List of works - David J Lloyd

A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity

scientific article

A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice

scientific journal article

A point mutation in Sec61alpha1 leads to diabetes and hepatosteatosis in mice

scientific article

A volumetric method for quantifying atherosclerosis in mice by using microCT: comparison to en face

scientific article (publication date: 2011)

Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models

scientific article published on 01 December 2018

Antidiabetic effects of 11beta-HSD1 inhibition in a mouse model of combined diabetes, dyslipidaemia and atherosclerosis.

scientific article

Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

scientific article

Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism

scientific article published on 05 October 2020

Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → σ*S-X) Interaction for Conformational Constraint

scientific article

Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts

scientific article published on December 2005

FGF21 promotes metabolic homeostasis via white adipose and leptin in mice

scientific article (publication date: 2012)

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

scientific article published on 7 October 2008

Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr.

scientific article published on 26 December 2007

Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes

scientific article published on 11 February 2016

Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice

scientific journal article

LMNA, encoding lamin A/C, is mutated in partial lipodystrophy.

scientific article

Lamin A/C gene: sex-determined expression of mutations in Dunnigan-type familial partial lipodystrophy and absence of coding mutations in congenital and acquired generalized lipoatrophy

article

Lessons from lipodystrophy:LMNA, encoding lamin A/C, in HIV therapy-associated lipodystrophy

article

Loss-of-function mutation in myostatin reduces tumor necrosis factor alpha production and protects liver against obesity-induced insulin resistance

scientific article published on 10 February 2009

Molecular targeting of the GK-GKRP pathway in diabetes

scientific article

New variants in the Enpp1 and Ptpn6 genes cause low BMD, crystal-related arthropathy, and vascular calcification

scientific article

Pharmacologic Effects of FGF21 Are Independent of the "Browning" of White Adipose Tissue.

scientific article published in May 2015

Pharmacological targeting of glucagon and glucagon-like peptide 1 receptors has different effects on energy state and glucose homeostasis in diet-induced obese mice

scientific article published on 6 April 2011

SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton

scientific article

Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis

scientific article

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept

scientific article

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles

scientific article

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series

scientific article

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket

scientific article

List of works by David J Lloyd

A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity

A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice

A point mutation in Sec61alpha1 leads to diabetes and hepatosteatosis in mice

A volumetric method for quantifying atherosclerosis in mice by using microCT: comparison to en face

Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models

Antidiabetic effects of 11beta-HSD1 inhibition in a mouse model of combined diabetes, dyslipidaemia and atherosclerosis.

Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism

Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → σ*S-X) Interaction for Conformational Constraint

Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts

FGF21 promotes metabolic homeostasis via white adipose and leptin in mice

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr.

Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes

Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice

LMNA, encoding lamin A/C, is mutated in partial lipodystrophy.

Lamin A/C gene: sex-determined expression of mutations in Dunnigan-type familial partial lipodystrophy and absence of coding mutations in congenital and acquired generalized lipoatrophy

Lessons from lipodystrophy:LMNA, encoding lamin A/C, in HIV therapy-associated lipodystrophy

Loss-of-function mutation in myostatin reduces tumor necrosis factor alpha production and protects liver against obesity-induced insulin resistance

Molecular targeting of the GK-GKRP pathway in diabetes

New variants in the Enpp1 and Ptpn6 genes cause low BMD, crystal-related arthropathy, and vascular calcification

Pharmacologic Effects of FGF21 Are Independent of the "Browning" of White Adipose Tissue.

Pharmacological targeting of glucagon and glucagon-like peptide 1 receptors has different effects on energy state and glucose homeostasis in diet-induced obese mice

SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton

Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket