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List of works by Ralf Michael Zwacka

A non-apoptotic role for caspase-9 in muscle differentiation

scientific article published on 28 October 2008

A novel method for the combined flow cytometric analysis of cell cycle and cytochrome c release

article

AAV-encoded expression of TRAIL in experimental human colorectal cancer leads to tumor regression.

scientific article published on March 2004

Adenovirus-mediated manganese superoxide dismutase gene transfer to hamster cheek pouch carcinoma cells.

scientific article published in December 1997

Age-dependent hypertension in Mpv17-deficient mice, a transgenic model of glomerulosclerosis and inner ear disease

scientific article published on 01 December 1999

Aspirin-induced activation of the NF-kappaB signaling pathway: a novel mechanism for aspirin-mediated apoptosis in colon cancer cells

scientific article (publication date: May 2001)

Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy

scientific article

Both human and mouse mesenchymal stem cells promote breast cancer metastasis.

scientific article

CD4(+) T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver

scientific article published on July 1997

Caspase-8L expression protects CD34+ hematopoietic progenitor cells and leukemic cells from CD95-mediated apoptosis

scientific article

Constitutively activated nuclear factor-kappaB, but not induced NF-kappaB, leads to TRAIL resistance by up-regulation of X-linked inhibitor of apoptosis protein in human cancer cells.

scientific article published on October 2006

DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer

scientific article

Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects

scientific article published on 21 February 2013

Development of a FACS-based Smac/DIABLO release assay to monitor individual drug responses and to pave the way towards patient-tailored therapies.

scientific article published on 16 April 2015

Effects of antioxidant enzyme overexpression on the invasive phenotype of hamster cheek pouch carcinoma cells.

scientific article published in September 1999

Expression of the recessive glomerulosclerosis gene Mpv17 regulates MMP-2 expression in fibroblasts, the kidney, and the inner ear of mice

scientific article

Functional rescue of the glomerulosclerosis phenotype in Mpv17 mice by transgenesis with the human Mpv17 homologue.

scientific article

Gene therapy for colon cancer.

scientific article

IFN-γ combined with targeting of XIAP leads to increased apoptosis-sensitisation of TRAIL resistant pancreatic carcinoma cells

scientific article

Immunolocalization and adenoviral vector-mediated manganese superoxide dismutase gene transfer to experimental oral tumors

scientific article published on June 2000

In situ trapping of initiator caspases reveals intermediate surprises.

scientific article published on 28 November 2006

Intratracheal injection of adenovirus containing the human MnSOD transgene protects athymic nude mice from irradiation-induced organizing alveolitis.

scientific article published in January 1999

Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor kappaB independently of IkappaB degradation

scientific article published on 01 October 1998

Loss of auditory function in transgenic Mpv17-deficient mice.

scientific article published in December 1997

Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells.

scientific article

Manganese superoxide dismutase protects nNOS neurons from NMDA and nitric oxide-mediated neurotoxicity.

scientific article published on March 1998

Mesenchymal stem cells expressing TRAIL lead to tumour growth inhibition in an experimental lung cancer model

scientific article published on 28 March 2008

MnSOD protects colorectal cancer cells from TRAIL-induced apoptosis by inhibition of Smac/DIABLO release.

scientific article

NF-kappaB kinetics predetermine TNF-alpha sensitivity of colorectal cancer cells

scientific article published in September 2000

NF-kappaB-independent sensitization of glioblastoma cells for TRAIL-induced apoptosis by proteasome inhibition.

scientific article published on 7 August 2006

Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells

scientific article published on September 1999

Overexpression of human superoxide dismutase inhibits oxidation of low-density lipoprotein by endothelial cells.

scientific article published in June 1998

Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy.

scientific article

Reactive oxygen species in oncogenic transformation

scientific article published on December 2003

Recombinant adenovirus-mediated cardiac gene transfer of superoxide dismutase and catalase attenuates postischemic contractile dysfunction

article

Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-kappaB activation.

scientific article

Redox gene therapy protects human IB-3 lung epithelial cells against ionizing radiation-induced apoptosis

scientific article published on June 1998

Subcellular site of superoxide dismutase expression differentially controls AP-1 activity and injury in mouse liver following ischemia/reperfusion

scientific article published in April 2001

Superoxide anions and endothelial cell proliferation in normoglycemia and hyperglycemia.

scientific article

TRAIL-induced apoptosis is preferentially mediated via TRAIL receptor 1 in pancreatic carcinoma cells and profoundly enhanced by XIAP inhibitors

scientific article published on 12 October 2010

Targeting of XIAP combined with systemic mesenchymal stem cell-mediated delivery of sTRAIL ligand inhibits metastatic growth of pancreatic carcinoma cells

scientific article published on November 2010

The TRAIL-receptor-1: TRAIL-receptor-3 and -4 ratio is a predictor for TRAIL sensitivity of cancer cells.

scientific article published on May 2009

The enigmatic roles of caspases in tumor development

scientific article

The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein producing reactive oxygen species

scientific article

The human homolog of the glomerulosclerosis gene Mpv17: structure and genomic organization

scientific article

The yeast TEL1 gene partially substitutes for human ATM in suppressing hyperrecombination, radiation-induced apoptosis and telomere shortening in A-T cells

scientific article

Therapeutic approaches for ischemia/reperfusion injury in the liver.

scientific article

Vitamin D3-24-hydroxylase (CYP24) as a potential target for intervention with diabetic and nondiabetic nephropathy

scientific article published on 01 January 2007

[Gene therapy strategies for colorectal cancer]

scientific article published on 01 March 2007

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