List of works - Begona Heras

A Molecular Chameleon for Mapping Subcellular Polarity in an Unfolded Proteome Environment

scientific article published on 11 December 2019

A periplasmic thioredoxin-like protein plays a role in defense against oxidative stress in Neisseria gonorrhoeae.

scientific article published on 17 August 2009

Antivirulence DsbA inhibitors attenuate <i>Salmonella enterica</i> serovar Typhimurium fitness without detectable resistance

scientific article published on 10 February 2021

Application of fragment-based screening to the design of inhibitors of Escherichia coli DsbA

scientific article

Autotransporter adhesins in Escherichia coli pathogenesis.

scientific article published on 30 June 2017

Bioinformatics Tools and Resources for Analyzing Protein Structures.

scientific article

Characterisation of a cell wall-anchored protein of Staphylococcus saprophyticus associated with linoleic acid resistance.

scientific article

Cloning and functional characterization of a homoglutathione synthetase from pea nodules.

scientific article

Cloning, expression, purification and characterization of a DsbA-like protein from Wolbachia pipientis.

scientific article

Comparative Sequence, Structure and Redox Analyses of Klebsiella pneumoniae DsbA Show That Anti-Virulence Target DsbA Enzymes Fall into Distinct Classes

scientific article

CrmA orthologs from diverse poxviruses potently inhibit caspases-1 and -8, yet cleavage site mutagenesis frequently produces caspase-1-specific variants

scientific article published on 07 May 2019

Crystal structures of the DsbG disulfide isomerase reveal an unstable disulfide.

scholarly article

Crystallization and preliminary diffraction analysis of a DsbA homologue from Wolbachia pipientis.

scientific article published on 31 January 2008

DSB proteins and bacterial pathogenicity.

scientific article published on 09 February 2009

Dehydration converts DsbG crystal diffraction from low to high resolution.

scientific article

Design, synthesis and biological evaluation of new 3-[(4-aryl)piperazin-1-yl]-1-arylpropane derivatives as potential antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT1A receptor antagonism

scientific article published on 01 May 2000

Differential homotypic and heterotypic interactions of antigen 43 (Ag43) variants in autotransporter-mediated bacterial autoaggregation

scientific article published on 31 July 2019

Expression and crystallization of SeDsbA, SeDsbL and SeSrgA from Salmonella enterica serovar Typhimurium

scientific article

INHIBITION OF DIVERSE DsbA ENZYMES IN MULTI-DsbA ENCODING PATHOGENS.

scientific article published on 14 December 2017

In vivo oxidative protein folding can be facilitated by oxidation-reduction cycling

scientific article

Laboratory evolution of one disulfide isomerase to resemble another

scientific article

Molecular and Structural Characterization of a Novel Escherichia coli Interleukin Receptor Mimic Protein

scientific article published on 15 March 2016

Molecular and structural insights into an asymmetric proteolytic complex (ClpP1P2) from Mycobacterium smegmatis

scientific article published on 02 December 2019

New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants.

scientific article

Nuclear phosphoinositides could bring FYVE alive.

scientific article

Post-crystallization treatments for improving diffraction quality of protein crystals.

scientific article

Production, biophysical characterization and initial crystallization studies of the N- and C-terminal domains of DsbD, an essential enzyme in Neisseria meningitidis.

scientific article

Rv2969c, essential for optimal growth inMycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases

scientific article

Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility.

scientific article published on 26 November 2015

Staphylococcus aureus DsbA does not have a destabilizing disulfide. A new paradigm for bacterial oxidative folding

scientific article

Structural Insights into the Role of the Cyclic Backbone in a Squash Trypsin Inhibitor

scientific article

Structural and Biochemical Characterization of Chlamydia trachomatis DsbA Reveals a Cysteine-Rich and Weakly Oxidising Oxidoreductase

scientific article

Structural and biochemical insights into the disulfide reductase mechanism of DsbD, an essential enzyme for neisserial pathogens

scientific article published on 04 September 2018

Structural and functional characterization of three DsbA paralogues from Salmonella enterica serovar Typhimurium

scientific article

Structure of the Acinetobacter baumannii Dithiol Oxidase DsbA Bound to Elongation Factor EF-Tu Reveals a Novel Protein Interaction Site

scientific article

Targeting Bacterial Dsb Proteins for the Development of Anti-Virulence Agents

scientific article

Targeting virulence not viability in the search for future antibacterials.

scientific article

The 1.2 Å resolution crystal structure of TcpG, the Vibrio cholerae DsbA disulfide-forming protein required for pilus and cholera-toxin production

scientific article

The Fragment-Based Development of a Benzofuran Hit as a New Class of Escherichia coli DsbA Inhibitors

scientific article published on 18 October 2019

The Scs disulfide reductase system cooperates with the metallochaperone CueP in Salmonella copper resistance

scientific article published on 23 August 2019

The acidic nature of the CcmG redox-active center is important for cytochrome c maturation in Escherichia coli.

scientific article

The antigen 43 structure reveals a molecular Velcro-like mechanism of autotransporter-mediated bacterial clumping

scientific article

The atypical thiol-disulfide exchange protein α-DsbA2 from Wolbachia pipientis is a homotrimeric disulfide isomerase

scientific article published on 26 February 2019

Unique structural features of a bacterial autotransporter adhesin suggest mechanisms for interaction with host macromolecules

scientific article published on 29 April 2019

Unraveling the redox properties of the global regulator FurA from Anabaena sp. PCC 7120: disulfide reductase activity based on its CXXC motifs.

scientific article published on 2 January 2014

List of works by Begona Heras

A Molecular Chameleon for Mapping Subcellular Polarity in an Unfolded Proteome Environment

A periplasmic thioredoxin-like protein plays a role in defense against oxidative stress in Neisseria gonorrhoeae.

Antivirulence DsbA inhibitors attenuate <i>Salmonella enterica</i> serovar Typhimurium fitness without detectable resistance

Application of fragment-based screening to the design of inhibitors of Escherichia coli DsbA

Autotransporter adhesins in Escherichia coli pathogenesis.

Bioinformatics Tools and Resources for Analyzing Protein Structures.

Characterisation of a cell wall-anchored protein of Staphylococcus saprophyticus associated with linoleic acid resistance.

Cloning and functional characterization of a homoglutathione synthetase from pea nodules.

Cloning, expression, purification and characterization of a DsbA-like protein from Wolbachia pipientis.

Comparative Sequence, Structure and Redox Analyses of Klebsiella pneumoniae DsbA Show That Anti-Virulence Target DsbA Enzymes Fall into Distinct Classes

CrmA orthologs from diverse poxviruses potently inhibit caspases-1 and -8, yet cleavage site mutagenesis frequently produces caspase-1-specific variants

Crystal structures of the DsbG disulfide isomerase reveal an unstable disulfide.

Crystallization and preliminary diffraction analysis of a DsbA homologue from Wolbachia pipientis.

DSB proteins and bacterial pathogenicity.

Dehydration converts DsbG crystal diffraction from low to high resolution.

Design, synthesis and biological evaluation of new 3-[(4-aryl)piperazin-1-yl]-1-arylpropane derivatives as potential antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT1A receptor antagonism

Differential homotypic and heterotypic interactions of antigen 43 (Ag43) variants in autotransporter-mediated bacterial autoaggregation

Expression and crystallization of SeDsbA, SeDsbL and SeSrgA from Salmonella enterica serovar Typhimurium

INHIBITION OF DIVERSE DsbA ENZYMES IN MULTI-DsbA ENCODING PATHOGENS.

In vivo oxidative protein folding can be facilitated by oxidation-reduction cycling

Laboratory evolution of one disulfide isomerase to resemble another

Molecular and Structural Characterization of a Novel Escherichia coli Interleukin Receptor Mimic Protein

Molecular and structural insights into an asymmetric proteolytic complex (ClpP1P2) from Mycobacterium smegmatis

New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants.

Nuclear phosphoinositides could bring FYVE alive.

Post-crystallization treatments for improving diffraction quality of protein crystals.

Production, biophysical characterization and initial crystallization studies of the N- and C-terminal domains of DsbD, an essential enzyme in Neisseria meningitidis.

Rv2969c, essential for optimal growth inMycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases

Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility.

Staphylococcus aureus DsbA does not have a destabilizing disulfide. A new paradigm for bacterial oxidative folding

Structural Insights into the Role of the Cyclic Backbone in a Squash Trypsin Inhibitor

Structural and Biochemical Characterization of Chlamydia trachomatis DsbA Reveals a Cysteine-Rich and Weakly Oxidising Oxidoreductase

Structural and biochemical insights into the disulfide reductase mechanism of DsbD, an essential enzyme for neisserial pathogens

Structural and functional characterization of three DsbA paralogues from Salmonella enterica serovar Typhimurium

Structure of the Acinetobacter baumannii Dithiol Oxidase DsbA Bound to Elongation Factor EF-Tu Reveals a Novel Protein Interaction Site

Targeting Bacterial Dsb Proteins for the Development of Anti-Virulence Agents

Targeting virulence not viability in the search for future antibacterials.

The 1.2 Å resolution crystal structure of TcpG, the Vibrio cholerae DsbA disulfide-forming protein required for pilus and cholera-toxin production

The Fragment-Based Development of a Benzofuran Hit as a New Class of Escherichia coli DsbA Inhibitors

The Scs disulfide reductase system cooperates with the metallochaperone CueP in Salmonella copper resistance

The acidic nature of the CcmG redox-active center is important for cytochrome c maturation in Escherichia coli.

The antigen 43 structure reveals a molecular Velcro-like mechanism of autotransporter-mediated bacterial clumping

The atypical thiol-disulfide exchange protein α-DsbA2 from Wolbachia pipientis is a homotrimeric disulfide isomerase

Unique structural features of a bacterial autotransporter adhesin suggest mechanisms for interaction with host macromolecules

Unraveling the redox properties of the global regulator FurA from Anabaena sp. PCC 7120: disulfide reductase activity based on its CXXC motifs.