List of works - Yu Wang

A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization.

scientific article published on 26 February 2009

A highly conserved tryptophan in the N-terminal variable domain regulates disulfide bond formation and oligomeric assembly of adiponectin

scientific journal article

APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice

scientific article

APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice ⬇️

scientific article published on May 7, 2012

Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway.

scientific article

Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue

scientific article published on 7 March 2017

Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome.

scientific article published on 19 January 2006

Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1.

scientific article

Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation

scientific article published on 22 January 2019

Adipokine Imbalance in the Pericardial Cavity of Cardiac and Vascular Disease Patients

scientific article

Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation.

scientific article

Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice ⬇️

scientific article published on May 7, 2013

Adiponectin as a negative regulator in obesity-related mammary carcinogenesis.

scientific article published on April 2007

Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities

scientific article

Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner.

scientific article published on 25 February 2005

Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice.

scientific article

Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice.

scientific article published on December 2006

Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway. ⬇️

scientific article

Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice.

scientific article published on 2 June 2014

Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1.

scientific article published on 13 August 2008

Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells.

scientific article

Amylin evokes phosphorylation of P20 in rat skeletal muscle

scientific article published on 01 August 1999

Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice

scientific article

Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells.

scientific article published in August 2010

Association of Genetic Variants in the Adiponectin Gene with Metabolic Syndrome: A Case-Control Study and a Systematic Meta-Analysis in the Chinese Population ⬇️

scientific article published on April 4, 2013

Calorie Restriction Prevents Metabolic Aging Caused by Abnormal SIRT1 Function in Adipose Tissues

scientific article published on 04 December 2014

Candida albicans biofilm formation is associated with increased anti-oxidative capacities.

scientific article published in July 2008

Carnitine palmitoyltransferase 1A prevents fatty acid-induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase ⬇️

scientific article published on May 1, 2011

Caspase-3 as a therapeutic target for heart failure.

scientific article published on 08 January 2013

Chronic treatment with growth hormone stimulates adiponectin gene expression in 3T3-L1 adipocytes.

scientific article published on August 2004

Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans.

scientific article published on 15 February 2011

Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study

scientific article published on 01 March 2007

Cloning and Characterization of Sirtuin3 (SIRT3).

scientific article published in January 2016

Constitutive activation of AMPK α1 in vascular endothelium promotes high-fat diet-induced fatty liver injury: role of COX-2 induction

scientific article published on January 2014

Differential genomic changes caused by cholesterol- and PUFA-rich diets in regenerated porcine coronary endothelial cells

scientific article published on 27 March 2012

Differential proteomic responses in hepatopancreas and adductor muscles of the green-lipped mussel Perna viridis to stresses induced by cadmium and hydrogen peroxide.

scientific article published on 20 May 2011

Emerging clinical and experimental evidence for the role of lipocalin-2 in metabolic syndrome.

scientific article

Endothelial SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase in smooth muscle cells

scientific article published on 01 March 2019

Enhanced production of recombinant secretory proteins in Pichia pastoris by optimizing Kex2 P1' site

scientific article

Epidermal fatty-acid-binding protein: a new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis

scientific article published on 04 July 2008

Epigallocatechin Gallate Elicits Contractions of the Isolated Aorta of the Aged Spontaneously Hypertensive Rat ⬇️

scientific article published on March 16, 2011

FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting

scientific article published on 14 July 2014

Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives.

scientific article published on April 2013

Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice

scientific article

Fluconazole resistance in Candida glabrata is associated with increased bud formation and metallothionein production.

scientific article published on 20 September 2012

Frontal-subcortical protein expression following prenatal exposure to maternal inflammation.

scientific article

Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes

scientific article published on 21 April 2007

High level expression, purification and characterization of active fusion human C1q and tumor necrosis factor related protein 2 (hCTRP2) in Escherichia coli

scientific article published on 29 March 2011

High plasma level of fibroblast growth factor 21 is an Independent predictor of type 2 diabetes: a 5.4-year population-based prospective study in Chinese subjects

scientific article

Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity

scientific article published on 23 March 2002

Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells

scientific article published on May 2002

In vitro and in vivo activity of a novel antifungal small molecule against Candida infections.

scientific article published on 22 January 2014

Insulin and insulin antagonists evoke phosphorylation of P20 at serine 157 and serine 16 respectively in rat skeletal muscle

scientific article published on 22 November 1999

Isoform-specific responses of metallothioneins in a marine pollution biomonitor, the green-lipped mussel Perna viridis, towards different stress stimulations

scientific article published on 16 June 2014

Large-scale production, purification and bioactivity assay of recombinant human interleukin-6 in the methylotrophic yeast Pichia pastoris ⬇️

scientific article published on December 22, 2010

Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity

scientific article

Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition

scientific article published on January 2012

Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation.

scientific article published on 22 November 2011

Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans.

scientific article

Local enrichment of fatty acid-binding protein 4 in the pericardial cavity of cardiovascular disease patients

scientific article published in PLoS ONE

Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice

scientific article

Maternal Serum and Breast Milk Adiponectin: The Association with Infant Adiposity Development.

scientific article published on 12 June 2018

Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment

scientific article published on 27 June 2017

Methods to investigate the role of SIRT1 in endothelial senescence

scientific article published on 01 January 2013

Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury.

scientific article published on October 2008

Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation.

scientific article

Natural product celastrol suppressed macrophage M1 polarization against inflammation in diet-induced obese mice via regulating Nrf2/HO-1, MAP kinase and NF-κB pathways.

scientific article published on 16 October 2017

New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein

scientific article published on 22 March 2011

No evidence of an effect of alterations in dietary fatty acids on fasting adiponectin over 3 weeks

scientific article published on 17 January 2008

Obesity, adipokines and cancer: an update.

scientific article

Overexpression of angiopoietin-like protein 4 alters mitochondria activities and modulates methionine metabolic cycle in the liver tissues of db/db diabetic mice

scientific article published on 09 January 2007

Post-translational modifications of adiponectin: mechanisms and functional implications.

scientific article published on February 2008

Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex

scientific article published on 18 April 2006

Postprandial response of adiponectin, interleukin-6, tumor necrosis factor-α, and C-reactive protein to a high-fat dietary load

scientific article published in April 2008

Pro-inflammatory adipokines as predictors of incident cancers in a Chinese cohort of low obesity prevalence in Hong Kong

scientific article

Prostaglandin E receptor subtype 4 regulates lipid droplet size and mitochondrial activity in murine subcutaneous white adipose tissue.

scientific article published on 22 May 2017

Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications.

scientific article published on March 2009

Proteomic analysis of adipocyte differentiation: Evidence that alpha2 macroglobulin is involved in the adipose conversion of 3T3 L1 preadipocytes

scientific article published on June 2004

Proteomic and functional characterization of endogenous adiponectin purified from fetal bovine serum

scientific article published in December 2004

Proteomic characterization of human serum proteins associated with the fat-derived hormone adiponectin

scientific article published in July 2006

Proteomics of drug resistance in Candida glabrata biofilms.

scientific article published in April 2010

Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation.

scientific article

Regulation and Quality Control of Adiponectin Assembly by Endoplasmic Reticulum Chaperone ERp44.

scientific article published on 9 June 2015

Reversal of diabetes-evoked changes in mitochondrial protein expression of cardiac left ventricle by treatment with a copper(II)-selective chelator

scientific article published on 13 March 2007

SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model ⬇️

scientific article published on 02 December 2010

SIRT1 in Endothelial Cells as a Novel Target for the Prevention of Early Vascular Aging

scientific article

SIRT1 in metabolic syndrome: Where to target matters ⬇️

scientific article published on August 24, 2012

Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort.

scientific article published on 9 July 2007

Skeletal phenotype of the leptin receptor-deficient db/db mouse

scientific article

Small lipid‐binding proteins in regulating endothelial and vascular functions: focusing on adipocyte fatty acid binding protein and lipocalin‐2 ⬇️

scientific article published on February 1, 2012

Structural Polymorphism of Oligomeric Adiponectin Visualized by Electron Microscopy

scientific article published on 12 June 2008

Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4.

scientific article

Synthetic peptides designed to modulate adiponectin assembly improve obesity-related metabolic disorders.

scientific article published on 25 September 2017

Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes

scientific article published on 9 March 2005

Tetra- and penta-acylated lipid A structures of Porphyromonas gingivalis LPS differentially activate TLR4-mediated NF-κB signal transduction cascade and immuno-inflammatory response in human gingival fibroblasts

scientific article

The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity.

scientific article published on 23 August 2017

The activities of lysyl hydroxylase 3 (LH3) regulate the amount and oligomerization status of adiponectin

scientific article

The use of lorcaserin in the management of obesity: a critical appraisal

scientific article

Toll-Like Receptor 4 Mutation Protects Obese Mice Against Endothelial Dysfunction by Decreasing NADPH Oxidase Isoforms 1 and 4 ⬇️

scientific article published on February 14, 2013

Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice ⬇️

scientific article published on January 17, 2012

Unraveling the resistance of microbial biofilms: Has proteomics been helpful? ⬇️

scientific article published on January 23, 2012

Upregulation of UCP2 by adiponectin: the involvement of mitochondrial superoxide and hnRNP K

scientific article

Upregulation of heme oxygenase 1 by hemin impairs endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat

scientific article published on 26 September 2011

Visualization and Quantification of Browning Using a Ucp1-2A-Luciferase Knock-in Mouse Model.

scientific article published on 8 November 2016

List of works by Yu Wang

A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization.

A highly conserved tryptophan in the N-terminal variable domain regulates disulfide bond formation and oligomeric assembly of adiponectin

APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice

APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice ⬇️

Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway.

Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue

Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome.

Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1.

Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation

Adipokine Imbalance in the Pericardial Cavity of Cardiac and Vascular Disease Patients

Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation.

Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice ⬇️

Adiponectin as a negative regulator in obesity-related mammary carcinogenesis.

Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities

Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner.

Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice.

Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice.

Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway. ⬇️

Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice.

Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1.

Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells.

Amylin evokes phosphorylation of P20 in rat skeletal muscle

Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice

Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells.

Association of Genetic Variants in the Adiponectin Gene with Metabolic Syndrome: A Case-Control Study and a Systematic Meta-Analysis in the Chinese Population ⬇️

Calorie Restriction Prevents Metabolic Aging Caused by Abnormal SIRT1 Function in Adipose Tissues

Candida albicans biofilm formation is associated with increased anti-oxidative capacities.

Carnitine palmitoyltransferase 1A prevents fatty acid-induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase ⬇️

Caspase-3 as a therapeutic target for heart failure.

Chronic treatment with growth hormone stimulates adiponectin gene expression in 3T3-L1 adipocytes.

Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans.

Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study

Cloning and Characterization of Sirtuin3 (SIRT3).

Constitutive activation of AMPK α1 in vascular endothelium promotes high-fat diet-induced fatty liver injury: role of COX-2 induction

Differential genomic changes caused by cholesterol- and PUFA-rich diets in regenerated porcine coronary endothelial cells

Differential proteomic responses in hepatopancreas and adductor muscles of the green-lipped mussel Perna viridis to stresses induced by cadmium and hydrogen peroxide.

Emerging clinical and experimental evidence for the role of lipocalin-2 in metabolic syndrome.

Endothelial SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase in smooth muscle cells

Enhanced production of recombinant secretory proteins in Pichia pastoris by optimizing Kex2 P1' site

Epidermal fatty-acid-binding protein: a new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis

Epigallocatechin Gallate Elicits Contractions of the Isolated Aorta of the Aged Spontaneously Hypertensive Rat ⬇️

FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting

Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives.

Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice

Fluconazole resistance in Candida glabrata is associated with increased bud formation and metallothionein production.

Frontal-subcortical protein expression following prenatal exposure to maternal inflammation.

Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes

High level expression, purification and characterization of active fusion human C1q and tumor necrosis factor related protein 2 (hCTRP2) in Escherichia coli

High plasma level of fibroblast growth factor 21 is an Independent predictor of type 2 diabetes: a 5.4-year population-based prospective study in Chinese subjects

Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity

Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells

In vitro and in vivo activity of a novel antifungal small molecule against Candida infections.

Insulin and insulin antagonists evoke phosphorylation of P20 at serine 157 and serine 16 respectively in rat skeletal muscle

Isoform-specific responses of metallothioneins in a marine pollution biomonitor, the green-lipped mussel Perna viridis, towards different stress stimulations

Large-scale production, purification and bioactivity assay of recombinant human interleukin-6 in the methylotrophic yeast Pichia pastoris ⬇️

Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity

Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition

Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation.

Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans.

Local enrichment of fatty acid-binding protein 4 in the pericardial cavity of cardiovascular disease patients

Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice

Maternal Serum and Breast Milk Adiponectin: The Association with Infant Adiposity Development.

Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment

Methods to investigate the role of SIRT1 in endothelial senescence

Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury.

Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation.

Natural product celastrol suppressed macrophage M1 polarization against inflammation in diet-induced obese mice via regulating Nrf2/HO-1, MAP kinase and NF-κB pathways.

New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein

No evidence of an effect of alterations in dietary fatty acids on fasting adiponectin over 3 weeks

Obesity, adipokines and cancer: an update.

Overexpression of angiopoietin-like protein 4 alters mitochondria activities and modulates methionine metabolic cycle in the liver tissues of db/db diabetic mice

Post-translational modifications of adiponectin: mechanisms and functional implications.

Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex

Postprandial response of adiponectin, interleukin-6, tumor necrosis factor-α, and C-reactive protein to a high-fat dietary load

Pro-inflammatory adipokines as predictors of incident cancers in a Chinese cohort of low obesity prevalence in Hong Kong

Prostaglandin E receptor subtype 4 regulates lipid droplet size and mitochondrial activity in murine subcutaneous white adipose tissue.

Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications.

Proteomic analysis of adipocyte differentiation: Evidence that alpha2 macroglobulin is involved in the adipose conversion of 3T3 L1 preadipocytes

Proteomic and functional characterization of endogenous adiponectin purified from fetal bovine serum