List of works - John Hadcock

AdipoR1 and 2 are expressed on warm sensitive neurons of the hypothalamic preoptic area and contribute to central hyperthermic effects of adiponectin

scientific article published on 17 September 2011

Bioisosteric replacement of the hydrazide pharmacophore of the cannabinoid-1 receptor antagonist SR141716A. Part I: potent, orally-active 1,4-disubstituted imidazoles.

scientific article published on 6 August 2009

Blockade of cannabinoid type 1 receptors augments the antiparkinsonian action of levodopa without affecting dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated rhesus monkeys

scientific article published on 13 July 2007

Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue

scientific article published on 21 December 2010

Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example

scientific article

Design of a Potent CB1 Receptor Antagonist Series: Potential Scaffold for Peripherally-Targeted Agents

scientific article

Discovery and biological characterization of capromorelin analogues with extended half-lives.

scientific article

Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity

scientific article

Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists ⬇️

scientific article published on February 23, 2012

Discovery of potent and orally bioavailable heterocycle-based beta3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity

scientific article published on 30 June 2007

Effects of alpha2-adrenoceptor antagonists on metabolic processes of swine: I. Effects on nonesterified fatty acid and plasma urea nitrogen concentrations in jugularly catheterized pigs

scientific article published on 01 July 1998

Effects of alpha2-adrenoceptor antagonists on metabolic processes of swine: II. Nitrogen balance responses

scientific article published on 01 July 1998

Functional coupling of a mammalian somatostatin receptor to the yeast pheromone response pathway.

scientific article

G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice

scientific journal article

Glucocorticoids down-regulate beta 1-adrenergic-receptor expression by suppressing transcription of the receptor gene

scientific article published on September 1994

Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists

scientific article published on 9 November 2012

Identification of a critical aspartate residue in transmembrane domain three necessary for the binding of somatostatin to the somatostatin receptor SSTR2

scientific article published on 01 November 1995

New bicyclic cannabinoid receptor-1 (CB1-R) antagonists.

scientific article published on 2 November 2005

Photoaffinity labeling of the guinea pig pulmonary mast cell beta-adrenergic receptor.

scientific article

Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs). Discovery of capromorelin.

scientific article

Quantitative in vitro and in vivo pharmacological profile of CE-178253, a potent and selective cannabinoid type 1 (CB1) receptor antagonist.

scientific article

Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15.

scientific article published in February 2018

The biology of β-adrenergic receptors: Analysis in human epidermoid carcinoma A431 cells ⬇️

scientific article published on January 1, 1991

The rat SSTR2 somatostatin receptor subtype is coupled to inhibition of cyclic AMP accumulation

scientific article published on 01 March 1993

Tissue-specific regulation of alpha 1B, beta 1, and beta 2-adrenergic receptor mRNAs by thyroid state in the rat.

scientific article published in August 1991

List of works by John Hadcock

AdipoR1 and 2 are expressed on warm sensitive neurons of the hypothalamic preoptic area and contribute to central hyperthermic effects of adiponectin

Bioisosteric replacement of the hydrazide pharmacophore of the cannabinoid-1 receptor antagonist SR141716A. Part I: potent, orally-active 1,4-disubstituted imidazoles.

Blockade of cannabinoid type 1 receptors augments the antiparkinsonian action of levodopa without affecting dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated rhesus monkeys

Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue

Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example

Design of a Potent CB1 Receptor Antagonist Series: Potential Scaffold for Peripherally-Targeted Agents

Discovery and biological characterization of capromorelin analogues with extended half-lives.

Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity

Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists ⬇️

Discovery of potent and orally bioavailable heterocycle-based beta3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity

Effects of alpha2-adrenoceptor antagonists on metabolic processes of swine: I. Effects on nonesterified fatty acid and plasma urea nitrogen concentrations in jugularly catheterized pigs

Effects of alpha2-adrenoceptor antagonists on metabolic processes of swine: II. Nitrogen balance responses

Functional coupling of a mammalian somatostatin receptor to the yeast pheromone response pathway.

G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice

Glucocorticoids down-regulate beta 1-adrenergic-receptor expression by suppressing transcription of the receptor gene

Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists

Identification of a critical aspartate residue in transmembrane domain three necessary for the binding of somatostatin to the somatostatin receptor SSTR2

New bicyclic cannabinoid receptor-1 (CB1-R) antagonists.

Photoaffinity labeling of the guinea pig pulmonary mast cell beta-adrenergic receptor.

Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs). Discovery of capromorelin.

Quantitative in vitro and in vivo pharmacological profile of CE-178253, a potent and selective cannabinoid type 1 (CB1) receptor antagonist.

Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15.

The biology of β-adrenergic receptors: Analysis in human epidermoid carcinoma A431 cells ⬇️

The rat SSTR2 somatostatin receptor subtype is coupled to inhibition of cyclic AMP accumulation

Tissue-specific regulation of alpha 1B, beta 1, and beta 2-adrenergic receptor mRNAs by thyroid state in the rat.