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List of works by Matthias Brock

A Non-canonical Melanin Biosynthesis Pathway Protects Aspergillus terreus Conidia from Environmental Stress

scientific article published on 26 April 2016

A highly conserved basidiomycete peptide synthetase produces a trimeric hydroxamate siderophore

scientific article

A multimodal imaging approach enables in vivo assessment of antifungal treatment in a mouse model of invasive pulmonary aspergillosis.

scientific article

A new high-performance heterologous fungal expression system based on regulatory elements from the Aspergillus terreus terrein gene cluster.

scientific article published on 16 March 2015

ATNT: an enhanced system for expression of polycistronic secondary metabolite gene clusters in Aspergillus niger

scientific article published on 19 December 2017

Acryloyl-CoA reductase from Clostridium propionicum. An enzyme complex of propionyl-CoA dehydrogenase and electron-transferring flavoprotein.

scientific article

Analysis of the regulation, expression, and localisation of the isocitrate lyase from Aspergillus fumigatus, a potential target for antifungal drug development.

scientific article

Application of bioluminescence imaging for in vivo monitoring of fungal infections.

scientific article

Aspergillus nidulans DigA, a potential homolog of Saccharomyces cerevisiae Pep3 (Vps18), is required for nuclear migration, mitochondrial morphology and polarized growth.

scientific article published on 5 October 2001

Aspergillus terreus Species Complex

scientific article published in 2021

Assessment of efficacy of antifungals against Aspergillus fumigatus: value of real-time bioluminescence imaging.

scientific article published on 15 April 2013

Back to the roots.

scientific article published in March 2009

Bioluminescent Aspergillus fumigatus, a new tool for drug efficiency testing and in vivo monitoring of invasive aspergillosis

scientific article published on 26 September 2008

Bringing light into the dark site of infection

scientific article published on 28 May 2015

Candida albicans Hap43 Domains Are Required under Iron Starvation but Not Excess.

scientific article published in December 2017

Candida albicans scavenges host zinc via Pra1 during endothelial invasion

scientific article

Candida albicans utilizes a modified β-oxidation pathway for the degradation of toxic propionyl-CoA.

scientific article published on 04 February 2014

Candida glabrata tryptophan-based pigment production via the Ehrlich pathway

scientific article

Characterisation of the laccase-encoding gene abr2 of the dihydroxynaphthalene-like melanin gene cluster of Aspergillus fumigatus

scientific article published on 19 September 2006

Characterization of an acyl-CoA: carboxylate CoA-transferase from Aspergillus nidulans involved in propionyl-CoA detoxification.

scientific article published on 4 March 2008

Connection of propionyl-CoA metabolism to polyketide biosynthesis in Aspergillus nidulans.

scientific article published on October 2004

Crystal Structure of 2-Methylisocitrate Lyase (PrpB) from Escherichia coli and Modelling of its Ligand Bound Active Centre

scientific article (publication date: 2 May 2003)

DIGE enables the detection of a putative serum biomarker of fungal origin in a mouse model of invasive aspergillosis.

scientific article published on 17 February 2012

Duality of liver and kidney lesions after systemic infection of immunosuppressed and immunocompetent mice with Aspergillus fumigatus.

scientific article published in January 2012

Dynamic Immune Cell Recruitment After Murine Pulmonary Aspergillus fumigatus Infection under Different Immunosuppressive Regimens

scientific article published on 13 July 2016

Embryonated eggs as an alternative infection model to investigate Aspergillus fumigatus virulence

scientific article

Encapsulation of Antifungals in Micelles Protects Candida albicans during Gall-Bladder Infection.

scientific article published on February 2017

Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans

scientific article (publication date: February 2007)

Evaluation of lysine biosynthesis as an antifungal drug target: biochemical characterization of Aspergillus fumigatus homocitrate synthase and virulence studies

scientific article

Exploring metabolic pathways in genome-scale networks via generating flux modes

scientific article published in 2010

Fungal metabolism in host niches.

scientific article published on 15 June 2009

Gene acquisition, duplication and metabolic specification: the evolution of fungal methylisocitrate lyases

scientific article published on 31 March 2011

Generation and phenotypic characterization of Aspergillus nidulans methylisocitrate lyase deletion mutants: methylisocitrate inhibits growth and conidiation.

scientific article published on September 2005

Hybrid in silico/in vitro target fishing to assign function to “orphan” compounds of food origin – The case of the fungal metabolite atromentin

scientific article published on 04 July 2018

Illuminating fungal infections with bioluminescence.

scientific article

In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis

scientific article

In vivo imaging of disseminated murine Candida albicans infection reveals unexpected host sites of fungal persistence during antifungal therapy

scientific article

Infection-Mediated Priming of Phagocytes Protects against Lethal Secondary Aspergillus fumigatus Challenge

scientific article

Lipid components of bile increase the protective effect of conjugated bile salts against antifungal drugs.

scientific article published on 21 August 2017

Longitudinal multimodal imaging-compatible mouse model of triazole-sensitive and -resistant invasive pulmonary aspergillosis

scientific article published in 2022

Lysine biosynthesis in microbes: relevance as drug target and prospects for β-lactam antibiotics production.

scientific article published on 19 March 2013

Methylcitrate cycle activation during adaptation of Fusarium solani and Fusarium verticillioides to propionyl-CoA-generating carbon sources.

scientific article published on 6 August 2009

Methylcitrate synthase from Aspergillus fumigatus is essential for manifestation of invasive aspergillosis.

scientific article published on January 2008

Methylcitrate synthase from Aspergillus fumigatus. Propionyl-CoA affects polyketide synthesis, growth and morphology of conidia.

scientific article published on July 2005

Molecular epidemiology and virulence assessment of Aspergillus fumigatus isolates from white stork chicks and their environment.

scientific article published on 8 September 2010

Multifactorial induction of an orphan PKS-NRPS gene cluster in Aspergillus terreus

scientific article published on 13 January 2011

Murine Infection Models for Aspergillus terreus Pulmonary Aspergillosis Reveal Long-term Persistence of Conidia and Liver Degeneration

article

Nutrient acquisition by pathogenic fungi: nutrient availability, pathway regulation, and differences in substrate utilization.

scientific article published on 08 May 2011

On the mechanism of action of the antifungal agent propionate.

scientific article

Oxidation of propionate to pyruvate in Escherichia coli. Involvement of methylcitrate dehydratase and aconitase

scientific article (publication date: December 2002)

Persistence versus escape: Aspergillus terreus and Aspergillus fumigatus employ different strategies during interactions with macrophages

scientific article

Persistence within dendritic cells marks an antifungal evasion and dissemination strategy of Aspergillus terreus

scientific article published on 6 September 2017

Phosphorylation is the major mechanism regulating isocitrate lyase activity in Paracoccidioides brasiliensis yeast cells

scientific article published on May 31, 2011

Phylogenetic and phenotypic characterisation of the 3-ketoacyl-CoA thiolase gene family from the opportunistic human pathogenic fungus Candida albicans

scientific article published on 4 July 2013

Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals

scientific article published on 14 July 2015

Re-characterisation of Saccharomyces cerevisiae Ach1p: fungal CoA-transferases are involved in acetic acid detoxification.

scientific article

Reducing hypoxia and inflammation during invasive pulmonary aspergillosis by targeting the Interleukin-1 receptor

scientific article

Sensitive bioluminescence imaging of fungal dissemination to the brain in mouse models of cryptococcosis

scientific article published on 17 June 2019

Terrein biosynthesis in Aspergillus terreus and its impact on phytotoxicity

scientific article published on 8 May 2014

The fungal α‐aminoadipate pathway for lysine biosynthesis requires two enzymes of the aconitase family for the isomerization of homocitrate to homoisocitrate

scientific article published on November 6, 2012

The glycolytic enzyme enolase represents a plasminogen-binding protein on the surface of a wide variety of medically important fungal species

scientific article published on 3 December 2015

Two novel species of arctic-alpine lichen-forming fungi (Ascomycota, Megasporaceae) from the Deosai Plains, Pakistan

scientific article published in 2024

Widespread Inter- and Intra-Domain Horizontal Gene Transfer of d-Amino Acid Metabolism Enzymes in Eukaryotes

scientific article