List of works - Albert Morales

A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target

scientific article published on 02 November 2019

ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading.

scientific article published on 23 May 2013

Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis

scientific article

Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis

scientific article published on March 2004

Angiogenin secretion from hepatoma cells activates hepatic stellate cells to amplify a self-sustained cycle promoting liver cancer

scientific article

Antiapoptotic BCL-2 proteins determine sorafenib/regorafenib resistance and BH3-mimetic efficacy in hepatocellular carcinoma.

scientific article published on 30 March 2018

Bone morphogenetic protein-9/activin-like kinase 1 axis a new target for hepatic regeneration and fibrosis treatment in liver injury

scientific article published in December 2017

Cell autonomous apoptosis defects in acid sphingomyelinase knockout fibroblasts.

scientific article published in January 2001

Ceramide generated by acidic sphingomyelinase contributes to tumor necrosis factor-α-mediated apoptosis in human colon HT-29 cells through glycosphingolipids formation

scientific article published on 01 August 2002

Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer's disease

scientific article published on 08 March 2021

Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death

scientific article

Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion

scientific article published on 04 June 2018

Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury.

scientific article

Critical role of mitochondrial glutathione in the survival of hepatocytes during hypoxia

scientific article

Critical role of tumor necrosis factor receptor 1, but not 2, in hepatic stellate cell proliferation, extracellular matrix remodeling, and liver fibrogenesis

scientific article published on July 2011

Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation.

scientific article

Defective TNF-α–mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice

Differential Role of Cathepsins S and B In Hepatic APC-Mediated NKT Cell Activation and Cytokine Secretion.

scientific article

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

scientific article published in Journal of Biological Chemistry

Dual Role of Mitochondrial Reactive Oxygen Species in Hypoxia Signaling: Activation of Nuclear Factor- B via c-SRC and Oxidant-Dependent Cell Death

article

Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes

scientific article

Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients

scientific article published on 03 August 2021

GD3 synthase overexpression sensitizes hepatocarcinoma cells to hypoxia and reduces tumor growth by suppressing the cSrc/NF-kappaB survival pathway

scientific article

Ganglioside GD3 sensitizes human hepatoma cells to cancer therapy

scientific article published on 25 September 2002

Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation

scientific article

Genetic and clinical data reinforce the role of GAS6 and TAM receptors in liver fibrosis.

scientific article published on 25 January 2016

Glycosphingolipids and cell death: one aim, many ways

scientific article

Glycosphingolipids and mitochondria: role in apoptosis and disease.

scientific article published in January 2004

Growth arrest-specific protein 6 is hepatoprotective against murine ischemia/reperfusion injury.

scientific article

Identification and functional analysis of mutations in FAD-binding domain of mitochondrial glycerophosphate dehydrogenase in caucasian patients with type 2 diabetes mellitus.

scientific article

Mechanism of mitochondrial glutathione-dependent hepatocellular susceptibility to TNF despite NF-kappaB activation.

scientific article

Mitochondrial Glutathione: Recent Insights and Role in Disease

scientific article published on 24 September 2020

Mitochondrial cholesterol accumulation in alcoholic liver disease: Role of ASMase and endoplasmic reticulum stress.

scientific article

Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma.

scientific article

Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis

scientific article published on September 2006

Mitochondrial glutathione, a key survival antioxidant

scientific article

Mitochondrial glutathione: features, regulation and role in disease

scientific article

Neutral sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes

scientific article

Niemann–Pick Disease versus acid sphingomyelinase deficiency

scientific article published on 01 January 2001

Orthoxenografts of testicular germ cell tumors demonstrate genomic changes associated with cisplatin resistance and identify PDMP as a re-sensitizing agent.

scientific article

Oxidative damage of mitochondrial and nuclear DNA induced by ionizing radiation in human hepatoblastoma cells

scientific article published on 01 August 1998

Oxidative inactivation of amyloid beta-degrading proteases by cholesterol-enhanced mitochondrial stress

scientific article published on 25 July 2019

Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo

article

Pharmacological modulation of sphingolipids and role in disease and cancer cell biology.

scientific article published on April 2007

Probiotic sonicates selectively induce mucosal immune cells apoptosis through ceramide generation via neutral sphingomyelinase

scientific article

Reactive oxygen species mediate liver injury through parenchymal nuclear factor-kappaB inactivation in prolonged ischemia/reperfusion

scientific article published on 06 April 2009

Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress

scientific article published on 04 November 2019

Redox control of liver function in health and disease

scientific article

Regorafenib Alteration of the BCL-xL/MCL-1 Ratio Provides a Therapeutic Opportunity for BH3-Mimetics in Hepatocellular Carcinoma Models

scientific article published on 01 February 2020

Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease

scientific article published on 29 May 2020

Reply

Role of Vitamin K-Dependent Factors Protein S and GAS6 and TAM Receptors in SARS-CoV-2 Infection and COVID-19-Associated Immunothrombosis

scientific article published on 28 September 2020

Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor

scientific article published on 01 December 1998

Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione.

