List of works - James Cantley

100 YEARS OF INSULIN: 100 years of insulin: progress, current perspectives and future challenges

scientific article published in March 2022

Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells

scientific article published on 29 July 2013

Circulating AFABP promotes insulin secretion

scientific article published on 06 July 2015

Continuous and non-invasive thermography of mouse skin accurately describes core body temperature patterns, but not absolute core temperature

scientific article published on 26 November 2020

DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake.

scientific article published on 9 July 2014

Deletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cells

scientific journal article

Deletion of protein kinase Cδ in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo.

scientific article published on 20 November 2010

Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.

scientific article published on 08 December 2008

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

scientific article published on 17 October 2018

Glucose homeostasis in mice is transglutaminase 2 independent

scientific article

High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice

scientific article published on 13 February 2018

Hmox1 (Heme Oxygenase-1) Protects Against Ischemia-Mediated Injury via Stabilization of HIF-1α (Hypoxia-Inducible Factor-1α)

scientific article published on 19 November 2020

Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity

scientific article

Inhibition of Y1 receptor signaling improves islet transplant outcome.

scientific article published on 8 September 2017

Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice.

scientific article published on 11 January 2006

Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells.

scientific article published on 23 October 2013

Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity.

scientific article published on 29 June 2015

Oleanolic acid reduces hyperglycemia beyond treatment period with Akt/FoxO1-induced suppression of hepatic gluconeogenesis in type-2 diabetic mice.

scientific article

Pancreatic PYY Is Critical in the Control of Insulin Secretion and Glucose Homeostasis in Female Mice.

scientific article

Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice

scientific article published on 29 March 2007

Prolyl-4-hydroxylase 3 maintains β cell glucose metabolism during fatty acid excess in mice

scientific article published in 2021

Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?

scientific article published on 16 May 2015

Sweet and sour β-cells: ROS and Hif1α induce Warburg-like lactate production during type 2 diabetes.

scientific article published on June 2013

The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis.

scientific article

The diverse roles of protein kinase C in pancreatic beta-cell function.

scientific article

The hypoxia response pathway and β-cell function.

scientific article published on October 2010

The radical-SAM enzyme Viperin catalyzes reductive addition of a 5'-deoxyadenosyl radical to UDP-glucose in vitro

scientific article

Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice.

scientific article

List of works by James Cantley

100 YEARS OF INSULIN: 100 years of insulin: progress, current perspectives and future challenges

Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells

Circulating AFABP promotes insulin secretion

Continuous and non-invasive thermography of mouse skin accurately describes core body temperature patterns, but not absolute core temperature

DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake.

Deletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cells

Deletion of protein kinase Cδ in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo.

Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

Glucose homeostasis in mice is transglutaminase 2 independent

High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice

Hmox1 (Heme Oxygenase-1) Protects Against Ischemia-Mediated Injury via Stabilization of HIF-1α (Hypoxia-Inducible Factor-1α)

Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity

Inhibition of Y1 receptor signaling improves islet transplant outcome.

Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice.

Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells.

Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity.

Oleanolic acid reduces hyperglycemia beyond treatment period with Akt/FoxO1-induced suppression of hepatic gluconeogenesis in type-2 diabetic mice.

Pancreatic PYY Is Critical in the Control of Insulin Secretion and Glucose Homeostasis in Female Mice.

Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice

Prolyl-4-hydroxylase 3 maintains β cell glucose metabolism during fatty acid excess in mice

Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?

Sweet and sour β-cells: ROS and Hif1α induce Warburg-like lactate production during type 2 diabetes.

The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis.

The diverse roles of protein kinase C in pancreatic beta-cell function.

The hypoxia response pathway and β-cell function.

The radical-SAM enzyme Viperin catalyzes reductive addition of a 5'-deoxyadenosyl radical to UDP-glucose in vitro

Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice.