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List of works by Marcelo A Comini

1H, 13C and 15N resonance assignment of the cytosolic dithiol glutaredoxin 1 from the pathogen Trypanosoma brucei

scientific article published on 19 September 2015

1H, 13C and 15N resonance assignment of the mature form of monothiol glutaredoxin 1 from the pathogen Trypanosoma brucei

scientific article published on 16 May 2014

5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms

scientific article

A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes

scientific article published on 31 January 2018

A simple, robust, and affordable bioluminescent assay for drug discovery against infective African trypanosomes

scientific article published on 20 January 2020

Alternative Thiol-Based Redox Systems.

scientific article

An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone.

scientific article published on 26 September 2019

Antitumor and antiparasitic activity of novel ruthenium compounds with polycyclic aromatic ligands

scientific article published on 09 June 2015

Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi.

scientific article published on 17 March 2016

Biosynthesis of trypanothione in Trypanosoma brucei brucei.

scientific article published in April 2003

Cytosolic peroxidases protect the lysosome of bloodstream African trypanosomes from iron-mediated membrane damage

scientific article

Cytotoxic interactions of methylene blue with trypanosomatid-specific disulfide reductases and their dithiol products.

scientific article published on 21 March 2008

Determination of acidity and nucleophilicity in thiols by reaction with monobromobimane and fluorescence detection

scientific article published on 04 January 2013

Diglycosyl diselenides alter redox homeostasis and glucose consumption of infective African trypanosomes

scientific article published on 12 August 2017

Evaluation of commercial enzyme-linked immunosorbent assay kits for detection of tuberculosis in Argentinean population.

scientific article published on February 2004

Expression, crystallization and preliminary X-ray crystallographic analysis of glucose-6-phosphate dehydrogenase from the human pathogen Trypanosoma cruzi in complex with substrate

scientific article published on 27 October 2011

Genetic and chemical analyses reveal that trypanothione synthetase but not glutathionylspermidine synthetase is essential for Leishmania infantum

scientific article published on 20 May 2014

Glucose-6-Phosphate Dehydrogenase from the Human Pathogen Trypanosoma cruzi Evolved Unique Structural Features to Support Efficient Product Formation

scientific article published on 28 March 2019

Glutaredoxin-deficiency confers bloodstream Trypanosoma brucei with improved thermotolerance

scientific article published on 5 February 2016

Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids

scientific article

Identification of novel bacterial plasminogen-binding proteins in the human pathogen Mycobacterium tuberculosis

scientific journal article

In vitro activity and mode of action of distamycin analogues against African trypanosomes.

scientific article

Iron–Sulfur Cluster Binding by Mitochondrial Monothiol Glutaredoxin-1 of Trypanosoma brucei : Molecular Basis of Iron–Sulfur Cluster Coordination and Relevance for Parasite Infectivity

scientific article

Kinetic studies reveal a key role of a redox-active glutaredoxin in the evolution of the thiol-redox metabolism of trypanosomatid parasites

scientific article published on 28 December 2018

Lipoamide dehydrogenase is essential for both bloodstream and procyclic Trypanosoma brucei ⬇️

scientific article published on July 4, 2011

Measurement and meaning of cellular thiol:disufhide redox status

scientific article published on 23 December 2015

Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania

scientific article published on 01 December 2020

Mono- and dithiol glutaredoxins in the trypanothione-based redox metabolism of pathogenic trypanosomes.

scientific article published on 25 October 2012

New heterobimetallic ferrocenyl derivatives are promising antitrypanosomal agents

scientific article published on 03 May 2019

New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents.

scientific article published on 2 December 2011

New red-shifted fluorescent biosensor for monitoring intracellular redox changes

scientific article published on 05 February 2019

Novel ruthenium(II) cyclopentadienyl thiosemicarbazone compounds with antiproliferative activity on pathogenic trypanosomatid parasites.

scientific article published on 30 June 2015

Ornithine decarboxylase or gamma-glutamylcysteine synthetase overexpression protects Leishmania (Vianna) guyanensis against antimony.

scientific article published on 3 February 2017

Oxidovanadium(IV) and dioxidovanadium(V) complexes of tridentate salicylaldehyde semicarbazones: searching for prospective antitrypanosomal agents

scientific article

Polyamine-Based Thiols in Trypanosomatids: Evolution, Protein Structural Adaptations, and Biological Functions.

scientific article

Preparative enzymatic synthesis of trypanothione and trypanothione analogues.

scientific article published on 25 May 2009

Production of Recombinant Trypanosoma cruzi Antigens in Leishmania tarentolae

scientific article published on 01 January 2019

Pt-Fe ferrocenyl compounds with hydroxyquinoline ligands show selective cytotoxicity on highly proliferative cells

scientific article published on 16 July 2019

Selenoproteins of African trypanosomes are dispensable for parasite survival in a mammalian host.

scientific article published on 11 March 2016

Synthesis of bicyclic 1,4-thiazepines as novel anti-Trypanosoma brucei brucei agents

scientific article published on 11 June 2019

The Thiol-polyamine Metabolism of Trypanosoma cruzi: Molecular Targets and Drug Repurposing Strategies

scientific article published on 01 January 2019

The lineage-specific, intrinsically disordered N-terminal extension of monothiol glutaredoxin 1 from trypanosomes contains a regulatory region

scientific article published in Scientific Reports

Trypanothione synthesis in crithidia revisited.

scientific article

Trypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi

article

Trypanothione: A unique bis-glutathionyl derivative in trypanosomatids ⬇️

scientific article published on 08 February 2013

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