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List of works by Brian K Kennedy

2nd interventions in aging conference

scientific article

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.

scientific article published on 7 October 2015

A Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy

scientific article published on 02 June 2020

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.

scientific article published on 18 June 2015

A genomic analysis of chronological longevity factors in budding yeast

scientific article

A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes.

scholarly article

A molecular mechanism of chronological aging in yeast.

scientific article published on 23 April 2009

A new connection between VHL and cancer threads through progerin.

scientific article published on 19 August 2013

A-type nuclear lamins act as transcriptional repressors when targeted to promoters.

scientific article published on 18 January 2009

A-type nuclear lamins, progerias and other degenerative disorders.

scientific article

Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans

scientific article

Aged Worms Erase Epigenetic History

scientific article published on 01 August 2011

Aging interventions get human.

scientific article published in January 2015

Aging: one thing leads to another

scientific article published on 01 December 2012

Asymmetric segregation: the shape of things to come?

scientific article published in February 2011

Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A.

scientific article published on 23 September 2009

C. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan Extension

scientific article

CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes.

scientific article published on February 2017

Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice

scientific article (publication date: 2012)

Cell biology. Rapamycin paradox resolved

scientific article published on 01 March 2012

Cell biology: High-tech yeast ageing

scientific article published on 06 June 2012

Cell-extrinsic defective lymphocyte development in Lmna(-/-) mice

scientific article

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.

scientific article

Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo.

scientific article published on July 2013

Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction"

scientific article published on 01 June 2006

Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity

scientific article published on 11 October 2012

Correction: Cardiomyocyte-Specific Expression of Lamin A Improves Cardiac Function in Lmna −/− Mice.

scientific article published on 17 September 2012

Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span

scientific article

Decreased proliferation kinetics of mouse myoblasts overexpressing FRG1.

scientific article

Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic

scientific article

Dialing down SUN1 for laminopathies

scientific article published on 01 April 2012

Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans

scientific article

Does Longer Lifespan Mean Longer Healthspan?

scientific article published on 26 May 2016

Does resveratrol activate yeast Sir2 in vivo?

scientific article published on 01 August 2007

Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice.

scientific article

Doxycycline: new tricks for an old drug.

scientific article published in August 2015

Drugs that modulate aging: the promising yet difficult path ahead

scientific article

Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import

scientific article (publication date: December 2014)

Evidence that S6K1, but not 4E-BP1, mediates skeletal muscle pathology associated with loss of A-type lamins.

scientific article

Evidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2.

scientific article

Genome-scale studies of aging: challenges and opportunities

scientific article

Geroscience: linking aging to chronic disease

scientific article

H2S to Mitigate Vascular Aging: A SIRT1 Connection.

scientific article published in March 2018

H3K36 methylation promotes longevity by enhancing transcriptional fidelity

scientific article published in July 2015

Heterotypic Signals from Neural HSF-1 Separate Thermotolerance from Longevity.

scientific article

Histone H4 lysine 16 acetylation regulates cellular lifespan

scientific article

Hot topics in aging research: protein translation and TOR signaling, 2010

scientific article

Hot topics in aging research: protein translation, 2009.

scientific article published on 11 September 2009

Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response

scientific article

Increased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice

scientific article

Integration of multiple nutrient cues and regulation of lifespan by ribosomal transcription factor Ifh1

scientific article published on 12 September 2013

Interventions to Slow Aging in Humans: Are We Ready?

scientific article

LMNA mutations in progeroid syndromes.

scientific article

Lamin A Δexon9 mutation leads to telomere and chromatin defects but not genomic instability.

scientific article published on September 2013

Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation

scientific journal article

Late-life rapamycin treatment reverses age-related heart dysfunction.

scientific article

Life history: mother-specific proteins that promote aging

scientific article published on 01 December 2014

Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span

scientific article published on 05 August 2020

Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response.

scientific article

Lifespan extension in Caenorhabditis elegans by complete removal of food

scientific article published in November 2006

Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.

scientific article

Mammalian Target of Rapamycin: A Target for (Lung) Diseases and Aging.

scientific article

Measuring replicative life span in the budding yeast

scientific article published on 25 June 2009

Medical research: treat ageing.

scientific article

Medicine. Progeria accelerates adult stem cell aging

scientific article published in Science

MicroRNA transcriptome analysis identifies miR-365 as a novel negative regulator of cell proliferation in Zmpste24-deficient mouse embryonic fibroblasts

scientific article published on 24 April 2015

Microbiome and Longevity: Gut Microbes Send Signals to Host Mitochondria

scientific article published in June 2017

Molecular mechanisms underlying genotype-dependent responses to dietary restriction.

scientific article published on 11 August 2013

Mouse models and aging: longevity and progeria

scientific article

Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity

scientific article

Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae

scientific article (publication date: February 1995)

Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase

scientific article published on 31 January 2014

Niche science: the aging stem cell.

scientific article

Nuclear organization of DNA replication in primary mammalian cells.

scientific article

Nuclear tumor suppressors in space and time.

scientific article

Old yeast can't handle the noise

scientific article published on 01 September 2010

PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae

scientific article published on 4 May 2015

Phosphorylation of connexin43 on S279/282 may contribute to laminopathy-associated conduction defects.

scientific article published on 21 December 2012

Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness

scientific article published on 04 October 2018

Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society

scientific article published on 29 September 2015

Proteasomes, Sir2, and Hxk2 form an interconnected aging network that impinges on the AMPK/Snf1-regulated transcriptional repressor Mig1.

scientific article

Protein translation, 2007.

scientific article published on 17 October 2007

Quantitative evidence for conserved longevity pathways between divergent eukaryotic species

scientific article published on 13 March 2008

Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast ⬇️

scientific article published on January 1, 2011

RB and lamins in cell cycle regulation and aging.

scientific article published on January 2014

Rapamycin Reverses Metabolic Deficits in Lamin A/C-Deficient Mice.

scientific article published in December 2016

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

scientific article published on July 2012

Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins

scientific article

Recent developments in yeast aging

scientific article

Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.

scientific article

Replicative aging in yeast: the means to the end

scientific article published on January 2008

Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria

scientific article

Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing.

scientific article published in January 2017

Ribosome Deficiency Protects Against ER Stress in Saccharomyces cerevisiae ⬇️

scientific article published on February 29, 2012

Ruminations on dietary restriction and aging.

scientific article published on June 2007

SIRT6, oxidative stress, and aging.

scientific article published on 19 January 2016

Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity

scientific article

Single-gene deletions that restore mating competence to diploid yeast.

scientific article

Sirtuins in aging and age-related disease.

scientific article published on July 2006

Sirtuins in yeast: phenotypes and tools

scientific article published on 01 January 2013

Stem Cell Models: A Guide to Understand and Mitigate Aging?

scientific article

Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging

scientific article

T(ell)TALE signs of aging

scientific article published on 10 March 2017

TOR and ageing: a complex pathway for a complex process.

scientific article

TOR on the brain.

scientific article published on 16 September 2010

Taurine deficiency as a driver of aging

scientific article published on 08 June 2023

Terconazole cream and suppositories: plasma terconazole following vaginal administration

The Buck Institute: an inside look.

scientific article

The Essence of Aging

scientific article published on 22 September 2015

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

scientific article

The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction.

scientific article

The TOR pathway comes of age

scientific article

The genetics of ageing: insight from genome-wide approaches in invertebrate model organisms.

scientific article

The replicative lifespan-extending deletion of SGF73 results in altered ribosomal gene expression in yeast.

scientific article published on 31 May 2017

The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1

scientific article

The yeast replicative aging model

scientific article published on 7 March 2018

Translational control of lipogenic enzymes in the cell cycle of synchronous, growing yeast cells

scientific article published on 5 January 2017

Trinations aging symposium.

scientific article published on June 2011

Unbalanced Growth, Senescence and Aging.

scientific article

Vacuolar dynamics and replicative aging.

scientific article published in August 2012

Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases.

scientific article published on May 2007

When lamins go bad: nuclear structure and disease

scientific article

Will the real aging Sirtuin please stand up?

scientific article

Yeast hypertrophy: cause or consequence of aging? Reply to Bilinski et al

scientific article published on 29 March 2012

Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.

scientific article published on April 2008

mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance

scientific article published in December 2017

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