and C

scientific article published on 01 May 2007

Neurotoxicity of European viperids in Italy: Pavia Poison Control Centre case series 2001-2011.

scientific article published on 7 April 2014

Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.

scientific article published on 21 October 2013

On the action of botulinum neurotoxins A and E at cholinergic terminals

scientific article published on 01 April 1998

Presynaptic enzymatic neurotoxins.

scientific article

Presynaptic receptor arrays for clostridial neurotoxins.

scientific article published in October 2004

Re-assembled botulinum neurotoxin inhibits CNS functions without systemic toxicity

scientific article published on 24 March 2011

Reversible skeletal neuromuscular paralysis induced by different lysophospholipids

scientific article published on 26 October 2006

SNARE motif and neurotoxins

scientific article published in Nature

Snake presynaptic neurotoxins with phospholipase A2 activity induce punctate swellings of neurites and exocytosis of synaptic vesicles

scientific article

Structural determinants of the specificity for synaptic vesicle-associated membrane protein/synaptobrevin of tetanus and botulinum type B and G neurotoxins

scientific article published on 01 August 1996

Substrate residues N-terminal to the cleavage site of botulinum type B neurotoxin play a role in determining the specificity of its endopeptidase activity

scientific article published on 01 May 1996

Tetanus neurotoxin-induced epilepsy in mouse visual cortex.

scientific article published on 11 May 2012

Tetanus neurotoxin.

scientific article published on 16 February 2013

Tetanus toxin receptor. Specific cross-linking of tetanus toxin to a protein of NGF-differentiated PC 12 cells.

scientific article

Tetanus toxin-sensitive VAMP-related proteins are present in murine macrophages.

scientific article

The N-terminal half of the receptor domain of botulinum neurotoxin A binds to microdomains of the plasma membrane

scientific article published on 20 January 2009

The metallo-proteinase activity of tetanus and botulism neurotoxins ⬇️

scientific article published on January 1, 1995

The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals.

scientific article

Thioredoxin and its reductase are present on synaptic vesicles, and their inhibition prevents the paralysis induced by botulinum neurotoxins.

scientific article

Toxicity of botulinum neurotoxins in central nervous system of mice

scientific article published in March 2003

Traffic of botulinum toxins A and E in excitatory and inhibitory neurons.

scientific article

Transient synaptic silencing of developing striate cortex has persistent effects on visual function and plasticity

scientific article

VAMP/synaptobrevin cleavage by tetanus and botulinum neurotoxins is strongly enhanced by acidic liposomes

scientific article published on 01 May 2003

Vesicle-associated membrane protein (VAMP)/synaptobrevin-2 is associated with dense core secretory granules in PC12 neuroendocrine cells.

scientific article published on January 1995

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