List of works - Jean-Michel Chezal

(123)I-BZA2 as a melanin-targeted radiotracer for the identification of melanoma metastases: results and perspectives of a multicenter phase III clinical trial.

scientific article published on 21 November 2013

3-(imidazo[1,2-a:5,4-b']dipyridin-2-yl)aniline inhibits pestivirus replication by targeting a hot spot drug binding pocket in the RNA-dependent RNA polymerase

scientific article published on 9 March 2016

99mTc-NTP 15-5 Imaging for Cartilage Involvement in Experimental Rheumatoid Arthritis: Comparison with Routinely Used Molecular Imaging Methods and Sensitivity to Chronic Nonsteroidal Antiinflammatory Drug Treatment

scientific article published on 3 April 2015

A"Proteoglycan targeting strategy" for the scintigraphic imaging and monitoring of the swarm rat chondrosarcoma orthotopic model

scientific article

Annexin A1 in primary tumors promotes melanoma dissemination.

scientific article published on 06 July 2014

Anti-melanoma efficacy of internal radionuclide therapy in relation to melanin target distribution.

scientific article

Antibody PEGylation in bioorthogonal pretargeting with trans-cyclooctene/tetrazine cycloaddition: in vitro and in vivo evaluation in colorectal cancer models

scientific article published on 2 November 2017

B16 melanoma secretomes and in vitro invasiveness: syntenin as an invasion modulator.

scientific article published in April 2010

Characterization of pro-invasive mechanisms and N-terminal cleavage of ANXA1 in melanoma.

scientific article

Characterization of the Covalent Binding ofN-Phenyl-N′-(2-chloroethyl)ureas to β-Tubulin: Importance of Glu198 in Microtubule Stability ⬇️

scientific article published on October 26, 2010

Design and preparation of aza-analogues of benzo[c]phenanthridine framework with cytotoxic and antiplasmodial activities

scientific article

Design, synthesis and in vitro drug release investigation of new potential 5-FU prodrugs.

scientific article published on 14 April 2011

Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to melanoma.

scientific article published on 10 July 2008

Development and Preliminary Evaluation of TFIB, a New Bimodal Prosthetic Group for Bioactive Molecule Labeling.

scientific article published on 24 November 2014

Development and characterization of a human three-dimensional chondrosarcoma culture for in vitro drug testing.

scientific article published on 13 July 2017

Development of a New Radiofluorinated Quinoline Analog for PET Imaging of Phosphodiesterase 5 (PDE5) in Brain

scientific article published on 21 April 2016

Development of a freeze-dried kit formulation for the preparation of 99mTc-NTP 15-5, a radiotracer for scintigraphic imaging of proteoglycans

scientific article published on 11 March 2015

Development of gadolinium based nanoparticles having an affinity towards melanin.

scientific article

Doxycycline and its quaternary ammonium derivative for adjuvant therapies of chondrosarcoma

scientific article published on 13 July 2017

Early detection and longitudinal monitoring of experimental primary and disseminated melanoma using [¹⁰F]ICF01006, a highly promising melanoma PET tracer.

scientific article published on 16 June 2012

Evaluation of new iodinated acridine derivatives for targeted radionuclide therapy of melanoma using 125I, an Auger electron emitter

scientific article published on 22 June 2010

Evaluation of radiolabeled (hetero)aromatic analogues of N-(2-diethylaminoethyl)-4-iodobenzamide for imaging and targeted radionuclide therapy of melanoma.

scientific article published on 16 May 2008

Evaluation of the Active Targeting of Melanin Granules after Intravenous Injection of Dendronized Nanoparticles

scientific article published on 4 January 2018

Evaluation of two (125)I-radiolabeled acridine derivatives for Auger-electron radionuclide therapy of melanoma.

scientific article published on 2 April 2014

First ex vivo study demonstrating that 99mTc-NTP 15-5 radiotracer binds to human articular cartilage ⬇️

scientific article published on August 4, 2011

Imidazonaphthyridine systems (part 2): Functionalization of the phenyl ring linked to the pyridine pharmacophore and its replacement by a pyridinone ring produces intriguing differences in cytocidal activity.

scientific article

In vitro and in vivo antimalarial activity of derivatives of 1,10-phenanthroline framework.

scientific article published in April 2006

In vivo efficacy of melanoma internal radionuclide therapy with a 131I-labelled melanin-targeting heteroarylcarboxamide molecule.

scientific article

In vivo evidence of the targeting of cartilaginous tissue by pyridinium functionalized nanoparticles

article

In vivo experimental imaging of osteochondral defects and their healing using 99mTc-NTP 15-5 radiotracer

scientific article published on 8 March 2012

In vivo scintigraphic imaging of proteoglycans

scientific article published on 01 January 2012

Internal dosimetry through GATE simulations of preclinical radiotherapy using a melanin-targeting ligand.

scientific article published on 8 April 2014

Intramolecular cyclization of N-phenyl N'(2-chloroethyl)ureas leads to active N-phenyl-4,5-dihydrooxazol-2-amines alkylating β-tubulin Glu198 and prohibitin Asp40.

scientific article published on March 2011

In vitro cytotoxic effects of DEHP-alternative plasticizers and their primary metabolites on a L929 cell line

scientific article published on 8 January 2017

Linker structure-activity relationships in fluorodeoxyglucose chlorambucil conjugates for tumor-targeted chemotherapy.

scientific article published on 30 August 2017

Melanoma affinity in mice and immunosuppressed sheep of [(125)I]N-(4-dipropylaminobutyl)-4-iodobenzamide, a new targeting agent.

scientific article

Melanoma-targeted delivery system (part 1): design, synthesis and evaluation of releasable disulfide drug by glutathione

scientific article published on 13 July 2015

Melanoma-targeted delivery system (part 2): Synthesis, radioiodination and biological evaluation in B16F0 bearing mice

scientific article published on 10 May 2016

New aldehyde and vinylsulfone proteasome inhibitors for targeted melanoma therapy

scientific article published on July 27, 2011

New opportunities with the Duff reaction

scientific article published on 03 July 2008

Novel imidazo[1,2-a]naphthyridinic systems (part 1): synthesis, antiproliferative and DNA-intercalating activities.

scientific article

PEGylation enhances the tumor selectivity of melanoma-targeted conjugates

scientific article published on 03 November 2014

Preparation of core/shell NaYF 4 :Yb,Tm@dendrons nanoparticles with enhanced upconversion luminescence for in vivo imaging

scientific article published on 09 June 2016

Proteoglycan-targeting applied to hypoxia-activated prodrug therapy in chondrosarcoma: first proof-of-concept.

scientific article published on 27 September 2017

Proteoglycans as Target for an Innovative Therapeutic Approach in Chondrosarcoma: Preclinical Proof of Concept.

scientific article published on 29 August 2016

Quaternary ammonium-melphalan conjugate for anticancer therapy of chondrosarcoma: in vitro and in vivo preclinical studies.

scientific article published on 16 April 2011

Radiation dosimetry of [131 I]ICF01012 in rabbits: Application to targeted radionuclide therapy for human melanoma treatment

scientific article published on 24 September 2018

Relevance of the POS-1 orthotopic model as an "imaging model" for in vivo and simultaneous monitoring of tumor proliferation and bone remodeling in osteosarcoma

scientific article published in February 2012

Short and efficient access to imidazo[1,2-a]pyrrolo[3,2-c]pyridine derivatives

Single photon emission computed tomography/positron emission tomography imaging and targeted radionuclide therapy of melanoma: new multimodal fluorinated and iodinated radiotracers

scientific article published on 21 March 2011

Small rigid platforms functionalization with quaternary ammonium: targeting extracellular matrix of chondrosarcoma.

scientific article

Spacer optimization of new conjugates for a melanoma-selective delivery approach

scientific article published on 01 October 2013

Structure-activity relationship study of hypoxia-activated prodrugs for proteoglycan-targeted chemotherapy in chondrosarcoma

scientific article published on 23 August 2018

Synthesis and Biological Evaluation of New Quinoxaline Derivatives of ICF01012 as Melanoma-Targeting Probes.

scientific article published on 20 February 2014

Synthesis and antiviral activity of an imidazo[1,2-a]pyrrolo[2,3-c]pyridine series against the bovine viral diarrhea virus

scientific article published on 20 January 2010

Synthesis and biological evaluation of indoloquinolines and pyridocarbazoles: a new example of unexpected photoreduction accompanying photocyclization.

scientific article published on September 2007

Synthesis and in vitro cytotoxic evaluation of new derivatives of pyrido[1,2-a]benzimidazolic ring system: the pyrido[1',2':1,2]imidazo[4,5-h]quinazolines.

scientific article

Synthesis and in vitro evaluation of new fluorinated quinoline derivatives with high affinity for PDE5: Towards the development of new PET neuroimaging probes.

scientific article published on 19 April 2017

Synthesis, radiofluorination, and in vivo evaluation of novel fluorinated and iodinated radiotracers for PET imaging and targeted radionuclide therapy of melanoma

scientific article published on 21 October 2013

Synthesis, radioiodination and in vivo screening of novel potent iodinated and fluorinated radiotracers as melanoma imaging and therapeutic probes ⬇️

scientific article published on March 24, 2013

Synthesis, radiolabeling and preliminary in vivo evaluation of multimodal radiotracers for PET imaging and targeted radionuclide therapy of pigmented melanoma

scientific article published on 21 January 2015

Targeted radionuclide therapy of melanoma: anti-tumoural efficacy studies of a new 131I labelled potential agent.

scientific article

Targeting DNA repair by coDbait enhances melanoma targeted radionuclide therapy

scientific article published on 12 February 2016

Targeting cyclic nucleotide phosphodiesterase 5 (PDE5) in brain: Toward the development of a PET radioligand labeled with fluorine-18

scientific article published on 28 January 2019

Tetraspanin 8 (TSPAN 8) as a potential target for radio-immunotherapy of colorectal cancer

scientific article

The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication

scientific article (publication date: October 2007)

The use of [(125)I] scintigraphic in vivo imaging in melanoma-bearing mice for a rapid prescreening of vectors to melanoma tissue

scientific article published on 01 October 2009

Theranostic Approach for Metastatic Pigmented Melanoma Using ICF15002, a Multimodal Radiotracer for Both PET Imaging and Targeted Radionuclide Therapy

scientific article published on 14 December 2016

[¹²³I]ICF01012 melanoma imaging and [¹³¹I]ICF01012 dosimetry allow adapted internal targeted radiotherapy in preclinical melanoma models.

scientific article

List of works by Jean-Michel Chezal

(123)I-BZA2 as a melanin-targeted radiotracer for the identification of melanoma metastases: results and perspectives of a multicenter phase III clinical trial.

3-(imidazo[1,2-a:5,4-b']dipyridin-2-yl)aniline inhibits pestivirus replication by targeting a hot spot drug binding pocket in the RNA-dependent RNA polymerase

99mTc-NTP 15-5 Imaging for Cartilage Involvement in Experimental Rheumatoid Arthritis: Comparison with Routinely Used Molecular Imaging Methods and Sensitivity to Chronic Nonsteroidal Antiinflammatory Drug Treatment

A"Proteoglycan targeting strategy" for the scintigraphic imaging and monitoring of the swarm rat chondrosarcoma orthotopic model

Annexin A1 in primary tumors promotes melanoma dissemination.

Anti-melanoma efficacy of internal radionuclide therapy in relation to melanin target distribution.

Antibody PEGylation in bioorthogonal pretargeting with trans-cyclooctene/tetrazine cycloaddition: in vitro and in vivo evaluation in colorectal cancer models

B16 melanoma secretomes and in vitro invasiveness: syntenin as an invasion modulator.

Characterization of pro-invasive mechanisms and N-terminal cleavage of ANXA1 in melanoma.

Characterization of the Covalent Binding ofN-Phenyl-N′-(2-chloroethyl)ureas to β-Tubulin: Importance of Glu198 in Microtubule Stability ⬇️

Design and preparation of aza-analogues of benzo[c]phenanthridine framework with cytotoxic and antiplasmodial activities

Design, synthesis and in vitro drug release investigation of new potential 5-FU prodrugs.

Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to melanoma.

Development and Preliminary Evaluation of TFIB, a New Bimodal Prosthetic Group for Bioactive Molecule Labeling.

Development and characterization of a human three-dimensional chondrosarcoma culture for in vitro drug testing.

Development of a New Radiofluorinated Quinoline Analog for PET Imaging of Phosphodiesterase 5 (PDE5) in Brain

Development of a freeze-dried kit formulation for the preparation of 99mTc-NTP 15-5, a radiotracer for scintigraphic imaging of proteoglycans

Development of gadolinium based nanoparticles having an affinity towards melanin.

Doxycycline and its quaternary ammonium derivative for adjuvant therapies of chondrosarcoma

Early detection and longitudinal monitoring of experimental primary and disseminated melanoma using [¹⁰F]ICF01006, a highly promising melanoma PET tracer.

Evaluation of new iodinated acridine derivatives for targeted radionuclide therapy of melanoma using 125I, an Auger electron emitter

Evaluation of radiolabeled (hetero)aromatic analogues of N-(2-diethylaminoethyl)-4-iodobenzamide for imaging and targeted radionuclide therapy of melanoma.

Evaluation of the Active Targeting of Melanin Granules after Intravenous Injection of Dendronized Nanoparticles

Evaluation of two (125)I-radiolabeled acridine derivatives for Auger-electron radionuclide therapy of melanoma.

First ex vivo study demonstrating that 99mTc-NTP 15-5 radiotracer binds to human articular cartilage ⬇️

Imidazonaphthyridine systems (part 2): Functionalization of the phenyl ring linked to the pyridine pharmacophore and its replacement by a pyridinone ring produces intriguing differences in cytocidal activity.

In vitro and in vivo antimalarial activity of derivatives of 1,10-phenanthroline framework.

In vivo efficacy of melanoma internal radionuclide therapy with a 131I-labelled melanin-targeting heteroarylcarboxamide molecule.

In vivo evidence of the targeting of cartilaginous tissue by pyridinium functionalized nanoparticles

In vivo experimental imaging of osteochondral defects and their healing using 99mTc-NTP 15-5 radiotracer

In vivo scintigraphic imaging of proteoglycans

Internal dosimetry through GATE simulations of preclinical radiotherapy using a melanin-targeting ligand.

Intramolecular cyclization of N-phenyl N'(2-chloroethyl)ureas leads to active N-phenyl-4,5-dihydrooxazol-2-amines alkylating β-tubulin Glu198 and prohibitin Asp40.

In vitro cytotoxic effects of DEHP-alternative plasticizers and their primary metabolites on a L929 cell line

Linker structure-activity relationships in fluorodeoxyglucose chlorambucil conjugates for tumor-targeted chemotherapy.

Melanoma affinity in mice and immunosuppressed sheep of [(125)I]N-(4-dipropylaminobutyl)-4-iodobenzamide, a new targeting agent.

Melanoma-targeted delivery system (part 1): design, synthesis and evaluation of releasable disulfide drug by glutathione

Melanoma-targeted delivery system (part 2): Synthesis, radioiodination and biological evaluation in B16F0 bearing mice

New aldehyde and vinylsulfone proteasome inhibitors for targeted melanoma therapy

New opportunities with the Duff reaction

Novel imidazo[1,2-a]naphthyridinic systems (part 1): synthesis, antiproliferative and DNA-intercalating activities.

PEGylation enhances the tumor selectivity of melanoma-targeted conjugates

Preparation of core/shell NaYF 4 :Yb,Tm@dendrons nanoparticles with enhanced upconversion luminescence for in vivo imaging

Proteoglycan-targeting applied to hypoxia-activated prodrug therapy in chondrosarcoma: first proof-of-concept.

Proteoglycans as Target for an Innovative Therapeutic Approach in Chondrosarcoma: Preclinical Proof of Concept.

Quaternary ammonium-melphalan conjugate for anticancer therapy of chondrosarcoma: in vitro and in vivo preclinical studies.

Radiation dosimetry of [131 I]ICF01012 in rabbits: Application to targeted radionuclide therapy for human melanoma treatment

Relevance of the POS-1 orthotopic model as an "imaging model" for in vivo and simultaneous monitoring of tumor proliferation and bone remodeling in osteosarcoma

Short and efficient access to imidazo[1,2-a]pyrrolo[3,2-c]pyridine derivatives

Single photon emission computed tomography/positron emission tomography imaging and targeted radionuclide therapy of melanoma: new multimodal fluorinated and iodinated radiotracers

Small rigid platforms functionalization with quaternary ammonium: targeting extracellular matrix of chondrosarcoma.

Spacer optimization of new conjugates for a melanoma-selective delivery approach

Structure-activity relationship study of hypoxia-activated prodrugs for proteoglycan-targeted chemotherapy in chondrosarcoma

Synthesis and Biological Evaluation of New Quinoxaline Derivatives of ICF01012 as Melanoma-Targeting Probes.

Synthesis and antiviral activity of an imidazo[1,2-a]pyrrolo[2,3-c]pyridine series against the bovine viral diarrhea virus

Synthesis and biological evaluation of indoloquinolines and pyridocarbazoles: a new example of unexpected photoreduction accompanying photocyclization.

Synthesis and in vitro cytotoxic evaluation of new derivatives of pyrido[1,2-a]benzimidazolic ring system: the pyrido[1',2':1,2]imidazo[4,5-h]quinazolines.

Synthesis and in vitro evaluation of new fluorinated quinoline derivatives with high affinity for PDE5: Towards the development of new PET neuroimaging probes.

Synthesis, radiofluorination, and in vivo evaluation of novel fluorinated and iodinated radiotracers for PET imaging and targeted radionuclide therapy of melanoma

Synthesis, radioiodination and in vivo screening of novel potent iodinated and fluorinated radiotracers as melanoma imaging and therapeutic probes ⬇️

Synthesis, radiolabeling and preliminary in vivo evaluation of multimodal radiotracers for PET imaging and targeted radionuclide therapy of pigmented melanoma

Targeted radionuclide therapy of melanoma: anti-tumoural efficacy studies of a new 131I labelled potential agent.

Targeting DNA repair by coDbait enhances melanoma targeted radionuclide therapy

Targeting cyclic nucleotide phosphodiesterase 5 (PDE5) in brain: Toward the development of a PET radioligand labeled with fluorine-18

Tetraspanin 8 (TSPAN 8) as a potential target for radio-immunotherapy of colorectal cancer

The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication

The use of [(125)I] scintigraphic in vivo imaging in melanoma-bearing mice for a rapid prescreening of vectors to melanoma tissue

Theranostic Approach for Metastatic Pigmented Melanoma Using ICF15002, a Multimodal Radiotracer for Both PET Imaging and Targeted Radionuclide Therapy

[¹²³I]ICF01012 melanoma imaging and [¹³¹I]ICF01012 dosimetry allow adapted internal targeted radiotherapy in preclinical melanoma models.