List of works - Florence Noble

"Mixed inhibitor-prodrug" as a new approach toward systemically active inhibitors of enkephalin-degrading enzymes

scientific article published on June 26, 1992

A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test

scientific article

Acute and long-term effects of ecstasy

scientific article published on October 2004

Acute systemic inflammation induces central mitochondrial damage and mnesic deficit in adult Swiss mice.

scientific article published in August 2007

Aminophosphinic inhibitors as transition state analogues of enkephalin-degrading enzymes: a class of central analgesics

scientific journal article

Analysis of transcriptional responses in the mouse dorsal striatum following acute 3,4-methylenedioxymethamphetamine (ecstasy): identification of extracellular signal-regulated kinase-controlled genes.

scientific article

Assessment of endogenous enkephalins efficacy in the hot plate test in mice: comparative study with morphine

scientific article published on 01 February 1995

Assessment of physical dependence after continuous perfusion into the rat jugular vein of the mixed inhibitor of enkephalin-degrading enzymes, RB 101.

scientific article

Association of aminopeptidase N and endopeptidase 24.15 inhibitors potentiate behavioral effects mediated by nociceptin/orphanin FQ in mice

scientific article published on 01 January 1997

BDNF During Withdrawal.

scientific article

Binding properties of a highly potent and selective iodinated aminopeptidase N inhibitor appropriate for radioautography

scientific article

Binding sites and transduction process of the cholecystokininB receptor: involvement of highly conserved aromatic residues of the transmembrane domains evidenced by site-directed mutagenesis

scientific article published on 01 May 1998

Blockade of acute microglial activation by minocycline promotes neuroprotection and reduces locomotor hyperactivity after closed head injury in mice: a twelve-week follow-up study.

scientific article published in May 2010

Blockade of morphine-induced behavioral sensitization by a combination of amisulpride and RB101, comparison with classical opioid maintenance treatments.

scientific article published on 12 March 2007

Buprenorphine is protective against the depressive effects of norbuprenorphine on ventilation

scientific article published on 16 September 2005

CB1 receptor knockout mice show similar behavioral modifications to wild-type mice when enkephalin catabolism is inhibited.

scientific article published on 27 October 2005

Characteristics of dual specificity phosphatases mRNA regulation by 3,4-methylenedioxymethamphetamine acute treatment in mice striatum.

scientific article

Cholecystokinin-A but not cholecystokinin-B receptor stimulation induces endogenous opioid-dependent antinociceptive effects in the hot plate test in mice

scientific article

Chronic and intermittent morphine treatment differently regulates opioid and dopamine systems: a role in locomotor sensitization ⬇️

scientific article published on February 22, 2011

Chronic morphine treatment modulates the extracellular levels of endogenous enkephalins in rat brain structures involved in opiate dependence: a microdialysis study.

scientific article published in February 2002

Comparison of the transcriptional responses induced by acute morphine, methadone and buprenorphine.

scientific article published on 24 April 2013

Comparison of tolerance to morphine-induced respiratory and analgesic effects in mice

scientific article

Current pharmacotherapies and immunotherapy in cocaine addiction

scientific article published on 21 December 2007

Current preclinical knowledge of the neurobiology of cocaine

scientific article

Cytoskeletal genes regulation by chronic morphine treatment in rat striatum.

scientific article

Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system.

scientific article published in March 2002

Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype

scientific article published on 13 August 2006

Delta9-tetrahydrocannabinol releases and facilitates the effects of endogenous enkephalins: reduction in morphine withdrawal syndrome without change in rewarding effect

scientific article published in May 2001

Depressant effect on a C-fibre reflex in the rat, of RB101, a dual inhibitor of enkephalin-degrading enzymes.

scientific article

Determination of 3,4-methylenedioxymethamphetamine and its five main metabolites in rat urine by solid-phase extraction and high performance liquid chromatography with on line mass spectrometry ⬇️

scientific article published on August 21, 2010

Differences among mouse strains in the regulation by mu, delta 1 and delta 2 opioid receptors of striatal adenylyl cyclases activated by dopamine D1 or adenosine A2a receptors

scientific journal article

Different patterns of administration modulate propensity of methadone and buprenorphine to promote locomotor sensitization in mice

scientific article published on 26 October 2012

Differential desensitization of mu- and delta- opioid receptors in selected neural pathways following chronic morphine treatment

scientific article published in January 1996

Effects of nitrous oxide on dopamine release in the rat nucleus accumbens and expectation of reward.

scientific article

Facilitation of enkephalins catabolism inhibitor-induced antinociception by drugs classically used in pain management

scientific article (publication date: September 2001)

Facilitation of enkephalins-induced delta-opioid behavioral responses by chronic amisulpride treatment.

scientific article published in January 2005

First discrete autoradiographic distribution of aminopeptidase N in various structures of rat brain and spinal cord using the selective iodinated inhibitor [125I]RB 129 ⬇️

scientific article published on January 1, 2001

High-protein-low-carbohydrate diet: deleterious metabolic and cardiovascular effects depend on age

scientific article published on 11 July 2014

Impact of P-glycoprotein at the blood-brain barrier on the uptake of heroin and its main metabolites: behavioral effects and consequences on the transcriptional responses and reinforcing properties

scientific article published on 5 April 2014

Importance of ERK activation in behavioral and biochemical effects induced by MDMA in mice.

scientific article published on 29 September 2003

In vivo visualization of delta opioid receptors upon physiological activation uncovers a distinct internalization profile

scientific article

Influence of cocaine administration patterns on dopamine receptor regulation.

scientific article published on 21 February 2014

Inhibition of the enkephalin-metabolizing enzymes by the first systemically active mixed inhibitor prodrug RB 101 induces potent analgesic responses in mice and rats ⬇️

scientific article published on April 1, 1992

Inhibitors of neprilysin: design, pharmacological and clinical applications.

scientific article

Involvement of D1 dopamine receptor in MDMA-induced locomotor activity and striatal gene expression in mice.

scientific article published on 20 March 2008

Lack of physical dependence in mice after repeated systemic administration of the mixed inhibitor prodrug of enkephalin-degrading enzymes, RB101

scientific article published on November 13, 1992

Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs.

scientific article

Methadone Reverses Analgesic Tolerance Induced by Morphine Pretreatment.

scientific article published on 21 September 2015

Modulation of MDMA-induced behavioral and transcriptional effects by the delta opioid antagonist naltrindole in mice.

scientific article published on July 2009

Netrin G1: its downregulation in the nucleus accumbens of cocaine-conditioned mice and genetic association in human cocaine dependence

scientific article published on 11 January 2017

New treatments for cocaine dependence: a focused review

scientific article

Nrxn3 upregulation in the globus pallidus of mice developing cocaine addiction

scientific article

Ontogenic and adult whole body distribution of aminopeptidase N in rat investigated by in vitro autoradiography.

scientific article published in February 2004

Opioid receptor desensitization: mechanisms and its link to tolerance

scientific article

Opposite role of delta 1- and delta 2-opioid receptors activated by endogenous or exogenous opioid agonists on the endogenous cholecystokinin system: further evidence for delta-opioid receptor heterogeneity.

scientific article

Pain-suppressive effects on various nociceptive stimuli (thermal, chemical, electrical and inflammatory) of the first orally active enkephalin-metabolizing enzyme inhibitor RB 120.

scientific article

Paradoxical analgesia induced by low doses of naloxone is not potentiated by complete inhibition of enkephalin degradation

scientific article published on 01 January 1994

Pharmacological activation of mGlu4 and mGlu7 receptors, by LSP2-9166, reduces ethanol consumption and relapse in rat.

scientific article published on 26 January 2018

Pharmacology of CCKRs and SAR studies of peptidic analog ligands

scientific article

Phenotypes of mice with invalidation of cholecystokinin (CCK(1) or CCK(2)) receptors.

scientific article

Phosphinic derivatives as new dual enkephalin-degrading enzyme inhibitors: synthesis, biological properties, and antinociceptive activities

scientific article published on 01 April 2000

Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors

scientific article published in January 2005

Plusridisciplinary approaches to understand the neutoxic effects of Ecstasy

scientific article published on May 1, 2003

Population pharmacokinetics of 3,4-methylenedioxymethamphetamine and main metabolites in rats.

scientific article published on 14 December 2009

Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation.

scientific article published in April 1992

Preproenkephalin knockout mice show no depression-related phenotype

scientific article published on 21 March 2007

Protection of endogenous enkephalin catabolism as natural approach to novel analgesic and antidepressant drugs.

scientific article

RB101(S), a dual inhibitor of enkephalinases does not induce antinociceptive tolerance, or cross-tolerance with morphine: a c-Fos study at the spinal level.

scientific article

Reduction of opioid dependence by the CB(1) antagonist SR141716A in mice: evaluation of the interest in pharmacotherapy of opioid addiction

scientific article

Regulation of genes involved in dopamine transporter modulation by acute cocaine in rat striatum.

scientific article published on 3 February 2006

Relationship between vulnerability to reinforcing effects of morphine and activity of the endogenous cholecystokinin system in Lewis and Fischer rats.

scientific article published on 11 February 2011

Repeated systemic administration of the mixed inhibitor of enkephalin-degrading enzymes, RB101, does not induce either antinociceptive tolerance or cross-tolerance with morphine

scientific article published on November 13, 1992

Rewarding or aversive effects of buprenorphine/naloxone combination (Suboxone) depend on conditioning trial duration.

scientific article published on 10 March 2014

Role of endogenous cholecystokinin in the facilitation of mu-mediated antinociception by delta-opioid agonists.

scientific article

Role of mGlu7 receptor in morphine rewarding effects is uncovered by a novel orthosteric agonist.

scientific article published on 4 January 2018

Selective opioid agonists and inhibitors of enkephalin degradation enzymes: pharmacological and clinical values

scientific article published on January 1, 1992

Self-reported sleep disturbances during cannabis withdrawal in cannabis-dependent outpatients with and without opioid dependence

scientific article

Sensitization to the conditioned rewarding effects of morphine modulates gene expression in rat hippocampus.

scientific article published on 2 October 2006

Short- and long-lasting behavioral and neurochemical adaptations: relationship with patterns of cocaine administration and expectation of drug effects in rats

scientific article published on 23 October 2012

Specific blockade of morphine- and cocaine-induced reinforcing effects in conditioned place preference by nitrous oxide in mice.

scientific article

Sprague-Dawley rats display metabolism-mediated sex differences in the acute toxicity of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy).

scientific article

Sprague-Dawley rats display sex-linked differences in the pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA).

scientific article published on 23 September 2009

Striatal dopamine D1 and D2 receptors are differentially regulated following buprenorphine or methadone treatment

scientific article published on 31 October 2014

Study of induced effects by selective CCKB agonists cholecystokinin in the nociception and behavior in rodents

scientific article published on November 1, 1992

Syndrome de sevrage au cannabis dans une population de patients mono- et polydépendants (cannabis et opiacés)

scientific article published on 05 February 2011

Synthesis and Biological Properties of New Constrained CCK-B Antagonists: Discrimination of Two Affinity States of the CCK-B Receptor on Transfected CHO Cells ⬇️

scientific article published on November 21, 1997

Temporal regulation of peripheral BDNF levels during cocaine and morphine withdrawal: comparison with a natural reward

scientific article

The cholecystokininB receptor is coupled to two effector pathways through pertussis toxin-sensitive and -insensitive G proteins

scientific article published on 01 July 1999

The opioid receptors as targets for drug abuse medication

scientific article published in 2015

The role of dopaminergic systems in opioid receptor desensitization in nucleus accumbens and caudate putamen of rat after chronic morphine treatment ⬇️

scientific article published on November 1, 1997

Tolerance to the reinforcing effects of morphine in delta9-tetrahydrocannabinol treated mice

scientific article published in August 2006

Transfer of neuroplasticity from nucleus accumbens core to shell is required for cocaine reward

scientific article

Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours.

scientific article published in October 2007

What brings neurobiology to addictions?

scientific article published on 25 March 2016

[Drug dependence: Progress in neurobiology and perspectives in therapeutics]

scientific article published on 05 October 2012

[Enkephalin catabolism inhibitors and antalgics of the future: from preclinical research to clinical trials]

scientific article published on 01 January 1999

List of works by Florence Noble

"Mixed inhibitor-prodrug" as a new approach toward systemically active inhibitors of enkephalin-degrading enzymes

A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test

Acute and long-term effects of ecstasy

Acute systemic inflammation induces central mitochondrial damage and mnesic deficit in adult Swiss mice.

Aminophosphinic inhibitors as transition state analogues of enkephalin-degrading enzymes: a class of central analgesics

Analysis of transcriptional responses in the mouse dorsal striatum following acute 3,4-methylenedioxymethamphetamine (ecstasy): identification of extracellular signal-regulated kinase-controlled genes.

Assessment of endogenous enkephalins efficacy in the hot plate test in mice: comparative study with morphine

Assessment of physical dependence after continuous perfusion into the rat jugular vein of the mixed inhibitor of enkephalin-degrading enzymes, RB 101.

Association of aminopeptidase N and endopeptidase 24.15 inhibitors potentiate behavioral effects mediated by nociceptin/orphanin FQ in mice

BDNF During Withdrawal.

Binding properties of a highly potent and selective iodinated aminopeptidase N inhibitor appropriate for radioautography

Binding sites and transduction process of the cholecystokininB receptor: involvement of highly conserved aromatic residues of the transmembrane domains evidenced by site-directed mutagenesis

Blockade of acute microglial activation by minocycline promotes neuroprotection and reduces locomotor hyperactivity after closed head injury in mice: a twelve-week follow-up study.

Blockade of morphine-induced behavioral sensitization by a combination of amisulpride and RB101, comparison with classical opioid maintenance treatments.

Buprenorphine is protective against the depressive effects of norbuprenorphine on ventilation

CB1 receptor knockout mice show similar behavioral modifications to wild-type mice when enkephalin catabolism is inhibited.

Characteristics of dual specificity phosphatases mRNA regulation by 3,4-methylenedioxymethamphetamine acute treatment in mice striatum.

Cholecystokinin-A but not cholecystokinin-B receptor stimulation induces endogenous opioid-dependent antinociceptive effects in the hot plate test in mice

Chronic and intermittent morphine treatment differently regulates opioid and dopamine systems: a role in locomotor sensitization ⬇️

Chronic morphine treatment modulates the extracellular levels of endogenous enkephalins in rat brain structures involved in opiate dependence: a microdialysis study.

Comparison of the transcriptional responses induced by acute morphine, methadone and buprenorphine.

Comparison of tolerance to morphine-induced respiratory and analgesic effects in mice

Current pharmacotherapies and immunotherapy in cocaine addiction

Current preclinical knowledge of the neurobiology of cocaine

Cytoskeletal genes regulation by chronic morphine treatment in rat striatum.

Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system.

Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype

Delta9-tetrahydrocannabinol releases and facilitates the effects of endogenous enkephalins: reduction in morphine withdrawal syndrome without change in rewarding effect

Depressant effect on a C-fibre reflex in the rat, of RB101, a dual inhibitor of enkephalin-degrading enzymes.

Determination of 3,4-methylenedioxymethamphetamine and its five main metabolites in rat urine by solid-phase extraction and high performance liquid chromatography with on line mass spectrometry ⬇️

Differences among mouse strains in the regulation by mu, delta 1 and delta 2 opioid receptors of striatal adenylyl cyclases activated by dopamine D1 or adenosine A2a receptors

Different patterns of administration modulate propensity of methadone and buprenorphine to promote locomotor sensitization in mice

Differential desensitization of mu- and delta- opioid receptors in selected neural pathways following chronic morphine treatment

Effects of nitrous oxide on dopamine release in the rat nucleus accumbens and expectation of reward.

Facilitation of enkephalins catabolism inhibitor-induced antinociception by drugs classically used in pain management

Facilitation of enkephalins-induced delta-opioid behavioral responses by chronic amisulpride treatment.

First discrete autoradiographic distribution of aminopeptidase N in various structures of rat brain and spinal cord using the selective iodinated inhibitor [125I]RB 129 ⬇️

High-protein-low-carbohydrate diet: deleterious metabolic and cardiovascular effects depend on age

Impact of P-glycoprotein at the blood-brain barrier on the uptake of heroin and its main metabolites: behavioral effects and consequences on the transcriptional responses and reinforcing properties

Importance of ERK activation in behavioral and biochemical effects induced by MDMA in mice.

In vivo visualization of delta opioid receptors upon physiological activation uncovers a distinct internalization profile

Influence of cocaine administration patterns on dopamine receptor regulation.

Inhibition of the enkephalin-metabolizing enzymes by the first systemically active mixed inhibitor prodrug RB 101 induces potent analgesic responses in mice and rats ⬇️

Inhibitors of neprilysin: design, pharmacological and clinical applications.

Involvement of D1 dopamine receptor in MDMA-induced locomotor activity and striatal gene expression in mice.

Lack of physical dependence in mice after repeated systemic administration of the mixed inhibitor prodrug of enkephalin-degrading enzymes, RB101

Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs.

Methadone Reverses Analgesic Tolerance Induced by Morphine Pretreatment.

Modulation of MDMA-induced behavioral and transcriptional effects by the delta opioid antagonist naltrindole in mice.

Netrin G1: its downregulation in the nucleus accumbens of cocaine-conditioned mice and genetic association in human cocaine dependence

New treatments for cocaine dependence: a focused review

Nrxn3 upregulation in the globus pallidus of mice developing cocaine addiction

Ontogenic and adult whole body distribution of aminopeptidase N in rat investigated by in vitro autoradiography.

Opioid receptor desensitization: mechanisms and its link to tolerance

Opposite role of delta 1- and delta 2-opioid receptors activated by endogenous or exogenous opioid agonists on the endogenous cholecystokinin system: further evidence for delta-opioid receptor heterogeneity.

Pain-suppressive effects on various nociceptive stimuli (thermal, chemical, electrical and inflammatory) of the first orally active enkephalin-metabolizing enzyme inhibitor RB 120.

Paradoxical analgesia induced by low doses of naloxone is not potentiated by complete inhibition of enkephalin degradation

Pharmacological activation of mGlu4 and mGlu7 receptors, by LSP2-9166, reduces ethanol consumption and relapse in rat.

Pharmacology of CCKRs and SAR studies of peptidic analog ligands

Phenotypes of mice with invalidation of cholecystokinin (CCK(1) or CCK(2)) receptors.

Phosphinic derivatives as new dual enkephalin-degrading enzyme inhibitors: synthesis, biological properties, and antinociceptive activities

Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors

Plusridisciplinary approaches to understand the neutoxic effects of Ecstasy

Population pharmacokinetics of 3,4-methylenedioxymethamphetamine and main metabolites in rats.

Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation.

Preproenkephalin knockout mice show no depression-related phenotype

Protection of endogenous enkephalin catabolism as natural approach to novel analgesic and antidepressant drugs.

RB101(S), a dual inhibitor of enkephalinases does not induce antinociceptive tolerance, or cross-tolerance with morphine: a c-Fos study at the spinal level.

Reduction of opioid dependence by the CB(1) antagonist SR141716A in mice: evaluation of the interest in pharmacotherapy of opioid addiction

Regulation of genes involved in dopamine transporter modulation by acute cocaine in rat striatum.

Relationship between vulnerability to reinforcing effects of morphine and activity of the endogenous cholecystokinin system in Lewis and Fischer rats.

Repeated systemic administration of the mixed inhibitor of enkephalin-degrading enzymes, RB101, does not induce either antinociceptive tolerance or cross-tolerance with morphine

Rewarding or aversive effects of buprenorphine/naloxone combination (Suboxone) depend on conditioning trial duration.

Role of endogenous cholecystokinin in the facilitation of mu-mediated antinociception by delta-opioid agonists.

Role of mGlu7 receptor in morphine rewarding effects is uncovered by a novel orthosteric agonist.

Selective opioid agonists and inhibitors of enkephalin degradation enzymes: pharmacological and clinical values

Self-reported sleep disturbances during cannabis withdrawal in cannabis-dependent outpatients with and without opioid dependence

Sensitization to the conditioned rewarding effects of morphine modulates gene expression in rat hippocampus.

Short- and long-lasting behavioral and neurochemical adaptations: relationship with patterns of cocaine administration and expectation of drug effects in rats