Search filters

List of works by Richard Stebbings

"Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics

scientific article published on 01 September 2007

A conditionally replicating SIV variant that can be used to study the mechanism of protection conferred by live attenuated SIV vaccines.

scientific article published on 3 October 2011

After TGN1412: recent developments in cytokine release assays.

scientific article

Allogeneic lymphocyte transfer in MHC-identical siblings and MHC-identical unrelated Mauritian cynomolgus macaques

scientific article

An autologous endothelial cell:peripheral blood mononuclear cell assay that detects cytokine storm responses to biologics.

scientific article published on 6 March 2015

Antibody C Region Influences TGN1412-like Functional Activity In Vitro

scientific article published on 12 November 2012

CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program

scientific article published on 01 April 2019

CD8+ lymphocytes do not mediate protection against acute superinfection 20 days after vaccination with a live attenuated simian immunodeficiency virus

scientific article

Comparison of Volumetric and Bead-Based Counting of CD34 Cells by Single-Platform Flow Cytometry

scientific article published on 20 February 2019

Comparison of novel methods for predicting the risk of pro-inflammatory clinical infusion reactions during monoclonal antibody therapy.

scientific article published on 30 June 2011

Comparison of peripheral blood phenotype in pathogenic and attenuated SIV infection.

scientific article

Conditionally-live attenuated SIV upregulates global T effector memory cell frequency under replication permissive conditions

scientific article published on 05 June 2013

Cytokine release assays: current practices and future directions.

scientific article published on 10 January 2014

Cytokine release: A workshop proceedings on the state-of-the-science, current challenges and future directions

scientific article published on 13 June 2016

Early biodistribution and persistence of a protective live attenuated SIV vaccine elicits localised innate responses in multiple lymphoid tissues

scientific article

Early potent protection against heterologous SIVsmE660 challenge following live attenuated SIV vaccination in Mauritian cynomolgus macaques.

scientific article

Endothelial cells co-stimulate peripheral blood mononuclear cell responses to monoclonal antibody TGN1412 in culture

scientific article published on 13 April 2011

Evasion of cytotoxic T lymphocyte (CTL) responses by nef-dependent induction of Fas ligand (CD95L) expression on simian immunodeficiency virus-infected cells.

scientific article

Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist

scientific article

Heterologous protection elicited by candidate monomeric recombinant HIV-1 gp120 vaccine in the absence of cross neutralising antibodies in a macaque model

scientific article

Higher mass meningococcal group C-tetanus toxoid vaccines conjugated with carbodiimide correlate with greater immunogenicity

scientific article published on 20 February 2020

How do we assure the quality of biological medicines?

scientific article

How predictive are in vitro assays for cytokine release syndrome in vivo? A comparison of methods reveals worrying differences in sensitivity and frequency of response.

scientific article published on 30 July 2013

Human CD4+ lymphocytes for antigen quantification: characterization using conventional flow cytometry and mass cytometry

scientific article published on 26 April 2012

Immunogenicity of a recombinant measles HIV-1 subtype C vaccine

scientific article published on 24 October 2013

Immunogenicity of a recombinant measles-HIV-1 clade B candidate vaccine

scientific article

Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFNβ interact with the endogenous cytokine and activate complement

scientific article published on 22 May 2013

Immunological responses and viral modulatory effects of vaccination with recombinant modified vaccinia virus Ankara (rMVA) expressing structural and regulatory transgenes of simian immunodeficiency virus (SIVmac32H/J5M).

scientific article published in April 2007

Improved in vitro methods to predict the in vivo toxicity in man of therapeutic monoclonal antibodies including TGN1412

scientific article published on 04 November 2009

Intra-dermal immunisation with SIV gag-based vaccines alone inhibits acquisition of SIVmac251.

scientific article published on 13 September 2012

Live attenuated simian immunodeficiency virus vaccination confers superinfection resistance against macrophage-tropic and neurovirulent wild-type SIV challenge

scientific article

Mechanisms of protection induced by attenuated simian immunodeficiency virus. II. Lymphocyte depletion does not abrogate protection.

scientific article published in September 1998

Mhc haplotype M3 is associated with early control of SHIVsbg infection in Mauritian cynomolgus macaques.

scientific article published in September 2010

Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells

scientific article (publication date: 3 September 2010)

Mucosal immunization in macaques upregulates the innate APOBEC 3G anti-viral factor in CD4(+) memory T cells.

scientific article published on 11 December 2008

Multicentre evaluation of stable reference whole blood for enumeration of lymphocyte subsets by flow cytometry

scientific article published on 22 June 2005

Occult replication of a conditionally-live attenuated SIV profoundly upregulates T effector memory cell frequency.

scientific article published on 3 October 2011

Quantification of cells with specific phenotypes I: determination of CD4+ cell count per microliter in reconstituted lyophilized human PBMC prelabeled with anti-CD4 FITC antibody

scientific article

Recent Advancements and Applications of Human Immune System Mice in Preclinical Immuno-Oncology

scientific article published on 18 December 2019

Replication kinetics and persistence of a conditionally live attenuated SIV (SIVrtTA) in vivo confers protection against SIVmac239 wild-type challenge in a rhesus macaque model

scientific article

Replication kinetics and persistence of a conditionally live attenuated SIV (SIVrtTA) in vivo confers protection against homologous and heterologous wild-type challenge in macaques

Resistance to superinfection by a vigorously replicating, uncloned stock of simian immunodeficiency virus (SIVmac251) stimulates replication of a live attenuated virus vaccine (SIVmacC8).

scientific article published in September 2008

Role of Occult and Post-acute Phase Replication in Protective Immunity Induced with a Novel Live Attenuated SIV Vaccine

scientific article (publication date: December 2016)

Safety of biologics, lessons learnt from TGN1412

scientific article

Safety pharmacology--current and emerging concepts.

scientific article

Severity of the TGN1412 trial disaster cytokine storm correlated with IL-2 release.

scientific article published on August 2013

Specific proliferative T cell responses and antibodies elicited by vaccination with simian immunodeficiency virus Nef do not confer protection against virus challenge.

scientific article published in November 2001

Use of human splenocytes in an innovative humanised mouse model for prediction of immunotherapy-induced cytokine release syndrome

scientific article published on 04 November 2020

Vaccination of Macaques with DNA Followed by Adenoviral Vectors Encoding Simian Immunodeficiency Virus (SIV) Gag Alone Delays Infection by Repeated Mucosal Challenge with SIV

scientific article published on 15 October 2019

Vaccination with live attenuated simian immunodeficiency virus causes dynamic changes in intestinal CD4+CCR5+ T cells

scientific article

Vaccination with live attenuated simian immunodeficiency virus for 21 days protects against superinfection

scientific article published in December 2004

Paulina is supported by:

About Paulina

Help