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List of works by Cristóbal de los Ríos

1,8-Naphthyridine derivatives as Cholinesterases Inhibitors and Cell Ca2+ Regulators, a Multitarget Strategy for Alzheimer's Disease ⬇️

scientific article published on November 1, 2011

A review of metal-catalyzed molecular damage: protection by melatonin

scientific article published on 05 April 2014

Analysis of gene expression profiles of CR80, a neuroprotective 1,8-Naphthyridine

scientific article published on 21 March 2018

Benzothiazepine CGP37157 Analogues Exert Cytoprotection in Various in Vitro Models of Neurodegeneration.

scientific article published on 20 July 2015

Benzothiazepine CGP37157 and its 2'-isopropyl analogue modulate Ca²⁺ entry through CALHM1.

scientific article published on 20 April 2015

Benzothiazepine CGP37157 and its isosteric 2'-methyl analogue provide neuroprotection and block cell calcium entry

scientific article

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6

scientific article published on 28 December 2019

Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles

scientific article published on 26 November 2010

Cholinesterase inhibitors: a patent review (2007 – 2011) ⬇️

scientific article published on 06 July 2012

Chromaffin cells as a model to evaluate mechanisms of cell death and neuroprotective compounds.

scientific article

Design and synthesis of multipotent 3-aminomethylindoles and 7-azaindoles with enhanced protein phosphatase 2A-activating profile and neuroprotection

scientific article published on 29 July 2018

Effects of novel tacripyrines ITH12117 and ITH12118 on rat vas deferens contractions, calcium transients and cholinesterase activity

scientific article published on 09 April 2011

Gramine Derivatives Targeting Ca(2+) Channels and Ser/Thr Phosphatases: A New Dual Strategy for the Treatment of Neurodegenerative Diseases

scientific article published on 9 June 2016

ITH12410/SC058: a new neuroprotective compound with potential in the treatment of Alzheimer's disease

scientific article published on 15 July 2014

ITH4012 (ethyl 5-amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylate), a novel acetylcholinesterase inhibitor with "calcium promotor" and neuroprotective properties

scientific article published on 26 April 2004

Indole-3-carbinol induces cMYC and IAP-family downmodulation and promotes apoptosis of Epstein-Barr virus (EBV)-positive but not of EBV-negative Burkitt's lymphoma cell lines.

scientific article published on 30 August 2014

Ischemic brain injury: New insights on the protective role of melatonin

scientific article published on 5 January 2017

Ligands for Ser/Thr phosphoprotein phosphatases: a patent review (2005-2015).

scientific article published on 7 February 2016

Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration

scientific article published on 12 May 2017

Modulation of serine/threonine phosphatases by melatonin: therapeutic approaches in neurodegenerative diseases

scientific article published on 19 June 2018

Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate.

scientific article published on 4 March 2010

Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine

scientific article published on 30 March 2012

Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chlo

scientific article published on 3 July 2010

Neuroprotective Effect of the Novel Compound ITH33/IQM9.21 Against Oxidative Stress and Na(+) and Ca(2+) Overload in Motor Neuron-like NSC-34 Cells

scientific article published on 28 April 2016

Neuroprotective profile of pyridothiazepines with blocking activity of the mitochondrial Na(+)/Ca(2+) exchanger.

scientific article published on 29 December 2015

New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition

scientific article published on 05 December 2019

New multipotent tetracyclic tacrines with neuroprotective activity

scientific article published on 26 September 2006

New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties

scientific article

Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease

scientific article published in December 2006

Novel tacrine derivatives that block neuronal calcium channels.

scientific article

Optimization of Bicyclic Lactam Derivatives as NMDA Receptor Antagonists

scientific article published on 20 February 2017

PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice

scientific article published on 13 June 2013

Polycyclic maleimide-based derivatives as first dual modulators of neuronal calcium channels and GSK-3β for Alzheimer's disease treatment

scientific article published on 03 December 2018

Reaction of optically active alpha-aminoallenylstannanes with aldehydes formed in situ from the Lewis-acid-catalyzed rearrangement of epoxides.

scientific article published in August 2005

Recent patents on calcium channel blockers: emphasis on CNS diseases.

scientific article published on September 2014

Substituent effect of N-benzylated gramine derivatives that prevent the PP2A inhibition and dissipate the neuronal Ca2+ overload, as a multitarget strategy for the treatment of Alzheimer's disease

scientific article published on 9 April 2018

Syntheses and reactions of optically active alpha-aminoallenylstannanes

scientific article published on 01 January 2004

Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues

Synthesis of 6-amino-1,4-dihydropyridines that prevent calcium overload and neuronal death

scientific article published on 5 July 2007

Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines.

scientific article published on 14 March 2011

Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists

scientific article published on 15 December 2010

Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease

scientific article published on 26 May 2011

Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.

scientific article published on 28 June 2012

Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/butyrylcholinesterase and modulators of Ca2+ channels and nicotinic receptors.

scientific article published in May 2004

Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of [...]

scientific article

Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives

scientific article published on July 2010

Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: effect against amyloid-β-induced neurotoxicity.

scientific article published on 4 February 2013

Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease

scientific article published on May 2009

Tetrabenazine Facilitates Exocytosis by Enhancing Calcium-Induced Calcium Release through Ryanodine Receptors

scientific article published on 17 June 2019

The quantal catecholamine release from mouse chromaffin cells challenged with repeated ACh pulses is regulated by the mitochondrial Na+ /Ca2+ exchanger

scientific article published on 16 December 2016

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