scientific article

Sphingolipids and cell death.

scientific article published on May 2007

Stromal interaction molecule 2 (STIM2) is frequently overexpressed in colorectal tumors and confers a tumor cell growth suppressor phenotype.

scientific article published on 30 August 2011

Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia–reperfusion injury

scientific article published on 29 October 2010

Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma

scientific article published on 22 January 2016

The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading

scientific article

Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alpha

scientific journal article

Transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine synthetase by ionizing radiation.

scientific article published in May 1998

Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: Effect of membrane physical properties andS-adenosyl-L-methionine

scientific article published on 01 September 1997

Tumor necrosis factor increases hepatocellular glutathione by transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine synthetase.

scientific article published on November 1997

jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans

scientific article

List of works by Albert Morales

A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target

ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading.

Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis

Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis

Angiogenin secretion from hepatoma cells activates hepatic stellate cells to amplify a self-sustained cycle promoting liver cancer

Antiapoptotic BCL-2 proteins determine sorafenib/regorafenib resistance and BH3-mimetic efficacy in hepatocellular carcinoma.

Bone morphogenetic protein-9/activin-like kinase 1 axis a new target for hepatic regeneration and fibrosis treatment in liver injury

Cell autonomous apoptosis defects in acid sphingomyelinase knockout fibroblasts.

Ceramide generated by acidic sphingomyelinase contributes to tumor necrosis factor-α-mediated apoptosis in human colon HT-29 cells through glycosphingolipids formation

Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer's disease

Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death

Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion

Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury.

Critical role of mitochondrial glutathione in the survival of hepatocytes during hypoxia

Critical role of tumor necrosis factor receptor 1, but not 2, in hepatic stellate cell proliferation, extracellular matrix remodeling, and liver fibrogenesis

Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation.

Defective TNF-α–mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice

Differential Role of Cathepsins S and B In Hepatic APC-Mediated NKT Cell Activation and Cytokine Secretion.

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

Dual Role of Mitochondrial Reactive Oxygen Species in Hypoxia Signaling: Activation of Nuclear Factor- B via c-SRC and Oxidant-Dependent Cell Death

Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes

Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients

GD3 synthase overexpression sensitizes hepatocarcinoma cells to hypoxia and reduces tumor growth by suppressing the cSrc/NF-kappaB survival pathway

Ganglioside GD3 sensitizes human hepatoma cells to cancer therapy

Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation

Genetic and clinical data reinforce the role of GAS6 and TAM receptors in liver fibrosis.

Glycosphingolipids and cell death: one aim, many ways

Glycosphingolipids and mitochondria: role in apoptosis and disease.

Growth arrest-specific protein 6 is hepatoprotective against murine ischemia/reperfusion injury.

Identification and functional analysis of mutations in FAD-binding domain of mitochondrial glycerophosphate dehydrogenase in caucasian patients with type 2 diabetes mellitus.

Mechanism of mitochondrial glutathione-dependent hepatocellular susceptibility to TNF despite NF-kappaB activation.

Mitochondrial Glutathione: Recent Insights and Role in Disease

Mitochondrial cholesterol accumulation in alcoholic liver disease: Role of ASMase and endoplasmic reticulum stress.

Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma.

Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis

Mitochondrial glutathione, a key survival antioxidant

Mitochondrial glutathione: features, regulation and role in disease

Neutral sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes

Niemann–Pick Disease versus acid sphingomyelinase deficiency

Orthoxenografts of testicular germ cell tumors demonstrate genomic changes associated with cisplatin resistance and identify PDMP as a re-sensitizing agent.

Oxidative damage of mitochondrial and nuclear DNA induced by ionizing radiation in human hepatoblastoma cells

Oxidative inactivation of amyloid beta-degrading proteases by cholesterol-enhanced mitochondrial stress

Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo

Pharmacological modulation of sphingolipids and role in disease and cancer cell biology.

Probiotic sonicates selectively induce mucosal immune cells apoptosis through ceramide generation via neutral sphingomyelinase

Reactive oxygen species mediate liver injury through parenchymal nuclear factor-kappaB inactivation in prolonged ischemia/reperfusion

Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress

Redox control of liver function in health and disease

Regorafenib Alteration of the BCL-xL/MCL-1 Ratio Provides a Therapeutic Opportunity for BH3-Mimetics in Hepatocellular Carcinoma Models

Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease

Reply

Role of Vitamin K-Dependent Factors Protein S and GAS6 and TAM Receptors in SARS-CoV-2 Infection and COVID-19-Associated Immunothrombosis

Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor

Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione.

Sphingolipids and cell death.

Stromal interaction molecule 2 (STIM2) is frequently overexpressed in colorectal tumors and confers a tumor cell growth suppressor phenotype.

Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia–reperfusion injury

Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma

The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading

Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alpha

Transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine synthetase by ionizing radiation.

Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: Effect of membrane physical properties andS-adenosyl-L-methionine

Tumor necrosis factor increases hepatocellular glutathione by transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine synthetase.

jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans