List of works - David J Erle

A distinctive alveolar macrophage activation state induced by cigarette smoking

scientific article

AGR2 is induced in asthma and promotes allergen-induced mucin overproduction.

scientific article

Abnormal alveolar development associated with elevated adenine nucleosides

scientific article

Activated alpha4 integrins are preferentially expressed on immature thymocytes and activated T cells.

scientific article published on June 2002

Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B.

scientific article published on 08 August 2013

Airway Mucus and Asthma: The Role of MUC5AC and MUC5B.

scientific article published on 29 November 2017

Airway epithelial miRNA expression is altered in asthma.

scientific article

Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients

scientific article

An engineered cardiac reporter cell line identifies human embryonic stem cell-derived myocardial precursors

scientific article (publication date: 2011)

An integrated nano-scale approach to profile miRNAs in limited clinical samples

scientific article published on November 2012

Apolipoprotein A1 potentiates lipoxin A4 synthesis and recovery of allergen-induced disrupted tight junctions in the airway epithelium.

scientific article published in August 2013

Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2

scientific article

Asthma investigators begin to reap the fruits of genomics

scientific article

Asthmatics with exacerbation during acute respiratory illness exhibit unique transcriptional signatures within the nasal mucosa

scientific article published on 17 January 2014

CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation

scientific article published on January 2009

CD40 Mediates Maturation of Thymic Dendritic Cells Driven by Self-Reactive CD4+ Thymocytes and Supports Development of Natural Regulatory T Cells

scientific article published on 10 January 2018

Characterization of the leukocyte integrin subunit beta 7.

scientific article published in February 1993

Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction

scientific article

Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes

scientific article

Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling

scientific article published on 16 July 2018

Correction: Delayed Goblet Cell Hyperplasia, Acetylcholine Receptor Expression, and Worm Expulsion in SMC-Specific IL-4Rα–Deficient Mice.

scientific article published on 27 April 2007

Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4Ralpha-deficient mice

scientific article

Differential expression of homing molecules on recirculating lymphocytes from sheep gut, peripheral, and lung lymph.

scientific article published in May 1996

Differential gene expression by integrin beta 7+ and beta 7- memory T helper cells

scientific article

Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma

scientific article published in July 2002

Disease-specific gene expression profiling in multiple models of lung disease

scientific article

Dissecting asthma using focused transgenic modeling and functional genomics

scientific article

Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity

scientific article

Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.

scientific article

Effect of exercise rate and route of inhalation on sulfur-dioxide-induced bronchoconstriction in asthmatic subjects.

scientific article

Effect of serial-day exposure to nitrogen dioxide on airway and blood leukocytes and lymphocyte subsets

scientific article published on May 2000

Efficient RNP-directed Human Gene Targeting Reveals SPDEF Is Required for IL-13-induced Mucostasis

scientific article published on 01 March 2020

Epithelial interleukin-25 is a key mediator in Th2-high, corticosteroid-responsive asthma

scientific article

Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma

scientific article published on 16 May 2016

Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes

scientific article published on July 1994

Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma.

scientific article

Flow Cytometric Analysis and Purification of Airway Epithelial Cell Subsets

scientific article published on 16 November 2020

Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids

scientific article

Genomics and proteomics of lung disease: conference summary

scientific article

Global Absence and Targeting of Protective Immune States in Severe COVID-19

scientific article published on 28 October 2020

Hands-on workshops as an effective means of learning advanced technologies including genomics, proteomics and bioinformatics

scientific article

How do integrins integrate? The role of cell adhesion receptors in differentiation and development

scientific article

IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production

scientific article

IL-17 and "TH2-high" asthma: Adding fuel to the fire?

scientific article published on 28 August 2014

IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production

scientific article published in September 2005

Identification of MiR-205 As a MicroRNA That Is Highly Expressed in Medullary Thymic Epithelial Cells

scientific article published on 13 August 2015

Identification of novel airway epithelial integrins using the homology-based polymerase chain reaction

scientific article published in March 1992

Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking

scientific article

Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin

scientific article

Increased DNA microarray hybridization specificity using sscDNA targets

scientific article

Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.

scientific article published on 20 March 2015

Influenza virus infection causes global respiratory tract B cell response modulation via innate immune signals.

scientific article published in February 2007

Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins.

scientific article

Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1.

scientific article

Intelectin is required for IL-13-induced monocyte chemotactic protein-1 and -3 expression in lung epithelial cells and promotes allergic airway inflammation.

scientific article

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

scientific article

Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types.

scientific article published in October 2001

Intraepithelial lymphocytes in the lung: a neglected lymphocyte population

scientific article published on April 2000

Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD.

scientific article published on 10 March 2016

Lung epithelial lining fluid T cell subsets defined by distinct patterns of beta 7 and beta 1 integrin expression

scientific article

Mapping the 17q12-21.1 Locus for Variants Associated with Early-onset Asthma in African Americans

scientific article published on 23 September 2020

Massively Parallel Identification of Regulatory Variants in Asthma

scientific article published on March 2016

Massively parallel functional annotation of 3' untranslated regions

scientific article published on 16 March 2014

MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production

scientific article published on February 2016

Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-β1.

scientific article

Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics

scientific article

Novel integrin alpha and beta subunit cDNAs identified in airway epithelial cells and lung leukocytes using the polymerase chain reaction.

scientific article

Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study

scientific article published in 2022

Polymerase chain reaction cloning with degenerate primers: homology-based identification of adhesion molecules.

scientific article

Preferential production of interferon-gamma by CD4+ T cells expressing the homing receptor integrin alpha4/beta7

scientific article

Presentation of integrins on leukocyte microvilli: a role for the extracellular domain in determining membrane localization

scientific article

Progress toward a systems biology approach to acute lung injury

scientific article published on 15 June 2007

Putting Mucins on the Map

scientific article published on 01 March 2019

Recent advances in molecular biological techniques and their relevance to pulmonary research

scientific article

Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering

scientific article

Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow.

scientific article published in July 1998

Selective expression of integrin alpha 4 beta 7 on a subset of human CD4+ memory T cells with Hallmarks of gut-trophism.

scientific article published in July 1993

Selective targeting of TGF-β activation to treat fibroinflammatory airway disease

scientific article

Spotted long oligonucleotide arrays for human gene expression analysis.

scientific article published on 12 June 2003

Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients

scientific article

Steps Toward Cell Therapy for Cystic Fibrosis

scientific article published on 10 July 2020

Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1

scientific article (publication date: August 1997)

Systemically dispersed innate IL-13-expressing cells in type 2 immunity

scientific article

T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire.

scientific article published on 4 February 2013

The Endoplasmic Reticulum Resident Protein AGR3. Required for Regulation of Ciliary Beat Frequency in the Airway.

scientific article published on 9 March 2015

The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells

scientific article published on 01 February 2002

The asthma channel? Stay tuned . . .

scientific article

The cell biology of asthma

scientific article

The epithelial anion transporter pendrin is induced by allergy and rhinovirus infection, regulates airway surface liquid, and increases airway reactivity and inflammation in an asthma model

scientific article

The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile.

scientific article

The protein disulfide isomerase AGR2 is essential for production of intestinal mucus

scientific article

The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.

scientific article published on 26 January 2014

The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.

scientific article published on 9 January 2012

Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands.

scientific article published on April 2009

Tissue signals imprint ILC2 identity with anticipatory function.

scientific article published on 10 September 2018

Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient Kit(W-sh)/Kit(W-sh) sash mice

scientific article published on January 2005

Toward a systematic understanding of mRNA 3' untranslated regions.

scientific article

Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS

scientific article published on 26 August 2021

Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

scientific article published on 24 August 2021

Use of spotted oligonucleotide arrays for large-scale analysis of mammalian gene expression

scientific article published on 01 March 2002

Whole Genome Sequencing Identifies Novel Functional Loci Associated with Lung Function in Puerto Rican Youth

scientific article published on 27 May 2020

Widespread Effects of Chemokine 3' Untranslated Regions on mRNA Degradation and Protein Production in Human Cells

scientific article published on 15 June 2018

List of works by David J Erle

A distinctive alveolar macrophage activation state induced by cigarette smoking

AGR2 is induced in asthma and promotes allergen-induced mucin overproduction.

Abnormal alveolar development associated with elevated adenine nucleosides

Activated alpha4 integrins are preferentially expressed on immature thymocytes and activated T cells.

Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B.

Airway Mucus and Asthma: The Role of MUC5AC and MUC5B.

Airway epithelial miRNA expression is altered in asthma.

Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients

An engineered cardiac reporter cell line identifies human embryonic stem cell-derived myocardial precursors

An integrated nano-scale approach to profile miRNAs in limited clinical samples

Apolipoprotein A1 potentiates lipoxin A4 synthesis and recovery of allergen-induced disrupted tight junctions in the airway epithelium.

Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2

Asthma investigators begin to reap the fruits of genomics

Asthmatics with exacerbation during acute respiratory illness exhibit unique transcriptional signatures within the nasal mucosa

CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation

CD40 Mediates Maturation of Thymic Dendritic Cells Driven by Self-Reactive CD4+ Thymocytes and Supports Development of Natural Regulatory T Cells

Characterization of the leukocyte integrin subunit beta 7.

Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction

Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes

Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling

Correction: Delayed Goblet Cell Hyperplasia, Acetylcholine Receptor Expression, and Worm Expulsion in SMC-Specific IL-4Rα–Deficient Mice.

Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4Ralpha-deficient mice

Differential expression of homing molecules on recirculating lymphocytes from sheep gut, peripheral, and lung lymph.

Differential gene expression by integrin beta 7+ and beta 7- memory T helper cells

Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma

Disease-specific gene expression profiling in multiple models of lung disease

Dissecting asthma using focused transgenic modeling and functional genomics

Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity

Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.

Effect of exercise rate and route of inhalation on sulfur-dioxide-induced bronchoconstriction in asthmatic subjects.

Effect of serial-day exposure to nitrogen dioxide on airway and blood leukocytes and lymphocyte subsets

Efficient RNP-directed Human Gene Targeting Reveals SPDEF Is Required for IL-13-induced Mucostasis

Epithelial interleukin-25 is a key mediator in Th2-high, corticosteroid-responsive asthma

Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma

Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes

Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma.

Flow Cytometric Analysis and Purification of Airway Epithelial Cell Subsets

Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids

Genomics and proteomics of lung disease: conference summary

Global Absence and Targeting of Protective Immune States in Severe COVID-19

Hands-on workshops as an effective means of learning advanced technologies including genomics, proteomics and bioinformatics

How do integrins integrate? The role of cell adhesion receptors in differentiation and development

IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production

IL-17 and "TH2-high" asthma: Adding fuel to the fire?

IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production

Identification of MiR-205 As a MicroRNA That Is Highly Expressed in Medullary Thymic Epithelial Cells

Identification of novel airway epithelial integrins using the homology-based polymerase chain reaction

Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking

Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin

Increased DNA microarray hybridization specificity using sscDNA targets

Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.

Influenza virus infection causes global respiratory tract B cell response modulation via innate immune signals.

Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins.

Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1.

Intelectin is required for IL-13-induced monocyte chemotactic protein-1 and -3 expression in lung epithelial cells and promotes allergic airway inflammation.

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types.

Intraepithelial lymphocytes in the lung: a neglected lymphocyte population

Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD.

Lung epithelial lining fluid T cell subsets defined by distinct patterns of beta 7 and beta 1 integrin expression

Mapping the 17q12-21.1 Locus for Variants Associated with Early-onset Asthma in African Americans

Massively Parallel Identification of Regulatory Variants in Asthma

Massively parallel functional annotation of 3' untranslated regions

MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production

Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-β1.

Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics

Novel integrin alpha and beta subunit cDNAs identified in airway epithelial cells and lung leukocytes using the polymerase chain reaction.

Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study

Polymerase chain reaction cloning with degenerate primers: homology-based identification of adhesion molecules.

Preferential production of interferon-gamma by CD4+ T cells expressing the homing receptor integrin alpha4/beta7

Presentation of integrins on leukocyte microvilli: a role for the extracellular domain in determining membrane localization

Progress toward a systems biology approach to acute lung injury

Putting Mucins on the Map

Recent advances in molecular biological techniques and their relevance to pulmonary research

Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering

Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow.

Selective expression of integrin alpha 4 beta 7 on a subset of human CD4+ memory T cells with Hallmarks of gut-trophism.

Selective targeting of TGF-β activation to treat fibroinflammatory airway disease

Spotted long oligonucleotide arrays for human gene expression analysis.