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List of works by Hans M Princen

APOE*3Leiden.CETP transgenic mice as model for pharmaceutical treatment of the metabolic syndrome

scientific article published on 16 January 2014

Absence of an atheroprotective effect of the garlic powder printanor in APOE*3-Leiden transgenic mice

scientific article published on 01 December 2004

Acute effects of ethanol intake on albumin and total protein synthesis in free and membrane-bound polyribosomes of rat liver ⬇️

scientific article published on September 28, 1981

Acyl-coenzyme A:cholesterol acyltransferase inhibitor, avasimibe, stimulates bile acid synthesis and cholesterol 7alpha-hydroxylase in cultured rat hepatocytes and in vivo in the rat

scientific article published on 01 August 1999

Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin

scientific article

Alirocumab, evinacumab, and atorvastatin triple therapy regresses plaque lesions and improves lesion composition in mice

scientific article published on 16 December 2019

Aliskiren inhibits atherosclerosis development and improves plaque stability in APOE*3Leiden.CETP transgenic mice with or without treatment with atorvastatin

scientific article published on 01 January 2012

Altered lipid metabolism in apolipoprotein E-deficient mice does not affect cholesterol balance across the liver

scientific article published on 01 July 1996

Anacetrapib reduces (V)LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9.

scientific article

Anacetrapib, but not evacetrapib, impairs endothelial function in CETP-transgenic mice in spite of marked HDL-C increase

scientific article published on 16 January 2017

Anti-PCSK9 antibodies inhibit pro-atherogenic mechanisms in APOE*3Leiden.CETP mice

scientific article published on 31 July 2019

Antioxidants and coronary heart disease.

scientific article

Apolipoprotein E polymorphism affects plasma levels of lipoprotein(a) ⬇️

scientific article published on October 1, 1991

Assay of cholesterol 7α-hydroxylase activity in rat hepatocytes in primary monolayer culture ⬇️

scientific article published on May 15, 1988

Atorvastatin accelerates clearance of lipoprotein remnants generated by activated brown fat to further reduce hypercholesterolemia and atherosclerosis

scientific article published on 26 October 2017

Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice

scientific article published on 14 September 2007

Autoantibodies against MDA-LDL in subjects with severe and minor atherosclerosis and healthy population controls.

scientific article published in May 1996

Beneficial effects of elafibranor on NASH in E3L.CETP mice and differences between mice and men

scientific article published on 03 March 2021

Bile acids exert negative feedback control on bile acid synthesis in cultured pig hepatocytes by suppression of cholesterol 7 alpha-hydroxylase activity

scientific article published on 01 November 1990

Both transient and continuous corticosterone excess inhibit atherosclerotic plaque formation in APOE*3-leiden.CETP mice

scientific article

Butyrate stimulates the secretion of apolipoprotein A-I and apolipoprotein B-100 in Hep G2 cells by different mechanisms

scientific article published on 01 October 1992

Cafestol, the Cholesterol-Raising Factor in Boiled Coffee, Suppresses Bile Acid Synthesis by Downregulation of Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase in Rat Hepatocytes ⬇️

scientific article published on November 1, 1997

Changes in the sequence content of albumin mRNA and in its translational activity in the rat liver with age

scientific article published on 01 October 1984

Cholesterol 7alpha-hydroxylase deficiency in mice on an APOE*3-Leiden background impairs very-low-density lipoprotein production.

scientific article published on 12 February 2004

Cholesterol 7α-Hydroxylase Deficiency in Mice on an APOE*3-Leiden Background Increases Hepatic ABCA1 mRNA Expression and HDL-Cholesterol

scientific article published on 28 September 2006

Colestilan decreases weight gain by enhanced NEFA incorporation in biliary lipids and fecal lipid excretion ⬇️

scientific article published on February 22, 2013

Common Variants Associated With <i>OSMR</i> Expression Contribute to Carotid Plaque Vulnerability, but Not to Cardiovascular Disease in Humans

scientific article published on 20 April 2021

Comparison of taurocholate accumulation in cultured hepatocytes of pig, rat and man.

scientific article

Consumption of black and green tea had no effect on inflammation, haemostasis and endothelial markers in smoking healthy individuals

scientific article published on 01 October 2000

Decrease of hemostatic cardiovascular risk factors by aggressive vs. conventional atorvastatin treatment in patients with Type 2 diabetes mellitus.

scientific article published in August 2003

Design of a targeted peptide nucleic acid prodrug to inhibit hepatic human microsomal triglyceride transfer protein expression in hepatocytes

scientific article published on 01 March 2002

Dietary vegetable oil and wood derived plant stanol esters reduce atherosclerotic lesion size and severity in apoE*3-Leiden transgenic mice.

scientific article published in August 2001

Direct evidence of transcriptional control of fibrinogen and albumin synthesis in rat liver during the acute phase response

scientific article published on 01 September 1981

Distribution of mRNAS of fibrinogen polypeptides and albumin in free and membrane-bound polyribosomes and induction of alpha-fetoprotein mRNA synthesis during liver regeneration after partial hepatectomy

scientific journal article

Distribution of perfluorooctanesulfonate and perfluorooctanoate into human plasma lipoprotein fractions

scientific article published on 24 February 2012

Dose Effects of Ammonium Perfluorooctanoate on Lipoprotein Metabolism in APOE*3-Leiden.CETP Mice

scientific article published on 01 April 2019

Effect of fish-oil-enriched margarine on plasma lipids, low-density-lipoprotein particle composition, size, and susceptibility to oxidation ⬇️

scientific article published on August 1, 1998

Effect of low dose atorvastatin versus diet-induced cholesterol lowering on atherosclerotic lesion progression and inflammation in apolipoprotein E*3-Leiden transgenic mice.

scientific article published on 28 October 2004

Effect of methylglyoxal on the physico-chemical and biological properties of low-density lipoprotein.

scientific article published on November 1998

Enhanced susceptibility of low-density lipoproteins to oxidation in coronary bypass patients with progression of atheroscerosis

scientific article published on 01 December 1995

Feedback inhibition of bile acid synthesis in cultured pig hepatocytes

scientific article published on 01 September 1988

Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression

scientific article published on 24 May 2007

Fenofibrate reduces atherogenesis in ApoE*3Leiden mice: evidence for multiple antiatherogenic effects besides lowering plasma cholesterol

scientific article published on 27 July 2006

Fine structure of Plasmodium berghei exoerythrocytic forms in cultured primary rat hepatocytes.

scientific article published in September 1984

Free cytoplasmic messenger ribonucleoprotein complexes from rabbit reticulocytes ⬇️

scientific article published on May 31, 1979

Genetic Analysis of Indicators of Cholesterol Synthesis and Absorption: Lathosterol and Phytosterols in Dutch Twins and Their Parents ⬇️

scientific article published on August 1, 2003

Hydroxylation, conjugation and sulfation of bile acids in primary monolayer cultures of rat hepatocytes

scientific article published on 01 August 1988

Increased fecal bile acid excretion in transgenic mice with elevated expression of human phospholipid transfer protein.

scientific article published on 20 March 2003

Inflammatory cytokine oncostatin M induces endothelial activation in macro- and microvascular endothelial cells and in APOE*3Leiden.CETP mice

scientific article published in PLoS ONE

Inhibition and induction of bile acid synthesis by ketoconazole. Effects on bile formation in the rat

scientific article published on 01 September 1989

Inhibition of apolipoprotein(a) synthesis in cynomolgus monkey hepatocytes by retinoids via involvement of the retinoic acid receptor

scientific article published on 01 July 1999

Innovative pharmaceutical interventions in cardiovascular disease: Focusing on the contribution of non-HDL-C/LDL-C-lowering versus HDL-C-raising: A systematic review and meta-analysis of relevant preclinical studies and clinical trials

scientific article published on 16 May 2015

Insulin suppresses apolipoprotein(a) synthesis by primary cultures of cynomolgus monkey hepatocytes

scientific article published on 01 January 1999

Insulin suppresses bile acid synthesis in cultured rat hepatocytes by down-regulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase gene transcription

scientific article published on 01 February 1995

LDL Oxidation and Extent of Coronary Atherosclerosis ⬇️

scientific article published on 01 February 1998

Lack of predictability of classical animal models for hypolipidemic activity: a good time for mice? ⬇️

scientific article published on September 1, 1998

Lipoprotein oxidation, antioxidants and cardiovascular risk: epidemiologic evidence ⬇️

scientific article published on October 1, 1997

Lipoprotein(a): relation to other risk factors and genetic heritability. Results from a Dutch parent-twin study.

scientific article published in February 1993

Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels.

scientific article

Metformin lowers plasma triglycerides by promoting VLDL-triglyceride clearance by brown adipose tissue in mice

scientific article

Mouse models for atherosclerosis and pharmaceutical modifiers.

scientific article published on 31 May 2007

Negative effects of rofecoxib treatment on cardiac function after ischemia-reperfusion injury in APOE3Leiden mice are prevented by combined treatment with thromboxane prostanoid-receptor antagonist S18886 (terutroban).

scientific article

Niacin Reduces Atherosclerosis Development in APOE*3Leiden.CETP Mice Mainly by Reducing NonHDL-Cholesterol.

scientific article

Niacin increases HDL by reducing hepatic expression and plasma levels of cholesteryl ester transfer protein in APOE*3Leiden.CETP mice.

scientific article published on 31 July 2008

Niacin reduces plasma CETP levels by diminishing liver macrophage content in CETP transgenic mice.

scientific article published on 27 June 2012

No effect of C-reactive protein on early atherosclerosis development in apolipoprotein E*3-leiden/human C-reactive protein transgenic mice.

scientific article published on 26 May 2005

No effect of fibrates on synthesis of apolipoprotein(a) in primary cultures of cynomolgus monkey and human hepatocytes: apolipoprotein A-I synthesis increased

scientific article published on 01 March 1998

No short-term effect of oral isotretinoin (13-cis retinoic acid) on lipoprotein(a) and HDL subclasses LP-A-I and LP-A-I:A-II in healthy volunteers

scientific article published on 01 July 1999

Oncostatin M reduces atherosclerosis development in APOE*3Leiden.CETP mice and is associated with increased survival probability in humans

scientific article published on 28 August 2019

One-step solvolysis of 3-, 7- and 12-sulfated free and conjugated bile acids

scientific article published on 01 November 1990

Oxidation of LDL and extent of peripheral atherosclerosis

scientific article published on 01 August 1999

PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol, and atherosclerosis in the absence of ApoE.

scientific article

Plasma annexin A5 level relates inversely to the severity of coronary stenosis

scientific article published on 12 March 2007

Reduced plasma cholesterol and increased fecal sterol loss in multidrug resistance gene 2 P-glycoprotein-deficient mice☆☆☆ ⬇️

scientific article published on May 1, 1998

Regulation of low density lipoprotein receptor activity in primary cultures of human hepatocytes by serum lipoproteins

scientific article published on 01 November 1986

Regulation of squalene synthetase activity in rat liver: elevation by cholestyramine, but no diurnal variation

scientific article published on 01 July 1986

Resveratrol protects against atherosclerosis, but does not add to the antiatherogenic effect of atorvastatin, in APOE*3-Leiden.CETP mice.

scientific article

Safety of long-term consumption of plant sterol esters-enriched spread.

scientific article published in May 2003

Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes

scientific article published on 21 August 2015

Seasonal Variation in Low Density Lipoprotein Oxidation and Antioxidant Status ⬇️

scientific article published on 01 July 1997

Sequence content of alpha-fetoprotein, albumin and fibrinogen polypeptide mRNAs in different organs, developing tissues and in liver during carcinogenesis in rats

scientific article published on 01 November 1982

Specific poly-A-binding protein of 76,000 molecular weight in polyribosomes is not present on poly A of free cytoplasmic mRNP.

scientific article

Stimulation of the LDL receptor activity in the human hepatoma cell line Hep G2 by high-density serum fractions

scientific article published on 01 February 1986

Structural Aspects of Bile Acids Involved in the Regulation of Cholesterol 7alpha-Hydroxylase and Sterol 27-Hydroxylase

scientific article published on 01 March 1995

Studies on the role of PPAR in the fibrate-modulated gene expression of apolipoprotein A-I, plasminogen activator inhibitor 1, and fibrinogen in primary hepatocyte cultures from cynomolgus monkey

scientific article published on 01 December 1996

Supplementation with vitamin E but not beta-carotene in vivo protects low density lipoprotein from lipid peroxidation in vitro. Effect of cigarette smoking

scientific article published on May 1, 1992

Susceptibility of low-density lipoproteins to oxidation in coronary bypass patients

scientific article published on 01 October 1992

The APOE3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis

scientific article published on 21 February 2019

The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden.CETP mice.

scientific article published on 19 June 2017

The BCR-ABL1 Inhibitors Imatinib and Ponatinib Decrease Plasma Cholesterol and Atherosclerosis, and Nilotinib and Ponatinib Activate Coagulation in a Translational Mouse Model.

scientific article

The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors

scientific article

The impact of metabolic syndrome and CRP on vascular phenotype in type 2 diabetes mellitus

The influence of glucocorticoid on albumin synthesis and its messenger RNA in rat in vivo and in hepatocyte suspension culture

scientific article published on 01 January 1985

Transcriptional regulation of the gene encoding cholesterol 7 alpha-hydroxylase in the rat.

scientific article published on August 1993

Variable cartilage degradation in mice with diet-induced metabolic dysfunction: food for thought.

scientific article published on 23 October 2017

Vitamin E inhibits lipid peroxidation-induced adhesion molecule expression in endothelial cells and decreases soluble cell adhesion molecules in healthy subjects

scientific article

α-Tocopherol levels in plasma in new-onset, insulin-dependent diabetes mellitus

scientific article published on 01 October 2004

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