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List of works by David G.I. Kingston

A Common Pharmacophore for Taxol and the Epothilones Based on the Biological Activity of a Taxane Molecule Lacking a C-13 Side Chain†

scientific article published on 01 April 2000

A DNA-damaging sesquiterpene and other constituents from Frullania nisquallensis

scientific article

A Synthetic Butenolide Diterpene is now a Natural Product Isolated from Metaporana sericosepala, a Plant from the Madagascar Dry Forest

scientific article

A fluorescence-based high-throughput assay for antimicrotubule drugs

scientific article

A natural love of natural products

scientific article

A new acylated oleanane triterpenoid from Couepia polyandra that inhibits the lyase activity of DNA polymerase beta

scientific article

A new bioactive diterpene glycoside from Molinaea retusa from the Madagascar dry forest

scientific article

A new labdane diterpene from Vitex cauliflora Moldenke from the Madagascar rainforest. ⬇️

scientific article published on 25 July 2009

A new triterpene saponin from Pittosporum viridiflorum from the Madagascar rainforest

scientific article published on January 2002

A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase beta lyase

scientific article

A novel cytotoxic guttiferone analogue from Garcinia macrophylla from the Suriname rainforest

scientific article

Acetals of three new cycloartane-type saponins from Egyptian collections of Astragalus tomentosus.

scientific article

Acetylated DNA-damaging clerodane diterpenes from Casearia sylvestris1Part 3 in the series “Search for bioactive compounds from Brazilian plant species”. For part 2 see [2]. Based on the M.Sc. thesis submitted by P.R.F. de C. to Universidade Esta

article

Alkaloids and aromatics of Cyathobasis fruticulosa (Bunge) Aellen

scientific article published in June 2005

An antiproliferative xanthone of Symphonia pauciflora from the Madagascar rainforest.

scientific article

An endogenous bile acid and dietary sucrose from skin secretions of alkaloid-sequestering poison frogs

scientific article published on 30 January 2012

Anibamine and Its Analogues: Potent Antiplasmodial Agents from Aniba citrifolia

scientific article published on 02 October 2019

Antimalarial 5,6-Dihydro-α-pyrones from Cryptocarya rigidifolia: Related Bicyclic Tetrahydro-α-Pyrones Are Artifacts1.

scientific article published on 4 June 2015

Antimalarial Use of Malagasy Plants is Poorly Correlated with Performance in Antimalarial Bioassays

scientific article published on 31 March 2017

Antimalarial activity of the isolates from the marine sponge Hyrtios erectus against the chloroquine-resistant Dd2 strain of Plasmodium falciparum

scientific article published on 01 September 2018

Antiplasmodial Chromanes and Chromenes from the Monotypic Plant Species Koeberlinia spinosa.

scientific article published on 19 October 2017

Antiplasmodial Diterpenoids and a Benzotropolone from Petradoria pumila

scientific article published on 08 May 2018

Antiplasmodial Isoflavanes and Pterocarpans from Apoplanesia paniculata

scientific article

Antiplasmodial Sesquiterpenoid Lactones from Trichospira verticillata: Structure Elucidation by Spectroscopic Methods and Comparison of Experimental and Calculated ECD Data.

scientific article

Antiplasmodial activity of compounds from Sloanea rhodantha (Baker) Capuron var. rhodantha from the Madagascar rain forest.

scientific article published on 7 November 2006

Antiplasmodial alkaloids from bulbs of Amaryllis belladonna Steud.

scientific article published on 11 November 2017

Antiplasmodial and antiproliferative pseudoguaianolides of Athroisma proteiforme from the Madagascar Dry Forest. ⬇️

scientific article

Antiplasmodial flavanones and a stilbene from Carpha glomerata

scientific article published on 04 September 2018

Antiplasmodial phloroglucinol derivatives from Syncarpia glomulifera

scientific article published on 9 April 2016

Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest

scientific article published on 19 June 2015

Antiproliferative Compounds from Ocotea macrocarpa from the Madagascar Dry Forest(1).

scientific article published on June 2015

Antiproliferative Constituents of the Roots of Ethiopian Podocarpus falcatus and Structure Revision of 2α-Hydroxynagilactone F and Nagilactone I.

scientific article

Antiproliferative Diterpenes from a Malleastrum sp. from the Madagascar dry forest

scientific article

Antiproliferative Homoisoflavonoids and Bufatrienolides from Urginea depressa ⬇️

scientific article published on 09 May 2013

Antiproliferative Trihydroxyalkylcyclohexenones from Pleiogynium timoriense. ⬇️

scientific article published in July 2015

Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest

scientific article published on 8 January 2016

Antiproliferative acetogenins from a Uvaria sp. from the Madagascar dry forest ⬇️

scientific article published on 2 December 2011

Antiproliferative and antimalarial anthraquinones of Scutia myrtina from the Madagascar forest. ⬇️

scientific article published on 20 February 2009

Antiproliferative and antiplasmodial compounds from selected Streptomyces species ⬇️

scientific article

Antiproliferative and antiplasmodial dimeric phloroglucinols from Mallotus oppositifolius from the Madagascar Dry Forest (1) ⬇️

scientific article

Antiproliferative bistramides from Trididemnum cyclops from Madagascar (1). ⬇️

scientific article

Antiproliferative cardenolide glycosides of Elaeodendron alluaudianum from the Madagascar Rainforest.

scientific article

Antiproliferative cardenolides from Pentopetia androsaemifolia Decne. from the Madagascar rain forest ⬇️

scientific article published on March 1, 2010

Antiproliferative cardenolides of an Elaeodendron sp. from the Madagascar rain forest(1) ⬇️

scientific article published on 5 June 2007

Antiproliferative cassane diterpenoids of Cordyla madagascariensis ssp. madagascariensis from the Madagascar rainforest ⬇️

scientific article published on 29 December 2007

Antiproliferative compounds from Pongamiopsis pervilleana from the Madagascar Dry Forest ⬇️

scientific article

Antiproliferative compounds of Artabotrys madagascariensis from the Madagascar rainforest.

scientific article published on January 2008

Antiproliferative compounds of Cyphostemma greveana from a Madagascar dry forest ⬇️

scientific article

Antiproliferative compounds of Helmiopsis sphaerocarpa from the Madagascar rainforest.

scientific article

Antiproliferative homoscalarane sesterterpenes from two Madagascan sponges

scientific article published on 6 April 2013

Antiproliferative limonoids of a Malleastrum sp. from the Madagascar rainforest. ⬇️

scientific article

Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest ⬇️

scientific article published on 28 February 2007

Antiproliferative triterpenoid saponins of Dodonaea viscosa from the Madagascar dry forest ⬇️

scientific article

Antiproliferative xanthones of Terminalia calcicola from the Madagascar rain forest ⬇️

scientific article published on 27 February 2007

Aphadilactones A-D, four diterpenoid dimers with DGAT inhibitory and antimalarial activities from a Meliaceae plant.

scientific article published on 23 December 2013

Astrotricoumarin, an antiproliferative 4'-hydroxy-2',3'-dihydroprenylated methylcoumarin from an Astrotrichilia sp. from the Madagascar dry forest.

scientific article

Bioactive Compounds fromCombretum erythrophyllum

scientific article published on 01 July 2000

Bioactive Neolignans and Other Compounds from Magnolia grandiflora L.: Isolation and Antiplasmodial Activity

scientific article published on 16 June 2017

Bioactive and other piperidine alkaloids from Cassia leptophylla

Bioactive and other sesquiterpenes from Chiloscyphus rivularis.

scientific article published in December 1997

Bioactive compounds from Stuhlmannia moavi from the Madagascar dry forest ⬇️

scientific article

Bioactive iridoids and a new lignan from Allamanda cathartica and Himatanthus fallax from the Suriname rainforest.

scientific article published in December 1997

Bioactive isomalabaricane triterpenoids from Rhabdastrella globostellata that stabilize the binding of DNA polymerase beta to DNA. ⬇️

scientific article

Bioactive oleanane glycosides from Polyscias duplicata from the Madagascar dry forest

scientific article published on April 2015

Bioactive saponins from Acacia tenuifolia from the suriname rainforest

scientific article

Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.

scientific article

Biodiversity conservation and drug discovery: Can they be combined? The Suriname and Madagascar experiences

scientific article

Bridging converts a noncytotoxic nor-paclitaxel derivative to a cytotoxic analogue by constraining it to the T-Taxol conformation

scientific article published on August 2006

Brominated sesquiterpenes from the red alga Laurencia obtusa.

scientific article

C6-C8 bridged epothilones: consequences of installing a conformational lock at the edge of the macrocycle.

scientific article published on 30 November 2011

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

Cardenolides of Leptadenia madagascariensis from the Madagascar dry forest. ⬇️

scientific article

Conformationally Constrained and Nanoparticle Targeted Paclitaxels

scientific article

Correction to Antiproliferative Trihydroxyalkylcyclohexenones from Pleiogynium timoriense.

scientific article published on 2 February 2016

Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research

scientific article published on 23 November 2018

Corrigendum to "Antiplasmodial phloroglucinol derivatives from Syncarpia glomulifera" [Bioorg. Med. Chem. 24 (2016) 2544-2548].

scientific article published on 9 March 2017

Cytotoxic and DNA damaging activity of some aporphine alkaloids from Stephania dinklagei.

scientific article published in September 2003

Cytotoxic and other compounds from Didymochlaena truncatula from the Madagascar rain forest ⬇️

scientific article published on February 2006

Cytotoxic cardenolide glycosides of Roupellina (Strophanthus) boivinii from the Madagascar rainforest. ⬇️

scientific article published on 8 November 2007

Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar ⬇️

scientific article published on February 2007

Cytotoxic compounds from Mundulea chapelieri from the Madagascar Rainforest.

scientific article published on March 2004

Cytotoxic compounds of Physena madagascariensis from the Madagascar rain forest paragraph sign

scientific article published on November 2006

Cytotoxic compounds of Schizolaena hystrix from the Madagascar rainforest

scientific article published on 10 August 2006

Cytotoxic diterpenes from Cassipourea madagascariensis from the Madagascar rainforest. ⬇️

scientific article published on February 2006

Cytotoxic diterpenoids from Podocarpus madagascariensis from the Madagascar rainforest

scientific article published on May 2006

Cytotoxic diterpenoids from two lianas from the Suriname rainforest

scientific article

Cytotoxic flavanones of Schizolaena hystrix from the Madagascar rainforest

scientific article

Cytotoxic sesquiterpene lactones from Vernonia pachyclada from the Madagascar rainforest ⬇️

scientific article published on September 2005

Cytotoxic triterpenoid saponins of Albizia gummifera from the Madagascar rain forest ⬇️

scientific article published on 31 January 2007

Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest.

scientific article published on June 2004

Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forest. ⬇️

scientific article

DNA damaging activities of methanol extract of Ajuga postii and iridoid glucoside reptoside.

scientific article published in July 2005

DNA damaging steroidal alkaloids from eclipta alba from the suriname rain forest ⬇️

scientific article

DNA-damaging steroidal alkaloids from Eclipta alba from the suriname rainforest1.

scientific article

Design and synthesis of C6-C8 bridged epothilone A.

scientific article published on 21 March 2008

Design and synthesis of a combinatorial chemistry library of 7-acyl, 10-acyl, and 7,10-diacyl analogues of paclitaxel (taxol) using solid phase synthesis

scientific article

Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation

scientific article

Design, synthesis and biological evaluation of a simplified fluorescently labeled discodermolide as a molecular probe to study the binding of discodermolide to tubulin.

scientific article

Design, synthesis and biological evaluation of bridged epothilone D analogues

scientific article

Design, synthesis, and bioactivities of steroid-linked taxol analogues as potential targeted drugs for prostate and breast cancer.

scientific article published on February 2004

Design, synthesis, and bioactivity of simplified paclitaxel analogs based on the T-Taxol bioactive conformation

scientific article published on 24 January 2006

Differential Effects of Paclitaxel (Taxol) Analogs Modified at Positions C-2, C-7, and C-3' on Tubulin Polymerization and Polymer Stabilization: Identification of a Hyperactive Paclitaxel Derivative

article

Dissecting paclitaxel-microtubule association: quantitative assessment of the 2'-OH group

scientific article published on 19 March 2013

Enhanced microtubule binding and tubulin assembly properties of conformationally constrained paclitaxel derivatives

scientific article published on 25 September 2007

Equilibrium Studies of a Fluorescent Paclitaxel Derivative Binding to Microtubules†

scientific article published on 01 January 2000

Euphane triterpenoids of Cassipourea lanceolata from the Madagascar rainforest

scientific article

Evaluation of the tubulin-bound paclitaxel conformation: synthesis, biology, and SAR studies of C-4 to C-3' bridged paclitaxel analogues

scientific article published on 31 January 2007

Exposing the tumor microenvironment: how gold nanoparticles enhance and refine drug delivery

scientific article published in June 2017

Facile AB ring cleavage reactions of taxoids

Flavanones from the Twigs and Barks of Artocarpus lakoocha Having Antiplasmodial and Anti-TB Activities

scientific article published on 01 January 2020

Four diphenylpropanes and a cycloheptadibenzofuran from Bussea sakalava from the Madagascar dry forest ⬇️

scientific article

Four diterpenoid inhibitors of Cdc25B phosphatase from a marine anemone

scientific article published on October 2005

Furoquinoline Alkaloids and Methoxyflavones from the Stem Bark of Melicope madagascariensis (Baker) T.G. Hartley

scientific article published on 21 September 2016

Furoquinoline alkaloids of Ertela (Monnieria) trifolia (L.) Kuntze from the Suriname rainforest ⬇️

scientific article

Galtonosides A-E: Antiproliferative and Antiplasmodial Cholestane Glycosides from Galtonia regalis

scientific article published on 31 March 2020

Genotoxicity and carcinogenicity in rats and mice of 2-amino-3,6-dihydro-3-methyl-7H-imidazolo[4,5-f]quinolin-7- one: an intestinal bacterial metabolite of 2-amino-3-methyl-3H-imidazo[4,5-f]quinoline.

scientific article published in January 1994

Guttiferones K and L, antiproliferative compounds of Rheedia calcicola from the Madagascar rain forest ⬇️

scientific article published on 10 March 2007

Halenaquinone and xestoquinone derivatives, inhibitors of Cdc25B phosphatase from a Xestospongia sp.

scientific article published on February 2005

Highly hydroxylated triterpenes from Salvia kronenburgii

scientific article published on January 2004

Identification of the structural region of taxol that may be responsible for cytokine gene induction and cytotoxicity in human ovarian cancer cells.

scientific article

Interaction of a Fluorescent Derivative of Paclitaxel (Taxol)1with Microtubules and Tubulin−Colchicine†

scientific article published on 01 November 1996

Ipomoeassin F, a new cytotoxic macrocyclic glycoresin from the leaves of Ipomoea squamosa from the Suriname rainforest ⬇️

scientific article

Ipomoeassins A-E, cytotoxic macrocyclic glycoresins from the leaves of Ipomoea squamosa from the Suriname rainforest.

scientific article

Isolation and absolute configuration of ent-Halimane diterpenoids from Hymenaea courbaril from the Suriname rain forest

scientific article

Isolation and characterization of antiplasmodial constituents from the marine sponge Coscinoderma sp

scientific article published on 01 November 2019

Isolation and synthesis of antiproliferative eupolauridine alkaloids of Ambavia gerrardii from the Madagascar Dry Forest. ⬇️

scientific article

Isolation and synthesis of two antiproliferative calamenene-type sesquiterpenoids from Sterculia tavia from the Madagascar rain forest. ⬇️

scientific article

Isolation of antiplasmodial anthraquinones from Kniphofia ensifolia, and synthesis and structure-activity relationships of related compounds ⬇️

scientific article

Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.

scientific article published on January 1994

Isolation of the New Antiplasmodial Butanolide Malleastrumolide A from a Malleastrum sp. (Meliaceae) from Madagascar

scientific article

Isolation, structure elucidation, and synthesis of antiplasmodial quinolones from Crinum firmifolium

scientific article

Isolation, synthesis, and structure-activity relationships of bioactive benzoquinones from Miconia lepidota from the Suriname rainforest.

scientific article

Kahiricosides II-V, cycloartane glycosides from an Egyptian collection of Astragalus kahiricus.

scientific article

Limonoids showing selective toxicity to DNA repair-deficient yeast and other constituents of Trichilia emetica.

scientific article published in February 1998

Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta

scientific article

Mechanism-based antitumor screening of Caribbean marine organisms: isolation and structure determination of novel diterpenoids from the gorgonian Eunicea tourneforti.

scientific article published in August 1995

Modern natural products drug discovery and its relevance to biodiversity conservation

scientific article

Mother nature's combinatorial libraries; their influence on the synthesis of drugs.

scientific article

Nanomolar Antimalarial Agents against Chloroquine-Resistant Plasmodium falciparum from Medicinal Plants and Their Structure-Activity Relationships.

scientific article

Neolignans and other metabolites from Ocotea cymosa from the Madagascar rain forest and their biological activities. ⬇️

scientific article published on 4 February 2015

New Antiplasmodial Diterpenes from Gutierrezia sarothrae

scientific article published on June 2016

New Cytotoxic Indole Alkaloids from Tabernaemontana calcarea from the Madagascar Rainforest ⬇️

scientific article published on April 1, 2003

New cytotoxic alkaloids from the wood of Vepris punctata from the Madagascar rainforest

scientific article published on April 2003

New cytotoxic alkyl phloroglucinols from Protorhus thouvenotii

scientific article published on July 2004

New cytotoxic bis 5-alkylresorcinol derivatives from the leaves of Oncostemon bojerianum from the Madagascar rainforest

scientific article published on November 2002

New cytotoxic coumarins and prenylated benzophenone derivatives from the bark of Ochrocarpos punctatus from the Madagascar rainforest

scientific article published on July 2002

New cytotoxic lupane triterpenoids from the twigs of Coussarea paniculata.

scientific article published in March 2003

New cytotoxic oleanane saponins from the infructescences of Polyscias amplifolia from the Madagascar rainforest

scientific article published on May 2003

New cytotoxic terpenoids from the wood of Vepris punctata from the Madagascar Rainforest

scientific article published on May 2004

New cytotoxic triterpene acids from aboveground parts of Manihot esculenta from the Suriname rainforest.

scientific article

New drug discovery from natural products. Foreword

scientific article published on 01 March 2010

New eudesmane derivatives from Melampodium camphoratum from the Suriname rainforest

scientific article

New lupane triterpenoids from Solidago canadensis that inhibit the lyase activity of DNA polymerase beta.

scientific article published on December 2004

New neolignans that inhibit DNA polymerase beta lyase.

scientific article

New potently bioactive alkaloids from Crinum erubescens

scientific article published on 30 August 2016

Nitrogen-containing dimeric nor-multiflorane triterpene from a Turraea sp.

scientific article

Norcucurbitacin gentiobiosides from Fevillea trilobata.

scientific article published in November 1994

Novel Dual-Action Targeted Nanomedicine in Mice With Metastatic Thyroid Cancer and Pancreatic Neuroendocrine Tumors.

scientific article published on 22 February 2018

Novel epothilone lactones by an unusual diversion of the Grubbs' metathesis reaction.

scientific article published on 9 February 2010

Phloroglucinols from the Roots of Garcinia dauphinensis and Their Antiproliferative and Antiplasmodial Activities

article

Promotion of tubulin assembly by poorly soluble taxol analogs

scientific article published on 30 October 2006

Rotational-echo double-resonance NMR distance measurements for the tubulin-bound Paclitaxel conformation

scientific article

Saponins and a lignan derivative of Terminalia tropophylla from the Madagascar Dry Forest. ⬇️

scientific article

Sesterterpenoids and an alkaloid from a Thorectandra sp. as inhibitors of the phosphatase Cdc25B.

scientific article

Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking

scientific article published on 2 March 2015

Special Issue in Honor of Professor Susan Band Horwitz.

scientific article published in March 2018

Structure Reassignment of Cryptorigidifoliols E and K.

scientific article

Structure and stereochemistry of new cytotoxic clerodane diterpenoids from the bark of Casearia lucida from the Madagascar rainforest.

scientific article published on February 2002

Structure elucidation of antiproliferative bisbenzylisoquinoline alkaloids from Anisocycla grandidieri from the Madagascar dry forest.

scientific article published on 10 June 2013

Studies on di- and triterpenoids from Salvia staminea with cytotoxic activity

scientific article

Survivin is not induced by novel taxanes

scientific article

Syntheses and bioactivities of macrocyclic paclitaxel bis-lactones

scientific article

Synthesis and Antimalarial Activity of Mallatojaponin C and Related Compounds

scientific article published on 26 May 2016

Synthesis and Biological Evaluation of 1-Deoxypaclitaxel Analogues

scientific article published on 01 March 1999

Synthesis and Evaluation of Doxorubicin-Loaded Gold Nanoparticles for Tumor-Targeted Drug Delivery.

scientific article published on 20 December 2017

Synthesis and Evaluation of Paclitaxel-Loaded Gold Nanoparticles for Tumor-Targeted Drug Delivery

scientific article published on 30 September 2016

Synthesis and bioactivity of a side chain bridged paclitaxel: A test of the T-Taxol conformation.

scientific article published on 21 March 2009

Synthesis and biological evaluation of C-3'NH/C-10 and C-2/C-10 modified paclitaxel analogues.

scientific article

Synthesis and biological evaluation of N-(arylsulfanyl)carbonyl analogues of paclitaxel (taxol).

scientific article published on April 2006

Synthesis and biological evaluation of amide-linked A-norpaclitaxels

Synthesis and structure-activity relationships of cytotoxic 7-hydroxy sterols.

scientific article published in May 1994

Synthesis of furanonaphthoquinones with hydroxyamino side chains.

scientific article published in July 1999

Synthesis of isotopically labeled epothilones

scientific article published on 05 December 2013

Tambouranolide, a new cytotoxic hydroxybutanolide from a Tambourissa sp. (Monimiaceae).

scientific article published on January 2007

Taxoids: cancer-fighting compounds from nature

scientific article published on March 2007

The bioactive Taxol conformation on beta-tubulin: experimental evidence from highly active constrained analogs.

scholarly article

The chemistry of taxol ⬇️

scientific article published on October 1, 1991

The quest for a simple bioactive analog of paclitaxel as a potential anticancer agent

scientific article

The search for novel drug leads for predominately antitumor therapies by utilizing mother nature's pharmacophoric libraries.

scientific article

The shape of things to come: structural and synthetic studies of taxol and related compounds

scientific article

The taxol pharmacophore and the T-taxol bridging principle.

scientific article

The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research

article by James B. McAlpine et al published 13 July 2018 in Natural Product Reports

Three new ellagic acid derivatives from the bark of Eschweilera coriacea from the Suriname rainforest.

scientific article

Tubulin-interactive natural products as anticancer agents

scientific article

Two New Alkaloids of the Crinane Series from Pancratium sickenbergeri

scientific article published on 01 April 2002

Two antiproliferative saponins of Tarenna grevei from the Madagascar dry forest [1].

scientific article

Two antiproliferative triterpene saponins from Nematostylis anthophylla from the highlands of Central Madagascar.

scientific article published on February 2013

Two new cytotoxic naphthoquinones from Mendoncia cowanii from the rainforest of Madagascar

scientific article

Two new isoflavone derivatives from the roots of an Egyptian collection of Lotus polyphyllos

scientific article published on August 2006

Two new triterpene esters from the twigs of Brachylaena ramiflora from the Madagascar rainforest

scientific article published on August 2002

What makes epothilones stick?

scientific article

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