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List of works by Jean-François Tanti

A Crk-II/TC10 signaling pathway is required for osmotic shock-stimulated glucose transport

scientific article

Adipose tissue microRNAs as regulators of CCL2 production in human obesity

scientific article

Alteration in insulin action: role of IRS-1 serine phosphorylation in the retroregulation of insulin signalling

scientific article published on February 2004

Alteration of insulin receptor kinase in obese, insulin-resistant mice.

scientific article

Alterations in insulin signalling pathway induced by prolonged insulin treatment of 3T3-L1 adipocytes

scientific article published on October 1995

Anti-inflammatory, cytotoxic and antimicrobial activities of Piper peltatum leaf extract

scientific article published on 14 December 2016

Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans

scientific article published on 16 March 2010

Assays of glucose entry, glucose transporter amount, and translocation

scientific article

Autoantibodies to the insulin receptor are infrequent findings in type 1 (insulin-dependent) diabetes mellitus of recent onset

scientific article published on 01 July 1990

Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage

scientific article published on December 2005

Brown adipose tissue in lean and obese mice. Insulin-receptor binding and tyrosine kinase activity

scientific article

C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet

article

Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice.

scientific article published on 21 August 2013

Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

scientific article published on 13 August 2009

Characterization of 6-deoxy-6-iodo-D-glucose: a potential new tool to assess glucose transport

scientific article published on 01 January 1997

Circulating Levels of Soluble Dipeptidyl Peptidase-4 Are Dissociated from Inflammation and Induced by Enzymatic DPP4 Inhibition

Cross-talk between the platelet-derived growth factor and the insulin signaling pathways in 3T3-L1 adipocytes

scientific article published on August 1997

DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes

scientific article published on 7 July 2016

Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice

scientific article

Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity.

scientific article

Different effects of insulin and platelet-derived growth factor on phosphatidylinositol 3-kinase at the subcellular level in 3T3-L1 adipocytes. A possible explanation for their specific effects on glucose transport.

scientific article

Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress.

scientific article published on 3 August 2006

Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and phosphatidylinositol 3-kinase activity

scientific article published on July 1993

ERK1 is dispensable for mouse pancreatic beta cell function but is necessary for glucose-induced full activation of MSK1 and CREB.

scientific article published on 18 July 2017

Effect of a thermogenic agent, BRL 26830A, on insulin receptors in obese mice

scientific article published on 01 August 1988

Effect of cyclic AMP-dependent protein kinase on insulin receptor tyrosine kinase activity.

scientific article published on July 1987

Effects of okadaic acid, an inhibitor of protein phosphatases-1 and -2A, on glucose transport and metabolism in skeletal muscle

scientific article published on 01 February 1991

Energy disruptors: rising stars in anticancer therapy?

scientific article

Enigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocation

scientific article

Essential role of chicken ovalbumin upstream promoter-transcription factor II in insulin secretion and insulin sensitivity revealed by conditional gene knockout.

scientific article published in May 2005

Expression of guanine-nucleotide-binding proteins in lean and obese insulin-resistant mice.

scientific article

Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling

scientific article published on December 2003

From insulin receptor signalling to Glut 4 translocation abnormalities in obesity and insulin resistance

scientific article

Functional labeling of insulin receptor subunits in live cells. Alpha 2 beta 2 species is the major autophosphorylated form

scientific article published on 01 December 1989

Glucose transporter in insulin sensitive tissues of lean and obese mice. Effect of the thermogenic agent BRL 26830A.

scientific article published in December 1990

Hepatocyte growth factor induces glucose uptake in 3T3-L1 adipocytes through A Gab1/phosphatidylinositol 3-kinase/Glut4 pathway

scientific article published on 6 February 2007

Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes

scientific article (publication date: 18 July 2003)

Hypoxia decreases insulin signaling pathways in adipocytes

scientific article

Hypoxia inhibits Cavin-1 and Cavin-2 expression and down-regulates caveolae in adipocytes.

scientific article published on 18 December 2014

Implication of MAP kinases in obesity-induced inflammation and insulin resistance

scientific article published on 8 September 2014

Implication of REDD1 in the activation of inflammatory pathways

scientific article published on August 2017

Implication of inflammatory signaling pathways in obesity-induced insulin resistance

scientific article (publication date: 2012)

Implication of the Tpl2 kinase in inflammatory changes and insulin resistance induced by the interaction between adipocytes and macrophages

scientific article published on January 2014

Inhibition of the GTPase Rac1 mediates the antimigratory effects of metformin in prostate cancer cells.

scientific article published on 19 December 2014

Inhibition of the MAP3 kinase Tpl2 protects rodent and human β-cells from apoptosis and dysfunction induced by cytokines and enhances anti-inflammatory actions of exendin-4.

scientific article published on 21 January 2016

Insulin and okadaic acid induce Rab4 redistribution in adipocytes

scientific journal article

Insulin induces REDD1 expression through hypoxia-inducible factor 1 activation in adipocytes

scientific article

Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase

scientific article published on November 1994

Insulin-like growth factor-I-stimulated glucose transport in myotubes derived from chicken muscle satellite cells

scientific article

Insulin-stimulated glucose transport in muscle. Evidence for a protein-kinase-C-dependent component which is unaltered in insulin-resistant mice

scientific article published on February 1989

Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression

scientific article published on 12 October 2006

Involvement of TNF-alpha in abnormal adipocyte and muscle sortilin expression in obese mice and humans.

scientific article

Isolation and characterization of a T lymphocyte mutant defective in the protein kinase C signal transduction pathway.

scientific article published on September 1991

MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632

scientific journal article

Maintenance of Macrophage Redox Status by ChREBP Limits Inflammation and Apoptosis and Protects against Advanced Atherosclerotic Lesion Formation.

scientific article published on 22 September 2015

Metabolic endotoxemia initiates obesity and insulin resistance

scientific article (publication date: July 2007)

Metformin and cancer therapy.

scientific article published on January 2012

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

scientific article

Metformin targets the GTPase Rac1 to inhibit prostate cancer cell migration.

scientific article published on 28 May 2014

Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.

scientific article published on 3 May 2011

Metformin-induced energy deficiency leads to the inhibition of lipogenesis in prostate cancer cells

scientific article

Molecular mechanism of insulin resistance

scientific article

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

scientific article

New perspectives for metformin in cancer therapy

scientific article published on 12 April 2013

Okadaic acid stimulates IGF-II receptor translocation and inhibits insulin action in adipocytes

article published in 1993

Osmotic regulation of cellular glucose uptake

scientific article published on January 2007

Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote Glut 4 translocation in adipocytes

scientific article

PGC-1α inhibits polyamine synthesis to suppress prostate cancer aggressiveness

scientific article published on 07 May 2019

Parallel changes in Glut 4 and Rab4 movements in two insulin-resistant states.

scientific article published on June 1994

Peroxovanadate induces tyrosine phosphorylation of phosphoinositide-dependent protein kinase-1

scientific article published on 01 November 2000

Polymyxin B inhibits insulin-induced glucose transporter and IGF II receptor translocation in isolated adipocytes

scientific article published in July 1992

Polymyxin B selectively inhibits insulin effects on transport in isolated muscle.

scientific article

Positive and negative regulation of glucose uptake by hyperosmotic stress

scientific article published on December 2003

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

scientific article (publication date: 2005)

Potential involvement of the carboxy-terminus of the Glut 1 transporter in glucose transport

scientific article published on November 1992

Potential role of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in insulin-stimulated glucose transporter 4 translocation in adipocytes

scientific article

Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes

scientific article published on May 1997

Prevention of mutagenesis: new potential mechanisms of metformin action in neoplastic cells

scientific article published on 01 April 2012

Rab4 is phosphorylated by the insulin-activated extracellular-signal-regulated kinase ERK1.

scientific article

Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance

scientific article published on 01 December 2018

Rab4b controls an early endosome sorting event by interacting with the γ-subunit of the clathrin adaptor complex 1.

scientific article published on 4 September 2013

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

scientific article published on June 2003

Regulated in development and DNA damage responses -1 (REDD1) protein contributes to insulin signaling pathway in adipocytes

scientific article

Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.

scientific article published on February 1994

Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death

scientific article published on 14 December 2012

Sirtuin 7: a new marker of aggressiveness in prostate cancer

scientific article

Subcellular distribution of low molecular weight guanosine triphosphate-binding proteins in adipocytes: colocalization with the glucose transporter Glut 4.

scientific article published in December 1991

Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells

scientific article published on 9 March 2010

The Tpl2 Kinase Regulates the COX-2/Prostaglandin E2 Axis in Adipocytes in Inflammatory Conditions

scientific article

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

scientific article published on 21 January 2008

The combination of metformin and 2-deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells

scholarly article by Issam Ben Sahra et al published 1 July 2010 in Autophagy

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells.

scientific article

The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes.

scientific article published on 31 January 2009

The interaction between the adaptor protein APS and Enigma is involved in actin organisation

scientific journal article

The lipid phosphatase SHIP2 controls insulin sensitivity

scientific journal article

Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis

scientific article

Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism

scientific article published on 16 March 2017

[Mechanisms of insulin resistance]

scientific article published on 01 January 1989

[Obesity, diabetes and insulin resistance. Alterations of insulin signalling]

scientific article published on 01 January 2006

p38MAP Kinase activity is required for human primary adipocyte differentiation

scientific article published on 13 November 2007

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