List of works - James M Holaska

A cytosolic activity distinct from crm1 mediates nuclear export of protein kinase inhibitor in permeabilized cells.

scientific article

An emerin "proteome": purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture.

scientific article

Ca2+-dependent nuclear export mediated by calreticulin

scientific article

DNA binding domains in diverse nuclear receptors function as nuclear export signals.

scientific article

Diseases of the Nucleoskeleton.

scientific article

Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice.

scientific article

Disruption of the lamin A and matrin-3 interaction by myopathic LMNA mutations

scientific article published on 6 May 2015

EDMD-Causing Emerin Mutant Myogenic Progenitors Exhibit Impaired Differentiation Using Similar Mechanisms

scientific article published on 15 June 2020

Emerin and histone deacetylase 3 (HDAC3) cooperatively regulate expression and nuclear positions of MyoD, Myf5, and Pax7 genes during myogenesis.

scientific article published on 24 September 2013

Emerin and the nuclear lamina in muscle and cardiac disease.

scientific article published on July 2008

Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery-Dreifuss muscular dystrophy

scientific article

Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane

scientific article

Emerin in health and disease

scientific article

Emerin inhibits Lmo7 binding to the Pax3 and MyoD promoters and expression of myoblast proliferation genes.

scientific article published on 26 April 2011

Emerin interacts in vitro with the splicing-associated factor, YT521-B

scientific article (publication date: June 2003)

Expression Profiling of Differentiating Emerin-Null Myogenic Progenitor Identifies Molecular Pathways Implicated in Their Impaired Differentiation.

scientific article published on 22 October 2017

Histone acetyltransferase inhibition rescues differentiation of emerin-deficient myogenic progenitors

scientific article published on 18 April 2020

Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export.

scientific article

LMO7-null mice exhibit phenotypes consistent with emery-dreifuss muscular dystrophy.

scientific article

Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes

scientific article

Loss of emerin alters myogenic signaling and miRNA expression in mouse myogenic progenitors

scientific article

MAPK signaling pathways and HDAC3 activity are disrupted during differentiation of emerin-null myogenic progenitor cells

scientific article

Nuclear membrane protein emerin: roles in gene regulation, actin dynamics and human disease.

scientific article

The Molecular Basis and Biologic Significance of the β-Dystroglycan-Emerin Interaction

scientific article published on 19 August 2020

The Nuclear Envelope Protein Emerin Binds Directly to Histone Deacetylase 3 (HDAC3) and Activates HDAC3 Activity ⬇️

scientific article published on May 8, 2012

The nuclear envelope, lamins and nuclear assembly.

scientific article

The use of permeabilized cell systems to study nuclear transport

scientific article

List of works by James M Holaska

A cytosolic activity distinct from crm1 mediates nuclear export of protein kinase inhibitor in permeabilized cells.

An emerin "proteome": purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture.

Ca2+-dependent nuclear export mediated by calreticulin

DNA binding domains in diverse nuclear receptors function as nuclear export signals.

Diseases of the Nucleoskeleton.

Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice.

Disruption of the lamin A and matrin-3 interaction by myopathic LMNA mutations

EDMD-Causing Emerin Mutant Myogenic Progenitors Exhibit Impaired Differentiation Using Similar Mechanisms

Emerin and histone deacetylase 3 (HDAC3) cooperatively regulate expression and nuclear positions of MyoD, Myf5, and Pax7 genes during myogenesis.

Emerin and the nuclear lamina in muscle and cardiac disease.

Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery-Dreifuss muscular dystrophy

Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane

Emerin in health and disease

Emerin inhibits Lmo7 binding to the Pax3 and MyoD promoters and expression of myoblast proliferation genes.

Emerin interacts in vitro with the splicing-associated factor, YT521-B

Expression Profiling of Differentiating Emerin-Null Myogenic Progenitor Identifies Molecular Pathways Implicated in Their Impaired Differentiation.

Histone acetyltransferase inhibition rescues differentiation of emerin-deficient myogenic progenitors

Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export.

LMO7-null mice exhibit phenotypes consistent with emery-dreifuss muscular dystrophy.

Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes

Loss of emerin alters myogenic signaling and miRNA expression in mouse myogenic progenitors

MAPK signaling pathways and HDAC3 activity are disrupted during differentiation of emerin-null myogenic progenitor cells

Nuclear membrane protein emerin: roles in gene regulation, actin dynamics and human disease.

The Molecular Basis and Biologic Significance of the β-Dystroglycan-Emerin Interaction

The Nuclear Envelope Protein Emerin Binds Directly to Histone Deacetylase 3 (HDAC3) and Activates HDAC3 Activity ⬇️

The nuclear envelope, lamins and nuclear assembly.

The use of permeabilized cell systems to study nuclear transport