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List of works by Dominique de Kleijn

10-years experience with the Athero-Express study

scientific article published on March 2012

A lipid-poor plaque and asymptomatic status in women are associated with higher peak systolic velocity on duplex ultrasound after carotid endarterectomy

scientific article published on 28 October 2014

Aberrant Splicing Promotes Proteasomal Degradation of L-type CaV1.2 Calcium Channels by Competitive Binding for CaVβ Subunits in Cardiac Hypertrophy

scientific article published on 12 October 2016

Acute-phase protein haptoglobin is a cell migration factor involved in arterial restructuring

scientific article

Adipocyte fatty acid binding protein in atherosclerotic plaques is associated with local vulnerability and is predictive for the occurrence of adverse cardiovascular events

scientific article

Age and coumarin-type anticoagulation are associated with the occurrence of intraplaque hemorrhage, while statins are associated less with intraplaque hemorrhage: a large histopathological study in carotid and femoral plaques

scientific article

Age-related changes in plaque composition: a study in patients suffering from carotid artery stenosis

scientific article published in May 2005

Athero-express: differential atherosclerotic plaque expression of mRNA and protein in relation to cardiovascular events and patient characteristics. Rationale and design.

scientific article published on January 2004

Atherosclerotic Plaque Biomarkers: Beyond the Horizon of the Vulnerable Plaque ⬇️

scientific article published on February 1, 2011

Atherosclerotic Plaque Vulnerability as an Explanation for the Increased Risk of Stroke in Elderly Undergoing Carotid Artery Stenting ⬇️

scientific article published on July 7, 2011

Atherosclerotic expansive remodeled plaques: a wolf in sheep's clothing

scientific article

Automated calcium scores collected during myocardial perfusion imaging improve identification of obstructive coronary artery disease

scientific article published on 19 November 2019

BLT1 antagonist LSN2792613 reduces infarct size in a mouse model of myocardial ischaemia-reperfusion injury

scientific article published on 8 October 2015

Biobanks and the search for predictive biomarkers of local and systemic outcome in atherosclerotic disease

scientific article published in January 2009

Biomarkers of Coronary Artery Disease Differ Between Asians and Caucasians in the General Population

scientific article published on 07 March 2015

Bridging innate immunity and myocardial ischemia/reperfusion injury: the search for therapeutic targets

scientific article published on January 2008

Carotid atherosclerotic plaque matrix metalloproteinase-12-positive macrophage subpopulation predicts adverse outcome after endarterectomy

scientific article published on 19 December 2012

Carotid atherosclerotic plaques in patients with transient ischemic attacks and stroke have unstable characteristics compared with plaques in asymptomatic and amaurosis fugax patients

scientific article published on December 2005

Cerebral Small Vessel Disease in Standard Pre-operative Imaging Reports Is Independently Associated with Increased Risk of Cardiovascular Death Following Carotid Endarterectomy

scientific article published on 21 April 2020

Circulating immunoglobulins are not associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis

scientific article

Circulating leukocyte and carotid atherosclerotic plaque telomere length: interrelation, association with plaque characteristics, and restenosis after endarterectomy

scientific article

Complement 5a Receptor deficiency does not influence adverse cardiac remodeling after pressure-overload in mice

scientific article published on 6 December 2017

Composition of carotid atherosclerotic plaque is associated with cardiovascular outcome: a prognostic study

scientific article

Cyclooxygenase-2 inhibition increases mortality, enhances left ventricular remodeling, and impairs systolic function after myocardial infarction in the pig.

scientific article published on 8 January 2007

Deep proteomic profiling of human carotid atherosclerotic plaques using multidimensional LC-MS/MS.

scientific article

Derivation and characterization of human fetal MSCs: an alternative cell source for large-scale production of cardioprotective microparticles.

scientific article

Different stages of intraplaque hemorrhage are associated with different plaque phenotypes: a large histopathological study in 794 carotid and 276 femoral endarterectomy specimens

scientific article published on 30 July 2011

Elevated Lp(a) (Lipoprotein[a]) Levels Increase Risk of 30-Day Major Adverse Cardiovascular Events in Patients Following Carotid Endarterectomy

scientific article published on 03 September 2020

Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells

scientific article published on 11 June 2007

Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

scientific article

Endogenous inflammatory molecules engage Toll-like receptors in cardiovascular disease

scientific article published on 30 April 2010

Ethnic differences in the association of QRS duration with ejection fraction and outcome in heart failure

scientific article published on 11 July 2016

Ethnicity Modifies Associations between Cardiovascular Risk Factors and Disease Severity in Parallel Dutch and Singapore Coronary Cohorts

scientific article published on 6 July 2015

Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury

scientific article published in February 2009

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

scientific article

Expansive arterial remodeling: location, location, location.

scientific article published on 5 February 2004

Extracellular Vesicle Proteins Associated with Systemic Vascular Events Correlate with Heart Failure: An Observational Study in a Dyspnoea Cohort

scientific article published on 28 January 2016

Extracellular Vesicle cystatin c is associated with unstable angina in troponin negative patients with acute chest pain

scientific article published on 05 August 2020

Extracellular vesicle markers in relation to obesity and metabolic complications in patients with manifest cardiovascular disease

scientific article published on 05 February 2014

Extracellular vesicle protein CD14 relates to common carotid intima-media thickness in eight-year-old children

scientific article published on 28 July 2014

Extracellular vesicle protein levels are related to brain atrophy and cerebral white matter lesions in patients with manifest vascular disease: the SMART-MR study

scientific article published on 14 January 2014

Extracellular vesicle-derived CD14 is independently associated with the extent of cardiovascular disease burden in patients with manifest vascular disease

scientific article published on 07 January 2014

Family history and polygenic risk of cardiovascular disease: Independent factors associated with secondary cardiovascular events in patients undergoing carotid endarterectomy

scientific article published on 03 May 2020

Flow dynamics and energy efficiency of flow in the left ventricle during myocardial infarction

scientific article published on 31 March 2017

Folic acid supplementation normalizes the endothelial progenitor cell transcriptome of patients with type 1 diabetes: a case-control pilot study

scientific article published on 25 August 2009

Functional role for toll-like receptors in atherosclerosis and arterial remodeling

scientific article published in October 2004

Gender differences in health-related quality of life in patients undergoing coronary angiography

scientific article

Generation of hybrid cell lines with endothelial potential from spontaneous fusion of adult bone marrow cells with embryonic fibroblast feeder

scientific article

Health-related quality of life and outcome in atherosclerosis - Does sex matter?

scientific article published on 24 March 2016

Hematological Parameters Improve Prediction of Mortality and Secondary Adverse Events in Coronary Angiography Patients: A Longitudinal Cohort Study

scientific article

Hematological Parameters Outperform Plasma Markers in Predicting Long-Term Mortality After Coronary Angiography

scientific article published in January 2017

High neutrophil numbers in human carotid atherosclerotic plaques are associated with characteristics of rupture-prone lesions

scientific article

Histological features of carotid plaque in patients with ocular ischemia versus cerebral events

scientific article published on 29 January 2013

Human Validation of Genes Associated With a Murine Atherosclerotic Phenotype

scientific article

Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes

scientific article published on 19 May 2016

IgM antibody level against proinflammatory bacterial peptidoglycan is inversely correlated with extent of atherosclerotic disease

scientific article published in April 2004

Immune regulatory cells: circulating biomarker factories in cardiovascular disease

scientific article published on August 2008

Impaired kidney function is associated with intraplaque hemorrhage in patients undergoing carotid endarterectomy

scientific article published on 22 September 2017

In vivo cell seeding with anti-CD34 antibodies successfully accelerates endothelialization but stimulates intimal hyperplasia in porcine arteriovenous expanded polytetrafluoroethylene grafts

scientific article published on 27 June 2005

Increase in collagen turnover but not in collagen fiber content is associated with flow-induced arterial remodeling

scientific article published on 10 November 2004

Increased arterial expression of a glycosylated haptoglobin isoform after balloon dilation

scientific article

Increased collagen turnover is only partly associated with collagen fiber deposition in the arterial response to injury

scientific article published on January 2004

Inter-Ethnic Differences in Quantified Coronary Artery Disease Severity and All-Cause Mortality among Dutch and Singaporean Percutaneous Coronary Intervention Patients

scientific article published on 6 July 2015

Isolation and Characterization of Exosome from Human Embryonic Stem Cell-Derived C-Myc-Immortalized Mesenchymal Stem Cells

scientific article published in January 2016

Leukocytic Toll-Like Receptor 2 Deficiency Preserves Cardiac Function And Reduces Fibrosis In Sustained Pressure Overload

scientific article published on 23 August 2017

Leukotriene B4 levels in human atherosclerotic plaques and abdominal aortic aneurysms

scientific article published on 27 January 2014

Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction

scientific article

Local atherosclerotic plaques are a source of prognostic biomarkers for adverse cardiovascular events

scientific article

Local overexpression of C-type natriuretic peptide ameliorates vascular adaptation of porcine hemodialysis grafts

scientific article published in May 2004

Lowering Low-Density Lipoprotein Particles in Plasma Using Dextran Sulphate Co-Precipitates Procoagulant Extracellular Vesicles

scientific article

Magnetic Resonance Imaging Identified Brain Ischaemia in Symptomatic Patients Undergoing Carotid Endarterectomy Is Related to Histologically Apparent Intraplaque Haemorrhage

scientific article published on 18 October 2019

Mast cells in human carotid atherosclerotic plaques are associated with intraplaque microvessel density and the occurrence of future cardiovascular events

scientific article published on 11 June 2013

Matrix metalloproteinase 2 is associated with stable and matrix metalloproteinases 8 and 9 with vulnerable carotid atherosclerotic lesions: a study in human endarterectomy specimen pointing to a role for different extracellular matrix metalloprotein

scientific article published on 8 December 2005

Matrix metalloproteinase inhibition reduces adventitial thickening and collagen accumulation following balloon dilation

scientific article published on September 2002

Matrix metalloproteinase inhibition reduces intimal hyperplasia in a porcine arteriovenous-graft model

scientific article published in February 2004

Microvesicle protein levels are associated with increased risk for future vascular events and mortality in patients with clinically manifest vascular disease

scientific article

Modulation of TGF-β/BMP-6 expression and increased levels of circulating smooth muscle progenitor cells in a type I diabetes mouse model

scientific article

Myocardial Injury Is Distinguished from Stable Angina by a Set of Candidate Plasma Biomarkers Identified Using iTRAQ/MRM-Based Approach

scientific article

Peptidoglycan increases firm adhesion of monocytes under flow conditions and primes monocyte chemotaxis

scientific article

Plasma extracellular vesicle proteins are associated with stress-induced myocardial ischemia in women presenting with chest pain

scientific article published on 23 July 2020

Polygenic Susceptibility of Aortic Aneurysms Associates to the Diameter of the Aneurysm Sac: the Aneurysm-Express Biobank Cohort

scientific article published on 27 December 2019

Preoperative hypertension is associated with atherosclerotic intraplaque hemorrhage in patients undergoing carotid endarterectomy

scientific article published on 22 September 2019

Prevalence and Clinical Significance of Diabetes in Asian Versus White Patients With Heart Failure

scientific article published on January 2017

Proteomics of plaques and novel sources of potential biomarkers for atherosclerosis

scientific article published on 09 July 2013

RANTES/CCL5 and risk for coronary events: results from the MONICA/KORA Augsburg case-cohort, Athero-Express and CARDIoGRAM studies

scientific article

Race/Ethnic Differences in the Associations of the Framingham Risk Factors with Carotid IMT and Cardiovascular Events

scientific article

Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium

scientific article published in November 2007

Severity of stable coronary artery disease and its biomarkers differ between men and women undergoing angiography

scientific article published on 4 February 2015

Sex differences in flow cytometry-based platelet reactivity in stable outpatients suspected of myocardial ischemia

scientific article published on 15 May 2020

Sex is associated with the presence of atherosclerotic plaque hemorrhage and modifies the relation between plaque hemorrhage and cardiovascular outcome

scientific article

Sex-Based Differences in the Performance of the HEART Score in Patients Presenting to the Emergency Department With Acute Chest Pain

scientific article published on 21 June 2017

Soluble ST2 levels are not associated with secondary cardiovascular events and vulnerable plaque phenotype in patients with carotid artery stenosis

scientific article

Spectroscopic intravascular photoacoustic imaging of lipids in atherosclerosis.

scientific article

Symptomatic carotid atherosclerotic disease: correlations between plaque composition and ipsilateral stroke risk

scientific article

TGF-β1 content in atherosclerotic plaques, TGF-β1 serum concentrations and incident coronary events

Targeted deletion of the inhibitory NF-kappaB p50 subunit in bone marrow-derived cells improves collateral growth after arterial occlusion

scientific article published on 21 May 2010

Targeted proteomics improves cardiovascular risk prediction in secondary prevention

scientific article published on 01 April 2022

Temporal changes of soluble ST2 after cardiovascular interventions

scientific article published on 6 December 2012

The TAXINOMISIS Project. A multidisciplinary approach for the development of a new risk stratification model for patients with asymptomatic carotid artery stenosis

scientific article published on 20 September 2020

The age- and sex-specific composition of atherosclerotic plaques in vascular surgery patients

scientific article published on 29 July 2020

The innate immune response in reperfused myocardium

scientific article published on 20 January 2012

The prognostic value of highly sensitive cardiac troponin assays for adverse events in men and women with stable heart failure and a preserved vs. reduced ejection fraction

scientific article

Time-Dependent Changes in Atherosclerotic Plaque Composition in Patients Undergoing Carotid Surgery

article

Type 2 diabetes is not associated with an altered plaque phenotype among patients undergoing carotid revascularization. A histological analysis of 1455 carotid plaques

scientific article

Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: the Athero-Express Genomics Study

scientific article published on 20 January 2015

Vascular remodeling and protease inhibition--bench to bedside

scientific article

Women Undergoing Coronary Angiography for Myocardial Infarction or Who Present With Multivessel Disease Have a Poorer Prognosis Than Men.

scientific article published on 07 September 2015

cNGR: a novel homing sequence for CD13/APN targeted molecular imaging of murine cardiac angiogenesis in vivo

scientific article

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